February 2019 PMID 30430746

Autophagy and aging: Maintaining the proteome through exercise and caloric restriction.

Kurt A Escobar, Nathan H Cole, Christine M Mermier, Trisha A VanDusseldorp

Mentions

87
Peak: 24 in Jun 2020
across 5 sources since Feb 2019

Extended reach

1,119,852
potential audience

Total likes

1,697

Video views

55,739

Mentions per month

Feb 2019 – Jan 2024

Where it's discussed

  • X / Twitter75 posts
  • Facebook4 posts
  • News3 articles
  • Blogs3 articles
  • YouTube2 videos

AI synopsis

What people are saying

The overall tone highlights strong support for the idea that exercise and caloric restriction enhance autophagy, with posts discussing cellular pathways and practical benefits, showing high interest and engagement, such as mention of maintaining cellular health and longevity.

AgreementStrong agreement

Most discussions support the ideas that exercise and caloric restriction promote autophagy and healthy aging, reflecting strong consensus.

InterestHigh interest

Posts consistently show high interest, referencing scientific pathways, health benefits, and practical implications, indicating engagement with the subject.

EngagementHigh engagement

Many comments delve into mechanisms, draw parallels with city systems, and challenge or expand on the topic, demonstrating deep engagement.

ImpactHigh impact

The discussions emphasize the significance of autophagy for longevity and health, suggesting the topic has a substantial influence on ideas about aging and wellness.

Abstract in brief

  • Autophagy helps maintain healthy cells by recycling damaged proteins and organelles, but its activity declines with age, leading to cellular dysfunction and aging-related diseases.
  • Both exercise and caloric restriction (CR) promote healthy aging by inhibiting TORC1, a key regulator that suppresses autophagy, thereby enhancing the cell’s ability to clear damaged components.
  • The longevity benefits of exercise and CR are likely due to their combined effects on balancing protein production and degradation, maintaining cellular health, and preserving the proteome as signaling pathways overlap.]

Top posts

Most liked on X and Bluesky
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

Autophagy and aging: Maintaining the proteome through exercise and caloric restriction Don't need to restrict calories, intermittent fasting will do the job. Exercise powerfully promotes autophagy. Inhibition of autophagy -> premature aging Get on it https://t.co/mTfFrk3Fxx

Jun 25, 2020 · 133 likes · 30 shares · 294,643 followers View post →
IberianCitizen
@IberianCitizen · X

Autofagia y envejecimiento: mantenimiento del proteoma mediante ejercicio y restricción calórica https://t.co/BGU9cH6ZsE https://t.co/vaNqJ9ce2W

Feb 26, 2021 · 70 likes · 10 shares · 12,900 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

https://t.co/mTfFrk3Fxx

Aug 1, 2022 · 48 likes · 4 shares · 294,643 followers View post →
IberianCitizen
@IberianCitizen · X

Una ciudad funciona mejor cuando el sistema de recogida de basuras trabaja correctamente. El ejercicio, para el cuerpo, sería como poner más camiones de basura e incineradoras. By

Nov 25, 2022 · 40 likes · 13 shares · 12,900 followers View post →
Agingdoc
@agingdoc1 · X

From: "Exercise and CR result in a concomitant downregulation of TORC1 activity and upregulation of autophagy in a number of tissues..." Though a bit date, a good discussion of common pathways https://t.co/y7ZgI9MEJZ https://t.co/hnIKItkxI6 https://t.co/bq3yWx6Bce

Jul 9, 2023 · 13 likes · 8 shares · 42,509 followers View post →
Isidoro Cano
@isidoro_cano · X

5/7 ¿Medicación prediabetes? ¿Qué explica la interacción? Además de efecto suelo en estudios, también importa la dosis ejercicio y metformina combinables. El efecto de ejercicio está en función de intensidad, duración y cronicidad y varía entre individuos https://t.co/Dq95xFwd3O https://t.co/dJ7ebNvjL6

