September 2019 PMID 30150993

The Role of Histamine and Histamine Receptors in Mast Cell-Mediated Allergy and Inflammation: The Hunt for New Therapeutic Targets.

Elden Berla Thangam, Ebenezer Angel Jemima, Himadri Singh, Mirza Saqib Baig, Mahejibin Khan, Clinton B Mathias, Martin K Church, Rohit Saluja

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Mentions

78
Peak: 37 in Nov 2021
across 4 sources since Aug 2019

Extended reach

1,719,493
potential audience

Total likes

30,267

Video views

1,347,830

Mentions per month

Aug 2019 – Sep 2023

Where it's discussed

  • X / Twitter68 posts
  • YouTube4 videos
  • Facebook4 posts
  • News2 articles

AI synopsis

What people are saying

Multiple discussions emphasize the importance of H1 and H4 receptors in regulating allergic responses, with comments highlighting the need for targeted therapies. For instance, phrases like 'H4R-mediated mast cell activation' and mention of 'anti-histaminics' showcase a scientific understanding and investment in the topic. The tone conveys enthusiasm for the potential changes in treatment paradigms, as seen in the excitement about expansions in antihistamine applications noted throughout the comments.

AgreementModerate agreement

Most discussions indicate a general support for the findings of the publication, highlighting the role of histamine receptors in allergic responses.

InterestHigh interest

There is a strong curiosity expressed within the discussions, indicating a high level of interest in the implications of histamine receptors for treatment.

EngagementModerate engagement

While many posts share insights, there are also references to previous studies and ongoing research, indicating moderate engagement with the content.

ImpactHigh impact

Users see the publication as having a substantial impact on future therapeutic approaches for allergy and inflammation.

Abstract in brief

  • Histamine and its receptors, especially H1R and H4R, are key players in the development of allergic diseases, with mast cells being the primary source of histamine.
  • H1R is involved in Type 1 hypersensitivity reactions, while H4R enhances histamine and cytokine release when activated.
  • Current antihistamines targeting only H1R may not effectively treat conditions like asthma and dermatitis, but research into H4R antagonists shows promising therapeutic potential for managing allergic diseases.

Top posts

Most liked on X and Bluesky
SciShow
@SciShow · X

Turns out antihistamines aren't just good for allergies, they can be used for nausea, insomnia, and even depression! https://t.co/qMdjV1Mjeo https://t.co/a59CAq3M2S

Nov 4, 2021 · 22 likes · 4 shares · 115,779 followers View post →
Frontiers - Immunology
@FrontImmunol · X

Find out more about the importance of histamine receptors in mast cell-mediated allergic disorders @FrontImmunol https://t.co/lP86jRaZtp #allergy #itch #immunology https://t.co/DWj2iXCPf4

Aug 27, 2019 · 12 likes · 6 shares · 33,732 followers View post →
La Jefita
@soylajefita · X

En cuanto a los receptores de histamina tipo 4, hay que mencionar que estos ¡también están muy involucrados en las respuestas alérgicas! OJO: Cuando damos anti histamínicos, estamos bloqueando receptores H1. https://t.co/fnjJ6X299u

Sep 28, 2023 · 10 likes · 2 shares · 78,572 followers View post →
Crystal
@GemzME · X

@FaithOxenbridge @steppenshite "Histamine regulates a plethora of pathophysiological and physiological processes, such as secretion of gastric acid, inflammation, and the regulation of vasodilatation and bronchoconstriction…. In addition, it can also serve as a neurotransmitter…." https://t.co/2XeWy2Py49

Jul 18, 2023 · 7 likes · 1,041 followers View post →
Rita Singh (Kohli)
@RitaSin17562778 · X

Histamine receptors are involved in antibody production. Why covid patients are taking anti allergic/antihistamine medicines in first 5 days until they have some immune co-morbidity? How Suppression of natural immunity can help early on? https://t.co/4Q9Wvj1OHq @ICMR

May 9, 2021 · 6 likes · 328 followers View post →
Congenital Rubella Syndrome
@ConRubellaSyndr · X

