J Am Coll Cardiol July 2018 PMID 29976291

Epinephrine Versus Norepinephrine for Cardiogenic Shock After Acute Myocardial Infarction.

Bruno Levy, Raphael Clere-Jehl, Annick Legras, Tristan Morichau-Beauchant, Marc Leone, Ganster Frederique, Jean-Pierre Quenot, Antoine Kimmoun, Alain Cariou, Johan Lassus, Veli-Pekka Harjola, Ferhat Meziani, Guillaume Louis, Patrick Rossignol, Kevin Duarte

Download social card

Mentions

81
Peak: 17 in Feb 2022
across 5 sources since Jul 2018

Extended reach

362,480
potential audience

Total likes

367

Video views

10,076

Mentions per month

Jul 2018 – Dec 2023

Where it's discussed

  • X / Twitter53 posts
  • Facebook17 posts
  • News4 articles
  • Blogs4 articles
  • YouTube3 videos

AI synopsis

What people are saying

The overall discussions reflect a strong focus on the safety and efficacy of norepinephrine versus epinephrine, as evidenced by comments like 'norepinephrine is probably preferred' and mentions of trials showing its potential superiority. The tone integrates clinical observations and research findings, demonstrating both interest and a recognition of the study's relevance for future treatment standards.

AgreementModerate agreement

Most discussions agree that norepinephrine might be preferable to epinephrine in cardiogenic shock, with some referencing studies and clinical experience supporting that view.

InterestHigh interest

Posts show high interest by referencing multiple trials and discussing the implications of the findings for clinical practice.

EngagementModerate engagement

Participants actively analyze the study's details, mentioning side effects, existing evidence, and practical considerations, indicating moderate engagement.

ImpactModerate impact

The discussions suggest the research could influence treatment decisions, especially as several posts question and compare vasopressor choices, highlighting a potential shift in clinical approaches.

Abstract in brief

  • This study compared the effects of epinephrine and norepinephrine in patients experiencing cardiogenic shock after a heart attack, finding similar impacts on heart function but a higher risk of refractory shock and adverse metabolic effects with epinephrine.
  • Despite no difference in cardiac output between the two drugs, epinephrine was linked to increased heart rate, lactic acidosis, and a higher frequency of severe shock, leading to early study termination.
  • Overall, norepinephrine appeared safer and more tolerable than epinephrine for managing cardiogenic shock post-myocardial infarction, highlighting the need for careful choice of vasopressor agents in this setting.]

Top posts

Most liked on X and Bluesky
Nick Johnson
@NickJohnsonMD · X

Interesting. Seems like data tilting toward norepinephrine in post arrest and early cardiogenic (https://t.co/n3welLOgAK) shock. Worry a bit about confounding by indication, but seems reasonable to pick norepi first for now. https://t.co/X2ridPH7zT

Feb 8, 2022 · 52 likes · 16 shares · 6,554 followers View post →
Diego Iglesias Álvarez
@diglalv · X

Acute MI and cardiogenic shock n=57: *(Dobutamine in 67% of both groups) -Adrenaline: ↑ heart rate, lactic acidosis, refractory shock. -Noradrenaline: = heart rate, earlier lactate clearance. -Similar SvO2 / ΔPCO2. Vasopressor of choice? https://t.co/CFTuKwP1Fd @JACCJournals https://t.co/RxHYzvYlq5

Dec 13, 2020 · 13 likes · 3 shares · 438 followers View post →
Orly Leiva, MD
@LeivaOrly · X

@IM_Crit_ In cardiogenic shock epinephrine is bad news tho (⬆️ refractory shock in AMI CS https://t.co/0oxyxbDfRq). When in doubt, levophed haha

Mar 30, 2022 · 12 likes · 3 shares · 3,791 followers View post →
SRLF
@La_SRLF · X

Sep 5, 2019 · 8 likes · 5 shares · 5,170 followers View post →
Tommaso Scquizzato, MD
@tscquizzato · X

In cardiogenic shock after #AMI evidences for norephinephrine and early revascularization of culprit vessels. @iccvanderhorst 1. https://t.co/bUnLcIIrLR 2. https://t.co/qNFCNrxvw9 @ESICM #LIVES2019 #FOAMed #FOAMcc https://t.co/8Lkwf1q1aZ

Sep 30, 2019 · 8 likes · 8 shares · 5,124 followers View post →
Nick Johnson
@NickJohnsonMD · X

