August 2018 PMID 30127713

N, N-Dimethyltryptamine (DMT), an Endogenous Hallucinogen: Past, Present, and Future Research to Determine Its Role and Function.

Steven A Barker

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Mentions

75
Peak: 4 in Jun 2024
across 6 sources since Feb 2019

Extended reach

193,024
potential audience

Total likes

3,506

Video views

89,382

Mentions per month

Feb 2019 – Nov 2025

Where it's discussed

  • X / Twitter35 posts
  • News26 articles
  • YouTube4 videos
  • Blogs4 articles
  • Facebook3 posts
  • Reddit3 posts

AI synopsis

What people are saying

Several discussions highlight the scientific nuances of DMT, such as its detection in neonatal rats and the body's capacity to produce it naturally, with words like 'significantly' and 'important' conveying genuine curiosity. The tone varies from technical inquiries to skeptical comments questioning the nature of DMT’s presence in humans, illustrating a mixture of interest and cautious evaluation.

AgreementLow agreement

Many discussions question or clarify the scientific understanding of endogenous DMT, indicating some skepticism or uncertainty, but also recognition of its potential importance.

InterestModerate interest

Several posts show curiosity, especially those mentioning DMT levels in the brain, its synthesis pathways, and its potential roles, reflecting genuine interest.

EngagementModerate engagement

There are technical exchanges about biochemical pathways and physiological effects, suggesting moderate but meaningful engagement

ImpactNeutral impact

While some posts discuss the biological and therapeutic implications, most seem to express preliminary curiosity rather than asserting high impact or immediate significance.

Abstract in brief

  • This report reviews the history, methods, and recent findings on the endogenous hallucinogen DMT, including its production and breakdown in the brain and body, and explores its potential roles as a neurotransmitter with possible therapeutic implications.
  • It highlights new research directions such as brain mapping of DMT-related enzymes, studies on its presence in the pineal gland, and investigations into its binding sites, aiming to clarify its natural function within the brain.
  • The report underscores the importance of differentiating between DMT's natural effects in the brain and those caused by external administration, advocating for further experiments to better understand its physiological roles.

Top posts

Most liked on X and Bluesky
human being human
@bazanovic · X

@NikaOneDay @Grinbergg45 We are all tweakers I'm afraid, because we all make DMT. https://t.co/Iq165SmX00 Yes smoking / vaping / IV-ing it I see the issues there, but we must not throw out the endogenous-baby with the alkaloid bathwater.

Apr 28, 2023 · 11 likes · 996 followers View post →
Steph Kent
@covertress · X

@TheProjectUnity DMT can be produced endogenously through fasting and mild dehydration. Shamen who went to meditate in the desert knew this. N, N-Dimethyltryptamine (DMT), an Endogenous Hallucinogen: Past, Present, and Future Research to Determine Its Role and Function https://t.co/efbgRnv6Id https://t.co/9bwAlWODR4

May 23, 2023 · 8 likes · 2 shares · 30,693 followers View post →
Seth Peribsen
@SPeribsen · X

We actually have many sites throughout the body that have the base components necessary for synthesis AND storage of endogenous DMT. And it's now known as a neurotransmitter, a neurohormone, neuroprotective, and neuroregulatory. https://t.co/h06udx7h59

Sep 4, 2023 · 7 likes · 3,973 followers View post →
Seth Peribsen
@SPeribsen · X

@BlackhawkOaks Are you referring to tryptophan? Endogenously that paths to dimethyltryptamine via AADC decarb, then double methylation via INMT. Not related to the other one you mentioned, doesn't base from tryptophan/tryptamine. No natural MDMA synthesis in the body. https://t.co/rpa8RxZ9IG

Apr 23, 2025 · 3 likes · 3,973 followers View post →
Jenny
@mommaleo · X

N, N-Dimethyltryptamine (DMT), an Endogenous Hallucinogen: Past, Present, and Future Research to Determine Its Role ... https://t.co/ZiYthyGG3f

Oct 2, 2022 · 2 likes · 28,574 followers View post →
Marco A Gudino
@MrcoGudino · X

For that matter, we do not fully understand the biochemistry of perception itself or how we live such a vivid and complex internal life in the absence of external stimulation. Front Neurosci. 2018; 12: 536. doi: 10.3389/fnins.2018.00536 Steven A. Barker