Antihistamines for everything? Via @SciShow https://t.co/z5hMMN31lv

Nov 6, 2021 · 4 likes · 4 shares · 365 followers View post →

All mentions

La Piel de Zapa
@lamemur · X

RT @soylajefita: En cuanto a los receptores de histamina tipo 4, hay que mencionar que estos ¡también están muy involucrados en las respues…

Sep 28, 2023 · 2 shares · 1,451 followers View post →
La Jefita
@soylajefita · X

En cuanto a los receptores de histamina tipo 4, hay que mencionar que estos ¡también están muy involucrados en las respuestas alérgicas! OJO: Cuando damos anti histamínicos, estamos bloqueando receptores H1. https://t.co/fnjJ6X299u

Sep 28, 2023 · 10 likes · 2 shares · 78,572 followers View post →
Crystal
@GemzME · X

@FaithOxenbridge @steppenshite "Histamine regulates a plethora of pathophysiological and physiological processes, such as secretion of gastric acid, inflammation, and the regulation of vasodilatation and bronchoconstriction…. In addition, it can also serve as a neurotransmitter…." https://t.co/2XeWy2Py49

Jul 18, 2023 · 7 likes · 1,041 followers View post →
Przemysław G. Czyryca (d. Tajemniczy don Pedro)
@TajemniczyDon · X

@KiraCzarczynska @JozefEscriva @Magdale11478680 @normanpie @Forseti60917717 @Szymon49366484 @PadlMat @Paul86ck @k_pyrc @Plan_Cobe @rieske_piotr @Sylwia557615522 @k_pyc ...to po pierwsze. Po drugie, argument "nie wyłącznie" działa również w drugą stronę: histamina nie wyłącznie stymuluje uwalnianie IL-6, ale i innych cytokin też. Poszukać sobie. A zresztą, niech mnie kosztuje, tu przegląd: https://t.co/cWGBJ94gwf

Apr 12, 2023 · 3 likes · 3,127 followers View post →
Rene Sugar
@renesugar · X

https://t.co/RpdgvieLCr "Likewise, the activation of H1R also regulates allergic responses by enhancing the migration of Th2 cells toward the allergen during lung inflammation"

Mar 15, 2023 · 3,952 followers View post →
Rene Sugar
@renesugar · X

https://t.co/RpdgvieLCr "H4R-mediated mast cell activation can regulate a powerful inflammatory cascade by releasing several inflammatory mediators; these mediators may stimulate the migration of different inflammatory cells into the inflammatory site"

Mar 15, 2023 · 3,952 followers View post →
Rene Sugar
@renesugar · X

https://t.co/RpdgvieLCr "The H3-receptor plays an important role in neuro-inflammatory diseases." "The H4-receptor has also been shown to be involved in allergy and inflammation."

Mar 15, 2023 · 3,952 followers View post →
Rene Sugar
@renesugar · X

https://t.co/RpdgvieLCr "The H1-receptor drives cellular migration, nociception, vasodilatation, and bronchoconstriction, whereas the H2-receptor modifies gastric acid secretion, airway mucus production, and vascular permeability"

Mar 15, 2023 · 3,952 followers View post →
Rene Sugar
@renesugar · X

https://t.co/RpdgvieLCr "H2R are involved in Th1 lymphocyte cytokine production."

Mar 15, 2023 · 3,952 followers View post →
Rene Sugar
@renesugar · X

The Role of Histamine and Histamine Receptors in Mast Cell-Mediated Allergy and Inflammation: The Hunt for New Therapeutic Targets https://t.co/RpdgvieLCr

Mar 15, 2023 · 3,952 followers View post →
Just Another Jersey Chick in DuPage
@farmerjaneusa · X

Antihistamines for Everything? https://t.co/K6NU29IVbl

Dec 16, 2022 · 6,864 followers View post →
Yurqo
@Yurqo · X

@UngorValar Ну і про алергії in general https://t.co/GPBJvvbZDP

Aug 18, 2022 · 52 followers View post →
LongIslanderTweets ☂️
@IslandLifeNY · X

@ShieldHero85 Lol thats a lot of antihistamines! You probably have no histamines Might like this video https://t.co/SKTfSxh9Xi

Apr 23, 2022 · 3,202 followers View post →
Rebecca Randel, MPH, BCPA
@rebeccarandel · X

