Ageing Res Rev November 2018 PMID 30048806

The age-related loss of skeletal muscle mass and function: Measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans.

D J Wilkinson, M Piasecki, P J Atherton

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The group shows strong agreement on the importance of understanding muscle decline during aging, with posts like RT @Omid_HopeUni highlighting 'muscle fibre atrophy and muscle fibre loss in humans,' indicating recognition of the article's detailed physiological insights. The tone varies from informational to inquisitive, reflecting both appreciation and curiosity about future applications and research implications.

AgreementModerate agreement

Most discussions recognize the significance of the article's findings on muscle loss with aging, with many emphasizing the importance of understanding muscle atrophy and fibre loss.

InterestHigh interest

Posts demonstrate high interest, referencing detailed concepts such as muscle fibre atrophy, motor neuron degeneration, and implications for aging health.

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Several discussions delve into the physiological mechanisms, questions about future research, and potential countermeasures, indicating a moderate level of engagement.

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The discussions suggest that the article adds meaningful insight to aging and muscle health, which could influence health strategies and research directions.

Abstract in brief

Sarcopenia, the age-related decline in muscle mass and strength, increases the risk of frailty, chronic diseases, and mortality, with muscle loss starting from middle age and potentially reaching 50% by old age.
The decline in muscle size is mainly due to muscle fibre atrophy caused by imbalances in protein synthesis and breakdown, influenced by reduced responsiveness (anabolic resistance) to exercise and nutrition signals.
Loss of muscle fibres also occurs through motor neuron degeneration, but more research is needed on how this contributes to muscle decline in humans; understanding both fibre atrophy and fibre loss is crucial for developing effective countermeasures.

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The age-related loss of skeletal muscle mass and function: Measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans.

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Abstract in brief

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All mentions

Weight Loss Strategies for Men Over 40 Without Dieting

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