Clin Transl Sci January 2019 PMID 30387917

Effects of Common CYP1A2 Genotypes and Other Key Factors on Intraindividual Variation in the Caffeine Metabolic Ratio: An Exploratory Analysis.

Dan-Dan Tian, Senthil Natesan, John R White, Mary F Paine

Mentions

12
Peak: 2 in Aug 2022
across 3 sources since Jan 2022

Extended reach

4,922
potential audience

Total likes

37

Video views

612

Mentions per month

Jan 2022 – Oct 2025

Where it's discussed

  • X / Twitter6 posts
  • News4 articles
  • YouTube2 videos

AI synopsis

What people are saying

The social discussions predominantly focus on affirming the study's core methods, such as the use of caffeine as a biomarker and the examination of induction factors, evidenced by phrases like 'established marker' and 'evaluated effects,' which indicate a general understanding but limited depth of analysis.

AgreementModerate agreement

The posts recognize the importance of using caffeine's metabolic ratio as a marker for CYP1A2 activity, showing moderate agreement with the study's focus.

InterestModerate interest

The discussions reflect a moderate level of curiosity, mainly emphasizing the methodological aspects like caffeine administration and factors evaluated.

EngagementNeutral engagement

There is limited deep engagement, as the posts mainly reiterate the study's basic points without detailed analysis or critique.

ImpactNeutral impact

The discussions do not indicate a significant impact or shift in perspective but acknowledge the study's relevance in caffeine metabolism research.

Abstract in brief

  • The study examined how genetic factors related to the CYP1A2 enzyme, along with other factors like sex, age, oral contraceptive use, and smoking status, influence the variability in caffeine metabolism within individuals.
  • It found that regardless of genetic makeup or lifestyle factors, the intraindividual variation in caffeine metabolism was about 30%, which is important for designing future pharmacokinetic studies involving caffeine.
  • The researchers suggest using a variation value of 30% when planning studies to better understand how drugs interact with caffeine metabolism, although further research is needed to confirm these findings.]

Top posts

Most liked on X and Bluesky
NaPDI
@NaPDICenter · X

The caffeine metabolic ratio is an established marker for cytochrome P450 1A2 activity. In this exploratory analysis @NaPDICenter scientists administered caffeine on 5 occasions to evaluate the effects of CYP1A2 induction status & other factors. https://t.co/l8602f2Tul https://t.co/QreXzv1rMu

Nov 21, 2022 · 3 likes · 1 share · 323 followers View post →
NaPDI
@NaPDICenter · X

The caffeine metabolic ratio is an established marker for cytochrome P450 1A2 activity. In this exploratory analysis @NaPDICenter scientists administered caffeine on 5 occasions to evaluate the effects of CYP1A2 induction status & other factors. https://t.co/l8602fkuSV

Aug 12, 2022 · 3 likes · 1 share · 323 followers View post →
NaPDI
@NaPDICenter · X

The caffeine metabolic ratio is an established marker for cytochrome P450 1A2 activity. In this exploratory analysis @NaPDICenter scientists administered caffeine on 5 occasions to evaluate the effects of CYP1A2 induction status & other factors. https://t.co/l8602f2Tul

Jan 21, 2022 · 2 likes · 323 followers View post →
Susan Egbert, PharmD (she/her)
@lichenlady94 · X

RT @NaPDICenter: The caffeine metabolic ratio is an established marker for cytochrome P450 1A2 activity. In this exploratory analysis @NaPD…

Nov 21, 2022 · 1 share · 1,505 followers View post →
Susan Egbert, PharmD (she/her)
@lichenlady94 · X

RT @NaPDICenter: The caffeine metabolic ratio is an established marker for cytochrome P450 1A2 activity. In this exploratory analysis @NaPD…

Aug 12, 2022 · 1 share · 1,505 followers View post →
NaPDI
@NaPDICenter · X

The caffeine metabolic ratio is an established marker for cytochrome P450 1A2 activity. In this exploratory analysis @NaPDICenter scientists administered caffeine on 5 occasions to evaluate the effects of CYP1A2 induction status & other factors. https://t.co/l8602fkuSV

Apr 10, 2023 · 323 followers View post →

All mentions

NaPDI
@NaPDICenter · X

The caffeine metabolic ratio is an established marker for cytochrome P450 1A2 activity. In this exploratory analysis @NaPDICenter scientists administered caffeine on 5 occasions to evaluate the effects of CYP1A2 induction status & other factors. https://t.co/l8602fkuSV

Apr 10, 2023 · 323 followers View post →
Susan Egbert, PharmD (she/her)
@lichenlady94 · X

RT @NaPDICenter: The caffeine metabolic ratio is an established marker for cytochrome P450 1A2 activity. In this exploratory analysis @NaPD…

Nov 21, 2022 · 1 share · 1,505 followers View post →
NaPDI
@NaPDICenter · X

The caffeine metabolic ratio is an established marker for cytochrome P450 1A2 activity. In this exploratory analysis @NaPDICenter scientists administered caffeine on 5 occasions to evaluate the effects of CYP1A2 induction status & other factors. https://t.co/l8602f2Tul https://t.co/QreXzv1rMu

Nov 21, 2022 · 3 likes · 1 share · 323 followers View post →
Susan Egbert, PharmD (she/her)
@lichenlady94 · X

RT @NaPDICenter: The caffeine metabolic ratio is an established marker for cytochrome P450 1A2 activity. In this exploratory analysis @NaPD…

Aug 12, 2022 · 1 share · 1,505 followers View post →
NaPDI
@NaPDICenter · X

The caffeine metabolic ratio is an established marker for cytochrome P450 1A2 activity. In this exploratory analysis @NaPDICenter scientists administered caffeine on 5 occasions to evaluate the effects of CYP1A2 induction status & other factors. https://t.co/l8602fkuSV

Aug 12, 2022 · 3 likes · 1 share · 323 followers View post →
NaPDI
@NaPDICenter · X

The caffeine metabolic ratio is an established marker for cytochrome P450 1A2 activity. In this exploratory analysis @NaPDICenter scientists administered caffeine on 5 occasions to evaluate the effects of CYP1A2 induction status & other factors. https://t.co/l8602f2Tul

Jan 21, 2022 · 2 likes · 323 followers View post →