October 2018 PMID 30066368

Short-chain fatty acids: microbial metabolites that alleviate stress-induced brain-gut axis alterations.

Marcel van de Wouw, Marcus Boehme, Joshua M Lyte, Niamh Wiley, Conall Strain, Orla O'Sullivan, Gerard Clarke, Catherine Stanton, Timothy G Dinan, John F Cryan

Mentions

28
Peak: 4 in Nov 2019
across 6 sources since Aug 2018

Extended reach

62,136
potential audience

Total likes

1,084

Video views

19,266

Mentions per month

Aug 2018 – Aug 2025

Where it's discussed

  • News13 articles
  • X / Twitter6 posts
  • Blogs5 articles
  • YouTube2 videos
  • Bluesky1 posts
  • Facebook1 posts

AI synopsis

What people are saying

The discussions highlight the promising role of SCFAs in alleviating stress-related effects, exemplified by phrases like 'wow' and questions about mechanisms. The tone reflects enthusiasm and curiosity, with posts emphasizing the potential for therapeutic development and recognizing the contributions of research teams, thus supporting moderate to high interest and agreement.

AgreementModerate agreement

Most posts acknowledge the positive findings, with some emphasizing the potential therapeutic implications of SCFAs.

InterestHigh interest

Discussions show high interest, especially with posts questioning mechanisms and therapeutic potential, reflecting curiosity and relevance.

EngagementModerate engagement

The posts include references to mechanisms, team acknowledgments, and calls to explore applications, indicating a moderate level of engagement.

ImpactModerate impact

While the discussion recognizes significance, it primarily remains within the realm of research endorsement rather than demonstrating immediate or profound societal impact.

Abstract in brief

  • Short-chain fatty acids (SCFAs) are microbial metabolites that can help reduce stress-induced changes in the brain-gut axis, such as behaviors associated with depression and increased intestinal permeability, though they do not affect overall body weight or the gene expression of certain SCFA receptors.
  • Chronic psychosocial stress alters gut microbiota and causes behavioral and physiological issues, but supplementing with SCFAs in mice can alleviate some of these stress-related effects, indicating a potential for microbiota-targeted therapies for stress-related disorders.
  • The study highlights the important role of microbiota-derived SCFAs in maintaining brain and gut health under stress, emphasizing their potential to modulate immune function, behavior, and metabolism through gut-brain communication pathways.]

Top posts

Most liked on X and Bluesky
humanOS.me
@humanOS_me · X

Short‐chain fatty acids: microbial metabolites that alleviate stress‐induced brain–gut axis alterations. https://t.co/ltJwAVEK9z

Nov 5, 2019 · 12 likes · 1 share · 9,636 followers View post →
Dr. Sheba A-J
@ShebaAJ · X

Short chain fatty acids block selective effects of chronic psychosocial stress. wow. What is the mechanism tho? can we mine these molecules for therapy? https://t.co/CmkfBtgW89 @jfcryan @iScience_CP

Aug 6, 2020 · 4 likes · 2 shares · 2,989 followers View post →
UltimApe
@ultimape · X

"Considering that these behavioural parameters are negatively affected by chronic (psychosocial) stress [...], we hypothesised that SCFA supplementation could ameliorate these psychosocial stress‐induced behavioural deficits." https://t.co/dZHrFUILR1

Oct 20, 2020 · 1 like · 1 share · 6,767 followers View post →
John F. Cryan
@jfcryan · X

RT @ShebaAJ: Short chain fatty acids block selective effects of chronic psychosocial stress. wow. What is the mechanism tho? can we mine t…

Aug 6, 2020 · 2 shares · 22,436 followers View post →
Geoffroy Mallaret
@MallaretG · X

RT @ShebaAJ: Short chain fatty acids block selective effects of chronic psychosocial stress. wow. What is the mechanism tho? can we mine t…

Aug 6, 2020 · 2 shares · 622 followers View post →
Andrés Mora
@AndrsEMG · X

RT @humanOS_me: Short‐chain fatty acids: microbial metabolites that alleviate stress‐induced brain–gut axis alterations. https://t.co/ltJw…

Nov 5, 2019 · 1 share · 212 followers View post →

All mentions

UltimApe
@ultimape · X

"Considering that these behavioural parameters are negatively affected by chronic (psychosocial) stress [...], we hypothesised that SCFA supplementation could ameliorate these psychosocial stress‐induced behavioural deficits." https://t.co/dZHrFUILR1

Oct 20, 2020 · 1 like · 1 share · 6,767 followers View post →
Geoffroy Mallaret
@MallaretG · X

RT @ShebaAJ: Short chain fatty acids block selective effects of chronic psychosocial stress. wow. What is the mechanism tho? can we mine t…

Aug 6, 2020 · 2 shares · 622 followers View post →
John F. Cryan
@jfcryan · X

RT @ShebaAJ: Short chain fatty acids block selective effects of chronic psychosocial stress. wow. What is the mechanism tho? can we mine t…

Aug 6, 2020 · 2 shares · 22,436 followers View post →
Dr. Sheba A-J
@ShebaAJ · X

Short chain fatty acids block selective effects of chronic psychosocial stress. wow. What is the mechanism tho? can we mine these molecules for therapy? https://t.co/CmkfBtgW89 @jfcryan @iScience_CP

Aug 6, 2020 · 4 likes · 2 shares · 2,989 followers View post →
Andrés Mora
@AndrsEMG · X

RT @humanOS_me: Short‐chain fatty acids: microbial metabolites that alleviate stress‐induced brain–gut axis alterations. https://t.co/ltJw…

