March 2020 PMID 30318013

Pharmacokinetic and Pharmacodynamic Aspects of Peyote and Mescaline: Clinical and Forensic Repercussions.

Ricardo Jorge Dinis-Oliveira, Carolina Lança Pereira, Diana Dias da Silva

Mentions

17
Peak: 2 in Aug 2020
across 3 sources since Aug 2020

Extended reach

21,974
potential audience

Total likes

581

Video views

15,581

Mentions per month

Aug 2020 – Feb 2025

Where it's discussed

  • News8 articles
  • X / Twitter7 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions demonstrate a balanced interest in the pharmacological aspects while highlighting potential societal and clinical impacts, such as the mention of mescaline's low addiction and its religious use, with tone and wording emphasizing scientific curiosity and cautious optimism about its therapeutic possibilities, but also skepticism about the broader implications of its recreational use.

AgreementModerate agreement

Most discussions acknowledge the safety profile and clinical relevance of mescaline, with positive remarks about its mild intoxications and low dependence potential.

InterestHigh interest

There is high interest, as evidenced by engaged comments about therapeutic potential and specific references to pharmacokinetics and clinical effects.

EngagementModerate engagement

Posts show moderate engagement, with some users discussing the pharmacological details and implications for forensic and clinical contexts.

ImpactModerate impact

The discussions suggest the article could influence medical understanding and forensic approaches regarding mescaline and peyote, though the overall scope appears somewhat limited to academic and clinical audiences.

Abstract in brief

  • This article reviews how mescaline, found in Peyote, affects the body through its pharmacokinetics (how the drug is processed) and pharmacodynamics (how it affects the body), highlighting its metabolic profile, clinical effects, and variability in responses.
  • Mescaline interacts mainly with serotonin receptors, leading to effects similar to other psychedelics like LSD, including hallucinations and euphoria, but it typically causes mild intoxications without significant addiction or dependence.
  • Despite its illegal use being less common than substances like cocaine or cannabis, mescaline is used in Native American religious rituals, and health professionals face challenges due to limited toxicological testing; its metabolism produces primarily trimethoxyphenylacetic acid, with some minor metabolites that could have forensic or clinical importance.]

Top posts

Most liked on X and Bluesky
Psychedelic Association of Canada
@cdnpsychedelic · X

Addiction and dependence to Mescaline are practically absent and it is clear that most intoxications appear to be mild and are unlikely to produce life threatening symptoms, which favors the interest in the therapeutic potential of the drugs of the class. https://t.co/X2Rj8dsHZ8

Aug 22, 2020 · 5 likes · 3 shares · 2,760 followers View post →
EAPCCT
@eapcct · X

Pharmacokinetic and Pharmacodynamic Aspects of Peyote and Mescaline: Clinical and Forensic Repercussions https://t.co/h7gpKMK6fk

Dec 15, 2022 · 3 likes · 1,755 followers View post →
beadwork.io
@beadworkIO · X

RT @PedroAlvarezOr2: Pharmacokinetic and Pharmacodynamic Aspects of Peyote and Mescaline: Clinical and Forensic Repercussions Ricardo Jorg…

Nov 14, 2020 · 1 share · 1,149 followers View post →
Harsh Taneja
@harshtan · X

RT @cdnpsychedelic: Addiction and dependence to Mescaline are practically absent and it is clear that most intoxications appear to be mild…

Aug 22, 2020 · 3 shares · 325 followers View post →
Pedro Alvarez Ortega Jr.
@PedroAlvarezOr2 · X

Pharmacokinetic and Pharmacodynamic Aspects of Peyote and Mescaline: Clinical and Forensic Repercussions Ricardo Jorge Dinis-Oliveira, Carolina Lança Pereira, and Diana Dias da Silva “Peyote is poorly understood”

Nov 13, 2020 · 1 share · 178 followers View post →
Gaetano Lardieri
@EntheoG108 · X

https://t.co/3krJBm49nP

Jul 10, 2022 · 172 followers View post →

All mentions

EAPCCT
@eapcct · X

Pharmacokinetic and Pharmacodynamic Aspects of Peyote and Mescaline: Clinical and Forensic Repercussions https://t.co/h7gpKMK6fk

Dec 15, 2022 · 3 likes · 1,755 followers View post →
Gaetano Lardieri
@EntheoG108 · X

https://t.co/3krJBm49nP

Jul 10, 2022 · 172 followers View post →
Ronit
@Ronit15643377 · X

Pharmacokinetic and Pharmacodynamic Aspects of Peyote and Mescaline: Clinical and Forensic Repercussions | Bentham Science They pretty much sprinkle it on anything here….hence the massive fatal car crashes and accidents .

Nov 3, 2021 · 39 followers View post →
beadwork.io
@beadworkIO · X

RT @PedroAlvarezOr2: Pharmacokinetic and Pharmacodynamic Aspects of Peyote and Mescaline: Clinical and Forensic Repercussions Ricardo Jorg…

Nov 14, 2020 · 1 share · 1,149 followers View post →
Pedro Alvarez Ortega Jr.
@PedroAlvarezOr2 · X

Pharmacokinetic and Pharmacodynamic Aspects of Peyote and Mescaline: Clinical and Forensic Repercussions Ricardo Jorge Dinis-Oliveira, Carolina Lança Pereira, and Diana Dias da Silva “Peyote is poorly understood”

Nov 13, 2020 · 1 share · 178 followers View post →
Harsh Taneja
@harshtan · X

RT @cdnpsychedelic: Addiction and dependence to Mescaline are practically absent and it is clear that most intoxications appear to be mild…

Aug 22, 2020 · 3 shares · 325 followers View post →
Psychedelic Association of Canada
@cdnpsychedelic · X

Addiction and dependence to Mescaline are practically absent and it is clear that most intoxications appear to be mild and are unlikely to produce life threatening symptoms, which favors the interest in the therapeutic potential of the drugs of the class. https://t.co/X2Rj8dsHZ8

Aug 22, 2020 · 5 likes · 3 shares · 2,760 followers View post →