Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly.
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Sep 2018 – Dec 2025Where it's discussed
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What people are saying
Discussions consistently reference the ASPREE study’s results on the increased bleeding risk and lack of cardiovascular benefit from low-dose aspirin in healthy elderly individuals. Words like 'game changer' and references to clinical guidelines demonstrate the tone’s seriousness and the community's engagement in reevaluating preventive protocols, indicating broad awareness and potential impact on health recommendations.
Most discussions highlight the study's findings that low-dose aspirin does not significantly reduce cardiovascular events and increases bleeding risks, showing strong consensus.
The topic provokes high interest due to its implications for preventive healthcare in the elderly and ongoing debates about aspirin use.
Participants critically analyze the methodology, share opinions on clinical practice, and cite examples like the ASPREE trial, indicating deep engagement.
The collective discussions emphasize a shift in medical guidelines and patient management, reflecting a high potential for influencing clinical decisions.
Abstract in brief
- The study investigated whether taking low-dose aspirin helps prevent cardiovascular events in healthy elderly people, finding that it did not significantly lower the risk but increased the chance of major bleeding.
- Participants aged 70 or older (or 65+ for certain racial groups) were randomly given aspirin or a placebo, with about 19,114 enrolled and followed for approximately 4.7 years.
- The results showed similar rates of cardiovascular disease in both groups, but the aspirin group had a higher incidence of major hemorrhages, indicating potential risks without clear preventive benefits in this population.
Top posts
Most liked on X and BlueskyInpatient Lesson of the Day 7: I remember the findings from this 2018 @NEJM study that aspirin ⬆️ bleeding risk but didn't ⬇️ CVD risk in the elderly. What I didn't remember is that "elderly" was defined as >70 for White and >65 for Black/Hispanic.
Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly @NEJM https://t.co/oEIgh43oXv A practice changing study showing the lack of benefit (and actual risk) of taking low dose aspirin for adults > 65.
Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy E... https://t.co/mnKeysR1WF vía @YouTube
@nicheunal https://t.co/vPV5UKfNIn
DMだからといって,一次予防のアスピリンのルーチン使用は推奨されない 特に高齢者では注意が必要ですよね ■ASPREE試験 米・豪の高齢者(≧70y)約2万人対象のRCT 一次予防のアスピリン ⇨全死亡率が有意に上昇 ⇨CVD,死亡,認知症,身体障害の複合エンドポイント改善せず https://t.co/2JRd4TOJMJ https://t.co/5Cmy3VwBkg
All mentions
Aspirin Use in Elderly: Cardiovascular Benefits and Bleeding Risks
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La Aspirina causa más daños que beneficios, de acuerdo a este estudio donde se demostró que las personas que usan las aspirinas tienen un mayor riesgo de derrame cerebral e infarto cardíaco. Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly | New
The use of low-dose aspirin as a primary prevention strategy in older adults resulted in a significantly higher risk of major hemorrhage and did not result in a significantly lower risk of cardiovascular disease than placebo. https://t.co/1BoIgi6g28
Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly https://t.co/1BoIgi6g28
@DtrMgr @MeetsLight Sulla taitaa olla analogiat päin persettä. Tikku olisi se az mutta e-pilleri se tukki (1000 veritulppaa per miljoona käyttäjää). Entä aspiriini "tappava"? Ao. mukaan laskin: 2400 vaarallista suurta verenvuotoa vuodessa per miljoona käyttäjää. https://t.co/hwwX7bxf6n
RT @stanete: @Holmes1618 @foundmyfitness @hubermanlab Aspirin did not result in a significantly lower risk of cardiovascular events; 19,114…
@Holmes1618 @foundmyfitness @hubermanlab Aspirin did not result in a significantly lower risk of cardiovascular events; 19,114 people were enrolled (half aspirin and half placebo). https://t.co/G85MQCQAul
O uso de aspirina em baixa dose para prevenção primária em idosos não reduziu significativamente o risco de doenças cardiovasculares e aumentou o risco de hemorragias maiores. Ref.: DOI: 10.1056/NEJMoa1805819
70歳以上の健康な高齢者にアスピリンを投与したら出血合併症が多くて、脳梗塞は減らなかったので勧められないだった気がしたけど、アスピリンはtrial が多すぎて当てにならない系か? https://t.co/ngjePmzQwM https://t.co/EWjEEEJ5gk
@chanelsocial 100% de acuerdo. Se ha publicado al respecto y hay guías clínicas con esas indicaciones. https://t.co/oKlfxQyr6F
初回報告はこれ(NEJM 2018) 高齢者の一次予防としての低用量アスピリンは、大出血のリスクはプラセボと比較して有意に高く、心血管疾患のリスクは有意に低下しない。 高齢者の定義は日本とは違う点に注意 (70歳以上、もしくは米国内の65歳以上の blacks and Hispanics) https://t.co/oQwV27rY2z
RT @Dr_ppooohh: ■ASPREE試験 米・豪の健康高齢者(≧70y)約2万人対象のRCT一次予防のアスピリン100mg ⇨アスピリン投与群では全死亡率が有意に高い ⇨CVD,死亡,認知症,身体障害の複合エンドポイントはプラセボと有意差なし https://t.c…
■ASPREE試験 米・豪の健康高齢者(≧70y)約2万人対象のRCT一次予防のアスピリン100mg ⇨アスピリン投与群では全死亡率が有意に高い ⇨CVD,死亡,認知症,身体障害の複合エンドポイントはプラセボと有意差なし https://t.co/FCWbudXD7l
This came out ~5 years ago (I’m sure people know before, too): https://www.nejm.org/doi/full/10.1056/NEJMoa1805819 So what’s going on? Clinicians don’t know? Poor communication to patients through various means? Unwillingness to stop taking it (security blanket)? Combination?
RT @Dr_ppooohh: DMだからといって,一次予防のアスピリンのルーチン使用は推奨されない 特に高齢者では注意が必要ですよね ■ASPREE試験 米・豪の高齢者(≧70y)約2万人対象のRCT 一次予防のアスピリン ⇨全死亡率が有意に上昇 ⇨CVD,死亡,認知症,…
RT @Dr_ppooohh: DMだからといって,一次予防のアスピリンのルーチン使用は推奨されない 特に高齢者では注意が必要ですよね ■ASPREE試験 米・豪の高齢者(≧70y)約2万人対象のRCT 一次予防のアスピリン ⇨全死亡率が有意に上昇 ⇨CVD,死亡,認知症,…
RT @Dr_ppooohh: DMだからといって,一次予防のアスピリンのルーチン使用は推奨されない 特に高齢者では注意が必要ですよね ■ASPREE試験 米・豪の高齢者(≧70y)約2万人対象のRCT 一次予防のアスピリン ⇨全死亡率が有意に上昇 ⇨CVD,死亡,認知症,…
RT @Dr_ppooohh: DMだからといって,一次予防のアスピリンのルーチン使用は推奨されない 特に高齢者では注意が必要ですよね ■ASPREE試験 米・豪の高齢者(≧70y)約2万人対象のRCT 一次予防のアスピリン ⇨全死亡率が有意に上昇 ⇨CVD,死亡,認知症,…
RT @Dr_ppooohh: DMだからといって,一次予防のアスピリンのルーチン使用は推奨されない 特に高齢者では注意が必要ですよね ■ASPREE試験 米・豪の高齢者(≧70y)約2万人対象のRCT 一次予防のアスピリン ⇨全死亡率が有意に上昇 ⇨CVD,死亡,認知症,…
RT @Dr_ppooohh: DMだからといって,一次予防のアスピリンのルーチン使用は推奨されない 特に高齢者では注意が必要ですよね ■ASPREE試験 米・豪の高齢者(≧70y)約2万人対象のRCT 一次予防のアスピリン ⇨全死亡率が有意に上昇 ⇨CVD,死亡,認知症,…
DMだからといって,一次予防のアスピリンのルーチン使用は推奨されない 特に高齢者では注意が必要ですよね ■ASPREE試験 米・豪の高齢者(≧70y)約2万人対象のRCT 一次予防のアスピリン ⇨全死亡率が有意に上昇 ⇨CVD,死亡,認知症,身体障害の複合エンドポイント改善せず https://t.co/2JRd4TOJMJ https://t.co/5Cmy3VwBkg
Aspirinin Sağlıklı Yaşlılarda Kardiyovasküler Olaylar ve Kanama Üzerine Etkisi https://t.co/RyfWEGf0qU
@Poppyjuice @hansel21_ @stewardmogs @thesassymicrobe @LarcombePeter @DrAseemMalhotra @InCytometry @SwaledaleMutton @TwitterSafety @Twitter https://t.co/qZI9hMitme "The use of low-dose aspirin as a primary prevention strategy in older adults resulted in a significantly higher risk of major hemorrhage and did not result in a significantly lower risk of cardiovascular disease than placebo."