Dec 5, 2020 · 2 likes · 440 followers View post →

All mentions

Awaken The “I AM” | r/microdosing | Mush Love
@LiveInMushLove · X

RT @LiveInMushLove: #Endogenous #DMT [#EndoDMT] in Nature: A Comprehensive Reference Table [Jul 2025] | N, N-Dimethyltryptamine (DMT), an E…

Oct 5, 2025 · 1 share · 738 followers View post →
Awaken The “I AM” | r/microdosing | Mush Love
@LiveInMushLove · X

#Endogenous #DMT [#EndoDMT] in Nature: A Comprehensive Reference Table [Jul 2025] | N, N-Dimethyltryptamine (DMT), an Endogenous Hallucinogen: Past, Present, and Future Research to Determine Its Role and Function | Frontiers in Neuroscience [Aug 2018]: https://t.co/LLS1VzEoQv https://t.co/zpS71fgDcb

Sep 25, 2025 · 1 share · 738 followers View post →
Seth Peribsen
@SPeribsen · X

@BlackhawkOaks Are you referring to tryptophan? Endogenously that paths to dimethyltryptamine via AADC decarb, then double methylation via INMT. Not related to the other one you mentioned, doesn't base from tryptophan/tryptamine. No natural MDMA synthesis in the body. https://t.co/rpa8RxZ9IG

Apr 23, 2025 · 3 likes · 3,973 followers View post →
Koopa Troopa
@EdDubois87 · X

https://t.co/nO8njE2y31 #Meditation

Nov 15, 2024 · 1 like · 1,099 followers View post →
qikka
@qikka2886 · X

@GaryMarcus Oh funny thing, america has fun laws like that since 1973 eating protein or sleeping makes your work product "product of crime" so us govt can just take everyones shit https://t.co/kDPsNxsEoD

Aug 7, 2024 · 179 followers View post →
CONSCIENCIACIUDADANA
@CONSCIENCIACIU1 · X

Información

Jun 3, 2024 · 3 followers View post →
EDGR | 7coatl
@troublego · X

#DMT https://t.co/hiDtAhz7pk

Jun 2, 2024 · 258 followers View post →
Scholar009
@Skill2230 · X

RT @Tenchi: DMT

Jun 1, 2024 · 1 share · 15 followers View post →
Beto
@beto_capote · X

https://t.co/INd2O6LtYC

Jun 1, 2024 · 182 followers View post →
Tenchi
@Tenchi · X

DMT

May 31, 2024 · 1 share · 105 followers View post →
ísis
@afrocansada · X

fontes (algumas): https://t.co/YsZ9ppdiMw https://t.co/WZ8xtTDoj2 https://t.co/qj21wjhPp1 https://t.co/AQDMlfw31n

Jan 12, 2024 · 1,127 followers View post →
Javi Ciborro
@papayaykware · X

https://t.co/w9W1hN82Ze N, N-Dimetiltriptamina (DMT), un Alucinógeno Endógeno: Investigación Pasada, Presente y Futura para Determinar Su Papel y Función

Oct 31, 2023 · 8,032 followers View post →
Dr. Jenny Martin
@JennymartinDr · X

DMT is detected in the brain of neonatal rats from birth. DMT levels remain low until day 17, when they increase significantly and then return to the initial low levels for all subsequent ages. https://t.co/9dFrbUjCFz #psychedelics https://t.co/qRUANXGokt

Sep 6, 2023 · 3,470 followers View post →
Seth Peribsen
@SPeribsen · X

We actually have many sites throughout the body that have the base components necessary for synthesis AND storage of endogenous DMT. And it's now known as a neurotransmitter, a neurohormone, neuroprotective, and neuroregulatory. https://t.co/h06udx7h59

Sep 4, 2023 · 7 likes · 3,973 followers View post →
Buddhi369
@Buddhivegan369 · X

RT @covertress: @TheProjectUnity DMT can be produced endogenously through fasting and mild dehydration. Shamen who went to meditate in th…

May 23, 2023 · 2 shares · 1,476 followers View post →
Steph Kent
@covertress · X

@TheProjectUnity DMT can be produced endogenously through fasting and mild dehydration. Shamen who went to meditate in the desert knew this. N, N-Dimethyltryptamine (DMT), an Endogenous Hallucinogen: Past, Present, and Future Research to Determine Its Role and Function https://t.co/efbgRnv6Id https://t.co/9bwAlWODR4

May 23, 2023 · 8 likes · 2 shares · 30,693 followers View post →
Johann Gregor Mendel
@Me1Gregor · X

N, N-Dimethyltryptamine (DMT), an Endogenous Hallucinogen: Past, Present, and Future Research to Determine Its Role and Function https://t.co/UDsSYz2HK3

Apr 29, 2023 · 2 likes · 275 followers View post →
human being human
@bazanovic · X

@NikaOneDay @Grinbergg45 We are all tweakers I'm afraid, because we all make DMT. https://t.co/Iq165SmX00 Yes smoking / vaping / IV-ing it I see the issues there, but we must not throw out the endogenous-baby with the alkaloid bathwater.

