PubHawk
September 2018 PMID 30209232

Human-like Cmah inactivation in mice increases running endurance and decreases muscle fatigability: implications for human evolution.

Jonathan Okerblom, William Fletes, Hemal H Patel, Simon Schenk, Ajit Varki, Ellen C Breen

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Mentions

74
Peak: 4 in Jan 2019
across 6 sources since Jan 2019

Extended reach

512,367
potential audience

Total likes

7,720

Video views

291,687

Mentions per month

Jan 2019 – Jan 2025

Where it's discussed

  • News33 articles
  • X / Twitter17 posts
  • Blogs15 articles
  • YouTube3 videos
  • Facebook3 posts
  • Reddit3 posts

AI synopsis

What people are saying

The discussions reflect a strong interest in the genetic alterations represented in the research, with comments like 'génétique cette fois' emphasizing new insights into human evolution. The tone varies from curiosity about ancestral adaptations to speculation about broader implications, supported by mentions of 'favourable endurance' and 'independent mutation,' which highlight the relevance and potential impact of the findings.

AgreementModerate agreement

The discussions generally acknowledge the significance of the research's findings, with some posts referencing the genetic implications for human endurance.

InterestHigh interest

Posts display a high level of curiosity about the implications for human evolution and endurance, indicating strong interest.

EngagementModerate engagement

Some discussions delve into the genetic aspects and potential evolutionary advantages, showing moderate engagement.

ImpactModerate impact

The posts suggest the research might influence understandings of human physiology and evolution, but mostly in an academic context, indicating moderate perceived impact.

Abstract in brief

  • Humanlike inactivation of the Cmah gene in mice leads to increased endurance and resistance to muscle fatigue, suggesting genetic factors may have contributed to human long-distance running ability.
  • The study found that mice lacking this gene had more capillaries in their muscles, improved oxygen use, and better overall muscle performance, which may have helped early humans adapt during their transition to open savannah environments.
  • This research implies that genetic changes, such as the loss of the Cmah gene, could have provided evolutionary advantages related to endurance and resource exploration in human ancestors.
Read the full abstract

Top posts

Most liked on X and Bluesky
Semih Tareen
@virusfantom · X

Kaynak: https://t.co/urJRmiTTDP

Jan 28, 2022 · 25 likes · 2 shares · 149,650 followers View post →
Fabien Abraini
@Fabiensapiens · X

Une autre modification survenue chez les premiers humains, génétique cette fois. Une modification qui elle aussi pourrait être favorable à l’endurance. https://t.co/qqjKVqHCVJ

Dec 1, 2019 · 19 likes · 13,169 followers View post →
Rock Mada
@RackMada · X

ולזמן ממושך יותר! הסברה היא שמוטציה בגן גורמת לזמינות חמצן גבוהה יותר בשרירים ולפיכך סיבולת גבוהה יותר. למאמר המלא: https://t.co/WeyWSvJR3l

Jan 7, 2019 · 1 like · 36,482 followers View post →
Society for Sports Neuroscience
@NeuroSports_ · X

Original article: https://t.co/s07DuQtezx

Jan 1, 2019 · 1 like · 818 followers View post →
JOY
@joyreneemiles · X

Benefits of Eating Tuna on Keto (& Why I Eat a Lot of It) https://t.co/VxYGdePYBI via @YouTube

Sep 25, 2021 · 1 like · 637 followers View post →
Hiren Joshi
@hirenj · X

@chrashwood Brings this paper to mind.. https://t.co/2iJT6I2TW3

Jul 3, 2023 · 1 like · 627 followers View post →

All mentions

Benefits of Tuna in a Keto Diet Explained

In this video, Thomas DeLauer discusses the benefits of tuna consumption on a keto diet. Sponsored by Wild Planet from Thrive Market, the content aims to provide viewers with insights into the nutritional advantages of…

Thomas DeLauer · Sep 25, 2021 160,361 views
Hiren Joshi
@hirenj · X

@chrashwood Brings this paper to mind.. https://t.co/2iJT6I2TW3

Jul 3, 2023 · 1 like · 627 followers View post →
Manfromtoronto
@torontoman1990 · X