@OneArmWonder @CatherineCounts @EmmaWender @SayreMR @SeattleFire @uwmnewsroom @UWashEM @mollyvandyke This is not a study of push-dose vasoactives. And distributive shock is incredibly common following ROSC and a key feature of the post-arrest syndrome. AND norepinephrine is probably preferred as first-line for cardiogenic shock. https://t.co/n3welLOgAK

Dec 5, 2023 · 3 likes · 6,554 followers View post →

All mentions

Safety of Norepinephrine Infusions in Surgery

This video discusses the safety of using norepinephrine infusions through peripheral IV lines during surgery. With a review of 14,385 patients, the study suggests a very low risk of complications, significantly aiding…

Ta de Clinicagem · Jan 29, 2023 4,898 views

Weekly Update on Cardiological Advances

The Café com Journal series delivers a weekly update on recent cardiology publications. In today's session, we discuss original articles from JACC, BMJ, and Circulation, highlighting key findings and new guidelines…

CardioLearning · Jul 10, 2018 564 views
Nick Johnson
@NickJohnsonMD · X

@OneArmWonder @CatherineCounts @EmmaWender @SayreMR @SeattleFire @uwmnewsroom @UWashEM @mollyvandyke This is not a study of push-dose vasoactives. And distributive shock is incredibly common following ROSC and a key feature of the post-arrest syndrome. AND norepinephrine is probably preferred as first-line for cardiogenic shock. https://t.co/n3welLOgAK

Dec 5, 2023 · 3 likes · 6,554 followers View post →
Todd Eury
@ToddEury · X

RT @PharmacyToDose: #TrialOfTheDay for July 10th is the OptimaCC trial A study challenging the status quo vasopressor treatment in cardiog…

Jul 10, 2023 · 2 shares · 2,162 followers View post →
Pharmacy Podcast Network
@PharmacyPodcast · X

RT @PharmacyToDose: #TrialOfTheDay for July 10th is the OptimaCC trial A study challenging the status quo vasopressor treatment in cardiog…

Jul 10, 2023 · 2 shares · 29,737 followers View post →
Pharmacy To Dose: The Critical Care Podcast
@PharmacyToDose · X

#TrialOfTheDay for July 10th is the OptimaCC trial A study challenging the status quo vasopressor treatment in cardiogenic shock Open-access article link: https://t.co/PS5hh3wNRk #pharmicu #pharmem #emrx #twitterx #foamed #foamcc #cardiotwitter #cardiogenicshock #vasopressor https://t.co/WOpXBybinc

Jul 10, 2023 · 2 likes · 2 shares · 6,818 followers View post →
Pharmacy To Dose: The Critical Care Podcast
@PharmacyToDose · X

#TrialOfTheDay for July 10th is the OptimaCC trial A study challenging the status quo vasopressor treatment in cariogenic shock Open-access article link: https://t.co/PS5hh3wNRk #pharmicu #pharmem #emrx #twitterx #foamed #foamcc #cardiotwitter #cardiogenicshock #vasopressor https://t.co/N2R4cCOpIT

Jul 10, 2023 · 6,818 followers View post →
Ryan Feldman (empoisonpharmd.bsky.social)
@EMPoisonPharmD · X

@plastic_baggy17 @Q2turnQueen In this study patients had a mean of 0.6 and 0.7 mcg/kg/min of NE/EPI https://t.co/TQpsECbxDe. When researching this paper I encountered many trials that exceeded what it seems some institutions might consider "high" https://t.co/5Tv2FXUMVo

Jun 5, 2023 · 4,691 followers View post →
Nick Mark MD
@nickmmark · X

@MattStier_PSTP @YukiKotani5 Agree re VANISH & VASO. I agree that theoretically epi could have more arrhythmias. It’s true that the absence of evidence isn’t always reassuring, and Epi’s clearly got more side effects vs NE in the trials we have (not necessarily more arrhythmias tho). https://t.co/YoJD5TgFCz

Jan 18, 2023 · 1 like · 65,450 followers View post →
narco polo
@mfab112 · X

@airambulancedoc @CRM_saves_lives @red_capDE @Moeritzl @Nell781 @schnudelmann https://t.co/kLiJb4ni5b https://t.co/nQ4NelxNgN In der LL Infarktbedingter Schock als "kann", wenn NA und Dobu keine ausreichende Stabilisierung - klingt für mich eher als Ultima ratio.