Oct 18, 2020 · 10 likes · 3 shares · 3,190 followers View post →

All mentions

Longevity for everyone
@Happy_Long_Life · X

@bryan_johnson Autophagy and aging: Maintaining the proteome through exercise and caloric restriction. https://t.co/wH8NY5LSlM

Jul 24, 2023 · 1 share · 124 followers View post →
Mind Your Science!
@MindYourSci · X

RT @agingdoc1: From: "Exercise and CR result in a concomitant downregulation of TORC1 activity and upregulation of autophagy in a number of…

Jul 12, 2023 · 8 shares · 132 followers View post →
aesthebi
@103_Takashi · X

RT @agingdoc1: From: "Exercise and CR result in a concomitant downregulation of TORC1 activity and upregulation of autophagy in a number of…

Jul 10, 2023 · 8 shares · 1,874 followers View post →
AmericanEgoist
@AmericanEgoist · X

RT @agingdoc1: From: "Exercise and CR result in a concomitant downregulation of TORC1 activity and upregulation of autophagy in a number of…

Jul 9, 2023 · 8 shares · 160 followers View post →
Cláudia
@claudianutri · X

RT @agingdoc1: From: "Exercise and CR result in a concomitant downregulation of TORC1 activity and upregulation of autophagy in a number of…

Jul 9, 2023 · 8 shares · 138 followers View post →
Javed Alam
@jalam1001 · X

RT @agingdoc1: From: "Exercise and CR result in a concomitant downregulation of TORC1 activity and upregulation of autophagy in a number of…

Jul 9, 2023 · 8 shares · 1,008 followers View post →
John Greene
@Greene_Thoughts · X

RT @agingdoc1: From: "Exercise and CR result in a concomitant downregulation of TORC1 activity and upregulation of autophagy in a number of…

Jul 9, 2023 · 8 shares · 1,722 followers View post →
JPA
@JPAsunset · X

RT @agingdoc1: From: "Exercise and CR result in a concomitant downregulation of TORC1 activity and upregulation of autophagy in a number of…

Jul 9, 2023 · 8 shares · 1,091 followers View post →
Agingdoc
@agingdoc1 · X

From: "Exercise and CR result in a concomitant downregulation of TORC1 activity and upregulation of autophagy in a number of tissues..." Though a bit date, a good discussion of common pathways https://t.co/y7ZgI9MEJZ https://t.co/hnIKItkxI6 https://t.co/bq3yWx6Bce

Jul 9, 2023 · 13 likes · 8 shares · 42,509 followers View post →
Gerardo
@rejasborjas · X

RT @IberianCitizen: Una ciudad funciona mejor cuando el sistema de recogida de basuras trabaja correctamente. El ejercicio, para el cuerpo,…

Nov 28, 2022 · 13 shares · 6,520 followers View post →
ErikaSibaja
@FtSibaja · X

RT @IberianCitizen: Una ciudad funciona mejor cuando el sistema de recogida de basuras trabaja correctamente. El ejercicio, para el cuerpo,…

Nov 26, 2022 · 13 shares · 200 followers View post →
juls
@luthor21 · X

RT @IberianCitizen: Una ciudad funciona mejor cuando el sistema de recogida de basuras trabaja correctamente. El ejercicio, para el cuerpo,…

Nov 26, 2022 · 13 shares · 39 followers View post →
Nutr. Victor Jauregui
@VictorNutr95 · X

RT @IberianCitizen: Una ciudad funciona mejor cuando el sistema de recogida de basuras trabaja correctamente. El ejercicio, para el cuerpo,…

Nov 26, 2022 · 13 shares · 49 followers View post →
Lourdes Peláez
@lourdes_pelaez · X

RT @IberianCitizen: Una ciudad funciona mejor cuando el sistema de recogida de basuras trabaja correctamente. El ejercicio, para el cuerpo,…

Nov 26, 2022 · 13 shares · 1,237 followers View post →
Felipe Montecino
@felipe_ciencias · X

RT @IberianCitizen: Una ciudad funciona mejor cuando el sistema de recogida de basuras trabaja correctamente. El ejercicio, para el cuerpo,…