Benefits of Eating Tuna on Keto (& Why I Eat a Lot of It) https://t.co/tsPcB8c4EY via @YouTube

Aug 13, 2022 · 1 followers View post →
Seçkin Sosyal
@seckinsosyal · X

RT @virusfantom: Kaynak: https://t.co/urJRmiTTDP

Jan 29, 2022 · 2 shares · 173 followers View post →
Gokkurt Beyazsu
@gokkurt_aksu · X

RT @virusfantom: Kaynak: https://t.co/urJRmiTTDP

Jan 28, 2022 · 2 shares · 1,082 followers View post →
Semih Tareen
@virusfantom · X

Kaynak: https://t.co/urJRmiTTDP

Jan 28, 2022 · 25 likes · 2 shares · 149,650 followers View post →
TheCarnivoreTriathlete
@anders_edstrom · X

Benefits of Eating Tuna on Keto (& Why I Eat a Lot of It) https://t.co/zgEoQdkogM via @YouTube

Oct 3, 2021 · 500 followers View post →
David Thomas
@davidthomasweb · X

https://t.co/pBvo1vPbEz https://t.co/Tb4J8elxap Speed Up Your Metabolism for Weight Loss Success Many of us are interested in losing a few pounds, but weight loss seems to be a long, hard process for

Sep 25, 2021 · 3 followers View post →
JOY
@joyreneemiles · X

Benefits of Eating Tuna on Keto (& Why I Eat a Lot of It) https://t.co/VxYGdePYBI via @YouTube

Sep 25, 2021 · 1 like · 637 followers View post →
Cheo (Chāy Ō)
@CheoWalker · X

Thomas DeLauer Benefits of Eating Tuna on Keto (& Why I Eat a Lot of It) https://t.co/QexIH1uQfI #keto

Sep 25, 2021 · 351 followers View post →
Shaun Scott
@upyrbike · X

@Qafzeh Full paper here: 2018 “Human-like Cmah inactivation in mice increases running endurance and decreases muscle fatigability: implications for human evolution” https://t.co/jnPYe37NWB

Nov 21, 2020 · 1,438 followers View post →
Fabien Abraini
@Fabiensapiens · X

Une autre modification survenue chez les premiers humains, génétique cette fois. Une modification qui elle aussi pourrait être favorable à l’endurance. https://t.co/qqjKVqHCVJ

Dec 1, 2019 · 19 likes · 13,169 followers View post →
Han
@Han11810862 · X

Human-like Cmah inactivation in mice increases running endurance and decreases muscle fatigability: implications for human evolution | Proceedings of the Royal Society B: Biological Sciences https://t.co/b69EHJxcL4

Nov 12, 2019 · 7 followers View post →
Reda
@Reda_ · X

Human-like Cmah inactivation in mice increases running endurance and decreases muscle fatigability: implications for human evolution | Proceedings of the Royal Society B: Biological Sciences https://t.co/QDzLkiMPwB

Apr 8, 2019 · 14,760 followers View post →
Jesús R Huertas
@jesus_huertas · X

La inactivación del gen que nos permitió correr https://t.co/gB1F9WX3p0

Jan 11, 2019 · 313 followers View post →
Rock Mada
@RackMada · X

ולזמן ממושך יותר! הסברה היא שמוטציה בגן גורמת לזמינות חמצן גבוהה יותר בשרירים ולפיכך סיבולת גבוהה יותר. למאמר המלא: https://t.co/WeyWSvJR3l

Jan 7, 2019 · 1 like · 36,482 followers View post →
Dr. Wile E. Coyote
@CaffeineMD · X

Interesante hallazgo de una mutación única que explica en forma independiente la alta tolerancia del humano al ejercicio aeróbico, comprando con otros primates. Texto completo disponible https://t.co/rZUU9QoUTI

Jan 3, 2019 · 658 followers View post →
Society for Sports Neuroscience
@NeuroSports_ · X

Original article: https://t.co/s07DuQtezx

Jan 1, 2019 · 1 like · 818 followers View post →