August 2018 PMID 30080852

A systematic review of hepatitis B virus (HBV) drug and vaccine escape mutations in Africa: A call for urgent action.

Jolynne Mokaya, Anna L McNaughton, Martin J Hadley, Apostolos Beloukas, Anna-Maria Geretti, Dominique Goedhals, Philippa C Matthews

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Mentions

Peak: 2 in Mar 2021

across 2 sources since Mar 2021

Extended reach

3,363

potential audience

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Video views

609

Mentions per month

Mar 2021 – May 2021

Where it's discussed

YouTube2 videos
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AI synopsis

What people are saying

The discussions demonstrate strong backing for the article’s conclusions, with users emphasizing the importance of addressing drug resistance and vaccine escape mutations, as seen in comments about urgent action and lab assessments. Tone and words like 'call for urgent action' and 'significant risk' underscore the seriousness and potential global health impact of the findings.

AgreementModerate agreement

Most discussions recognize the importance and seriousness of the review, showing support for the call to action.

InterestHigh interest

Posts indicate high interest, with users engaging actively and referencing specific aspects of the research.

EngagementModerate engagement

Users are deeply engaged, discussing mutations, implications for vaccine efficacy, and potential solutions.

ImpactHigh impact

Discussions emphasize the high impact of the findings, highlighting the urgent need for improved diagnostics and treatments.

Abstract in brief

The study highlights the presence of drug resistance and vaccine escape mutations in hepatitis B virus (HBV) in Africa, emphasizing the risk they pose to current prevention and treatment efforts, especially in regions with high HBV and HIV co-infection.
Most data were collected from HIV-HBV coinfected groups, revealing common resistance mutations like rtM204IV and vaccine escape mutations such as rtM204VI, rtL180M, and rtV173L, which are present in a significant portion of the population.
The review underscores the urgent need for better diagnostic tools, ongoing laboratory assessment, and widespread use of tenofovir, while calling for more research to understand the clinical impact of emerging resistant polymorphisms.

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All mentions

Assessing Risks and Challenges of Pandemic Vaccination Strategies

This video discusses the implications of mass vaccination during a pandemic, potential immune escape, and virus evolution, highlighting the need for re-evaluating current vaccination strategies in light of recent…

DharshanaK · Mar 31, 2021 432 views

Understanding Immune Escape and Vaccine Challenges in Pandemics

Geert Vanden Bossche warns about immune escape and challenges in vaccination strategies amidst global pandemics. The video discusses vaccine efficacy, virus mutations, and the need for re-evaluating current approaches…

DharshanaK · Mar 28, 2021 177 views

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