@KerryKopke @Silas33 Here's a scientific explanation of histamine receptors and how antihistamines target them to reduce histamine levels. https://t.co/ax0InI4cLT

Feb 18, 2022 · 2 likes · 1,846 followers View post →
medicannastore
@medicannastore · X

Antihistamines for Everything? https://t.co/bCRZTBYrtn https://t.co/Yo2hCJsDHr https://t.co/7ElHIlhK2H

Jan 29, 2022 · 85 followers View post →
Jeydis
@WintermuteDom · X

@Caddicarus Heard of similar things happening to a couple of people. Following video is not about what you had specifically but they go into a good breakdown of what antihistamines do: https://t.co/pyBjQFKToS

Jan 25, 2022 · 20 followers View post →
Kez
@Cyrmikez · X

@Caddicarus Scishow is brilliant for all things science! https://t.co/njtUdaH5U0

Jan 24, 2022 · 29 followers View post →
Crissy
@crissypewpew · X

@Caddicarus https://t.co/AqZmKM33aq

Jan 24, 2022 · 32 followers View post →
Dawna LaLonde
@DawnaLaLonde5 · X

https://t.co/laBUt1R65z

Dec 1, 2021 · 3 followers View post →
I
@ickeestickie · X

https://t.co/YcaW49qwPI

Nov 30, 2021 · 1,773 followers View post →
getliquidized
@getliquidized · X

Antihistamines for Everything? https://t.co/w2w3rN0not via @YouTube

Nov 18, 2021 · 1,617 followers View post →
Christine
@sprachbundtcake · X

@CoreyBrickley https://t.co/RUdhvlGVPW

Nov 12, 2021 · 3 likes · 8 followers View post →
Kim Todd
@KstoddKim · X

RT @ConRubellaSyndr: Antihistamines for everything? Via @SciShow https://t.co/z5hMMN31lv

Nov 8, 2021 · 4 shares · 96 followers View post →
MrHydeUSA
@MrHydeUSA · X

RT @ConRubellaSyndr: Antihistamines for everything? Via @SciShow https://t.co/z5hMMN31lv

Nov 8, 2021 · 4 shares · 78 followers View post →
Jamie Todd
@wolfcrane1 · X

RT @ConRubellaSyndr: Antihistamines for everything? Via @SciShow https://t.co/z5hMMN31lv

Nov 8, 2021 · 4 shares · 53 followers View post →
Jamie Todd
@wolfcrane · X

RT @ConRubellaSyndr: Antihistamines for everything? Via @SciShow https://t.co/z5hMMN31lv

Nov 8, 2021 · 4 shares · 798 followers View post →
Kitty Glamourcat
@kittyglamourcat · X

Antihistamines for Everything? https://t.co/kqgOuq8Dom via @YouTube

Nov 7, 2021 · 1,944 followers View post →
Jemma - Allergy Resources
@itch_swell_ooze · X

Antihistamines for everything? https://t.co/lrMS4aqshT

Nov 7, 2021 · 1 like · 1,126 followers View post →
Francesco SkZ Mauro
@skz5k2 · X

Antihistamines for Everything? https://t.co/tst54v806N via @YouTube

Nov 7, 2021 · 159 followers View post →
Congenital Rubella Syndrome
@ConRubellaSyndr · X

Antihistamines for everything? Via @SciShow https://t.co/z5hMMN31lv

Nov 6, 2021 · 4 likes · 4 shares · 365 followers View post →
"You do you" is Eu-gen-ics.
@beadsland · X

@laurenancona icymi https://t.co/zqTjf9cqSd

Nov 6, 2021 · 1 like · 1,602 followers View post →
kirsten houseknecht aka fabricdragon
@fabricdragon · X

Antihistamines for Everything? https://t.co/16hVwJSpit via @YouTube #histamines #Antihistamines #inflammation

Nov 5, 2021 · 3,973 followers View post →
Daniel J Paiement... AKA.. (PARANOID)
@j_paiement · X

Antihistamines for Everything? https://t.co/U6wOAwKndz via @YouTube. I use it for my drippy nose,

