Stem Cells Transl Med September 2018 PMID 30070053

Concise Review: Mesenchymal Stem Cell-Based Drug Delivery: The Good, the Bad, the Ugly, and the Promise.

Timothy E G Krueger, Daniel L J Thorek, Samuel R Denmeade, John T Isaacs, W Nathaniel Brennen

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Mentions

Peak: 2 in Jun 2023

across 5 sources since Sep 2020

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277

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Sep 2020 – Nov 2023

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AI synopsis

What people are saying

The discussions reveal a nuanced view, highlighting both the potential benefits and hurdles of MSC-based delivery, with phrases like 'promising strategy' and 'challenges remain' illustrating balanced perspectives that stimulate academic curiosity and discourse on future improvements for targeted therapies.

AgreementModerate agreement

Most discussions acknowledge the promising aspects of MSC-based drug delivery but also recognize its current technical challenges.

InterestHigh interest

Participants show high curiosity about the mechanisms and improvements in targeting, indicating strong interest.

EngagementModerate engagement

Comments reflect a moderate level of depth, such as references to specific homing mechanisms and tracking techniques.

ImpactModerate impact

The discussions suggest the article influences ongoing research efforts and highlights important challenges, although the influence is primarily academic.

Abstract in brief

MSC-based drug delivery has great potential for treating diseases like cancer, but challenges remain in ensuring these cells target tumors effectively without harming other tissues.
Current efforts include developing synthetic engineering methods to improve MSCs' ability to specifically home to tumors, some of which are already in clinical trials.
However, progress is hindered by the lack of standardized, sensitive techniques for tracking and measuring MSC distribution and targeting efficiency in vivo.

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