Acta Neuropathol Commun November 2018 PMID 30409187

Nicotine promotes neuron survival and partially protects from Parkinson's disease by suppressing SIRT6.

Justin W Nicholatos, Adam B Francisco, Carolyn A Bender, Tiffany Yeh, Fraz J Lugay, Jairo E Salazar, Christin Glorioso, Sergiy Libert

Download social card

Mentions

68
Peak: 8 in Jan 2025
across 5 sources since Nov 2019

Extended reach

130,379
potential audience

Total likes

53

Video views

45

Mentions per month

Nov 2019 – Nov 2025

Where it's discussed

  • X / Twitter50 posts
  • Reddit12 posts
  • News3 articles
  • YouTube2 videos
  • Instagram1 posts

AI synopsis

What people are saying

Discussions frequently reference the neuroprotective effects of nicotine and its potential to treat Parkinson’s, with phrases like 'supports the research' and remarks about 'medical benefits' reflecting excitement and seriousness. The tone, including shared studies and personal stories, underscores a collective recognition of the research's importance and potential paradigm shift.

AgreementStrong agreement

Most discussions support the study’s findings, emphasizing nicotine’s neuroprotective potential and its relationship to reducing Parkinson’s risk.

InterestHigh interest

The posts demonstrate high interest, with many referencing studies, potential treatments, and personal connections to Parkinson’s disease.

EngagementHigh engagement

Users engage deeply by discussing methods, citing scientific literature, and sharing personal anecdotes, showing active involvement.

ImpactHigh impact

The conversations highlight significant implications for Parkinson’s research and possible treatment strategies, indicating high perceived impact.

Abstract in brief

  • Nicotine helps neurons survive and may protect against Parkinson's disease by reducing the levels of a protein called SIRT6, which is higher in Parkinson's patients.
  • The study shows that lowering SIRT6 levels decreases brain damage related to Parkinson's, while increasing SIRT6 makes the disease worse; nicotine appears to accelerate SIRT6 degradation, offering neuroprotection.
  • This suggests that targeting SIRT6 could be a potential strategy for treating Parkinson's and other neurodegenerative diseases, as it may play a harmful role in disease progression.]

Top posts

Most liked on X and Bluesky
INNCOorg
@INNCOorg · X

@AMacnevins @SmokeFreeFdn @JayHart909 @RiccardoPolosa Aubergine & tomato also contain nicotine. Many plants produce own pesticidal repellent: Chilli Peppers & basil. Thankfully humans are not insects and neither are Vapers. Nicotine shows a protective effect against Parkinson’s. The dose maketh the poison. https://t.co/gkxF1nqvW7

Jul 22, 2020 · 8 likes · 3 shares · 4,791 followers View post →
Clive Bates
@Clive_Bates · X

@RushmoreExt23 @markhweiss A different study points towards a nicotine interaction with Parkinson disease: https://t.co/i1fjqRae96

Feb 13, 2022 · 7 likes · 2 shares · 13,485 followers View post →
Allison
@alli_vapes · X

"Nicotine promotes neuron survival and partially protects from Parkinson’s disease by suppressing SIRT6" https://t.co/A5LfbnmdH5

Jun 14, 2022 · 6 likes · 4 shares · 7,756 followers View post →
qubitTwit
@qubitTwit · X

2 of 2 References: 1.Nicotine and Neurodegenerative Diseases: •Understanding How Nicotine Might Actually Help Treat Parkinson’s Disease: (https://t.co/veyTzO0DhF) •Nicotine promotes neuron survival and partially protects from Parkinson’s disease: (https://t.co/2ZBPV2Mwyr?) https://t.co/VymUuI3Qid

Jan 14, 2025 · 6 likes · 7 shares · 1,294 followers View post →
Michael Redfearn
@RedfearnMike · X

@SamirBecic @EdwardHubert4 @HFRevolution @Clive_Bates On Parkinson's disease "Epidemiological studies consistently show that the use of tobacco reduces the risk of Parkinson's. We report that nicotine reduces the abundance of SIRT6 in neuronal culture and brain tissue." https://t.co/bk2budRzOF

