Addict Biol September 2019 PMID 29949228

Abuse liability and therapeutic potential of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7-hydroxymitragynine.

Scott E Hemby, Scot McIntosh, Francisco Leon, Stephen J Cutler, Christopher R McCurdy

Mentions

34
Peak: 5 in Sep 2020
across 6 sources since Jul 2018

Extended reach

19,705
potential audience

Total likes

97

Video views

3,114

Mentions per month

Jul 2018 – Dec 2025

Where it's discussed

  • X / Twitter15 posts
  • News8 articles
  • Facebook5 posts
  • Reddit3 posts
  • YouTube2 videos
  • Blogs1 articles

AI synopsis

What people are saying

Overall, the discussion balances concerns about kratom’s abuse potential—evident in statements like 'kratom can be highly addictive'—with recognition of its therapeutic potential, such as mentions of MG reducing morphine intake. The tone varies from cautionary to informative, with users referencing scientific sources to support their views, demonstrating a moderate level of interest and engagement about the complex effects of kratom.

AgreementModerate agreement

Most discussions agree that kratom contains both addictive and therapeutic elements, with some posts emphasizing its abuse potential and others highlighting its medicinal use.

InterestModerate interest

Participants show moderate interest, citing specific studies and legislative actions, but not deeply analyzing the detailed scientific findings.

EngagementModerate engagement

Engagement is moderate; users quote research statements, share personal experiences, and reference legislative debates, indicating ongoing discussion rather than passive acknowledgment.

ImpactModerate impact

The discourse could influence public perception and policy regarding kratom, as posts address both its risks and benefits, reflecting potential societal impact.

Abstract in brief

  • Kratom, derived from Mitragyna speciosa, contains alkaloids like mitragynine (MG) and 7-hydroxymitragynine (7HMG), which share pain-relief and behavioral effects similar to morphine but differ in their potential for abuse.
  • Research shows that 7HMG can be self-administered by rats, indicating it has reinforcing and addictive properties, partly mediated through opioid receptors, and prior exposure to 7HMG increases the likelihood of subsequent morphine intake.
  • Conversely, MG does not appear to have abuse potential; it reduces morphine consumption, making it a promising candidate for treating opioid dependence, while 7HMG's high abuse risk suggests it could contribute to opiate misuse.

Top posts

Most liked on X and Bluesky
Mac Haddow
@HaddowMac · X

https://t.co/xWEMGafgkD

Sep 12, 2020 · 11 likes · 3 shares · 5,468 followers View post →
Melody
@MelodyHope5 · X

Kansas Legislature looks at Kratom info in Addiction Biology Journal Abuse liability and therapeutic potential of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7-hydroxymitragynine. https://t.co/yjWEkRLiOP https://t.co/kka0NW2uvX

Mar 30, 2023 · 3 likes · 1 share · 1,382 followers View post →
Mary Ann
@Dunkel_MA · X

@LBoucherAuthor @MelodyHope5 Here is another article about kratom aiding in addiction. https://t.co/pQtnJPNsZH

Jun 11, 2019 · 2 likes · 147 followers View post →
The Kratom Sobriety Podcast
@kratomsobriety · X

@MelodyHope5 @TrueBlazersFan Melody, constantly posting science bits out of context doesn't change the fact that kratom can be highly addictive. FACT. https://t.co/W3G601TgYb "7-HMG should be considered a kratom constituent with high abuse potential that may also increase the intake of other opiates.”

Jun 20, 2023 · 1 like · 262 followers View post →
Mary Ann
@Dunkel_MA · X

@KRTV https://t.co/2vm4SmU4Di

May 6, 2020 · 1 like · 147 followers View post →
Mary Ann
@Dunkel_MA · X

@USDTL https://t.co/2vm4SmU4Di

Aug 29, 2019 · 1 like · 147 followers View post →

All mentions

Science Index
@ScienceIndex_ · X

Abuse liability and therapeutic potential of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7-hydroxymitragynine https://t.co/ZPtwh3o1q1 https://t.co/NexISYnblO

Nov 25, 2023 · 1,005 followers View post →
The Kratom Sobriety Podcast
@kratomsobriety · X

@MelodyHope5 @TrueBlazersFan Melody, constantly posting science bits out of context doesn't change the fact that kratom can be highly addictive. FACT. https://t.co/W3G601TgYb "7-HMG should be considered a kratom constituent with high abuse potential that may also increase the intake of other opiates.”

