Proc Natl Acad Sci U S A July 2018 PMID 29987027

Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle.

Jakob Wefers, Dirk van Moorsel, Jan Hansen, Niels J Connell, Bas Havekes, Joris Hoeks, Wouter D van Marken Lichtenbelt, Hélène Duez, Esther Phielix, Andries Kalsbeek, Mark V Boekschoten, Guido J Hooiveld, Matthijs K C Hesselink, Sander Kersten, Bart Staels

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Mentions

43
Peak: 7 in Nov 2023
across 5 sources since Jan 2019

Extended reach

410,466
potential audience

Total likes

219

Video views

6,329

Mentions per month

Jan 2019 – Dec 2024

Where it's discussed

  • News20 articles
  • X / Twitter15 posts
  • Facebook4 posts
  • YouTube2 videos
  • Blogs2 articles

AI synopsis

What people are saying

The overall tone reflects a mix of curiosity and modest concern about how circadian misalignment affects health, illustrated by posts linking the findings to conditions like diabetes and mentioning lifestyle factors, with phrases like 'implications for shift workers' and 'detrimental effects on health,' which show an awareness of potential significance without overstating the impact.

AgreementNeither agree nor disagree

The majority of discussions acknowledge the study's findings on circadian misalignment's effects on insulin sensitivity, though some dismiss personal claims or sensationalize the results.

InterestModerate interest

Most posts show a moderate interest in the topic, especially among those concerned with health and metabolic issues, but some discussions lack depth or specific engagement with the research details.

EngagementModerate engagement

Several posts reference concepts like insulin resistance and the health risks of night work, indicating curiosity and some engagement with the implications, though fewer provide detailed analysis.

ImpactModerate impact

The discussions suggest awareness that the research could influence health understanding and lifestyle choices, but they are not emphasizing immediate or widespread change.

Abstract in brief

  • Short-term circadian misalignment, caused by a 12-hour shift in daily routines, decreases insulin sensitivity in human skeletal muscle, mainly by reducing glucose disposal rates.
  • Muscle biopsies show that the molecular circadian clock in skeletal muscle is not synchronized with behavioral changes, and key energy pathways like PPAR are affected, disrupting energy metabolism.
  • These findings suggest that circadian misalignment could be a reason for higher risks of developing type 2 diabetes in shift workers, linking disrupted sleep-wake cycles to metabolic health problems.

Top posts

Most liked on X and Bluesky
PNASNews
@PNASNews · X

Shift workers, facing circadian misalignment, are at higher risk for metabolic diseases like type 2 diabetes. A study provides insights into the detrimental consequences of night shift work on overall health. In @NPR: https://t.co/gMoEXjy6gk In PNAS: https://t.co/T9nl6CsWun https://t.co/wXn0Ry0Iev

Apr 6, 2024 · 9 likes · 7 shares · 181,310 followers View post →
Cynthia Thurlow, NP
@_CynthiaThurlow · X

how to become insulin resistant in less than 24hrs....tune into my Youtube video to learn more https://t.co/vKirf6SpPC

Mar 1, 2024 · 8 likes · 56,059 followers View post →
Cynthia Thurlow, NP
@_CynthiaThurlow · X

Latest Youtube video focusing in on how you can become insulin resistant within 24hrs..hint, it is all lifestyle mediated https://t.co/vKirf6SpPC

Nov 6, 2023 · 6 likes · 1 share · 56,059 followers View post →
Michael Mindrum, MD
@MichaelMindrum · X

Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle. https://t.co/hIyZgxws3r

Jan 18, 2019 · 6 likes · 9,556 followers View post →
Cynthia Thurlow, NP
@_CynthiaThurlow · X

Insulin resistance is a key factor in chronic disease and contributes to many symptoms women experience during menopause. Learn the biggest mistake that causes insulin resistance the fastest here: https://t.co/vKirf6SpPC

Nov 15, 2023 · 3 likes · 3 shares · 56,059 followers View post →
Ariakas Enoreth
@Aenoreth · X

Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle https://t.co/hLDk5m9uEX

Jan 13, 2019 · 1 like · 1,008 followers View post →

All mentions

Ankit Singla
@In_AnkitSingla · X

RT @PNASNews: Shift workers, facing circadian misalignment, are at higher risk for metabolic diseases like type 2 diabetes. A study provide…

Apr 7, 2024 · 7 shares · 1,480 followers View post →
syawal™ シ
@syawal · X

RT @PNASNews: Shift workers, facing circadian misalignment, are at higher risk for metabolic diseases like type 2 diabetes. A study provide…

Apr 7, 2024 · 7 shares · 3,183 followers View post →
Alejandro Montenegro
@aemonten · X

RT @PNASNews: Shift workers, facing circadian misalignment, are at higher risk for metabolic diseases like type 2 diabetes. A study provide…

Apr 6, 2024 · 7 shares · 9,047 followers View post →
human-ish
@CANALI3N · X

RT @PNASNews: Shift workers, facing circadian misalignment, are at higher risk for metabolic diseases like type 2 diabetes. A study provide…

Apr 6, 2024 · 7 shares · 1,640 followers View post →
PNASNews
@PNASNews · X

Shift workers, facing circadian misalignment, are at higher risk for metabolic diseases like type 2 diabetes. A study provides insights into the detrimental consequences of night shift work on overall health. In @NPR: https://t.co/gMoEXjy6gk In PNAS: https://t.co/T9nl6CsWun https://t.co/wXn0Ry0Iev

Apr 6, 2024 · 9 likes · 7 shares · 181,310 followers View post →
Cynthia Thurlow, NP
@_CynthiaThurlow · X

how to become insulin resistant in less than 24hrs....tune into my Youtube video to learn more https://t.co/vKirf6SpPC

Mar 1, 2024 · 8 likes · 56,059 followers View post →
Daniel Steckler
@DanielSteckler · X

RT @_CynthiaThurlow: Insulin resistance is a key factor in chronic disease and contributes to many symptoms women experience during menopau…

Nov 15, 2023 · 3 shares · 41 followers View post →
roberto
@rwpsports · X

RT @_CynthiaThurlow: Insulin resistance is a key factor in chronic disease and contributes to many symptoms women experience during menopau…

Nov 15, 2023 · 3 shares · 127 followers View post →
Tia Reid, MHP, NNP
@carbaddictcoach · X

RT @_CynthiaThurlow: Insulin resistance is a key factor in chronic disease and contributes to many symptoms women experience during menopau…

Nov 15, 2023 · 3 shares · 4,335 followers View post →
Cynthia Thurlow, NP
@_CynthiaThurlow · X

Insulin resistance is a key factor in chronic disease and contributes to many symptoms women experience during menopause. Learn the biggest mistake that causes insulin resistance the fastest here: https://t.co/vKirf6SpPC

Nov 15, 2023 · 3 likes · 3 shares · 56,059 followers View post →
Jeri Zee
@zee_jeri · X

RT @_CynthiaThurlow: Latest Youtube video focusing in on how you can become insulin resistant within 24hrs..hint, it is all lifestyle media…

Nov 6, 2023 · 1 share · 352 followers View post →
Cynthia Thurlow, NP
@_CynthiaThurlow · X

Latest Youtube video focusing in on how you can become insulin resistant within 24hrs..hint, it is all lifestyle mediated https://t.co/vKirf6SpPC

Nov 6, 2023 · 6 likes · 1 share · 56,059 followers View post →
Michael Mindrum, MD
@MichaelMindrum · X

Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle. https://t.co/hIyZgxws3r

Jan 18, 2019 · 6 likes · 9,556 followers View post →
Ariakas Enoreth
@Aenoreth · X

Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle https://t.co/hLDk5m9uEX

Jan 13, 2019 · 1 like · 1,008 followers View post →
Larronde Esteban
@EstebanDL · X

@GDPando Te paso algo de lo que tengo a mano, en la compu tengo mas... https://t.co/KX0M5TONxq https://t.co/gTC4yoaNW5 https://t.co/euDxtpON9W https://t.co/qvKxpv5Yhf (no directo con dieta) https://t.co/QjlcjQwH00 (diabetes) hay mas, pero twitter es tirano

Jan 11, 2019 · 23,784 followers View post →