Resveratrol reduces albuminuria in diabetic nephropathy: A randomized double-blind placebo-controlled clinical trial.

Abstract in brief

• Resveratrol, a natural antioxidant found in grape skins and red wine, was tested in a clinical trial and found to significantly reduce urinary albumin levels in patients with diabetic nephropathy (DN), suggesting potential kidney protection.
• The study showed that resveratrol did not affect estimated glomerular filtration rate (eGFR) or serum creatinine but increased serum antioxidant enzymes and lowered urine albumin-creatinine ratio, even after accounting for other factors.
• Improvements in albuminuria were linked to reductions in waist circumference and increases in nitric oxide, indicating lifestyle or metabolic factors might influence the treatment's effectiveness.