Apr 28, 2023 · 11 likes · 996 followers View post →
Paul
@netfire4 · X

@Frankentanken1 @chrsdcook @SFDAOffice @SFPD @BrookeJenkinsSF @SFGate We all are, each of us being inherently illegal for the neurotransmitters used in our mind(DMT) https://t.co/Jwsx8XNJMu

Jan 18, 2023 · 1,144 followers View post →
Quantum Financial System
@HRHGODOFALLGODS · X

@POTUS https://t.co/EuFwt5dfxx I am putting you on this synthesized as an entheogen. This is going to begin healing your pineal gland and making you feel lucid and sharp again. @FLOTUS Jill take care of this. It will fix his mind. War is coming. I need him at his best.

Nov 6, 2022 · 155 followers View post →
Jeff Knox
@mrjeffknox · X

@implicateflow https://t.co/5W80mVxsZI

Oct 6, 2022 · 3,358 followers View post →
Jenny
@mommaleo · X

N, N-Dimethyltryptamine (DMT), an Endogenous Hallucinogen: Past, Present, and Future Research to Determine Its Role ... https://t.co/ZiYthyGG3f

Oct 2, 2022 · 2 likes · 28,574 followers View post →
Amir Zen
@AmirZenOfficial · X

“…the data suggest that DMT is both endogenous and possesses the properties of a neurotransmitter…” https://t.co/oofWuBXqnF

Jul 16, 2022 · 1,836 followers View post →
Fustbariclation
@fustbariclation · X

@milesdeweydiii @qikipedia Entheogens are an important adjunct to life. So important that our own body manufacturers DMT. https://t.co/H9fNCwQkcx

Mar 1, 2022 · 2,160 followers View post →
ppchuman oid
@ppchuman · X

https://t.co/77rVEz9CAE DMT does what? https://t.co/rbulg8yHcx Trace Amine Associated Receptors/TAARs do what?

Feb 6, 2022 · 1 like · 206 followers View post →
Marco A Gudino
@MrcoGudino · X

For that matter, we do not fully understand the biochemistry of perception itself or how we live such a vivid and complex internal life in the absence of external stimulation. Front Neurosci. 2018; 12: 536. doi: 10.3389/fnins.2018.00536 Steven A. Barker

Dec 5, 2020 · 2 likes · 440 followers View post →
Michel Blanc
@Blanc07Michel · X

RT @FrontNeurosci: N, N-Dimethyltryptamine (DMT), an Endogenous Hallucinogen: Past, Present, and Future Research to Determine Its Role and…

Nov 7, 2020 · 4 shares · 1,669 followers View post →
Atheist God, Not a Parody
@hesanaughtyboy · X

@JustMW84 @SecularOutpost @Youthresist In your hypothesis I got as far as DMT which was not far in to your hypothesis and you talk about it as true yet science has not found your statement to be true it is found in plants it has not been found in humans chemicals to make it are. Read this https://t.co/BPY7VCjEQ8

Aug 25, 2020 · 4,161 followers View post →
Vudúcratas
@Vuducratas · X

RT @z0mbi0sis:

May 18, 2020 · 2 shares · 786 followers View post →
Baal
@Baalzabut · X

RT @z0mbi0sis:

May 18, 2020 · 2 shares · 572 followers View post →
Zombiosis
@z0mbi0sis · X

May 18, 2020 · 2 likes · 2 shares · 116 followers View post →
CXXXII, Imperator
@tuotolA · X

RT @tuotolA: https://t.co/OBM9EnzLi6

Apr 2, 2020 · 1 share · 401 followers View post →
CXXXII, Imperator
@tuotolA · X

https://t.co/OBM9EnzLi6

Mar 31, 2020 · 1 share · 401 followers View post →
Phil E. Parry
@RiggerStar · X

https://t.co/T4Kxq6z3Rb

Oct 28, 2019 · 249 followers View post →
M Zappaterra MD, PhD
@alllove101 · X

https://t.co/R4ujWE729i

Feb 2, 2019 · 44 followers View post →