Non-Antibiotic Herbal Therapy (BNO 1045) versus Antibiotic Therapy (Fosfomycin Trometamol) for the Treatment of Acute Lower Uncomplicated Urinary Tract Infections in Women: A Double-Blind, Parallel-Group, Randomized, Multicentre, Non-Inferiority Phase III Trial.

Abstract in brief

• This Phase III clinical trial compared herbal therapy BNO 1045 (Canephron N) to the antibiotic fosfomycin trometamol (FT) for treating acute lower uncomplicated urinary tract infections (uUTIs) in women aged 18-70, and found BNO 1045 to be noninferior in preventing the need for additional antibiotics.
• The study showed similar rates of adverse events between both treatments, with gastrointestinal issues more common in the FT group and pyelonephritis in the BNO 1045 group, but no deaths or discontinuations due to side effects.
• BNO 1045 could offer an alternative to antibiotics for uUTIs, potentially supporting efforts to reduce antibiotic use and combat antimicrobial resistance.]