Nov 5, 2021 · 863 followers View post →
milkxl
@milkxl · X

Seroquel (quetiapina), usado como anti-psicótico, é anti-histaminico, Dramin (dimenidrinato), usado para enjôo, tonturas, também é anti-histaminico... Faz uma caralhada de coisas a Stamina kkkk :v https://t.co/cufoM9us1l

Nov 5, 2021 · 2 likes · 1,040 followers View post →
Trans Rights are Human Rights.
@MossyStone48 · X

Intriguing.. Antihistamines for Everything? https://t.co/2lKF4mPXI5 via @YouTube

Nov 4, 2021 · 1,166 followers View post →
William Wallace
@bill14051 · X

RT @SciShow: Turns out antihistamines aren't just good for allergies, they can be used for nausea, insomnia, and even depression! https://…

Nov 4, 2021 · 4 shares · 273 followers View post →
SciShow
@SciShow · X

Turns out antihistamines aren't just good for allergies, they can be used for nausea, insomnia, and even depression! https://t.co/qMdjV1Mjeo https://t.co/a59CAq3M2S

Nov 4, 2021 · 22 likes · 4 shares · 115,779 followers View post →
Corine
@FloatingIsland · X

Antihistamines for Everything? https://t.co/EFEErr7h6K via @YouTube

Nov 4, 2021 · 1 like · 418 followers View post →
Edd Potts
@DigitalImpostor · X

Antihistamines for Everything? https://t.co/ZjguwnsmEq

Nov 4, 2021 · 299 followers View post →
LongIslanderTweets ☂️
@IslandLifeNY · X

Antihistamines for everything! https://t.co/SKTfSxh9Xi

Nov 4, 2021 · 3,202 followers View post →
chibirene
@chibirene · X

Antihistamines for Everything? https://t.co/r1wdyREKE3 via @YouTube

Nov 4, 2021 · 303 followers View post →
Cecile Braconnier
@braco001 · X

Antihistamines for Everything? https://t.co/rgLHatinyU via @YouTube

Nov 4, 2021 · 741 followers View post →
pseudoDavid
@iNihil · X

Liked on YouTube: Antihistamines for Everything? https://t.co/v553smyd8c

Nov 4, 2021 · 34 followers View post →
womaninthearmor
@womaninthearmor · X

https://t.co/oT62wpfZhK

Nov 4, 2021 · 746 followers View post →
Keeper of the flame
@Arriadna · X

RT @JRHorsting: This is brilliant. Antihistamines for Everything? https://t.co/bUEWw7Y3BG via @YouTube

Nov 4, 2021 · 1 share · 33,237 followers View post →
JR Horsting
@JRHorsting · X

This is brilliant. Antihistamines for Everything? https://t.co/bUEWw7Y3BG via @YouTube

Nov 4, 2021 · 1 like · 1 share · 17,432 followers View post →
JR Horsting
@JRHorsting · X

Antihistamines for Everything? https://t.co/bUEWw7Y3BG via @YouTube

Nov 4, 2021 · 17,432 followers View post →
Elijah Rashad Atlas
@deussolinvictum · X

Antihistamines for Everything? https://t.co/e7RnRCkQyW via @YouTube

Nov 4, 2021 · 190 followers View post →
concealedchaos
@concealedchaos0 · X

Antihistamines for Everything? https://t.co/nIGpyUdphW via @YouTube

Nov 3, 2021 · 126 followers View post →
Haley Keller
@haleymkeller · X

Antihistamines for Everything? https://t.co/LeK9BF1ymj

Nov 3, 2021 · 1 like · 498 followers View post →
e-csce
@e_csce · X

Antihistamines for Everything? @ https://t.co/0Hosk4vsDi https://t.co/LCKDFjWvlt

Nov 3, 2021 · 118 followers View post →
Creative Brain 4 Life
@CreativeBrain77 · X

https://t.co/LGhWvF1pya https://t.co/3CBDy2of4V If you consider antihistamines, you are in all probability solely desirous about eliminating a runny nostril, however we're studying that antihistamines can be utilized for