RT @RawdyReales: @nicheunal https://t.co/vPV5UKfNIn
@nicheunal https://t.co/vPV5UKfNIn
RT @buntype1600: @Dr_ppooohh これですね。 「一次予防目的のアスピリンは出血が増えるだけで、心血管イベントは減らさない」 https://t.co/W43xdy61pX
RT @buntype1600: @Dr_ppooohh これですね。 「一次予防目的のアスピリンは出血が増えるだけで、心血管イベントは減らさない」 https://t.co/W43xdy61pX
RT @buntype1600: @Dr_ppooohh これですね。 「一次予防目的のアスピリンは出血が増えるだけで、心血管イベントは減らさない」 https://t.co/W43xdy61pX
RT @buntype1600: @Dr_ppooohh これですね。 「一次予防目的のアスピリンは出血が増えるだけで、心血管イベントは減らさない」 https://t.co/W43xdy61pX
#ASA Como prevención primaria de eventos cardiovasculares #ASPREE: ASA 100mg/d como prevención primaria en adultos sanos, NO previene eventos cardiovasculares y sí aumenta el riesgo de hemorragia DOI: 10.1056/NEJMoa1805819 https://t.co/9QzwWO3FCJ
El uso de aspirina en dosis bajas como estrategia de prevención primaria en adultos mayores resultó en un riesgo significativamente mayor de hemorragia mayor y no resultó en un riesgo significativamente menor de enfermedad cardiovascular que el placebo https://t.co/aGuNLoAuoB
RT @ryoma_tanaka: アスピリンについてのスタディーが3つNEJMに発表されましたね。 出血が増えて悪性疾患が増えて心血管疾患は減らなくて、死亡リスクは増えるという何だか大変な結果になっています。 https://t.co/tdsfmj8miC https://t…
Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly | NEJM https://t.co/UedKFUholZ
RT @EricTopol: The results on lack of any cardiovascular benefit but increase in bleeding https://t.co/102822NSxC @NEJM https://t.co/9QhEwY…
RT @MaRkusSide: USPSTF пришла к выводу, что что доказательств того, что использование низких доз аспирина снижает частоту или смертность от…
RT @MaRkusSide: USPSTF пришла к выводу, что что доказательств того, что использование низких доз аспирина снижает частоту или смертность от…
RT @MaRkusSide: USPSTF пришла к выводу, что что доказательств того, что использование низких доз аспирина снижает частоту или смертность от…
RT @CarlosdelRio7: Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly @NEJM https://t.co/oEIgh43oXv A practice…
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RT @CarlosdelRio7: Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly @NEJM https://t.co/oEIgh43oXv A practice…
RT @CarlosdelRio7: Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly @NEJM https://t.co/oEIgh43oXv A practice…
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RT @EricTopol: The results on lack of any cardiovascular benefit but increase in bleeding https://t.co/102822NSxC @NEJM https://t.co/9QhEwY…
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RT @CarlosdelRio7: Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly @NEJM https://t.co/oEIgh43oXv A practice…
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RT @EricTopol: The results on lack of any cardiovascular benefit but increase in bleeding https://t.co/102822NSxC @NEJM https://t.co/9QhEwY…
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RT @EricTopol: The results on lack of any cardiovascular benefit but increase in bleeding https://t.co/102822NSxC @NEJM https://t.co/9QhEwY…
RT @emrkar: 65 yaşın üzerinde primer proflaksi için asprin kullanımının faydası yok, zararı var. https://t.co/E3k6FEyYwM
RT @CarlosdelRio7: Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly @NEJM https://t.co/oEIgh43oXv A practice…