Nov 5, 2019 · 1 share · 212 followers View post →
humanOS.me
@humanOS_me · X

Short‐chain fatty acids: microbial metabolites that alleviate stress‐induced brain–gut axis alterations. https://t.co/ltJwAVEK9z

Nov 5, 2019 · 12 likes · 1 share · 9,636 followers View post →
Marcus Böhme
@boehmemarcus.bsky.social · Bluesky

Our latest paper is out on short-chain fatty acids alleviating stress‐induced brain‐gut axis alterations. Delighted to be a part of a great team @jfcryan, @TedDinan @OrlaOS, @UCCpsychiatry, @Stancat01. Well done @marcel_wouw https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP276431

Aug 1, 2018 View post →
The Early Life Exposome and Autism Risk A Role For The Maternal ...
News

doi:10.1113/ (7):1269–1279. doi:10.1136/gutjnl-2017-314050. JP276431. GUT MICROBES 27. 170. Soliman ML, Rosenberger TA. Acetate supplementa with autism ...

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jir-18-13183 | PDF | Inflammatory Bowel Disease | Gastrointestinal ...
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doi:10.1113/JP276431 56. Marin IA, Goertz JE, Ren T, et al. Microbiota alteration is associated with the development of stress-induced despair behavior. Sci ...

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https://doi.org/10.1113/JP276431. https://doi.org/10.1016/j.biopsych.2016.12.031. 406. Shultz SR, MacFabe DF, Ossenkopp K-P, Scratch S, Whelan J, Taylor R ...

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1 s2.0 S0361923022000375 Main | PDF
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microbiota-immune-brain axis development in premature neonates with brain J. Physiol. 596 (20), 4923–4944. https://doi.org/10.1113/JP276431. damage. Cell Host ...

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Artículo Lactobacillus | PDF | Microbiota | Metabolomics
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doi: 10.1113/JP276431 hup.2624. Frontiers in Immunology 13 frontiersin.org. You might also like. Flat 3. PDF. No ratings yet. Flat 3. 3 pages. Journal of ...

Dec 18, 2025 View →
Bilimsel Gerçekler
Facebook

J Physiol. 2018; 596(20):4923-4944. doi:10.1113/JP276431. Rogers GB, Keating DJ, Young RL, Wong ML, Licinio J, Wesselingh S. From gut dysbiosis to altered ...

Dec 18, 2025 View →
Fcimb 13 1069954 Highlighted | PDF | Biology
News

doi: 10.1113/JP276431 treatment. Nat. Commun. 8 (1), 1785. doi: 10.1038/s41467-017-01682-2 Zhang, P., and Gregg, E. (2017). Global economic burden of ...

Dec 18, 2025 View →
1 s2.0 S0031938422003602 Main | PDF | Hypothalamic–Pituitary ...
News

596 (2020) 4843–4855, https://doi.org/10.1002/jcp.29362. (20) (2018) 4923–4944, https://doi.org/10.1113/JP276431. [140] S.J. Rhee, H. Kim, Y. Lee, et al ...

Dec 18, 2025 View →
10 1002@jnr 24476 | PDF
News

https​://doi.org/10.1113/JP276431 Steptoe, A., Hamer, M., & Chida, Y. (2007). The effects of acute psy‐ van den Biggelaar, A. H., Gussekloo, J., de Craen ...

Dec 18, 2025 View →
Is there a disconnect between how your brain and gut communicate ...
Blogs

... doi: 10.1113/JP276431. April 2nd, 2024. By Andreu Prados. Categories: Anxiety & Depression, Gut Brain Axis, Gut Microbiota, News Watch. Tagged: Anxiety ...

Dec 18, 2025 View →
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Blogs

... doi: 10.1113/JP276431. abril 2nd, 2024. By Andreu Prados. Categorias: Ansiedad y depresión, Eje cerebro-intestino, Microbiota intestinal, News Watch.

Dec 18, 2025 View →
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Blogs

... doi: 10.1113/JP276431. avril 2nd, 2024. Par Andreu Prados. Catégories: Anxiété et dépression, Connexion cerveau-intestin, Microbiote intestinal, News ...

Dec 18, 2025 View →
B-Bots to the rescue | MIT Technology Review
Blogs

https://doi.org/10.1113/JP276431; Zhang, B.; Chen, T.; Cao, M.; Yuan, C.; Reiter, R. J.; Zhao, Z.; Zhao, Y.; Chen, L.; Fan, W.; Wang, X ...

Aug 26, 2025 View →
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https://doi.org/10.1113/JP276431; Hosseini, E.; Grootaert, C.; Verstraete, W.; & Van de Wiele, T. Propionate as a health-promoting microbial ...

May 23, 2025 View →
Microbiota and the social brain | Science
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10.1113/JP276431. GO TO REFERENCE. Crossref · PubMed · Web of Science · Google Scholar. 35. B. B. Nankova, R. Agarwal, D. F. MacFabe, E. F. La ...

Nov 1, 2019 View →
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doi: 10.1113/ · JP276431; pmid: 30066368. 35. B. B. Nankova, R. Agarwal, D. F. MacFabe, E. F. La Gamma,. Enteric bacterial metabolites propionic ...

Nov 1, 2019 View →
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Source: The Journal of Physiology 31 July 2018 DOI : 10.1113/JP276431 Short‐chain fatty acids: microbial metabolites that alleviate stress‐ ...

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Published online ahead of print: doi.org/10.1113/JP276431. “Short-Chain Fatty Acids: Microbial Metabolites That Alleviate Stress-Induced ...

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doi/10.1113/JP276431. Journal information: Journal of Physiology. Provided by The Physiological Society. + Explore further. Short-chain fatty ...

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