Sep 19, 2022 · 4 likes · 2 shares · 2,653 followers View post →
Christin Glorioso, MD PhD
@DrGlorioso · X

@mjoh090 @BradStanfieldMD @CharlesMBrenner Serg Libert (former Guarente, Calico) and I showed KO of Sirt6 was protective for Parkinson's. https://t.co/cjgILFVxif

Apr 19, 2022 · 4 likes · 1 share · 1,667 followers View post →

All mentions

Ann Currie
@Annpcurrie · X

RT @qubitTwit: 2 of 2 References: 1.Nicotine and Neurodegenerative Diseases: •Understanding How Nicotine Might Actually Help Treat Parki…

Jan 17, 2025 · 7 shares · 1,960 followers View post →
kissXbitch
@kissXbitch · X

RT @qubitTwit: 2 of 2 References: 1.Nicotine and Neurodegenerative Diseases: •Understanding How Nicotine Might Actually Help Treat Parki…

Jan 15, 2025 · 7 shares · 238 followers View post →
Dino Bob Cicada Green
@DinoCicada · X

RT @qubitTwit: 2 of 2 References: 1.Nicotine and Neurodegenerative Diseases: •Understanding How Nicotine Might Actually Help Treat Parki…

Jan 15, 2025 · 7 shares · 16,443 followers View post →
DalGal75
@DalGal1957 · X

RT @qubitTwit: 2 of 2 References: 1.Nicotine and Neurodegenerative Diseases: •Understanding How Nicotine Might Actually Help Treat Parki…

Jan 14, 2025 · 7 shares · 7,907 followers View post →
Angela Fulmer
@AngelaFulmer8 · X

RT @qubitTwit: 2 of 2 References: 1.Nicotine and Neurodegenerative Diseases: •Understanding How Nicotine Might Actually Help Treat Parki…

Jan 14, 2025 · 7 shares · 50 followers View post →
CreateVixon
@01Triers · X

RT @qubitTwit: 2 of 2 References: 1.Nicotine and Neurodegenerative Diseases: •Understanding How Nicotine Might Actually Help Treat Parki…

Jan 14, 2025 · 7 shares · 75 followers View post →
qubitTwit
@qubitTwit · X

RT @qubitTwit: 2 of 2 References: 1.Nicotine and Neurodegenerative Diseases: •Understanding How Nicotine Might Actually Help Treat Parki…

Jan 14, 2025 · 7 shares · 1,294 followers View post →
qubitTwit
@qubitTwit · X

2 of 2 References: 1.Nicotine and Neurodegenerative Diseases: •Understanding How Nicotine Might Actually Help Treat Parkinson’s Disease: (https://t.co/veyTzO0DhF) •Nicotine promotes neuron survival and partially protects from Parkinson’s disease: (https://t.co/2ZBPV2Mwyr?) https://t.co/VymUuI3Qid

Jan 14, 2025 · 6 likes · 7 shares · 1,294 followers View post →
Mandy
@MissyVonStrudel · X

Grab a zyn. Seriously though. Praying for you Brett! https://t.co/93sI9zOMY0 https://t.co/66MQ4fMkEL

Sep 27, 2024 · 1,511 followers View post →
Sascha
@Black_BriarWeed · X

@morgenthau15 https://t.co/vUCrCypaaA

Sep 11, 2024 · 1 like · 132 followers View post →
John Ennis
@johnennis · X

@roxdtvc @BlackLabelAdvsr Etc. https://t.co/Sy7KrVemt9

Jun 22, 2024 · 1 like · 9,477 followers View post →
MidWestDog9
@MidWestDag9 · X

Tobacco/Nicotine is being investigated as helpful in treating Parkinson's Disease and Alzheimer's. https://t.co/q8pAKmQ9Xn

