PubHawk
PLoS Biol June 2018 PMID 29927970

CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system-New mode of action for caffeine.

Niloofar Ale-Agha, Christine Goy, Philipp Jakobs, Ioakim Spyridopoulos, Stefanie Gonnissen, Nadine Dyballa-Rukes, Karin Aufenvenne, Florian von Ameln, Mark Zurek, Tim Spannbrucker, Olaf Eckermann, Sascha Jakob, Simone Gorressen, Marcel Abrams, Maria Grandoch

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Mentions

25
Peak: 4 in Feb 2019
across 2 sources since Jul 2018

Extended reach

372,941
potential audience

Total likes

10,970

Video views

207,420

Mentions per month

Jul 2018 – Sep 2024

Where it's discussed

  • X / Twitter23 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions consistently demonstrate strong agreement and interest, with posts citing studies that show caffeine enhances mitochondrial function and cardioprotection via mitochondrial p27, such as claims that drinking 4 cups of coffee daily can lower heart attack risks. The tone combines scientific references with personal or practical insights, highlighting the perceived clinical importance of these findings.

AgreementStrong agreement

Most posts strongly support the positive effects of caffeine on mitochondrial and cardiac health, emphasizing its protective and regenerative roles.

InterestHigh interest

The discussions reflect high interest by highlighting potential clinical benefits, referencing specific mechanisms involving mitochondrial p27 and cardioprotection.

EngagementHigh engagement

Posts are highly engaged, with many sharing detailed scientific insights, examples of research findings, and personal interpretations about dosage and individual variability.

ImpactHigh impact

The collective tone underscores a belief in the significant impact of this research, suggesting dietary or lifestyle implications such as coffee consumption for heart health.

Abstract in brief

  • CDKN1Bp27, traditionally known as a cell cycle inhibitor, is also located in mitochondria where it enhances mitochondrial functions like membrane potential, ATP production, and supporting cell movement, especially in endothelial cells.
  • Mitochondrial p27 plays a crucial role in protecting heart cells from apoptosis, aiding in cardiac cell differentiation, and its presence is vital for mitochondrial respiration, which decreases with aging and p27 deficiency, but can be temporarily improved with caffeine.
  • Caffeine influences mitochondrial processes by increasing mitochondrial p27 levels, inducing gene changes relevant to mitochondria, reducing heart damage after myocardial infarction, and improving mitochondrial respiration, especially in aged or p27-deficient models.
Read the full abstract

Top posts

Most liked on X and Bluesky
Andrea Branda-Sica
@AndreaBranda8 · X

Tomar 4 tazas de café por día estás protegiendo tu corazón, este estudio lo confirmó

May 16, 2020 · 17 likes · 2 shares · 4,275 followers View post →
KJK
@kjkoch · X

Eric Topol: For coffee lovers: a new mechanism by which caffeine protect the heart https://t.co/MkQ5VlHsxd @PLOSBiology #OA 4 cups, mitochondria, p27 and you're good to go!☕️☕️☕️☕️ ;-) (from mice model) https://t.co/hXlO42cJk0 #medicine https://t.co/RuEVV57xmH

Feb 10, 2019 · 7 likes · 3 shares · 483 followers View post →
Reality Check Marker
@RealCheckMarker · X

Best example to demonstrate how indidual are unique, caffeine (black coffee/tea/medication) positive stimulate mitochondia. Is not universal for all patient, or same benefit at different stage. Caffeine & even Vitamin can act as inhibitor other medication. https://t.co/PPTgx8Llui

Aug 29, 2022 · 5 likes · 5,372 followers View post →
Anna Tchélico
@AnnaCelico · X

@venlafaxina150 Estudos têm mostrado que pessoas que bebem quatro xícaras de café por dia têm um menor risco de morrer de um ataque cardíaco https://t.co/rRrnJoAnQ8

Nov 25, 2021 · 2 likes · 17,438 followers View post →
Anna Tchélico
@AnnaCelico · X

Estudos têm mostrado que pessoas que bebem quatro xícaras de café por dia têm um menor risco de morrer de um ataque cardíaco https://t.co/rRrnJoAnQ8

Nov 25, 2021 · 1 like · 17,438 followers View post →
Name Cannot be Blank
@nara___narayana · X

@Grimhood I've actually read some evidence that points to a mean of around 3 cups per day of coffee being maximally beneficial. Coffee could have benefits to mitochondrial function??? https://t.co/wQ1vpK6egM

Aug 5, 2019 · 1 like · 751 followers View post →

All mentions

Jonathan Watters
@JW_Elev8Wellnes · X

@0xMert_ Considering caffeine improves cardiac function and mitochondrial health of every tissue in the body, from brain, to nerves, to the immune system and critical organ function, removing it presents ZERO benefit for any populations: https://t.co/eh3bXCsIo9

Sep 23, 2024 · 286 followers View post →
Jonathan Watters
@JW_Elev8Wellnes · X

@B_Holmer Well, it improves mitochondrial function in neural and cardiac tissue dramatically: https://t.co/eh3bXCsayB So, although it contains no kcals, it certainly improves cellular capacity to utilize kcals.

May 3, 2024 · 1 like · 286 followers View post →
Jonathan Watters
@JW_Elev8Wellnes · X

@TheAllenYe Well, it improves mitochondrial function in neural and cardiac tissue dramatically: https://t.co/eh3bXCsayB So, although it contains no kcals, it certainly improves cellular capacity to utilize kcals.

