Front Immunol July 2019 PMID 29892288

A Positive Feedback Amplifier Circuit That Regulates Interferon (IFN)-Stimulated Gene Expression and Controls Type I and Type II IFN Responses.

Agata Michalska, Katarzyna Blaszczyk, Joanna Wesoly, Hans A R Bluyssen

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Mentions

Peak: 5 in Feb 2022

across 2 sources since Nov 2020

Extended reach

6,175

potential audience

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506

Mentions per month

Nov 2020 – Sep 2022

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X / Twitter9 posts
YouTube2 videos

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What people are saying

The overall sentiment features modest engagement and interest, exemplified by mentions of publications reaching citation milestones and references to related topics like COVID-19, but little detailed discussion of the molecular mechanisms, which keeps the perceived impact neutral. The tone and content suggest casual sharing rather than deep scientific debate.

AgreementNeither agree nor disagree

The posts show a neutral stance, with only one mentioning a positive outcome related to citations, while others do not directly comment on the article’s content.

InterestModerate interest

Some posts express curiosity or mention related topics like COVID-19 and genetic susceptibility, indicating moderate interest.

EngagementModerate engagement

The discussions include retweets, brief mentions, and a suggestion to review the article, indicating a superficial level of interaction.

ImpactNeutral impact

The posts do not suggest significant influence on broader scientific or public health discussions, reflecting a moderate or negligible expected impact.

Abstract in brief

The article discusses how interferons (IFN-I and IFN-II) activate gene expression via specific molecules like STAT1, STAT2, IRF9, and IRF1, which regulate immune responses.
It introduces the concept of a complex feedback amplifier circuit inside cells that involves both phosphorylated and unphosphorylated forms of these molecules, helping to sustain and control long-term gene activation in response to interferons.
This intracellular amplifier, made up of different molecular complexes, is important for regulating how cells respond over time to interferons, although the exact steps and mechanisms are still being researched.]

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All mentions

Genetic Factors Contributing to Severe COVID-19 Outcomes

A genome wide association study identifies gene variants like OAS3, DPP9, TYK2, and IFNAR2 linked to severe COVID symptoms, highlighting their role in interferon immune response and disease severity.

The Cynical Philosopher · Dec 13, 2020 495 views

Genetic Variants Linked to Severe COVID-19 Risk Explained

A genomewide association study identifies gene variants, including OAS3, DPP9, TYK2, and IFNAR2, that are overrepresented in severe COVID-19 cases. The video explains how these genes are involved in the interferon…

HEALTH-HEALTH: 245k views : 3hours ago... · Sep 20, 2022 11 views

EDS Expert Patient

@expertpatientuk · X

@Primary_Immune https://t.co/mAittGRBT3

Aug 20, 2022 · 167 followers View post →

Polonium Foundation

@polonium_org · X

RT @AgataSekrecka: Woo… my first publication reached 100 citation

Feb 6, 2022 · 4 shares · 2,370 followers View post →

Saravanan

@biosaran2004 · X

RT @AgataSekrecka: Woo… my first publication reached 100 citation

Feb 5, 2022 · 4 shares · 196 followers View post →

Jan Brezovsky

@JanBrezovsky1 · X

RT @AgataSekrecka: Woo… my first publication reached 100 citation

Feb 5, 2022 · 4 shares · 514 followers View post →

Ashraf Saad, bridging Glycobiology and Oncology!

@AsAshraf123321 · X

RT @AgataSekrecka: Woo… my first publication reached 100 citation

Feb 5, 2022 · 4 shares · 1,644 followers View post →

Agata Sekrecka

@AgataSekrecka · X

Woo… my first publication reached 100 citation

Feb 4, 2022 · 22 likes · 4 shares · 153 followers View post →

Mσɳιƙα Aɯιȥҽɳ

@monika137131 · X

RT @monika137131: COVID 19 | Genetic Susceptibility #COVID19 #CovidVaccine https://t.co/ifoKgasqGy via @YouTube

Dec 17, 2020 · 1 share · 276 followers View post →

Mσɳιƙα Aɯιȥҽɳ

@monika137131 · X

COVID 19 | Genetic Susceptibility #COVID19 #CovidVaccine https://t.co/ifoKgasqGy via @YouTube

Dec 17, 2020 · 1 like · 1 share · 276 followers View post →

Janet Alderton

@janet_alderton · X

@YoDoctorYo @Cov19longtail Don't know if this review of positive feedback and Interferon gamma might be helpful: https://t.co/Ap8zpO4AwR

Nov 2, 2020 · 30 followers View post →

A Positive Feedback Amplifier Circuit That Regulates Interferon (IFN)-Stimulated Gene Expression and Controls Type I and Type II IFN Responses.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Genetic Factors Contributing to Severe COVID-19 Outcomes

Genetic Variants Linked to Severe COVID-19 Risk Explained