Amino Acids October 2018 PMID 30006659

High glycine concentration increases collagen synthesis by articular chondrocytes in vitro: acute glycine deficiency could be an important cause of osteoarthritis.

Patricia de Paz-Lugo, José Antonio Lupiáñez, Enrique Meléndez-Hevia

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Mentions

54
Peak: 7 in Jan 2021
across 4 sources since May 2020

Extended reach

625,626
potential audience

Total likes

4,181

Video views

156,315

Mentions per month

May 2020 – Nov 2025

Where it's discussed

  • X / Twitter30 posts
  • Reddit17 posts
  • News5 articles
  • YouTube2 videos

AI synopsis

What people are saying

The group generally agrees that glycine plays a crucial role in collagen synthesis and osteoarthritis prevention, as seen in comments about its high collagen content and its affordability compared to other supplements. The tone varies from informational to personal, with some participants experimenting with glycine intake or questioning its sole benefits, indicating both interest and deep engagement in evaluating its potential impact.

AgreementStrong agreement

Most discussions support the idea that increasing glycine could help with cartilage health and osteoarthritis prevention, with some posters emphasizing its affordability and importance.

InterestModerate interest

Participants show a moderate level of curiosity, sharing personal experiences with supplementation and discussing potential benefits, though some comments are more observational than exploratory.

EngagementHigh engagement

Many posts reference multiple sources, share personal reactions, and ask questions about glycine's effects, indicating a deep engagement with the topic.

ImpactHigh impact

The discussions highlight the potential of glycine supplementation to influence osteoarthritis outcomes, suggesting a significant perceived impact on health strategies.

Abstract in brief

  • The study shows that increasing glycine, especially at higher concentrations, significantly boosts collagen production by cartilage cells, suggesting that a diet rich in glycine could help repair cartilage and prevent osteoarthritis.
  • While proline and lysine improve collagen synthesis at low to moderate levels within normal physiological ranges, their effects plateau at around 10 mM, unlike glycine, which continues to have a positive impact at higher concentrations.
  • The findings imply that a glycine deficiency might be a key factor in reduced collagen synthesis in osteoarthritis, and enhancing glycine intake could be a promising strategy for cartilage regeneration and joint health.]

Top posts

Most liked on X and Bluesky
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

Glycine deficiency could be an important cause of osteoarthritis "increasing glycine in the diet may well be a strategy for helping cartilage regeneration... which could contribute to the treatment and prevention of osteoarthritis." https://t.co/54msZ6s8lS

Jun 24, 2023 · 48 likes · 5 shares · 308,947 followers View post →
HeightOptimized
@HeightOptimized · X

https://t.co/iAq6fXiTzk

Nov 11, 2025 · 23 likes · 3 shares · 20,414 followers View post →
Rene Sugar
@renesugar · X

"Glycine makes up around 33% of the collagen in the human body." High glycine concentration increases collagen synthesis by articular chondrocytes in vitro: acute glycine deficiency could be an important cause of osteoarthritis https://t.co/p3YKieJE20 https://t.co/6uAM9rYKig

Jan 3, 2023 · 5 likes · 2 shares · 3,985 followers View post →
Rene Sugar
@renesugar · X

High glycine concentration increases collagen synthesis by articular chondrocytes in vitro: acute glycine deficiency could be an important cause of osteoarthritis https://t.co/p3YKieJE20 "Glycine makes up around 33% of the collagen in the human body."

Feb 28, 2023 · 5 likes · 2 shares · 3,985 followers View post →
Kille Tölönen
@Neonomide · X

@ScepticalDoctor Would glycine alone explain some of the seen benefits? Super cheap compared to collagen formulas (at least here): https://t.co/cnPGtAWlLn

May 6, 2023 · 4 likes · 925 followers View post →
Prof. Dr. Sanjeev Bagai
@BagaiDr · X

High glycine concentration increases collagen synthesis by articular chondrocytes in vitro: acute glycine deficiency could be an important cause of osteoarthritis | Amino Acids. https://t.co/nyCPpn9p2h