May 3, 2024 · 286 followers View post →
mira mcnair
@McnairMira · X

RT @JW_Elev8Wellnes: @BioLayne cardiac cell function improves w coffee: https://t.co/eh3bXCsIo9

Apr 5, 2024 · 1 share · 1,060 followers View post →
Jonathan Watters
@JW_Elev8Wellnes · X

@BioLayne cardiac cell function improves w coffee: https://t.co/eh3bXCsIo9

Apr 4, 2024 · 1 share · 286 followers View post →
Lucidite Love
@LuciditeLove · X

My mitochondria Loves coffee for scientific reasons

Aug 31, 2023 · 1 like · 532 followers View post →
Declan Waugh
@DeclanWaugh · X

@AngryCardio If you are saying that all of the referenced studies in this review (below) are meaningless clinically you need to show us supporting evidence. Caffeine has been shown to enhance PGC1α expression which has been shown to have clinical significance → https://t.co/wUGLaA7dSz

Aug 20, 2023 · 1,360 followers View post →
Declan Waugh
@DeclanWaugh · X

@AngryCardio Caffeine also appears to have a protective influence on mitochondria and improves mitochondria-dependent processes in heart cells and that physiological concentrations of caffeine have a protective effect. https://t.co/wUGLaA7dSz

Aug 20, 2023 · 1,360 followers View post →
Reality Check Marker
@RealCheckMarker · X

Best example to demonstrate how indidual are unique, caffeine (black coffee/tea/medication) positive stimulate mitochondia. Is not universal for all patient, or same benefit at different stage. Caffeine & even Vitamin can act as inhibitor other medication. https://t.co/PPTgx8Llui

Aug 29, 2022 · 5 likes · 5,372 followers View post →
Anna Tchélico
@AnnaCelico · X

Estudos têm mostrado que pessoas que bebem quatro xícaras de café por dia têm um menor risco de morrer de um ataque cardíaco https://t.co/rRrnJoAnQ8

Nov 25, 2021 · 1 like · 17,438 followers View post →
Anna Tchélico
@AnnaCelico · X

@venlafaxina150 Estudos têm mostrado que pessoas que bebem quatro xícaras de café por dia têm um menor risco de morrer de um ataque cardíaco https://t.co/rRrnJoAnQ8

Nov 25, 2021 · 2 likes · 17,438 followers View post →
Carol Evans, MD
@Carol_Evans_MD · X

CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system-N… https://t.co/71UJ2YAr00

Jul 21, 2020 · 4,036 followers View post →
jorge fernandez
@fernandez1869 · X

@ETSshow Caffeine in coffee is cardioprotective (at a dosage of about 4 cups of coffee) via mitochondrial p27. Improves endothelial and myofibroblast functioning and insulin sensitivity. Double expresso before run :) https://t.co/XJR6QaLqkS

Jul 1, 2020 · 1 like · 132 followers View post →
Graziela Olivieri
@Grace4519 · X

RT @AndreaBranda8: Tomar 4 tazas de café por día estás protegiendo tu corazón, este estudio lo confirmó

May 16, 2020 · 2 shares · 2,899 followers View post →
Miguel Di Bono
@dibonomiguel · X

RT @AndreaBranda8: Tomar 4 tazas de café por día estás protegiendo tu corazón, este estudio lo confirmó

May 16, 2020 · 2 shares · 3,391 followers View post →
Andrea Branda-Sica
@AndreaBranda8 · X

Tomar 4 tazas de café por día estás protegiendo tu corazón, este estudio lo confirmó

May 16, 2020 · 17 likes · 2 shares · 4,275 followers View post →
Ben Locwin
@BenLocwin · X

@DrOz That's even often too little. 4-5 cups per day maximizes the beneficial effects. https://t.co/Uk9ZzoyOdl

Nov 16, 2019 · 757 followers View post →
Name Cannot be Blank
@nara___narayana · X

@Grimhood I've actually read some evidence that points to a mean of around 3 cups per day of coffee being maximally beneficial. Coffee could have benefits to mitochondrial function??? https://t.co/wQ1vpK6egM

Aug 5, 2019 · 1 like · 751 followers View post →
Karen Oshiro
@Oshirokgn · X

RT @kjkoch: Eric Topol: For coffee lovers: a new mechanism by which caffeine protect the heart https://t.co/MkQ5VlHsxd @PLOSBiology #OA 4 c…

Feb 11, 2019 · 3 shares · 60 followers View post →
Edison A. Carrasco
@Kroquemort2 · X

RT @kjkoch: Eric Topol: For coffee lovers: a new mechanism by which caffeine protect the heart https://t.co/MkQ5VlHsxd @PLOSBiology #OA 4 c…

Feb 11, 2019 · 3 shares · 208 followers View post →
PLOS Biology
@PLOSBiology · X

RT @kjkoch: Eric Topol: For coffee lovers: a new mechanism by which caffeine protect the heart https://t.co/MkQ5VlHsxd @PLOSBiology #OA 4 c…

Feb 11, 2019 · 3 shares · 102,764 followers View post →
KJK
@kjkoch · X

Eric Topol: For coffee lovers: a new mechanism by which caffeine protect the heart https://t.co/MkQ5VlHsxd @PLOSBiology #OA 4 cups, mitochondria, p27 and you're good to go!☕️☕️☕️☕️ ;-) (from mice model) https://t.co/hXlO42cJk0 #medicine https://t.co/RuEVV57xmH

Feb 10, 2019 · 7 likes · 3 shares · 483 followers View post →
Joey C
@jc_4180 · X

Ale-Agha et al. showed that caffeine triggers the movement of p27 into mitochondria, promoting protection and repair of heart cells. It is also suggested that mitochondrial p27 is the reason why caffeine can even help after heart attack! #biom4180 https://t.co/Jowvm8Pvul

Jan 17, 2019 · 21 followers View post →