RT @EricTopol: The results on lack of any cardiovascular benefit but increase in bleeding https://t.co/102822NSxC @NEJM https://t.co/9QhEwY…
RT @EricTopol: The results on lack of any cardiovascular benefit but increase in bleeding https://t.co/102822NSxC @NEJM https://t.co/9QhEwY…
65 yaşın üzerinde primer proflaksi için asprin kullanımının faydası yok, zararı var. https://t.co/E3k6FEyYwM
RT @EricTopol: The results on lack of any cardiovascular benefit but increase in bleeding https://t.co/102822NSxC @NEJM https://t.co/9QhEwY…
RT @EricTopol: The results on lack of any cardiovascular benefit but increase in bleeding https://t.co/102822NSxC @NEJM https://t.co/9QhEwY…
RT @CarlosdelRio7: Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly @NEJM https://t.co/oEIgh43oXv A practice…
RT @CarlosdelRio7: Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly @NEJM https://t.co/oEIgh43oXv A practice…
RT @CarlosdelRio7: Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly @NEJM https://t.co/oEIgh43oXv A practice…
RT @CarlosdelRio7: Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly @NEJM https://t.co/oEIgh43oXv A practice…
RT @CarlosdelRio7: Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly @NEJM https://t.co/oEIgh43oXv A practice…
Dirían los grandes "Game changer"
RT @CarlosdelRio7: Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly @NEJM https://t.co/oEIgh43oXv A practice…
RT @CarlosdelRio7: Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly @NEJM https://t.co/oEIgh43oXv A practice…
RT @CarlosdelRio7: Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly @NEJM https://t.co/oEIgh43oXv A practice…
Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly @NEJM https://t.co/oEIgh43oXv A practice changing study showing the lack of benefit (and actual risk) of taking low dose aspirin for adults > 65.
Aspirin Use to Prevent 1st Heart Attack or Stroke Should Be Curtailed, U.S. Panel Says https://t.co/FkdAlsh60s Yep, right out of my M1 lecture
Que dice The New Egland Journal of Medicine sobre el uso frecuente de la aspirina para prevenir algunos problemas de salud? Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly | NEJM https://t.co/Q6lx62yd4s
@fladdict 脳梗塞や心筋梗塞を起こしたことがない人の場合は、心筋梗塞や脳梗塞は減らず、脳出血などはちょっと増えるからですね。 https://t.co/CQruiGHPeU https://t.co/QdHKNkcFSc
RT @UREssien: Inpatient Lesson of the Day 7: I remember the findings from this 2018 @NEJM study that aspirin ⬆️ bleeding risk but didn't…
RT @UREssien: Inpatient Lesson of the Day 7: I remember the findings from this 2018 @NEJM study that aspirin ⬆️ bleeding risk but didn't…
RT @UREssien: Inpatient Lesson of the Day 7: I remember the findings from this 2018 @NEJM study that aspirin ⬆️ bleeding risk but didn't…
RT @UREssien: Inpatient Lesson of the Day 7: I remember the findings from this 2018 @NEJM study that aspirin ⬆️ bleeding risk but didn't…
RT @UREssien: Inpatient Lesson of the Day 7: I remember the findings from this 2018 @NEJM study that aspirin ⬆️ bleeding risk but didn't…
RT @UREssien: Inpatient Lesson of the Day 7: I remember the findings from this 2018 @NEJM study that aspirin ⬆️ bleeding risk but didn't…
RT @UREssien: Inpatient Lesson of the Day 7: I remember the findings from this 2018 @NEJM study that aspirin ⬆️ bleeding risk but didn't…
