August 2019 PMID 30321335

Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions.

Roger Bouillon, Claudio Marcocci, Geert Carmeliet, Daniel Bikle, John H White, Bess Dawson-Hughes, Paul Lips, Craig F Munns, Marise Lazaretti-Castro, Andrea Giustina, John Bilezikian

Mentions

56
Peak: 10 in Oct 2020
across 5 sources since Jul 2019

Extended reach

139,366
potential audience

Total likes

808

Video views

17,607

Mentions per month

Jul 2019 – Nov 2025

Where it's discussed

  • X / Twitter30 posts
  • News15 articles
  • Facebook5 posts
  • YouTube3 videos
  • Blogs3 articles

AI synopsis

What people are saying

Several discussions express agreement with the article's emphasis on vitamin D's well-established skeletal benefits and its potential extraskeletal effects, with phrases like 'vitD's role in bone health' and 'controversial but promising findings.' The tone is analytical and curious, featuring references to ongoing research debates and clinical implications, reflecting high interest and moderate engagement that recognizes the article's importance in ongoing scientific conversations.

AgreementModerate agreement

Most discussions acknowledge the established roles of vitamin D in bone health and agree with the scientific consensus presented in the publication.

InterestHigh interest

The discussions show a high level of curiosity about vitamin D's effects beyond bones and the ongoing debates, indicating strong engagement.

EngagementModerate engagement

Many references and mentions of specific studies and mechanisms suggest users are actively engaging with the complex content.

ImpactModerate impact

The discussions highlight the significance of understanding vitamin D's multiple roles, although some comments indicate the evidence is still developing, suggesting moderate impact.

Abstract in brief

  • Vitamin D's primary role is to regulate bone health by facilitating calcium absorption, preventing conditions like rickets and osteomalacia, especially with daily supplementation of 400-800 IU.
  • Beyond bones, vitamin D influences various bodily functions such as immune response, cell growth, muscle function, skin health, and metabolism, with evidence suggesting many extraskeletal effects.
  • While observational studies link low vitamin D levels to numerous diseases and some clinical trials support further benefits of supplementation, definitive conclusions are still under investigation, highlighting the need for more research.

Top posts

Most liked on X and Bluesky
Endocrine Society Journals
@EndoSocJournals · X

"#VitaminD deficiency enhances the risk of #osteoporoticfractures and is associated with many #diseases. We review what is established and what is plausible regarding the health effects of vitamin D." #EndocrineReviews #OpenAccess #OpenAccessWeek2020 https://t.co/1UnBzLw7xB

Oct 22, 2020 · 17 likes · 9 shares · 9,882 followers View post →
Gema López Gallardo
@gglg12 · X

Revisión sobre vitamina D en #Endocrinereviews by #bilezikian y cols. https://t.co/rizal0YsBD

Jul 15, 2019 · 11 likes · 2 shares · 1,644 followers View post →
Endocrine Society Journals
@EndoSocJournals · X

Benefits of vitamin D? Yes for bone development, and for some other things circumstantially, on various grounds, but ...it's complicated. Evidence in some conditions unclear. Review of this controversial topic in #EndocrineReviews @TheEndoSociety #bone https://t.co/xfuNjEJwvO

Jul 19, 2019 · 9 likes · 12 shares · 9,882 followers View post →
Sociedad SEEN
@sociedadSEEN · X

“Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions” La #vitaminaD previene y cura el #raquitismonutricional, pero la implementación de una estrategia preventiva adecuada sigue siendo problemática en muchos países: https://t.co/9VcEJTwVaJ https://t.co/64gtAJ0lPl

Aug 9, 2019 · 4 likes · 2 shares · 17,220 followers View post →
tune
@keisuke4713 · X

vitDの骨格・骨格外作用 https://t.co/DSi8w6tAJy vitD、適応免疫、自己免疫 マクロファージとDC 循環25OHDから1,25(OH)2D産生 自然免疫蛋白発現に対する1,25(OH)2Dシグナル VDR↑⇨遺伝子転写↑⇨パターン認識受容体シグナル伝達の上下流で自然免疫応答を調節 vitDシグナルがT細胞サブタイプに影響 https://t.co/6Cv8zoeMHb

Feb 20, 2022 · 3 likes · 2 shares · 3,744 followers View post →
Yo.Vivo.D
@YoVivoD · X

Referencias: Bouillon R, Marcocci C, Carmeliet G, Bikle D, White JH, DawsonHughes B, Lips P, Munns CF, Lazaretti-Castro M, Giustina A, Bilezikian J (2019) Skeletal and extraskeletal actions of vitamin D: current evidence and outstanding questions. Endocr Rev 40: 1109–115

