Gut June 2019 PMID 30108163

Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome.

QiQi Zhou, Meghan L Verne, Jeremy Z Fields, John J Lefante, Sarpreet Basra, Habeeb Salameh, G Nicholas Verne

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Mentions

48
Peak: 3 in Sep 2021
across 6 sources since Jul 2021

Extended reach

68,771
potential audience

Total likes

399

Video views

17,645

Mentions per month

Jul 2021 – Jul 2025

Where it's discussed

  • X / Twitter14 posts
  • News14 articles
  • Facebook8 posts
  • Blogs5 articles
  • YouTube4 videos
  • Reddit3 posts

AI synopsis

What people are saying

The digital discussions reflect an overall positive reception of the study, with users referencing its promising results, such as citing that glutamine 'dramatically and safely reduced all major IBS-related endpoints,' and expressing interest in larger clinical trials. The tone and choice of words like 'interesting,' 'spans,' 'showed,' and 'should be pursued' convey curiosity and a recognition of the study's potential importance, contributing to the moderate scores across all dimensions.

AgreementModerate agreement

Most discussions recognize the positive findings of the study, highlighting the potential benefits of glutamine for post-infectious IBS.

InterestModerate interest

Participants show moderate curiosity, referencing specific studies and potential clinical applications, indicating a genuine interest.

EngagementModerate engagement

Several comments delve into the mechanisms, previous research, and implications, demonstrating a thoughtful engagement with the topic.

ImpactModerate impact

The discussions suggest that if validated, the research could influence clinical approaches to managing IBS, indicating a modest but meaningful impact.

Abstract in brief

  • This study tested whether oral glutamine supplements can help patients with post-infectious irritable bowel syndrome (IBS) who experience diarrhea and increased intestinal permeability, finding that glutamine significantly improved symptoms, bowel habits, stool consistency, and gut permeability compared to a placebo over 8 weeks.
  • The trial involved 54 patients taking glutamine and 52 taking a placebo, with results showing that 43% of the glutamine group had a major reduction in IBS severity versus only 3% in the placebo group, and glutamine also improved secondary measures like stool form and intestinal permeability with minimal side effects.
  • The researchers suggest that glutamine, which appears to restore gut barrier function and reduce IBS symptoms safely, warrants larger clinical trials to confirm benefits, understand how it works, and evaluate impacts on patients’ quality of life.]

Top posts

Most liked on X and Bluesky
Jeffrey Roberts, MS BSc
@IBSpatient · X

Does anyone in #GItwitter have any clinical experience using L-Glutamine supplements to manage #diarrhea and/or #IBS? I found one small study published in 2018 with surprisingly interesting results, https://t.co/V9okjGjxft

Jun 27, 2023 · 13 likes · 2 shares · 1,896 followers View post →
FODMAP-News by Beatrice Schilling
@SchillingBea · X

#Glutamin könnte bei #RDS-PI hilfreich sein, zeigt kleine Studie. Spannender Ansatz, der weiterverfolgt werden sollte! Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome | Gut https://t.co/b6G1FScY8p

Sep 26, 2021 · 5 likes · 2 shares · 242 followers View post →
Dr. med. Elisabeth Schieffer
@SchiefferDr · X

@angryhacademic In a dysmetabolic state proteins can be used as fuel for mitochondrial energy, carnitin is one important part in this. In addition glutamine has been discussed for improvement of gut health after infections and irritable Bowle syndrome. https://t.co/I8vk5ujnCM

Jul 11, 2022 · 3 likes · 639 followers View post →
Crypto Charlie
@Charlene_Mattie · X

@DrNeilStone NEVER? "All those...."? Your gross generalizations are both hyperbolic & misleading. At least try to be honest, accurate & trustworthy in your science communication efforts. Creatine https://t.co/0y2hNJPNEV Glutamine https://t.co/R6qHpmg2OG EAAs https://t.co/0NQETou7o8

May 12, 2025 · 2 likes · 178 followers View post →
Marie Bern
@mariebernatchez · X

@Gilbro2010 Intéressant. Tu peux essayer en attenant la L-Glutamine qui réduit la perméabilité intestinale. https://t.co/NutXpgV2Ek https://t.co/0n2tCZcJBH https://t.co/LVhFCRDCIx

Jul 31, 2025 · 1 like · 1,936 followers View post →
Gut&Brain | Samuel Díaz
@GutandBrain · X

Hicieron un buen cribado antes del estudio, descartando SIBO, celiaquía, EII, enfermedad hepática, pancreatitis, etc. Aunque el autoregistro de síntomas siempre tendrá sus limitaciones. Referencia: https://t.co/GTyVtkjGYO