Jun 20, 2023 · 1 like · 262 followers View post →
Plants not pills
@hipieswereright · X

RT @MelodyHope5: Kansas Legislature looks at Kratom info in Addiction Biology Journal Abuse liability and therapeutic potential of the Mi…

Mar 30, 2023 · 1 share · 275 followers View post →
Melody
@MelodyHope5 · X

Kansas Legislature looks at Kratom info in Addiction Biology Journal Abuse liability and therapeutic potential of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7-hydroxymitragynine. https://t.co/yjWEkRLiOP https://t.co/kka0NW2uvX

Mar 30, 2023 · 3 likes · 1 share · 1,382 followers View post →
Gold Star Botanicals LLC
@goldstarkratom · X

@mattamyers @mordecaidesign @jeeves_c I'm sorry your personal experience from improper use made you rude & as biased as I am. "...MG (Mitragyna speciosa) does not have abuse potential and reduces morphine intake, desired characteristics of candidate pharmacotherapies for opiate addiction..." https://t.co/FoBwzdu2zS

Oct 30, 2020 · 425 followers View post →
D. Evans
@HopAlongLefty · X

RT @HaddowMac: https://t.co/xWEMGafgkD

Sep 13, 2020 · 3 shares · 1,107 followers View post →
Wiwid
@Wiwidpoerwito · X

RT @HaddowMac: https://t.co/xWEMGafgkD

Sep 12, 2020 · 3 shares · 833 followers View post →
Kratom Theory
@Botanist_Beauty · X

RT @HaddowMac: https://t.co/xWEMGafgkD

Sep 12, 2020 · 3 shares · 2,131 followers View post →
Laurie Otto
@TabooKittynme · X

RT @HaddowMac: https://t.co/xWEMGafgkD

Sep 12, 2020 · 3 shares · 885 followers View post →
Mac Haddow
@HaddowMac · X

https://t.co/xWEMGafgkD

Sep 12, 2020 · 11 likes · 3 shares · 5,468 followers View post →
Mary Ann
@Dunkel_MA · X

@KRTV https://t.co/2vm4SmU4Di

May 6, 2020 · 1 like · 147 followers View post →
Darlene Gansel
@darling888 · X

RT @skherbalist: “New Science Study at odds with FDA claim that #kratom is a Narcotic Like Opioid” https://t.co/Xh9yAngbO1! Remember that k…

Jan 24, 2020 · 6 shares · 780 followers View post →
Mary Ann
@Dunkel_MA · X

@USDTL https://t.co/2vm4SmU4Di

Aug 29, 2019 · 1 like · 147 followers View post →
Melody
@MelodyHope5 · X

@Dr_Anonymous33 @TDEMomof3 @casekaem @AnitaM86 Abuse liability and therapeutic potential of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7-hydroxymitragynine. https://t.co/EzJW1e3zoe

Aug 17, 2019 · 1,382 followers View post →
Mary Ann
@Dunkel_MA · X

@LBoucherAuthor @MelodyHope5 Here is another article about kratom aiding in addiction. https://t.co/pQtnJPNsZH

Jun 11, 2019 · 2 likes · 147 followers View post →
Test | PDF | Medicine | Opioid
News

Doi: 10.1097/ Doi: 10.1111/ADB.12639. YCO.0000000000000621. 21. Hanapi NA, Chear NJY, Azizi J, et al. 14. Luliana S, Robiyanto R, Islamy MR, Kratom ...

Dec 13, 2025 View →
Kratom PRO
Facebook

doi: 10.1111/adb.12639. [Epub ahead of print], Abuse liability and therapeutic potential of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7 ...

Dec 13, 2025 View →
Nepalese Agriculrue in The Pretext of Climate Change and ...
News

ADB. (2006) Agriculture Development project at Pinder valley. Annual ... doi:10.1111/j.1461-0248.2005.00782.x. Vattala, H., Wratten, S., Phillips, C ...