Jun 22, 2022 · 2 likes · 5,571 followers View post →
Syed Shahrul Naz
@drshahrul80 · X

RT @LeivaOrly: @IM_Crit_ In cardiogenic shock epinephrine is bad news tho (⬆️ refractory shock in AMI CS https://t.co/0oxyxbDfRq). When in…

Mar 31, 2022 · 3 shares · 6,925 followers View post →
Natalie Lavergne
@LavergneNatalie · X

RT @LeivaOrly: @IM_Crit_ In cardiogenic shock epinephrine is bad news tho (⬆️ refractory shock in AMI CS https://t.co/0oxyxbDfRq). When in…

Mar 31, 2022 · 3 shares · 1,236 followers View post →
Bhavna Seth
@Seth_Bhavna · X

RT @LeivaOrly: @IM_Crit_ In cardiogenic shock epinephrine is bad news tho (⬆️ refractory shock in AMI CS https://t.co/0oxyxbDfRq). When in…

Mar 31, 2022 · 3 shares · 1,866 followers View post →
Orly Leiva, MD
@LeivaOrly · X

@IM_Crit_ In cardiogenic shock epinephrine is bad news tho (⬆️ refractory shock in AMI CS https://t.co/0oxyxbDfRq). When in doubt, levophed haha

Mar 30, 2022 · 12 likes · 3 shares · 3,791 followers View post →
Cory Schlobohm PharmD BCEMP
@cbohm21 · X

@PharmD_intheED Also this https://t.co/pAIx6Jflj4

Mar 26, 2022 · 1 like · 244 followers View post →
Yusuf EP
@YusufEP2 · X

RT @NickJohnsonMD: Interesting. Seems like data tilting toward norepinephrine in post arrest and early cardiogenic (https://t.co/n3welLOgAK…

Feb 14, 2022 · 16 shares · 54 followers View post →
Jeanette Kurbedin
@jkurbedin · X

RT @NickJohnsonMD: Interesting. Seems like data tilting toward norepinephrine in post arrest and early cardiogenic (https://t.co/n3welLOgAK…

Feb 12, 2022 · 16 shares · 645 followers View post →
Nick Johnson
@NickJohnsonMD · X

@pedrodammert @CarlbomMD Agreed. Some randomized trial data in an adjacent population (https://t.co/n3welM5jCK), but agree that needs to be studied prospectively in post-arrest patients.

Feb 11, 2022 · 1 like · 6,554 followers View post →
Syed Shahrul Naz
@drshahrul80 · X

RT @NickJohnsonMD: Interesting. Seems like data tilting toward norepinephrine in post arrest and early cardiogenic (https://t.co/n3welLOgAK…

Feb 11, 2022 · 16 shares · 6,925 followers View post →
Stijn BLOT
@StijnBLOT · X

RT @NickJohnsonMD: Interesting. Seems like data tilting toward norepinephrine in post arrest and early cardiogenic (https://t.co/n3welLOgAK…

Feb 9, 2022 · 16 shares · 623 followers View post →
SA
@drsaeedayed · X

RT @NickJohnsonMD: Interesting. Seems like data tilting toward norepinephrine in post arrest and early cardiogenic (https://t.co/n3welLOgAK…

Feb 9, 2022 · 16 shares · 31 followers View post →
vincenzo
@arialciao1 · X

RT @NickJohnsonMD: Interesting. Seems like data tilting toward norepinephrine in post arrest and early cardiogenic (https://t.co/n3welLOgAK…

Feb 9, 2022 · 16 shares · 30 followers View post →
Giuseppe Citerio
@Dr_Cit · X

RT @NickJohnsonMD: Interesting. Seems like data tilting toward norepinephrine in post arrest and early cardiogenic (https://t.co/n3welLOgAK…

Feb 9, 2022 · 16 shares · 7,993 followers View post →
Maura Walsh
@MauraWalshEMCCM · X

RT @NickJohnsonMD: Interesting. Seems like data tilting toward norepinephrine in post arrest and early cardiogenic (https://t.co/n3welLOgAK…

Feb 9, 2022 · 16 shares · 270 followers View post →
Intensive Care Medicine
@yourICM · X

RT @NickJohnsonMD: Interesting. Seems like data tilting toward norepinephrine in post arrest and early cardiogenic (https://t.co/n3welLOgAK…

Feb 9, 2022 · 16 shares · 75,406 followers View post →
Nick Johnson
@NickJohnsonMD · X

@MercadalJordi @luigizattera @yourICM @Dr_Cit @nickmmark @FOAMecmo @LionelLamhaut @JoeTonnaMD @EM_RESUS @stlegriel @jas_soar @DrMCecconi Perhaps, but we also have randomized data in cardiogenic shock due to ACS still suggesting that norepi is at least as good if not superior: https://t.co/n3welM5jCK