Nov 11, 2025 · 3 likes · 1 share · 34,609 followers View post →

All mentions

karenk_____
@karenk_____ · X

RT @HeightOptimized: https://t.co/iAq6fXiTzk

Nov 12, 2025 · 3 shares · 911 followers View post →
AMARESH KUMAR
@amareshskumar · X

RT @HeightOptimized: https://t.co/iAq6fXiTzk

Nov 12, 2025 · 3 shares · 1,274 followers View post →
Lee Flynn
@learnin_as_i_go · X

RT @BagaiDr: High glycine concentration increases collagen synthesis by articular chondrocytes in vitro: acute glycine deficiency could be…

Nov 11, 2025 · 1 share · 430 followers View post →
Prof. Dr. Sanjeev Bagai
@BagaiDr · X

High glycine concentration increases collagen synthesis by articular chondrocytes in vitro: acute glycine deficiency could be an important cause of osteoarthritis | Amino Acids. https://t.co/nyCPpn9p2h

Nov 11, 2025 · 3 likes · 1 share · 34,609 followers View post →
HeightOptimized
@HeightOptimized · X

https://t.co/iAq6fXiTzk

Nov 11, 2025 · 23 likes · 3 shares · 20,414 followers View post →
Hibiscus
@Hibisket007 · X

Just got some of this today and I’m trying it right now. I put a tbs in water and it doesn’t taste bad at all. Glycine Nutrition Advice - Glycine Supplementation https://t.co/UpDi04zXeA via @YouTube

Oct 11, 2025 · 1 like · 2,919 followers View post →
中武 壮以知
@soichinakatake · X

「食事中のグリシンを増やすことは、コラーゲン合成を促進することで軟骨再生を助ける戦略である可能性」 High glycine concentration increases collagen synthesis by articular chondrocytes in vitro: acute glycine deficiency ... https://t.co/w81us94BR1

Sep 3, 2024 · 138 followers View post →
健康ノート
@JuStADOcToR_Jp · X

High glycine concentration increases collagen synthesis by articular chondrocytes in vitro: acute glycine deficiency could be an important cause of osteoarthritis - PMC https://t.co/BzP63V4m7S

Sep 3, 2024 · 110 followers View post →
FERGOLO11
@FERGOLO11 · X

@AlpacaAurelius the study excerpt is talking about glycine, glycine is much cheaper than collagen. 10 gm per day glycine + low dose proline & lysine https://t.co/QXG1usGso6

Mar 12, 2024 · 87 followers View post →
能量魔法师
@KaspaASI · X

甘氨酸缺乏可能是骨关节炎的重要原因 “在饮食中增加甘氨酸很可能是帮助软骨再生的一种策略……这可能有助于治疗和预防骨关节炎。” https://t.co/8zKkLFmHJy

Nov 28, 2023 · 2 likes · 18,568 followers View post →
Jen
@Celestite66 · X

RT @Mangan150: Glycine deficiency could be an important cause of osteoarthritis "increasing glycine in the diet may well be a strategy for…

Nov 28, 2023 · 5 shares · 2,414 followers View post →
kike
@FUENTESMANZULLI · X

RT @Mangan150: Glycine deficiency could be an important cause of osteoarthritis "increasing glycine in the diet may well be a strategy for…

Jun 26, 2023 · 5 shares · 249 followers View post →
Bill
@fourthgulch · X

RT @Mangan150: Glycine deficiency could be an important cause of osteoarthritis "increasing glycine in the diet may well be a strategy for…

Jun 24, 2023 · 5 shares · 600 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

Glycine deficiency could be an important cause of osteoarthritis "increasing glycine in the diet may well be a strategy for helping cartilage regeneration... which could contribute to the treatment and prevention of osteoarthritis." https://t.co/54msZ6s8lS

Jun 24, 2023 · 48 likes · 5 shares · 308,947 followers View post →
Wolfey102
@Wolfey102 · X

Glycine Nutrition Advice - Glycine Supplementation https://t.co/G4e8YO5iBh via @YouTube

Jun 12, 2023 · 677 followers View post →
健康ノート
@JuStADOcToR_Jp · X

High glycine concentration increases collagen synthesis by articular chondrocytes in vitro: acute glycine deficiency could be an important cause of osteoarthritis - PMC https://t.co/BzP63V4m7S

