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The discussions show active engagement with details from the research, referencing the specific composition of diets that impact weight gain in mice, such as the percentage of fat versus carbohydrates. Phrases like 'this is just the tip of the iceberg' and 'the best-controlled studies support this' indicate a tone of excitement and urgency for further exploration of the topic, highlighting a strong belief in the significance of these findings.
Most discussions affirm the findings of the article, with many users corroborating the role of dietary fat in energy regulation and adiposity.
Participants express significant curiosity about the implications of the study, as indicated by frequent references and requests for related research.
Many commenters engage with the content by discussing specifics of diet formulations and their observed effects in both animal studies and their relevance to human diets.
The community perceives the publication's findings as having noteworthy implications for understanding dietary impacts on obesity.
@davidludwigmd Except, when you completely control the sugar level they still get fat in relation to increasing fat in the diet up to about 60% by calories. see https://t.co/elKzw0Td7G a study that used 30 diets controlled for macronutrient contents which they mysteriously forgot to cite.
Dietary Fat, but Not Protein or Carbohydrate, Regulates Energy Intake and Causes Adiposity in Mice (2018) https://t.co/18EASlZ2SU https://t.co/C9z5lJZbhX
@garytaubes I am wondering if you read our paper in Cell metabolism in 2018 showing that when you completely control the sugar levels it's still increasing fat in the diet that makes mice fat. 30 diets, 5 strains, >1000 mice. https://t.co/elKzw0Td7G
This echoes the findings of @JohnSpeakman4, whose large, detailed study reported that dietary fat, but not carbohydrate/sugar, is the primary macronutrient that drives body fat gain in mice. https://t.co/lrlWBlF83K
Interestingly, sucrose (which is a 50:50 glucose:fructose disaccharide) was not very fattening and did not lead to metabolic problems, consistent with previous findings like those from @johnspeakman4 group. https://t.co/lrlWBlF83K
@ggkuhnle It's worth noting that solid sugars aren't very fattening in rodents and don't seem to have much impact on adiposity in human RCTs. Liquid sugars appear to be more fattening. https://t.co/VTsObeSwdX
This video explores how highly processed foods, particularly fats, influence weight gain and appetite. Recent research indicates that dietary fat significantly regulates energy intake and triggers brain pathways…
Exploring how dietary choices, particularly the intake of fats, influence our brain chemistry and eating behaviors. High-fat diets are linked to increased energy consumption and obesity, activating brain pathways that…
@JimSiverts @DrEenfeldt @ProfTimNoakes except when it doesn't https://t.co/elKzw0Td7G
@tednaiman @TamarHaspel @martykendall2 @mats_cedervall @deirdre_tobias @NutritionMadeS3 @eatlikeanimals @DrRagnar @NourishedbySci @GardnerPhD @theproof @MyNutritionSci @drgabriellelyon yes there is. check out our paper in cell metabolism from 2018. no effect of protein over range 5 to 30% by calories https://t.co/elKzw0TKXe
@DoctorTro This is just the tip of the iceberg of satiety per calorie studies I would like to see.