Feb 9, 2022 · 6,554 followers View post →
Stephen Bernard
@AmbVicMedic · X

RT @NickJohnsonMD: Interesting. Seems like data tilting toward norepinephrine in post arrest and early cardiogenic (https://t.co/n3welLOgAK…

Feb 9, 2022 · 16 shares · 1,399 followers View post →
Samantha Fernandez, MD
@DrSamanthaF · X

RT @NickJohnsonMD: Interesting. Seems like data tilting toward norepinephrine in post arrest and early cardiogenic (https://t.co/n3welLOgAK…

Feb 8, 2022 · 16 shares · 2,380 followers View post →
Joseph Tonna
@JoeTonnaMD · X

RT @NickJohnsonMD: Interesting. Seems like data tilting toward norepinephrine in post arrest and early cardiogenic (https://t.co/n3welLOgAK…

Feb 8, 2022 · 16 shares · 1,254 followers View post →
David Carlbom
@CarlbomMD · X

RT @NickJohnsonMD: Interesting. Seems like data tilting toward norepinephrine in post arrest and early cardiogenic (https://t.co/n3welLOgAK…

Feb 8, 2022 · 16 shares · 1,848 followers View post →
Tommaso Scquizzato, MD
@tscquizzato · X

RT @NickJohnsonMD: Interesting. Seems like data tilting toward norepinephrine in post arrest and early cardiogenic (https://t.co/n3welLOgAK…

Feb 8, 2022 · 16 shares · 5,124 followers View post →
Nick Johnson
@NickJohnsonMD · X

Interesting. Seems like data tilting toward norepinephrine in post arrest and early cardiogenic (https://t.co/n3welLOgAK) shock. Worry a bit about confounding by indication, but seems reasonable to pick norepi first for now. https://t.co/X2ridPH7zT

Feb 8, 2022 · 52 likes · 16 shares · 6,554 followers View post →
Siddharth Dugar MD FCCM,FCCM,FASE
@siddharth_dugar · X

@fabio_taccone @yourICM @DrMCecconi @Dr_Cit @FOAMecmo @msh_manu @ElieAzoulay5 @Manu_Malbrain @criticcaredoc @AlhazzaniW @iwashyna 2018 study showing norepi May be better in Acute MI associated cardiogenic shock. https://t.co/KjFaAgZ6sW

Oct 28, 2021 · 1 like · 1,879 followers View post →
Ryan Feldman (empoisonpharmd.bsky.social)
@EMPoisonPharmD · X

(ALSO bonus tweet not a fan of DA or EPI in CS d/t limited data showing potentially worse outcomes like pro arrhythmic data w/ DA in CS https://t.co/U4jo9YdGD2, and potentially worse outcome w/ EPI in ischemic CS https://t.co/VpDqeBqh1Q). NE +Dobut for life! #Medtwitter

Feb 27, 2021 · 2 likes · 4,691 followers View post →
Zorba Blázquez Bermejo
@ZorbaBlazquez · X

RT @diglalv: Acute MI and cardiogenic shock n=57: *(Dobutamine in 67% of both groups) -Adrenaline: ↑ heart rate, lactic acidosis, refractor…

Dec 13, 2020 · 3 shares · 1,138 followers View post →
Javier L. Pais
@javierlopezpais · X

RT @diglalv: Acute MI and cardiogenic shock n=57: *(Dobutamine in 67% of both groups) -Adrenaline: ↑ heart rate, lactic acidosis, refractor…

Dec 13, 2020 · 3 shares · 1,570 followers View post →
Diego Iglesias Álvarez
@diglalv · X

Acute MI and cardiogenic shock n=57: *(Dobutamine in 67% of both groups) -Adrenaline: ↑ heart rate, lactic acidosis, refractory shock. -Noradrenaline: = heart rate, earlier lactate clearance. -Similar SvO2 / ΔPCO2. Vasopressor of choice? https://t.co/CFTuKwP1Fd @JACCJournals https://t.co/RxHYzvYlq5

Dec 13, 2020 · 13 likes · 3 shares · 438 followers View post →
Cápsulas De Medicina Crítica
@capsulas_de · X

#Adrenalina vs #norepinefrina en choque cardiogénico post #IAM https://t.co/XlxNXKTliE https://t.co/imJZImuZ8M