RT @UREssien: Inpatient Lesson of the Day 7: I remember the findings from this 2018 @NEJM study that aspirin ⬆️ bleeding risk but didn't…
RT @UREssien: Inpatient Lesson of the Day 7: I remember the findings from this 2018 @NEJM study that aspirin ⬆️ bleeding risk but didn't…
RT @UREssien: Inpatient Lesson of the Day 7: I remember the findings from this 2018 @NEJM study that aspirin ⬆️ bleeding risk but didn't…
RT @UREssien: Inpatient Lesson of the Day 7: I remember the findings from this 2018 @NEJM study that aspirin ⬆️ bleeding risk but didn't…
RT @UREssien: Inpatient Lesson of the Day 7: I remember the findings from this 2018 @NEJM study that aspirin ⬆️ bleeding risk but didn't…
RT @UREssien: Inpatient Lesson of the Day 7: I remember the findings from this 2018 @NEJM study that aspirin ⬆️ bleeding risk but didn't…
RT @UREssien: Inpatient Lesson of the Day 7: I remember the findings from this 2018 @NEJM study that aspirin ⬆️ bleeding risk but didn't…
RT @UREssien: Inpatient Lesson of the Day 7: I remember the findings from this 2018 @NEJM study that aspirin ⬆️ bleeding risk but didn't…
RT @UREssien: Inpatient Lesson of the Day 7: I remember the findings from this 2018 @NEJM study that aspirin ⬆️ bleeding risk but didn't…
Inpatient Lesson of the Day 7: I remember the findings from this 2018 @NEJM study that aspirin ⬆️ bleeding risk but didn't ⬇️ CVD risk in the elderly. What I didn't remember is that "elderly" was defined as >70 for White and >65 for Black/Hispanic.
RT @Luke_629: Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly アスピリンは脳出血は減少させるが、心血管イベントには有意差なし。NEJM https://t…
Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly アスピリンは脳出血は減少させるが、心血管イベントには有意差なし。NEJM https://t.co/o0MPRE4sdJ
Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy E... https://t.co/mnKeysR1WF vía @YouTube
Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly | NEJM https://t.co/pFQ2l8WrZz
Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly | NEJM https://t.co/axTkOqhHeW
Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly https://t.co/ZUNYbcn86O https://t.co/0sCD3yjqWB
RT @neuropuc: @EBlackburnMD Así es! Estudio ASPREE
@EBlackburnMD Así es! Estudio ASPREE
RT @NEJM: ASPREE trial: Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly https://t.co/XPjVR3gDh4 Editorial:…
If healthy, an aspirin a day may not be helpful according to a new report. Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly https://t.co/KO7YyfKZk8 #prevention #stroke #cardiovascular https://t.co/iQlnM9VYxt
Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly | NEJM https://t.co/ajAMGFWw5S
Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly https://t.co/G5xkuLG7H8
Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly. - PubMed - NCBI https://t.co/KV7F1Xfm5v
McNeil JJ, Wolfe R, Woods RL, et al, for the ASPREE Investigator Group. Effect of aspirin on cardiovascular events and bleeding in the healthy elderly. N Engl J Med 2018;379(16):1509-1518.
Effect of #Aspirin on #Cardiovascular Events and #Bleeding in the Healthy #Elderly | #NEJM https://t.co/fIQKi5ohye
Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly | NEJM https://t.co/VnaleDtwN4
Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly | NEJM https://t.co/0sguDvV3um