@richcollins I use the term "refined high-fat diets" in an attempt to communicate that this is a specific type of pelleted rodent diet that's high in fat. That said, the fat itself does play an important causal role in the fattening effect. https://t.co/VTsObeSwdX
RT @JohnSpeakman4: @tednaiman @realDaveFeldman If the animal is a mouse then the answer is no. To make a mouse obese you need to feed it a…
@tednaiman @realDaveFeldman If the animal is a mouse then the answer is no. To make a mouse obese you need to feed it a diet where about 40-60% of calories come from fat, 20% from protein and the balance comes from carbs. Here are a couple of papers on it https://t.co/elKzw0TKXe https://t.co/wDakANdH7k
@exfatloss @PenelopeFigtree @TuckerGoodrich @AsarCadyn @MohammedAlo @HarvardChanSPH @fire_bottle https://t.co/elKzw0TKXe
@LingTolls Notice how the middle fat intake is the fattest https://t.co/qWdATV61Sf https://t.co/91HX8uGlVN
@deirdre_tobias Also, how well controlled a trial is for the fat/CHO swap in inversely related to its duration. As you know, it's hard to tightly control variables in long-term diet trials. The best controlled of all are the rodent studies, especially this one. https://t.co/lrlWBlo51K
@tednaiman @eatlikeanimals @JohnSpeakman4 But it doesn't. So let's move on. We know what drives 'hedonics', and it's consistent with the experimental *and* epidemiologic evidence of what changed. https://t.co/ZI5F7V2xaN #lcl6 https://t.co/fCHG21PKEG
RT @TuckerGoodrich: Ted has become too Enamored of pretty pictures. Here's the fact: Protein leverage doesn't exist. https://t.co/ZI5F7…
Ted has become too Enamored of pretty pictures. Here's the fact: Protein leverage doesn't exist. https://t.co/ZI5F7V2xaN https://t.co/Qad6qlzdOJ https://t.co/xvtByrBpwy
@watchingFed And when we test it experimentally, nothing happens. https://t.co/ZI5F7V2xaN https://t.co/E437xrYK2P
@martykendall2 @tednaiman @DoctorTro "Protein leverage has been observed in a wide range of living organisms, from slime to apes and, of course, humans." When they did a specific test of it, it didn't exist. https://t.co/ZI5F7V2xaN https://t.co/4vhgfn1M0I
@lcmail2 Think it’s this https://t.co/dv7t1rS1Xz
@pablomorentin check out details and diet ordering codes in this paper 4/4 https://t.co/elKzw0Td7G
RT @sterlingmdphd: Highly processed foods tend to contain proportions of fats and carbohydrates that are not typically found in unprocessed…
Highly processed foods tend to contain proportions of fats and carbohydrates that are not typically found in unprocessed foods. This episode focuses on how the ratio of macronutrients may influence caloric intake. https://t.co/QQ7RIu3U5m #diet, #fitness, #science, #education
@EmilPopovic @MirekB12 @Lenislavka https://t.co/effosi8Hy2
@ggkuhnle It's worth noting that solid sugars aren't very fattening in rodents and don't seem to have much impact on adiposity in human RCTs. Liquid sugars appear to be more fattening. https://t.co/VTsObeSwdX
RT @JohnSpeakman4: @exfatloss @Classimo3 @fire_bottle a mix matching the standard American diet which has large amounts of saturated and un…
@exfatloss @Classimo3 @fire_bottle a mix matching the standard American diet which has large amounts of saturated and unsaturated fats in it ...see https://t.co/elKzw0TKXe
@Maratosflier @OKalliokoski Its the fat though that makes them fat not the sucrose. check out the variable sucrose series in this. https://t.co/elKzw0TKXe
@OKalliokoski It depends a bit on strain, and the exact fat level but it is super robust. literally hundreds of studies. Here is a large study my own group did.. https://t.co/elKzw0Td7G
@DKThomp @KevinH_PhD @JohnSpeakman4 At this point even peons like me could make the case at this point. I’ll end on these: these mice he talks about… their weight gain is a function of their fat intake https://t.co/r8raG5qGpp And low-carb diets have no better 5 year efficacy than any other diet
@nicknorwitz Sort of, but it is characterized by its fat content because of this: https://t.co/r8raG5qGpp
RT @TuckerGoodrich: Wouldn't it be great if a nutritionist actually knew the effects of food in obesity? https://t.co/I4znJKx3vy https://t…
RT @TuckerGoodrich: Wouldn't it be great if a nutritionist actually knew the effects of food in obesity? https://t.co/I4znJKx3vy https://t…
RT @TuckerGoodrich: Wouldn't it be great if a nutritionist actually knew the effects of food in obesity? https://t.co/I4znJKx3vy https://t…
Wouldn't it be great if a nutritionist actually knew the effects of food in obesity? https://t.co/I4znJKx3vy https://t.co/67TDbYg2nC https://t.co/fiahKco1gz
RT @JohnSpeakman4: @davidludwigmd Except, when you completely control the sugar level they still get fat in relation to increasing fat in t…