Nov 26, 2022 · 13 shares · 541 followers View post →
Malkovich
@amvslp · X

RT @IberianCitizen: Una ciudad funciona mejor cuando el sistema de recogida de basuras trabaja correctamente. El ejercicio, para el cuerpo,…

Nov 26, 2022 · 13 shares · 560 followers View post →
Helga
@Aisha12895124 · X

RT @IberianCitizen: Una ciudad funciona mejor cuando el sistema de recogida de basuras trabaja correctamente. El ejercicio, para el cuerpo,…

Nov 26, 2022 · 13 shares · 4,395 followers View post →
angeles puga rosas
@PugaRosas · X

RT @IberianCitizen: Una ciudad funciona mejor cuando el sistema de recogida de basuras trabaja correctamente. El ejercicio, para el cuerpo,…

Nov 25, 2022 · 13 shares · 201 followers View post →
Omar Hammouda
@HammoudaOm · X

RT @IberianCitizen: Una ciudad funciona mejor cuando el sistema de recogida de basuras trabaja correctamente. El ejercicio, para el cuerpo,…

Nov 25, 2022 · 13 shares · 805 followers View post →
Oscar Andres
@OscarAndresMD · X

RT @IberianCitizen: Una ciudad funciona mejor cuando el sistema de recogida de basuras trabaja correctamente. El ejercicio, para el cuerpo,…

Nov 25, 2022 · 13 shares · 549 followers View post →
Dr. Alfonso Pérez, MD, PhD
@DAlfonsoBP · X

RT @IberianCitizen: Una ciudad funciona mejor cuando el sistema de recogida de basuras trabaja correctamente. El ejercicio, para el cuerpo,…

Nov 25, 2022 · 13 shares · 921 followers View post →
IberianCitizen
@IberianCitizen · X

Una ciudad funciona mejor cuando el sistema de recogida de basuras trabaja correctamente. El ejercicio, para el cuerpo, sería como poner más camiones de basura e incineradoras. By

Nov 25, 2022 · 40 likes · 13 shares · 12,900 followers View post →
BioEnergetic Breaux
@ColliNof1 · X

You don’t have to fast to get autophagy. Exercise does it too! https://t.co/dmYV7G9l1L

Oct 22, 2022 · 2 likes · 6,984 followers View post →
CalerieLife
@CalerieLife · X

Autophagy cleans up the cells & during aging it declines. Exercise & calorie restriction (CR) aid in promoting autophagy in the brain & in the tissues. Exercise & CR may balance the making & recycling of cellular proteins to help increase longevity. https://t.co/woRHwENbo9

Oct 18, 2022 · 66 followers View post →
Debashis Basu
@Moneylifers · X

RT @Mangan150: https://t.co/mTfFrk3Fxx

Aug 2, 2022 · 4 shares · 61,378 followers View post →
G
@G92030005 · X

RT @Mangan150: https://t.co/mTfFrk3Fxx

Aug 1, 2022 · 4 shares · 10 followers View post →
L.T.V.
@L_T_Vu · X

RT @Mangan150: https://t.co/mTfFrk3Fxx

Aug 1, 2022 · 4 shares · 84 followers View post →
Carolus
@pilardalaro · X

RT @Mangan150: https://t.co/mTfFrk3Fxx

Aug 1, 2022 · 4 shares · 83 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

https://t.co/mTfFrk3Fxx

Aug 1, 2022 · 48 likes · 4 shares · 294,643 followers View post →
Carlos Colmenero
@colme99 · X

RT @SaulNutri: Por su parte, tanto el ejercicio como la restricción calórica potencian la homeostasis celular por medio de la eliminación d…

Dec 17, 2021 · 1 share · 77 followers View post →
Saúl Sánchez
@SaulNutri · X

Por su parte, tanto el ejercicio como la restricción calórica potencian la homeostasis celular por medio de la eliminación de orgánulos disfuncionales y sustancias de desecho. Podrían influir positivamente sobre la longitud de los telómeros. https://t.co/BdtB3IXYPh