May 3, 2024 · 414 followers View post →
Taylor Tyler
@taylortylerr · X

@jonreismanMD @creepydotorg Nicotine is a nootropic and neuroprotectant https://t.co/PHi2NuH8yH

Apr 26, 2024 · 1 like · 919 followers View post →
Dr. Heath Motley
@DrHeathMotley · X

RT @DrHeathMotley: @JessicaRainvil3 @AllBiteNoBark88 https://t.co/tFfmOt4ka2 https://t.co/TVJS1vxChZ Nicotine promotes neuron survival an…

Mar 13, 2024 · 1 share · 894 followers View post →
Dr. Heath Motley
@DrHeathMotley · X

@JessicaRainvil3 @AllBiteNoBark88 https://t.co/tFfmOt4ka2 https://t.co/TVJS1vxChZ Nicotine promotes neuron survival and partially protects from Parkinson’s disease by suppressing SIRT6 https://t.co/KjdkgUq4ES

Mar 13, 2024 · 1 like · 1 share · 894 followers View post →
KnZ
@_KnZ · X

ニコチンは神経細胞の寿命を促進し、パーキンソン病を予防する https://t.co/vZIUj7JPKb

Mar 9, 2024 · 2,711 followers View post →
Scottie SleepyHead
@thesedaysgoby · X

RT @YabaiKeikai: One of most in depth studies I’ve ever read. The lengths these guys went to prove a point is commendable. They built a cu…

Mar 1, 2024 · 1 share · 340 followers View post →
Mayor Yabai
@YabaiKeikai · X

One of most in depth studies I’ve ever read. The lengths these guys went to prove a point is commendable. They built a custom cigarette smoking vacuum extraction device in order to create tobacco extract for cell studies. https://t.co/xMDtqw1j68

Mar 1, 2024 · 1 like · 1 share · 3,268 followers View post →
joe blogs
@its_all_lies_7 · X

@aractic @StrayDogNZ no you are. https://t.co/fiAs3hWkZg

Feb 2, 2024 · 193 followers View post →
joe blogs
@its_all_lies_7 · X

@lorrainesplace @StrayDogNZ nicotine and caffeine both have health benefits. Coffee is a perfectly good delivery vehicle for caffeine as long as not full of sugar. Cigarets on the other hand are not a good delivery vehicle for nicotine. But that doesn't make nicotine bad. https://t.co/fiAs3hWkZg

Feb 2, 2024 · 193 followers View post →
Fox
@Toby_fuchs · X

@KoNekoEko @cnviolations Because they are confusing consuming nicotine with smoking. Nicotine itself is has been found to be a neuroprotective agent - to a degree. https://t.co/yHo5czSpI8 https://t.co/nnZ03XjuwA https://t.co/yJbeeO6aSX

Jan 11, 2024 · 56 followers View post →
CRIStina CANNONE
@CristinaCannone · X

@StefanoSplendo2 @LauraRewind @controlgroup22 @Ardito98731919 @liliaragnar @ccombercat @itsmeback_ @carlo_conforti @viva_ziaMimma @ThomBal8 @barbarab1974 «La nicotina promuove la sopravvivenza dei neuroni e protegge parzialmente dal morbo di Parkinson sopprimendo la SIRT6.» https://t.co/m09KBYxwql https://t.co/hULP2iW6g5

Sep 18, 2023 · 4 likes · 42 followers View post →
CRIStina CANNONE
@CristinaCannone · X

@FmMosca «La nicotina promuove la sopravvivenza dei neuroni e protegge parzialmente dal morbo di Parkinson sopprimendo la SIRT6.» https://t.co/m09KBYxwql https://t.co/wVDHVTmnIT

Sep 18, 2023 · 1 like · 42 followers View post →
Dan
@TheDaning · X

Parkinson’s runs in my family. Nicotine has long been known to be a neuroprotective agent for Parkinson's disease. A U.S. Government-sponsored study of health among 200,000 veterans reported that smoking reduced Parkinson’s related deaths by 64%! https://t.co/QH1oj3nHck

Aug 21, 2023 · 1 like · 283 followers View post →
Christin Glorioso, MD PhD
@DrGlorioso · X

@DocLarus It's the opposite direction of our earlier findings with Sirt6 & PD in mice and humans. "Our data suggest that SIRT6 plays a pathogenic and pro-inflammatory role in Parkinson's...Inhibition of SIRT6 may be a promising strategy to ameliorate Parkinson's" https://t.co/q7BrSz7xeX.