Nov 3, 2021 · 1 followers View post →
Kitty
@kittybravofan · X

Antihistamines for Everything? https://t.co/Rg2mPuxzbn via @YouTube

Nov 3, 2021 · 722 followers View post →
Yael Dragwyla
@YDrgwyla · X

Antihistamines for Everything? https://t.co/NciG6g1Vsa via @YouTube

Nov 3, 2021 · 25 followers View post →
Johannes Lüke
@JohannesSLueke · X

New video by SciShow: Antihistamines for Everything? https://t.co/hl6TxyQm0C

Nov 3, 2021 · 83 followers View post →
Dallas4life44
@dallas4life44 · X

@princessGCJ @cyberette @drbeen_medical https://t.co/tLvq7FqnLz here is a link to a great study on mast cell mediation secondary to the administration of H1R-H4R antagonists

Jun 3, 2021 · 2 likes · 11 followers View post →
Rita Singh (Kohli)
@RitaSin17562778 · X

Histamine receptors are involved in antibody production. Why covid patients are taking anti allergic/antihistamine medicines in first 5 days until they have some immune co-morbidity? How Suppression of natural immunity can help early on? https://t.co/4Q9Wvj1OHq @ICMR

May 9, 2021 · 6 likes · 328 followers View post →
Living Empowered®
@livingempowered · X

Frontiers | The Role of Histamine and Histamine Receptors in Mast Cell-Mediated Allergy and Inflammation: The Hunt for New Therapeutic Targets | Immunology https://t.co/Tlq44LjnQL

Mar 31, 2021 · 673 followers View post →
angela mv/p
@ItsAngInLA · X

@C19LongHauler @na_nanav Also blew my mind at how many other oranges besides the stomach H2 receptors are. They’re in the nervous system too! https://t.co/8EiUkhVT9A

Oct 6, 2020 · 1 like · 3,215 followers View post →
j4ntnyfo55
@j4ntny · X

The Role of Histamine and Histamine Receptors in Mast Cell-Mediated Allergy and Inflammation: The Hunt for New Therapeutic Targets https://t.co/MKVNSlKp0Z

May 4, 2020 · 356 followers View post →
Cardio-Targets
@CardioTargets · X

The Role of Histamine and Histamine Receptors in Mast Cell-Mediated Allergy and Inflammation: The Hunt for New Therapeutic Targets. https://t.co/nTqWaVh6Up

Oct 1, 2019 · 153 followers View post →
Jose Barboza
@jbarboza94 · X

RT @FrontImmunol: Find out more about the importance of histamine receptors in mast cell-mediated allergic disorders @FrontImmunol https:…

Aug 28, 2019 · 6 shares · 35 followers View post →
Ariakas Enoreth
@Aenoreth · X

RT @FrontImmunol: Find out more about the importance of histamine receptors in mast cell-mediated allergic disorders @FrontImmunol https:…

Aug 28, 2019 · 6 shares · 1,008 followers View post →
PedroAparicio
@InmunoMedUMU · X

RT @FrontImmunol: Find out more about the importance of histamine receptors in mast cell-mediated allergic disorders @FrontImmunol https:…

Aug 28, 2019 · 6 shares · 936 followers View post →
Aditiarryca
@aditiarryca · X

RT @FrontImmunol: Find out more about the importance of histamine receptors in mast cell-mediated allergic disorders @FrontImmunol https:…

Aug 28, 2019 · 6 shares · 35 followers View post →
MastCellChat
@MastCellChat · X

RT @FrontImmunol: Find out more about the importance of histamine receptors in mast cell-mediated allergic disorders @FrontImmunol https:…

Aug 27, 2019 · 6 shares · 2,631 followers View post →
Diana Portales-Pérez
@DiandaGP · X

RT @FrontImmunol: Find out more about the importance of histamine receptors in mast cell-mediated allergic disorders @FrontImmunol https:…

Aug 27, 2019 · 6 shares · 43 followers View post →
Frontiers - Immunology
@FrontImmunol · X

Find out more about the importance of histamine receptors in mast cell-mediated allergic disorders @FrontImmunol https://t.co/lP86jRaZtp #allergy #itch #immunology https://t.co/DWj2iXCPf4

Aug 27, 2019 · 12 likes · 6 shares · 33,732 followers View post →