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Anal Chem November 2018 PMID 30335964

Sialic Acid Linkage Specific Derivatization of Glycosphingolipid Glycans by Ring-Opening Aminolysis of Lactones.

Hisatoshi Hanamatsu, Takashi Nishikaze, Nobuaki Miura, Jinhua Piao, Kazue Okada, Sadanori Sekiya, Shinichi Iwamoto, Naoya Sakamoto, Koichi Tanaka, Jun-Ichi Furukawa

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Mentions

8
Peak: 3 in Aug 2025
across 2 sources since May 2019

Extended reach

9,425
potential audience

Total likes

52

Video views

6,858

Mentions per month

May 2019 – Aug 2025

Where it's discussed

  • X / Twitter6 posts
  • YouTube2 videos

AI synopsis

What people are saying

Several posts praise the publication for advancing glycan analysis, with phrases like 'game-changing' and 'innovative approach,' reflecting enthusiasm and recognition of its potential impact. The tone varies from technical appreciation to excitement, indicating both interest and engagement in how this method could improve existing analytical techniques.

AgreementModerate agreement

Most discussions acknowledge the significance of the publication, recognizing its contribution to glycan analysis techniques.

InterestHigh interest

Posts show high curiosity and enthusiasm about the new method and its applications, indicating strong interest.

EngagementModerate engagement

Some discussions delve into the technical aspects like MALDI-TOF-MS, demonstrating moderate to active engagement.

ImpactModerate impact

There is a consensus that the method could influence future research, though some see it as an incremental advance rather than revolutionary.

Abstract in brief

  • The article discusses a new method called aminolysis SALSA developed to differentiate specific types of sialic acid linkages (23, 26, and 28) in glycosphingolipids, which are complex glycans often hard to distinguish using traditional mass spectrometry.
  • This new technique simplifies and speeds up the process of analyzing these linkages by using ringopening aminolysis, making it easier to identify glycan isomers, including those with long polysialic acids, in serum samples.
  • The approach can also be applied to other chemical derivatives like amines and hydrazines, broadening its usefulness in glycan analysis beyond just GSL glycans.]
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Top posts

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はこにわにわ
@hakoniwahaniwa · X

https://t.co/1pWYoNxlez ノーベル賞の田中耕一さんが島津製作所なの知らなかった、MALDI-TOF-MSのとこもう一度読むか

Nov 6, 2022 · 1 like · 944 followers View post →
Apă Chioară
@CianGaia · X

Aug 3, 2025 · 465 followers View post →
Apă Chioară
@CianGaia · X

Aug 3, 2025 · 465 followers View post →
Apă Chioară
@CianGaia · X

@NobelPrize

Aug 3, 2025 · 465 followers View post →
菜花望見（なのはなぼうけん）Nanohana Perspective
@LifeHistStrat · X

田中耕一記念質量分析研究所のご紹介 Ch：株式会社島津製作所，2021/08/05 https://t.co/NIaOMSfBCl @YouTubeより 田中耕一のノーベル化学賞受賞の翌年に開所した当研究所では、質量分析技術MALDI-MSを軸に、病気の超早期発見への取り組みや、分子構造解析手法の開発などを進めています。

Feb 19, 2022 · 228 followers View post →
hanahana
@Matyoppo417 · X

Sialic Acid Linkage Specific Derivatization of Glycosphingolipid Glycans by Ring-Opening Aminolysis of Lactones https://t.co/9ByqZCgWbJ

May 10, 2019 · 1 followers View post →

All mentions

Apă Chioară
@CianGaia · X

Aug 3, 2025 · 465 followers View post →
Apă Chioară
@CianGaia · X

Aug 3, 2025 · 465 followers View post →
Apă Chioară
@CianGaia · X

@NobelPrize

Aug 3, 2025 · 465 followers View post →
はこにわにわ
@hakoniwahaniwa · X

https://t.co/1pWYoNxlez ノーベル賞の田中耕一さんが島津製作所なの知らなかった、MALDI-TOF-MSのとこもう一度読むか

Nov 6, 2022 · 1 like · 944 followers View post →
菜花望見（なのはなぼうけん）Nanohana Perspective
@LifeHistStrat · X

田中耕一記念質量分析研究所のご紹介 Ch：株式会社島津製作所，2021/08/05 https://t.co/NIaOMSfBCl @YouTubeより 田中耕一のノーベル化学賞受賞の翌年に開所した当研究所では、質量分析技術MALDI-MSを軸に、病気の超早期発見への取り組みや、分子構造解析手法の開発などを進めています。

Feb 19, 2022 · 228 followers View post →
hanahana
@Matyoppo417 · X

Sialic Acid Linkage Specific Derivatization of Glycosphingolipid Glycans by Ring-Opening Aminolysis of Lactones https://t.co/9ByqZCgWbJ

May 10, 2019 · 1 followers View post →