Jan 23, 2023 · 1 like · 1,667 followers View post →
Michael Redfearn
@RedfearnMike · X

@TomJenkins1911 @VLNSmoking Nicotine is a nueroprotectant against Parkinson's https://t.co/bk2budR1Z7

Oct 6, 2022 · 2,653 followers View post →
Southernvaper
@Southernvaper1 · X

RT @RedfearnMike: @SamirBecic @EdwardHubert4 @HFRevolution @Clive_Bates On Parkinson's disease "Epidemiological studies consistently show t…

Sep 20, 2022 · 2 shares · 1,596 followers View post →
PantherNoster
@PantherNoster · X

RT @RedfearnMike: @SamirBecic @EdwardHubert4 @HFRevolution @Clive_Bates On Parkinson's disease "Epidemiological studies consistently show t…

Sep 19, 2022 · 2 shares · 2,870 followers View post →
Michael Redfearn
@RedfearnMike · X

@SamirBecic @EdwardHubert4 @HFRevolution @Clive_Bates On Parkinson's disease "Epidemiological studies consistently show that the use of tobacco reduces the risk of Parkinson's. We report that nicotine reduces the abundance of SIRT6 in neuronal culture and brain tissue." https://t.co/bk2budRzOF

Sep 19, 2022 · 4 likes · 2 shares · 2,653 followers View post →
Philip
@kafkaguy · X

@theElegantWorm My granddad went from classically trained pianist playing Chopin beautifully to struggling to tear a coupon. Parkinsons runs in my family, if I have to go black market to get my medicinal nicotine so be it. https://t.co/CylJMg9TlT

Jun 23, 2022 · 1 like · 3,077 followers View post →
TheUSVA
@TheUsva · X

RT @alli_vapes: "Nicotine promotes neuron survival and partially protects from Parkinson’s disease by suppressing SIRT6" https://t.co/A5Lfb…

Jun 14, 2022 · 4 shares · 902 followers View post →
A@gurno
@Agurno · X

RT @alli_vapes: "Nicotine promotes neuron survival and partially protects from Parkinson’s disease by suppressing SIRT6" https://t.co/A5Lfb…

Jun 14, 2022 · 4 shares · 299 followers View post →
PantherNoster
@PantherNoster · X

RT @alli_vapes: "Nicotine promotes neuron survival and partially protects from Parkinson’s disease by suppressing SIRT6" https://t.co/A5Lfb…

Jun 14, 2022 · 4 shares · 2,870 followers View post →
durand benoit
@benoit_durand · X

RT @alli_vapes: "Nicotine promotes neuron survival and partially protects from Parkinson’s disease by suppressing SIRT6" https://t.co/A5Lfb…

Jun 14, 2022 · 4 shares · 2,078 followers View post →
Allison
@alli_vapes · X

"Nicotine promotes neuron survival and partially protects from Parkinson’s disease by suppressing SIRT6" https://t.co/A5LfbnmdH5

Jun 14, 2022 · 6 likes · 4 shares · 7,756 followers View post →
(((Phroexus)))
@phroex · X

RT @DrGlorioso: @mjoh090 @BradStanfieldMD @CharlesMBrenner Serg Libert (former Guarente, Calico) and I showed KO of Sirt6 was protective fo…

Apr 19, 2022 · 1 share · 2,773 followers View post →
Christin Glorioso, MD PhD
@DrGlorioso · X

@mjoh090 @BradStanfieldMD @CharlesMBrenner Serg Libert (former Guarente, Calico) and I showed KO of Sirt6 was protective for Parkinson's. https://t.co/cjgILFVxif