Apr 27, 2020 · 10,107 followers View post →
Syed Shahrul Naz
@drshahrul80 · X

RT @EMPoisonPharmD: Based on data EPI seems reasonable in normal heart/distributive shocks. EPI data in CS scant at best, but available dat…

Apr 20, 2020 · 1 share · 6,925 followers View post →
Ryan Feldman (empoisonpharmd.bsky.social)
@EMPoisonPharmD · X

Based on data EPI seems reasonable in normal heart/distributive shocks. EPI data in CS scant at best, but available data signals concern that warrants further exploration (https://t.co/rKhcq8Y8TS , https://t.co/xX5hatMojD) #FOAMcc 3/6

Apr 20, 2020 · 2 likes · 1 share · 4,691 followers View post →
Evangelos Papadomichelakis
@edpapado · X

RT @tscquizzato: In cardiogenic shock after #AMI evidences for norephinephrine and early revascularization of culprit vessels. @iccvanderho…

Oct 7, 2019 · 8 shares · 76 followers View post →
Antonella degani
@Antonelladegan3 · X

RT @tscquizzato: In cardiogenic shock after #AMI evidences for norephinephrine and early revascularization of culprit vessels. @iccvanderho…

Oct 1, 2019 · 8 shares · 751 followers View post →
MadanKumar Narayanan
@MadanNarayanan · X

RT @tscquizzato: In cardiogenic shock after #AMI evidences for norephinephrine and early revascularization of culprit vessels. @iccvanderho…

Oct 1, 2019 · 8 shares · 1,516 followers View post →
Giovanni Landoni, MD
@giovannilandoni · X

RT @tscquizzato: In cardiogenic shock after #AMI evidences for norephinephrine and early revascularization of culprit vessels. @iccvanderho…

Sep 30, 2019 · 8 shares · 4,667 followers View post →
Segun Olusanya (He/Him) iceman_ex@critcare.social
@iceman_ex · X

RT @tscquizzato: In cardiogenic shock after #AMI evidences for norephinephrine and early revascularization of culprit vessels. @iccvanderho…

Sep 30, 2019 · 8 shares · 19,584 followers View post →
Rosi moquete
@RosiRosiw11 · X

RT @tscquizzato: In cardiogenic shock after #AMI evidences for norephinephrine and early revascularization of culprit vessels. @iccvanderho…

Sep 30, 2019 · 8 shares · 197 followers View post →
Medicritica
@medicritica · X

RT @tscquizzato: In cardiogenic shock after #AMI evidences for norephinephrine and early revascularization of culprit vessels. @iccvanderho…

Sep 30, 2019 · 8 shares · 2,627 followers View post →
@load-depentent.bsky.social
@load_dependent · X

RT @tscquizzato: In cardiogenic shock after #AMI evidences for norephinephrine and early revascularization of culprit vessels. @iccvanderho…

Sep 30, 2019 · 8 shares · 3,922 followers View post →
Tommaso Scquizzato, MD
@tscquizzato · X

In cardiogenic shock after #AMI evidences for norephinephrine and early revascularization of culprit vessels. @iccvanderhorst 1. https://t.co/bUnLcIIrLR 2. https://t.co/qNFCNrxvw9 @ESICM #LIVES2019 #FOAMed #FOAMcc https://t.co/8Lkwf1q1aZ

Sep 30, 2019 · 8 likes · 8 shares · 5,124 followers View post →
Tahar Chouihed
@TCHO3105 · X

@fluidloading @Rhazelovitch @Brain_Juice Et reoooooohhhhhhh Interesting article "Epinephrine Versus Norepinephrine for Cardiogenic Shock After Acute Myocardial Infarction" (via #pubmedontap) https://t.co/paLQF0hvon

Sep 18, 2019 · 1,548 followers View post →
Dr Switch
@aswoui · X

RT @La_SRLF:

Sep 6, 2019 · 5 shares · 39 followers View post →
Syed Shahrul Naz
@drshahrul80 · X

RT @La_SRLF:

Sep 5, 2019 · 5 shares · 6,925 followers View post →
Prof. Eric AZABOU
@eric_azabou · X

RT @La_SRLF:

Sep 5, 2019 · 5 shares · 2,508 followers View post →
SRLF
@La_SRLF · X

Sep 5, 2019 · 8 likes · 5 shares · 5,170 followers View post →
Chih King
@chih_king · X

Epinephrine Versus Norepinephrine for Cardiogenic Shock After Acute Myocardial Infarction. - PubMed - NCBI https://t.co/ieK96kckyT

Jun 30, 2019 · 83 followers View post →