Cell Metab December 2018 PMID 30146488

Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis.

Joanna Kalucka, Laura Bierhansl, Nadine Vasconcelos Conchinha, Rindert Missiaen, Ilaria Elia, Ulrike Brüning, Samantha Scheinok, Lucas Treps, Anna Rita Cantelmo, Charlotte Dubois, Pauline de Zeeuw, Jermaine Goveia, Annalisa Zecchin, Federico Taverna, Francisco Morales-Rodriguez

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Peak: 8 in Nov 2024

across 4 sources since Nov 2024

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What people are saying

The discussions demonstrate high engagement with technical details, such as the role of Notch signaling activating CPT1a, and emphasize the research's potential impact on vascular health. Words like 'landmark revisit' and phrases about 'vasculoprotection' underline excitement and recognition of importance, reflecting an overall positive and engaged response.

AgreementModerate agreement

Most discussions acknowledge and support the significance of the research findings.

InterestHigh interest

Posts use enthusiastic language like 'landmark revisit' and highlight key mechanisms like Notch signaling and CPT1a, showing high curiosity.

EngagementHigh engagement

Comments delve into detailed interpretations, referencing molecular pathways and potential therapeutic implications, indicating deep involvement.

ImpactHigh impact

Posts emphasize the potential for new treatments and the importance of understanding endothelial metabolism, suggesting considerable influence.

Abstract in brief

Quiescent endothelial cells (QECs) increase fatty acid oxidation (FAO) threefold compared to proliferating endothelial cells (PECs), not for growth but to maintain redox balance via NADPH regeneration, which protects blood vessels from oxidative stress.
Loss of FAO regulation, especially through CPT1A, leads to endothelial dysfunction, increased oxidative stress, and higher vulnerability to inflammatory conditions like LPS exposure and inflammatory bowel disease.
The Notch1 signaling pathway controls FAO use for redox balance in QECs, and supplementing with acetate can restore endothelial health and reduce oxidative damage, highlighting potential therapeutic strategies.]

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Role of Fatty Acid Oxidation in Endothelial Cell Vasoprotection

Quiescent endothelial cells increase fatty acid oxidation for redox balance and vasoprotection. Loss of FAO regulation leads to endothelial dysfunction and oxidative stress, with Notch1 signaling and acetate…

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