Apr 19, 2022 · 4 likes · 1 share · 1,667 followers View post →
TomCat
@avrg_art_njoyer · X

@Nat_the_twat_ @micktheskinz tabaco as a medicinal plant has therapeutic qualities. nicotine alleviates parkinson's symptoms. Everything you were taught about tobacco is a lie https://t.co/iXdXfMFUYH

Mar 17, 2022 · 524 followers View post →
Castello
@castello2 · X

RT @Clive_Bates: @RushmoreExt23 @markhweiss A different study points towards a nicotine interaction with Parkinson disease: https://t.co/i…

Feb 13, 2022 · 2 shares · 3,152 followers View post →
Rawg Slinkard
@Rawgster · X

RT @Clive_Bates: @RushmoreExt23 @markhweiss A different study points towards a nicotine interaction with Parkinson disease: https://t.co/i…

Feb 13, 2022 · 2 shares · 2,730 followers View post →
Clive Bates
@Clive_Bates · X

@RushmoreExt23 @markhweiss A different study points towards a nicotine interaction with Parkinson disease: https://t.co/i1fjqRae96

Feb 13, 2022 · 7 likes · 2 shares · 13,485 followers View post →
Michael Öberg
@obergmike · X

@charliedrummond @nz_voter Could have something to do with the fact that it doesn’t need to be prescribed as it is readily available. My boss has Parkinson’s and his Dr told him to get nicotine patches to help with symptoms. https://t.co/ZG5Lw9ubpG

Dec 8, 2021 · 233 followers View post →
AlSheikh
@Alsheikh_eth · X

النيكوتين ليس مادة سامة! Nicotine is neuro protective https://t.co/4Cm2SKXyZz https://t.co/k9bk1QO4qn

Oct 6, 2021 · 4,240 followers View post →
Barb Cook
@SpectrumBarb · X

@hbowly @Theautisticedu1 @hollieahughes Agreed. There is quite a lot of research on the benefits of nicotine, especially so with Parkinson’s & preventing prey bodies. Nicotine itself is not the problem and is an anti inflammatory. https://t.co/6Mrw6UGwFw

Sep 14, 2021 · 1 like · 1,389 followers View post →
Krystal Koivisto
@krystalb89 · X

@BuccGame @washingtonpost Here is one study showing it helpful with Parkinson's disease https://t.co/9roLgC4dZD

Apr 21, 2021 · 12 followers View post →
Jay Hart
@JayHart909 · X

RT @INNCOorg: @AMacnevins @SmokeFreeFdn @JayHart909 @RiccardoPolosa Aubergine & tomato also contain nicotine. Many plants produce own pesti…

Jul 22, 2020 · 3 shares · 4,118 followers View post →
Allison
@alli_vapes · X

RT @INNCOorg: @AMacnevins @SmokeFreeFdn @JayHart909 @RiccardoPolosa Aubergine & tomato also contain nicotine. Many plants produce own pesti…

Jul 22, 2020 · 3 shares · 7,756 followers View post →
Norbert Zillatron
@N_Zillatron · X

RT @INNCOorg: @AMacnevins @SmokeFreeFdn @JayHart909 @RiccardoPolosa Aubergine & tomato also contain nicotine. Many plants produce own pesti…

Jul 22, 2020 · 3 shares · 3,579 followers View post →
INNCOorg
@INNCOorg · X

@AMacnevins @SmokeFreeFdn @JayHart909 @RiccardoPolosa Aubergine & tomato also contain nicotine. Many plants produce own pesticidal repellent: Chilli Peppers & basil. Thankfully humans are not insects and neither are Vapers. Nicotine shows a protective effect against Parkinson’s. The dose maketh the poison. https://t.co/gkxF1nqvW7

Jul 22, 2020 · 8 likes · 3 shares · 4,791 followers View post →
crosspolar
@crosspolar · X

@hesaitix I gotchu man https://t.co/QZWY54UtIX

Jun 26, 2020 · 1 like · 463 followers View post →
The Nicotine Protocol | PDF | Anthrax | Escherichia Coli
News

A- Y- E- R, out of Germany, and Monsanto also creates genetically modified ... https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-018-0625-y

Dec 18, 2025 View →
Zhakuj Swoj Testosteron E Book | PDF
News

https://doi.org/10.1186/s40478-018-0625-y 78. Jie Zhao, June Yue Yan Leung, Shi Lin Lin, C. Mary Schooling, Cigarette smoking and testosterone in men and ...