Jun 8, 2023 · 110 followers View post →
Vladimir Heiskanen
@ValtsuH · X

@flowtiina @MaijaSol @UrsulaSchwab Äskeinen tulos oli ihmisillä, mutta myös esim koeputkessa kondrosyyteillä glysiinillä voi lisätä kollageenin tuotantoa: https://t.co/H8vILVgHGW

Jun 7, 2023 · 810 followers View post →
Kille Tölönen
@Neonomide · X

@ScepticalDoctor Would glycine alone explain some of the seen benefits? Super cheap compared to collagen formulas (at least here): https://t.co/cnPGtAWlLn

May 6, 2023 · 4 likes · 925 followers View post →
健康ノート
@JuStADOcToR_Jp · X

High glycine concentration increases collagen synthesis by articular chondrocytes in vitro: acute glycine deficiency could be an important cause of osteoarthritis - PMC https://t.co/BzP63V4m7S

Apr 22, 2023 · 1 like · 110 followers View post →
8Eevert ✨
@8Eevert · X

RT @renesugar: High glycine concentration increases collagen synthesis by articular chondrocytes in vitro: acute glycine deficiency could b…

Mar 1, 2023 · 2 shares · 1,171 followers View post →
Rene Sugar
@renesugar · X

High glycine concentration increases collagen synthesis by articular chondrocytes in vitro: acute glycine deficiency could be an important cause of osteoarthritis https://t.co/p3YKieJE20 "Glycine makes up around 33% of the collagen in the human body."

Feb 28, 2023 · 5 likes · 2 shares · 3,985 followers View post →
Marlene Robin
@TheVitalClub · X

RT @renesugar: "Glycine makes up around 33% of the collagen in the human body." High glycine concentration increases collagen synthesis by…

Jan 3, 2023 · 2 shares · 588 followers View post →
Naomi Harvey PhD #WearAMask
@Naomi_D_Harvey · X

RT @renesugar: "Glycine makes up around 33% of the collagen in the human body." High glycine concentration increases collagen synthesis by…

Jan 3, 2023 · 2 shares · 16,733 followers View post →
Rene Sugar
@renesugar · X

"Glycine makes up around 33% of the collagen in the human body." High glycine concentration increases collagen synthesis by articular chondrocytes in vitro: acute glycine deficiency could be an important cause of osteoarthritis https://t.co/p3YKieJE20 https://t.co/6uAM9rYKig

Jan 3, 2023 · 5 likes · 2 shares · 3,985 followers View post →
Rene Sugar
@renesugar · X

"Glycine makes up around 33% of the collagen in the human body." High glycine concentration increases collagen synthesis by articular chondrocytes in vitro: acute glycine deficiency could be an important cause of osteoarthritis https://t.co/p3YKieJE20 https://t.co/6uAM9rYKig

Jan 3, 2023 · 1 like · 3,985 followers View post →
#HelpYouGetGAINS
@helpYOUgetGAINS · X

Glycine Nutrition Advice - Glycine Supplementation https://t.co/cXOy0gEEKz via @YouTube https://t.co/dK4dJFOJ4z

Sep 27, 2022 · 16,796 followers View post →
Mass Migration
@BChinatti · X

RT @epigeneticcode: High glycine concentration increases #collagen synthesis by articular chondrocytes in vitro: acute glycine deficiency c…

Jan 20, 2022 · 1 share · 1,198 followers View post →
Healthspan
@epigeneticcode · X

High glycine concentration increases #collagen synthesis by articular chondrocytes in vitro: acute glycine deficiency could be an important cause of osteoarthritis glycine deficiency could be an important cause of #osteoarthritis https://t.co/eWgQa2I5xR

Jan 20, 2022 · 3 likes · 1 share · 356 followers View post →
Hypnosis4Gnosis
@HGnosis · X

Glycine Nutrition Advice - Glycine Supplementation https://t.co/2kOJovhGKS via @YouTube

Mar 14, 2021 · 94 followers View post →
Gabor Erdosi
@gerdosi · X

@PlomeekSoup @The_Nutrivore Sg like these? https://t.co/N2pCqE1A87 https://t.co/agpA35McTr

May 1, 2020 · 1 like · 25,813 followers View post →
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