November 2018 PMID 30404012

Brief Local Application of Progesterone via a Wearable Bioreactor Induces Long-Term Regenerative Response in Adult Xenopus Hindlimb.

Celia Herrera-Rincon, Annie S Golding, Kristine M Moran, Christina Harrison, Christopher J Martyniuk, Justin A Guay, Julia Zaltsman, Hayley Carabello, David L Kaplan, Michael Levin

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Mentions

Peak: 3 in Apr 2021

across 5 sources since Mar 2020

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AI synopsis

What people are saying

The discussions highlight the significance of methodological transparency, such as mentions of RRIDs to emphasize reproducibility, and reference the study’s innovative use of wearable bioreactors for limb regeneration. The tone is informative and appreciative, reflecting moderate interest in scientific advancements without extensive critique or deep engagement.

AgreementModerate agreement

Most discussions acknowledge the scientific significance of the study, especially regarding reproducibility and the innovative approach to tissue regeneration.

InterestModerate interest

Participants show some interest by referencing the publication's methods and implications, but overall engagement remains moderate.

EngagementNeutral engagement

Comments tend to be surface-level, primarily sharing links or general acknowledgments without deep analysis.

ImpactModerate impact

The focus on reproducibility and the presentation of a novel regenerative technique suggests some recognition of its potential importance, though far from transformative impact.

Abstract in brief

The study demonstrates that a wearable bioreactor delivering progesterone for 24 hours at the site of hindlimb amputation in adult Xenopus frogs can trigger long-term limb regeneration, forming paddle-like structures instead of simple spikes.
Using various analysis methods, researchers showed that these regenerated limbs had specific molecular markers, favorable tissue morphometry, and functional behaviors, indicating successful regeneration compared to untreated animals.
The findings suggest that brief, targeted delivery of small molecules like progesterone via an integrated device can serve as a promising approach to promote tissue regeneration in vertebrates, offering new strategies for limb repair therapies.]

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All mentions

Advances in Limb Regeneration with Bioelectricity and Hormone Delivery

Michael Levin discusses recent research on frog limb regeneration, focusing on a wearable bioreactor delivering progesterone to stimulate long-term limb regeneration, with potential applications for tissue repair…

NASJAQ · Feb 3, 2022 34,518 views

Advances in Bioelectricity for Regeneration and Human Enhancement

Bioelectricity enables limb regeneration and tissue repair. This video explores recent experiments with planarian worms, frogs, and tadpoles, showcasing potential future applications in limb regeneration, synthetic…

NASJAQ · Aug 25, 2020 22,617 views

RRID Robot

@RobotRrid · X

The authors of "Brief Local Application of Progesterone via a Wear…" (https://t.co/a5PftYiyRk) included RRIDs in their paper! Thank you for making your #methodsmatter. #ReproducibleResearch

Sep 7, 2021 · 161 followers View post →

OpenSci Talk

@OpenSciTalk · X

RT @RobotRrid: The authors of "untitled" (https://t.co/a5PftYiyRk) included RRIDs in their paper! RRIDs like this improve reproducibility i…

Aug 21, 2021 · 1 share · 4,085 followers View post →

RRID Robot

@RobotRrid · X

The authors of "untitled" (https://t.co/a5PftYiyRk) included RRIDs in their paper! RRIDs like this improve reproducibility in scientific research. #OpenScience #RRID

Aug 21, 2021 · 1 share · 161 followers View post →

Complex

@enerphyschem · X

06-Nov-2018 https://t.co/Brh0IZpWSG

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Common

@SciTechMachINe · X

06-Nov-2018 https://t.co/mX7Q5O3KeJ

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Absurd

@qualityisarul3 · X

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A_Yukita

@A_Yukita · X

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