RT @sguyenet: @davidludwigmd Most definitive rodent study: "We exposed C57BL/6 mice to 29 different diets varying from 8.3%-80% fat, 10%-8…
RT @JohnSpeakman4: @davidludwigmd Except, when you completely control the sugar level they still get fat in relation to increasing fat in t…
@davidludwigmd Most definitive rodent study: "We exposed C57BL/6 mice to 29 different diets varying from 8.3%-80% fat, 10%-80% carbohydrate, 5%-30% protein, and 5%-30% sucrose. Only increased dietary fat content was associated with elevated energy intake and adiposity." https://t.co/lrlWBlo51K
RT @JohnSpeakman4: @garytaubes I am wondering if you read our paper in Cell metabolism in 2018 showing that when you completely control the…
RT @JohnSpeakman4: @davidludwigmd Except, when you completely control the sugar level they still get fat in relation to increasing fat in t…
RT @JohnSpeakman4: @davidludwigmd Except, when you completely control the sugar level they still get fat in relation to increasing fat in t…
RT @JohnSpeakman4: @garytaubes I am wondering if you read our paper in Cell metabolism in 2018 showing that when you completely control the…
RT @JohnSpeakman4: @davidludwigmd Except, when you completely control the sugar level they still get fat in relation to increasing fat in t…
RT @JohnSpeakman4: @davidludwigmd Except, when you completely control the sugar level they still get fat in relation to increasing fat in t…
RT @JohnSpeakman4: @davidludwigmd Except, when you completely control the sugar level they still get fat in relation to increasing fat in t…
@garytaubes I am wondering if you read our paper in Cell metabolism in 2018 showing that when you completely control the sugar levels it's still increasing fat in the diet that makes mice fat. 30 diets, 5 strains, >1000 mice. https://t.co/elKzw0Td7G
@davidludwigmd Except, when you completely control the sugar level they still get fat in relation to increasing fat in the diet up to about 60% by calories. see https://t.co/elKzw0Td7G a study that used 30 diets controlled for macronutrient contents which they mysteriously forgot to cite.
RT @JohnSpeakman4: @ketogenician I would hope this does not become known as 'my combination'. But in multiple mouse strains of mice that c…
RT @JohnSpeakman4: @ketogenician I would hope this does not become known as 'my combination'. But in multiple mouse strains of mice that c…
@ketogenician I would hope this does not become known as 'my combination'. But in multiple mouse strains of mice that combo does produce the peak obesity levels. See plots in the paper plus https://t.co/elKzw0Td7G
@68grt @fleroy1974 @Cell_Metabolism yes good question. There are some data out there pointing to different fatty acid compositions affecting RMR and also Fiber. Not our work. effects of CHO disputed. In mice we found no big impacts of CHOs or protein. See https://t.co/elKzw0Td7G
RT @agingdoc1: Dietary Fat, but Not Protein or Carbohydrate, Regulates Energy Intake and Causes Adiposity in Mice (2018) https://t.co/18EA…
RT @agingdoc1: Dietary Fat, but Not Protein or Carbohydrate, Regulates Energy Intake and Causes Adiposity in Mice (2018) https://t.co/18EA…
RT @agingdoc1: Dietary Fat, but Not Protein or Carbohydrate, Regulates Energy Intake and Causes Adiposity in Mice (2018) https://t.co/18EA…
RT @agingdoc1: Dietary Fat, but Not Protein or Carbohydrate, Regulates Energy Intake and Causes Adiposity in Mice (2018) https://t.co/18EA…
RT @agingdoc1: Dietary Fat, but Not Protein or Carbohydrate, Regulates Energy Intake and Causes Adiposity in Mice (2018) https://t.co/18EA…
RT @agingdoc1: Dietary Fat, but Not Protein or Carbohydrate, Regulates Energy Intake and Causes Adiposity in Mice (2018) https://t.co/18EA…
RT @agingdoc1: Dietary Fat, but Not Protein or Carbohydrate, Regulates Energy Intake and Causes Adiposity in Mice (2018) https://t.co/18EA…
RT @agingdoc1: Dietary Fat, but Not Protein or Carbohydrate, Regulates Energy Intake and Causes Adiposity in Mice (2018) https://t.co/18EA…
Dietary Fat, but Not Protein or Carbohydrate, Regulates Energy Intake and Causes Adiposity in Mice (2018) https://t.co/18EASlZ2SU https://t.co/C9z5lJZbhX
Study: "Dietary Fat, but Not Protein or Carbohydrate, Regulates Energy Intake and Causes Adiposity in Mice" https://t.co/rCRrdCuWsT
RT @TuckerGoodrich: @garytaubes @nicole_tweddell I think the biggest difference between n-6 PUFA and carbohydrate as far as the evidence go…
@garytaubes @nicole_tweddell I think the biggest difference between n-6 PUFA and carbohydrate as far as the evidence goes is that the animal obesity-inducing experiments use carbs as the non-obesogenic control...