Aug 13, 2021 · 3 likes · 1 share · 1,108 followers View post →

All mentions

_24_com
@_24_com · X

RT @keisuke4713: vitDの骨格・骨格外作用 https://t.co/DSi8w6tAJy vitD、適応免疫、自己免疫 マクロファージとDC 循環25OHDから1,25(OH)2D産生 自然免疫蛋白発現に対する1,25(OH)2Dシグナル VDR↑⇨遺伝…

Jan 30, 2023 · 2 shares · 1,485 followers View post →
やっさん
@kuanyi_vet · X

RT @keisuke4713: vitDの骨格・骨格外作用 https://t.co/DSi8w6tAJy vitD、適応免疫、自己免疫 マクロファージとDC 循環25OHDから1,25(OH)2D産生 自然免疫蛋白発現に対する1,25(OH)2Dシグナル VDR↑⇨遺伝…

Feb 20, 2022 · 2 shares · 727 followers View post →
tune
@keisuke4713 · X

vitDの骨格・骨格外作用 https://t.co/DSi8w6tAJy vitD、適応免疫、自己免疫 マクロファージとDC 循環25OHDから1,25(OH)2D産生 自然免疫蛋白発現に対する1,25(OH)2Dシグナル VDR↑⇨遺伝子転写↑⇨パターン認識受容体シグナル伝達の上下流で自然免疫応答を調節 vitDシグナルがT細胞サブタイプに影響 https://t.co/6Cv8zoeMHb

Feb 20, 2022 · 3 likes · 2 shares · 3,744 followers View post →
Yo.Vivo.D
@YoVivoD · X

2. Bouillon R, Marcocci C, Carmeliet G, Bikle D, White JH, Dawson-Hughes B, Lips P, Munns CF, Lazaretti-Castro M, Giustina A, Bilezikian J. Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions. Endocr Rev. 2019 Aug 1;40(4):1109-1151.

Feb 4, 2022 · 1,108 followers View post →
Yo.Vivo.D
@YoVivoD · X

2. Bouillon R, Marcocci C, Carmeliet G, Bikle D, White JH, Dawson-Hughes B, Lips P, Munns CF, Lazaretti-Castro M, Giustina A, Bilezikian J. Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions. Endocr Rev. 2019 Aug 1;40(4):1109-1151.

Feb 4, 2022 · 1,108 followers View post →
Yo.Vivo.D
@YoVivoD · X

2. Bouillon R, Marcocci C, Carmeliet G, Bikle D, White JH, Dawson-Hughes B, Lips P, Munns CF, Lazaretti-Castro M, Giustina A, Bilezikian J. Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions. Endocr Rev. 2019 Aug 1;40(4):1109-1151.

Feb 4, 2022 · 1,108 followers View post →
Yo.Vivo.D
@YoVivoD · X

Referencia: 1. Bouillon R, Marcocci C, Carmeliet G, Bikle D, White JH, DawsonHughes B, Lips P, Munns CF, Lazaretti-Castro M, Giustina A, Bilezikian J (2019) Skeletal and extraskeletal actions of vitamin D: current evidence and outstanding questions. Endocr Rev 40: 1109–115

Dec 9, 2021 · 1,108 followers View post →
Nallely MayFer
@Nallemayorferna · X

RT @YoVivoD: Referencias: Bouillon R, Marcocci C, Carmeliet G, Bikle D, White JH, DawsonHughes B, Lips P, Munns CF, Lazaretti-Castro M, Giu…

Aug 13, 2021 · 1 share · 15 followers View post →
Yo.Vivo.D
@YoVivoD · X

Referencias: Bouillon R, Marcocci C, Carmeliet G, Bikle D, White JH, DawsonHughes B, Lips P, Munns CF, Lazaretti-Castro M, Giustina A, Bilezikian J (2019) Skeletal and extraskeletal actions of vitamin D: current evidence and outstanding questions. Endocr Rev 40: 1109–115

Aug 13, 2021 · 3 likes · 1 share · 1,108 followers View post →
Krasnov Ⓥ
@greennomad61 · X

@TomSwyers .@SciTechDaily1

Oct 30, 2020 · 14,049 followers View post →
Endocrine Society
@TheEndoSociety · X

RT @RevistaEndoMex: #OpenAccessWeek @EndoSocJournals https://t.co/BjMufpfmyL

Oct 25, 2020 · 1 share · 32,249 followers View post →
Revista Mexicana Endocrino Metabolismo & Nutricion
@RevistaEndoMex · X

#OpenAccessWeek @EndoSocJournals https://t.co/BjMufpfmyL

Oct 24, 2020 · 1 share · 1,436 followers View post →
ISCBH
@childrensbones · X

RT @EndoSocJournals: "#VitaminD deficiency enhances the risk of #osteoporoticfractures and is associated with many #diseases. We review wha…