Dec 18, 2025 View →
Kurdish Thinkers | ‎ـ جگەری توتن جگەرەی ئامادەکراوی کارگەکان ئەمە ...
Instagram

357 likes, 54 comments - kurdish_thinkers on December 21, 2024‎: "ـ جگەری توتن ✓ جگەرەی ئامادەکراوی کارگەکان ئەمە هاندان نییە کەسێک جگەرە ...

Dec 21, 2024 View →
Nikotin är en undermålig drog : r/swedishproblems
Reddit

... 10.1186/s40478-018-0625-y. Nikotin och Alzheimers: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1670208/ · https://pubmed.ncbi.nlm.nih.gov ...

Apr 23, 2023 View →
YSK: Smoking and vaping can cause permanent hearing damage : r ...
Reddit

https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-018-0625-y · https://pubmed.ncbi.nlm.nih.gov/11772120/ · https://www ...

Apr 6, 2023 View →
Du burde vite: Røyking og vaping kan forårsake permanent ...
Reddit

https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-018-0625-y · https://pubmed.ncbi.nlm.nih.gov/11772120/ · https://www ...

Apr 6, 2023 View →
你应该知道:吸烟和吸电子烟会导致永久性听力损伤: r/YouShouldKnow
Reddit

com/articles/10.1186/s40478-018-0625-y · https://pubmed.ncbi.nlm.nih.gov/11772120/ · https://www.frontiersin.org/articles/10.3389/fnmol ...

Apr 6, 2023 View →
Vad är era åsikter och erfarenheter kring vittsnus? Är det bättre än ...
Reddit

https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-018-0625-y · https://www.sciencedaily.com/releases/2016/09/160920160635.htm.

Feb 3, 2023 View →
Was sind eure Meinungen und Erfahrungen zu weißem Snus? Ist es ...
Reddit

https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-018-0625-y · https://www.sciencedaily.com/releases/2016/09/160920160635.htm.

Feb 3, 2023 View →
Какие у вас мнения и опыт насчет белого снюса? Он лучше ...
Reddit

https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-018-0625-y · https://www.sciencedaily.com/releases/2016/09/160920160635.htm.

Feb 3, 2023 View →
Is nicotine by itself harmful? : r/Nootropics
Reddit

... tenancient. • 4y ago. Actually it might be https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-018-0625-y · tallwizrd. • 4y ago.

Nov 20, 2021 View →
The number of Americans who are dying from Parkinson's disease ...
Reddit

... route, doesnt have to be smoking per se. https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-018-0625-y · cynicalspacecactus. • 4y ...

Oct 29, 2021 View →
Nicotine Causes Selective Degeneration In Brain : r/Nootropics
Reddit

In reality, nicotine use is associated with neuroprotection. https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-018-0625-y.

Aug 24, 2020 View →
Teen vaping is pathetic. : r/unpopularopinion
Reddit

https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-018-0625-y ... When are y'all gonna realize vaping is cringe? 19 upvotes ...

Jul 20, 2020 View →
Acute Administration of Nicotine Does Not Enhance Cognitive ...
Reddit

Slapbox. • 5y ago · https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-018-0625-y. Just one of many sources Mr. Genius.

Jul 9, 2020 View →
Reactions
News

2018, DOI: 10.1186/s40478-018-0625-y), and painting it as an unmitigated ill, isolated from the delivery systems known to harm human health ...

Nov 17, 2019 View →