RT @nikosbosse: Absolutely love this graphical paper abstract https://t.co/gvELJqKBhw https://t.co/DFhxOZH0vf
Absolutely love this graphical paper abstract https://t.co/gvELJqKBhw https://t.co/DFhxOZH0vf
@nieminm the diets we designed also have a sat:mufa:pufa and n-3:n-6 ratio that mimics the standard American diet. They are available directly from @ResearchDiets Their details are in this paper and the codes to order them are in supplementary https://t.co/elKzw0Td7G
@richcollins @SeedOilDsrspctr @valkenburgh @HeatherFurnas That's not the only study looking at the question... And not the most comprehensive. https://t.co/lwuezBsh7I @JohnSpeakman4 https://t.co/Iz3Y3SvSFc
@AnnChildersMD @JohnSpeakman4 @ResearchDiets His findings are consistent with the Deol paper. https://t.co/M4k5YjkgxB https://t.co/rMvyQvo0N1
@AnnChildersMD @TuckerGoodrich we dont use 'chow'. We use a specially designed matrix of 24 different diets that vary orthogonally in the macros, and is designed to mimic western diet fat composition. See Hu et al (2018) in Cell metabolism. https://t.co/elKzw0Td7G
RT @JohnSpeakman4: @nut_neuro @agingdoc1 @CellCellPress @mkaeberlein @DogAgingProject I think there is a lot of scope for improvement. I ha…
@nut_neuro @agingdoc1 @CellCellPress @mkaeberlein @DogAgingProject I think there is a lot of scope for improvement. I have been pretty active in discussions about eg housing temperatures and using appropriate diet formulations (see eg https://t.co/sDYahzzPFV and https://t.co/elKzw0Td7G) but facility cleanliness is a tough one
RT @whsource: This line of research is interesting and I look forward to refinements of the methods. I also think it's notable that the re…
RT @whsource: This line of research is interesting and I look forward to refinements of the methods. I also think it's notable that the re…
This line of research is interesting and I look forward to refinements of the methods. I also think it's notable that the results are consistent with rodent research, which also reports that dietary fat and liquid (but not solid) sugar are fattening. https://t.co/lrlWBlF83K
@MattYousefzadeh @Demarialab1 @mkaeberlein @UMCG_ERIBA @FEBSJournal Thanks for your comment. We never use 'chow' as control. Paper coming soon on why. The complete diets specs for our study were all previously published in Hu et al (2018) in @Cell_Metabolism (see below). Our diets are all irradiated. https://t.co/elKzw0Td7G
@aloesoil its in Hu et al (2018) in Cell metabolism. supplementary materials. if you cant find it give me a shout and I'll fish it out for you. https://t.co/elKzw0Td7G
@professor_myers https://t.co/NBwivkYYxh though I don’t think was exactly pair fed but ad lib. Need to delve into paper
@JamesWClement @JimJohnsonSci if you check out our studies you will see that we weigh and measure food intake every single day eg https://t.co/elKzw0Td7G more than 50,000 measurements of intake and mass
RT @whsource: @davidludwigmd Thanks. There are a number of testable hypotheses that have been proposed/tested, including by my former grou…
@davidludwigmd Thanks. There are a number of testable hypotheses that have been proposed/tested, including by my former group. https://t.co/5ePkMGzxXJ https://t.co/BE8Z88xvqD https://t.co/qXnytutJFs https://t.co/IGbYwSnJY9 https://t.co/sWcQf78xTS https://t.co/VTsObeAmZP https://t.co/ZRvpG4kTD8
RT @whsource: This echoes the findings of @JohnSpeakman4, whose large, detailed study reported that dietary fat, but not carbohydrate/sugar…
RT @whsource: This echoes the findings of @JohnSpeakman4, whose large, detailed study reported that dietary fat, but not carbohydrate/sugar…
RT @whsource: This echoes the findings of @JohnSpeakman4, whose large, detailed study reported that dietary fat, but not carbohydrate/sugar…