Jul 16, 2021 · 1 like · 90 followers View post →

All mentions

Marie Bern
@mariebernatchez · X

@Gilbro2010 Intéressant. Tu peux essayer en attenant la L-Glutamine qui réduit la perméabilité intestinale. https://t.co/NutXpgV2Ek https://t.co/0n2tCZcJBH https://t.co/LVhFCRDCIx

Jul 31, 2025 · 1 like · 1,936 followers View post →
Dr Ramon Rodrigues CRM 103977/MG
@drramonn · X

Referências: https://t.co/4mQOSilpTp

Jul 5, 2025 · 3 followers View post →
Crypto Charlie
@Charlene_Mattie · X

@DrNeilStone NEVER? "All those...."? Your gross generalizations are both hyperbolic & misleading. At least try to be honest, accurate & trustworthy in your science communication efforts. Creatine https://t.co/0y2hNJPNEV Glutamine https://t.co/R6qHpmg2OG EAAs https://t.co/0NQETou7o8

May 12, 2025 · 2 likes · 178 followers View post →
Jorge Luis Rodríguez .
@JL____Rodriguez · X

RT @IBSpatient: Does anyone in #GItwitter have any clinical experience using L-Glutamine supplements to manage #diarrhea and/or #IBS? I fou…

Jun 27, 2023 · 2 shares · 1,338 followers View post →
Shima Ghavimi
@ShimaghavimiMD · X

RT @IBSpatient: Does anyone in #GItwitter have any clinical experience using L-Glutamine supplements to manage #diarrhea and/or #IBS? I fou…

Jun 27, 2023 · 2 shares · 4,494 followers View post →
Jeffrey Roberts, MS BSc
@IBSpatient · X

Does anyone in #GItwitter have any clinical experience using L-Glutamine supplements to manage #diarrhea and/or #IBS? I found one small study published in 2018 with surprisingly interesting results, https://t.co/V9okjGjxft

Jun 27, 2023 · 13 likes · 2 shares · 1,896 followers View post →
Finne.
@martinfinne · X

Conclusions: In patients with IBS-D with intestinal hyperpermeability following an enteric infection, oral dietary glutamine supplements dramatically and safely reduced all major IBS-related endpoints. Large randomised clinical trials (RCTs) should .." https://t.co/XNrJkk3DqL

Jul 15, 2022 · 2,203 followers View post →
Dr. med. Elisabeth Schieffer
@SchiefferDr · X

@angryhacademic In a dysmetabolic state proteins can be used as fuel for mitochondrial energy, carnitin is one important part in this. In addition glutamine has been discussed for improvement of gut health after infections and irritable Bowle syndrome. https://t.co/I8vk5ujnCM

Jul 11, 2022 · 3 likes · 639 followers View post →
Dorothy Lawrence
@dorothylaws_ · X

RT @TomKindlon: "Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious #IrritableBowelSyndrome" "Oral di…

May 17, 2022 · 9 shares · 812 followers View post →
Emad El-Omar
@emadelomar · X

RT @SchillingBea: #Glutamin könnte bei #RDS-PI hilfreich sein, zeigt kleine Studie. Spannender Ansatz, der weiterverfolgt werden sollte! Ra…

Sep 26, 2021 · 2 shares · 3,875 followers View post →
Gut Journal
@Gut_BMJ · X

RT @SchillingBea: #Glutamin könnte bei #RDS-PI hilfreich sein, zeigt kleine Studie. Spannender Ansatz, der weiterverfolgt werden sollte! Ra…

Sep 26, 2021 · 2 shares · 31,177 followers View post →
FODMAP-News by Beatrice Schilling
@SchillingBea · X

#Glutamin könnte bei #RDS-PI hilfreich sein, zeigt kleine Studie. Spannender Ansatz, der weiterverfolgt werden sollte! Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome | Gut https://t.co/b6G1FScY8p

Sep 26, 2021 · 5 likes · 2 shares · 242 followers View post →
Finne.
@martinfinne · X

@DidrikSoderlind @CTviberg her har dere litt om en av de mest mobbede helsetilstander, fordi det ikke passer inn i evidensialistkultens tvangspregede tankemønster. aka kontroversielt. kål er ikke sunt, for alle, men for de fleste. kål er imidlertid rikt på bla glutamin: https://t.co/XNrJkklePl

Aug 3, 2021 · 2,203 followers View post →
Gut&Brain | Samuel Díaz
@GutandBrain · X

Hicieron un buen cribado antes del estudio, descartando SIBO, celiaquía, EII, enfermedad hepática, pancreatitis, etc. Aunque el autoregistro de síntomas siempre tendrá sus limitaciones. Referencia: https://t.co/GTyVtkjGYO

Jul 16, 2021 · 1 like · 90 followers View post →