Dec 13, 2025 View →
Climate Change GEMMES Vietnamese Version | PDF
News

Số quan sát 12,639 12,639 12,639 12,639 12,639 12,639 12,639 12,639. Lưu ý ... ADB, lượng mưa và thay đổi theo mùa do biến đổi độ và thời tiết cực đoan ...

Dec 13, 2025 View →
RMCP Vol. 16 Num. 2 (2025) : April-June (English Version) | PDF ...
News

https://www.adb.org/es/news/asia-infrastructure-needs- exceed-17 ... doi:10.1111/1541-4337.12890. 11. Zimmerman DR, Speer VC, Hays VW, Catron DV ...

Dec 13, 2025 View →
Global Trends & Challenges PDF | PDF | Anaerobic Digestion ...
News

Epub ahead of print; March 5. DOI: 10.1111/1751–7915.12079. Veuillet, F ... • The Asian Development Bank (ADB) has published a. External and internal ...

Dec 13, 2025 View →
Data Scopus2020 | PDF | Toxicology | Pharmacology
News

255 The Impact of F F Hasib, A D B Nurdiansyah, International Journal ... 10.1111/scs.12886 resiliency model to care Yusuf, Rachmat Hargono, Esther ...

Dec 13, 2025 View →
Role of FKBP5 and Its Genetic Mutations in Stress-Induced ...
News

related genes and heroin addiction: a role for a functional FKBP5 haplotype. patients. Bipolar Disord. (2018) 20:753–60. doi: 10.1111/bdi.12639 ... doi: 10.1111/ ...

Dec 13, 2025 View →
Research Kratom | PDF
News

... 10.1111/adb.12639 41. Ahmad, K.; Aziz, Z. Mitragyna speciosa use in the northern states of Malaysia: a cross-sectional study. Journal of Ethnopharmacology ...

Dec 13, 2025 View →
Spatiotemporal Evolution of #Air–#Sea #CO2 Flux in the ...
Facebook

com/EngineEco/posts/pfbid02sYgNVM3DyVBdUwXor jW3VSjW8kRoo81nrKzkVSoT3hW7x6vYYQ2R8YHwhr ZVY15kl #adb #asiandevelopmentbank #adbtransport ...

Dec 12, 2025 View →
Dirty McCurdy's War on 7-OH!Politics Masquerading as Research : r ...
Reddit

... 10.1111/adb.12639. In this paper, they claim that 7-HMG carries the risk of respiratory compromise while mitragynine increases respiration ...

Aug 1, 2025 View →
Role of Terrestrial Ecosystems in Planetary Stewardship
Facebook

... 10.1111/gcb. 12667/abstract 20. Climate change enhances the negative ... Bernacchi, C.J., Leakey, A.D.B., Heady, L.E., Morgan, P. B ...

Nov 26, 2024 View →
Apples vs. Apple Jacks | Psychology Today
Blogs

https://doi.org/10.1111/adb.12639. Huestis, M.A., Brett, M.A., Bothmer, J., Atallah, R.(2024) Human Mitragynine and 7-Hydroxymitragynine ...

Nov 7, 2024 View →
The woman's family is planning to also sue an Oregon-based ...
Facebook

com/doi/abs/10.1111/adb.12639. GIF, description not available, sent by Mary Ann Dunkel. onlinelibrary.wiley.com. 6 yrs. Mary Ann Dunkel.

Apr 30, 2020 View →
From the AKA Facebook page today : r/Kratomm
Reddit

The study can be found at Addiction Biology Kratom Article June 27 2018 https://onlinelibrary.wiley.com/doi/pdf/10.1111/adb.12639. Dr. Jack ...

Jul 4, 2018 View →
From AKA facebook page today. : r/kratom
Reddit

The study can be found at Addiction Biology Kratom Article June 27 2018 https://onlinelibrary.wiley.com/doi/pdf/10.1111/adb.12639. Dr. Jack ...

Jul 3, 2018 View →
The FDA remains committed to addressing the opioid epidemic on ...
Facebook

com/doi/pdf/10.1111/adb.12639. GIF, description not available, sent by Ar Bra Ty. onlinelibrary.wiley.com. 7 yrs. 1. Profile photo of Denise.

Jun 29, 2018 View →