This echoes the findings of @JohnSpeakman4, whose large, detailed study reported that dietary fat, but not carbohydrate/sugar, is the primary macronutrient that drives body fat gain in mice. https://t.co/lrlWBlF83K
@tomscott99 @whsource If we are doing mice stuff now, he might want to skim through this. https://t.co/r8raG5qGpp
@seldo Not true though in several respects. Lab animals do not remain lean on animal chow "even when it is high fat and nutritionally matched." They get fat...with no industrial lubricants antibiotics or lithium. see https://t.co/elKzw1aNZe
RT @whsource: @KevinH_PhD Also, the fact that dietary fat is the most fattening macronutrient in rodents. https://t.co/lrlWBlF83K
@KevinH_PhD Also, the fact that dietary fat is the most fattening macronutrient in rodents. https://t.co/lrlWBlF83K
RT @whsource: Interestingly, sucrose (which is a 50:50 glucose:fructose disaccharide) was not very fattening and did not lead to metabolic…
Interestingly, sucrose (which is a 50:50 glucose:fructose disaccharide) was not very fattening and did not lead to metabolic problems, consistent with previous findings like those from @johnspeakman4 group. https://t.co/lrlWBlF83K
@CaloriesProper @garytaubes @justinbonfini @BioLayne A thorough test of this hypothesis in mice does not support it https://t.co/AU4fsFhUTt
@garytaubes @CaloriesProper @SamueleMarcora @bigfatsurprise as for rodent models, how about feeding mice a range of diets, from very low carb to very low fat. Guess who gains the most fat? The high fat diet group: https://t.co/Rsx9eaSApb
@tednaiman Must emphasise that these results are correlational and not verified by genetic manipulation, and in mice. As regards evolutionary explanation I have no idea. Natural foods with this mix must be rare. https://t.co/elKzw0Td7G 2/2
@garytaubes @whsource @KevinH_PhD That is simply not true. C57BL/6 mice get fat on high fat diet but stay slim on a high carb diet because on high carbs they eat less food/energy. They are relatively food restricted and dont get fat (Hu et al 2018 Cell metabolism https://t.co/elKzw0Td7G
Further, not only several studies, both short term and long term, in humans and animals both have failed to reproduce this effect... https://t.co/usB3uXhz0p https://t.co/1If1TBSSAP https://t.co/NXTxVRqTwc https://t.co/CASTGKEDNb https://t.co/KLKAnsvtw9
@p70S6K My commentary is against his promotion of the carbohydrate-insulin model of obesity in general. Regardless, Dr. Speakman found that dietary fat was the only macronutrient consistently associated with fat gain in mice. Protein is another story. https://t.co/uwNnK0yXFT
RT @whsource: I think there are valid reasons to be skeptical of the finding (e.g., what else do gene variants do that cause us to eat more…
I think there are valid reasons to be skeptical of the finding (e.g., what else do gene variants do that cause us to eat more/less CHO). That said, it's consistent with animal research. https://t.co/lrlWBlF83K https://t.co/U89kW8UFJ0
RT @JohnSpeakman4: @ProfTimNoakes @I_mitochondria with respect that's incorrect. If we feed mice with diets containing fixed sucrose at 5%…
@ProfTimNoakes @I_mitochondria with respect that's incorrect. If we feed mice with diets containing fixed sucrose at 5% there is a strong effect of fat content, but we can take sucrose up to 73% with no impact. see https://t.co/elKzw1aNZe and https://t.co/nLUxKHMQQQ
@Maratosflier @davidludwigmd which is why in our original mouse diet study we included 5 strains as well as the 30 diets. https://t.co/oWszUKHpop but the point is our claim that CIM is wrong IN MICE was only ever sold as that. CIM does not explain link of macronutrients to body fatness IN MICE,
@patentbobm @LegendaryLifeP @maximumcharacte @kevinnbass https://t.co/99MdIRC2SC
@The_Nutrivore https://t.co/99MdIRC2SC