Oct 23, 2020 · 9 shares · 1,480 followers View post →
Claudio Chinaglia
@claudiochinagli · X

RT @EndoSocJournals: "#VitaminD deficiency enhances the risk of #osteoporoticfractures and is associated with many #diseases. We review wha…

Oct 22, 2020 · 9 shares · 119 followers View post →
Rafael Radaeli
@rfradaeli · X

RT @EndoSocJournals: "#VitaminD deficiency enhances the risk of #osteoporoticfractures and is associated with many #diseases. We review wha…

Oct 22, 2020 · 9 shares · 382 followers View post →
Mariam Beridze, MPH
@_MariamBeridze_ · X

RT @EndoSocJournals: "#VitaminD deficiency enhances the risk of #osteoporoticfractures and is associated with many #diseases. We review wha…

Oct 22, 2020 · 9 shares · 768 followers View post →
Waarom? Waardoor?
@chrisinactie · X

RT @EndoSocJournals: "#VitaminD deficiency enhances the risk of #osteoporoticfractures and is associated with many #diseases. We review wha…

Oct 22, 2020 · 9 shares · 2,232 followers View post →
BruceWolffenbuttel
@bhrw · X

RT @EndoSocJournals: "#VitaminD deficiency enhances the risk of #osteoporoticfractures and is associated with many #diseases. We review wha…

Oct 22, 2020 · 9 shares · 2,740 followers View post →
Endocrine Society Journals
@EndoSocJournals · X

"#VitaminD deficiency enhances the risk of #osteoporoticfractures and is associated with many #diseases. We review what is established and what is plausible regarding the health effects of vitamin D." #EndocrineReviews #OpenAccess #OpenAccessWeek2020 https://t.co/1UnBzLw7xB

Oct 22, 2020 · 17 likes · 9 shares · 9,882 followers View post →
Jose Jimenez-Vega
@jmjvega · X

Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions | Endocrine Reviews | Oxford Academic https://t.co/XOIbbnsIbc

Aug 25, 2019 · 235 followers View post →
Marta Araujo-Castro, MD, PhD
@Marta_Araujo_C · X

RT @sociedadSEEN: “Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions” La #vitaminaD previene y cu…

Aug 9, 2019 · 2 shares · 2,565 followers View post →
Tu Endocrino
@TuendocrinoSEEN · X

RT @sociedadSEEN: “Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions” La #vitaminaD previene y cu…

Aug 9, 2019 · 2 shares · 5,795 followers View post →
Sociedad SEEN
@sociedadSEEN · X

“Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions” La #vitaminaD previene y cura el #raquitismonutricional, pero la implementación de una estrategia preventiva adecuada sigue siendo problemática en muchos países: https://t.co/9VcEJTwVaJ https://t.co/64gtAJ0lPl

Aug 9, 2019 · 4 likes · 2 shares · 17,220 followers View post →
OSTEOPOROSIS_SEMI
@GtoSemi · X

Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions https://t.co/3O1JxxmeGS

Jul 24, 2019 · 784 followers View post →
fausto heredia z.
@drfherediaz · X

RT @EndoSocJournals: Benefits of vitamin D? Yes for bone development, and for some other things circumstantially, on various grounds, but…

Jul 19, 2019 · 12 shares · 4,377 followers View post →
ENDO-Clínica
@RAMIROBALDERAS1 · X

RT @EndoSocJournals: Benefits of vitamin D? Yes for bone development, and for some other things circumstantially, on various grounds, but…

Jul 19, 2019 · 12 shares · 302 followers View post →
Endocrine Society Journals
@EndoSocJournals · X

Benefits of vitamin D? Yes for bone development, and for some other things circumstantially, on various grounds, but ...it's complicated. Evidence in some conditions unclear. Review of this controversial topic in #EndocrineReviews @TheEndoSociety #bone https://t.co/xfuNjEJwvO

Jul 19, 2019 · 9 likes · 12 shares · 9,882 followers View post →
Rosa Casañ Fernandez
@RosaCasan · X

RT @gglg12: Revisión sobre vitamina D en #Endocrinereviews by #bilezikian y cols. https://t.co/rizal0YsBD

Jul 15, 2019 · 2 shares · 1,188 followers View post →
Alejandro RI
@AlejandroIzcoa · X

RT @gglg12: Revisión sobre vitamina D en #Endocrinereviews by #bilezikian y cols. https://t.co/rizal0YsBD

Jul 15, 2019 · 2 shares · 678 followers View post →
Gema López Gallardo
@gglg12 · X

Revisión sobre vitamina D en #Endocrinereviews by #bilezikian y cols. https://t.co/rizal0YsBD

Jul 15, 2019 · 11 likes · 2 shares · 1,644 followers View post →