Dec 17, 2021 · 7 likes · 1 share · 108,061 followers View post →
Dr L Boominathan PhD
@DrLBoominathan · X

Autophagy and aging: Maintaining the proteome through exercise and caloric restriction https://t.co/DqAzMEFfwX https://t.co/BJZLmVzQUt

Nov 19, 2021 · 889 followers View post →
Saúl Sánchez
@SaulNutri · X

@Broderil No hay debate, la restricción calórica alarga la vida. Sobre lo de las mascarillas...no hay evidencias a favor. Sí varias en contra en distintos contextos. https://t.co/BdtB3IXYPh

Jul 30, 2021 · 2 likes · 108,061 followers View post →
Anubis
@pacos7836 · X

RT @IberianCitizen: Autofagia y envejecimiento: mantenimiento del proteoma mediante ejercicio y restricción calórica https://t.co/BGU9cH6Zs…

Feb 27, 2021 · 10 shares · 1,133 followers View post →
ÁNGEL MORENO NUTRICIÓN
@ELNEW2 · X

RT @IberianCitizen: Autofagia y envejecimiento: mantenimiento del proteoma mediante ejercicio y restricción calórica https://t.co/BGU9cH6Zs…

Feb 27, 2021 · 10 shares · 270 followers View post →
Oscar Andres
@OscarAndresMD · X

RT @IberianCitizen: Autofagia y envejecimiento: mantenimiento del proteoma mediante ejercicio y restricción calórica https://t.co/BGU9cH6Zs…

Feb 27, 2021 · 10 shares · 549 followers View post →
JJ
@juanje1996 · X

RT @IberianCitizen: Autofagia y envejecimiento: mantenimiento del proteoma mediante ejercicio y restricción calórica https://t.co/BGU9cH6Zs…

Feb 27, 2021 · 10 shares · 1,063 followers View post →
Juan Ba
@Juan_Ba_ · X

RT @IberianCitizen: Autofagia y envejecimiento: mantenimiento del proteoma mediante ejercicio y restricción calórica https://t.co/BGU9cH6Zs…

Feb 27, 2021 · 10 shares · 387 followers View post →
Katherine Sepulveda
@sepulveda_kathy · X

RT @IberianCitizen: Autofagia y envejecimiento: mantenimiento del proteoma mediante ejercicio y restricción calórica https://t.co/BGU9cH6Zs…

Feb 26, 2021 · 10 shares · 213 followers View post →
Johan
@ArgentinoHuman · X

RT @IberianCitizen: Autofagia y envejecimiento: mantenimiento del proteoma mediante ejercicio y restricción calórica https://t.co/BGU9cH6Zs…

Feb 26, 2021 · 10 shares · 111 followers View post →
IberianCitizen
@IberianCitizen · X

Autofagia y envejecimiento: mantenimiento del proteoma mediante ejercicio y restricción calórica https://t.co/BGU9cH6ZsE https://t.co/vaNqJ9ce2W

Feb 26, 2021 · 70 likes · 10 shares · 12,900 followers View post →
Ana Piera #JuntosEsMasFacil
@ana_apiecar · X

RT @isidoro_cano: 5/7 ¿Medicación prediabetes? ¿Qué explica la interacción? Además de efecto suelo en estudios, también importa la dosis ej…

Oct 19, 2020 · 3 shares · 2,575 followers View post →
Isidoro Cano
@isidoro_cano · X

5/7 ¿Medicación prediabetes? ¿Qué explica la interacción? Además de efecto suelo en estudios, también importa la dosis ejercicio y metformina combinables. El efecto de ejercicio está en función de intensidad, duración y cronicidad y varía entre individuos https://t.co/Dq95xFwd3O https://t.co/dJ7ebNvjL6

Oct 18, 2020 · 10 likes · 3 shares · 3,190 followers View post →
Kristifer
@Kristiferd · X

RT @agingdoc1: Autophagy and aging: Maintaining the proteome through exercise and caloric restriction https://t.co/C4ruyIdbxo

Sep 18, 2020 · 2 shares · 56 followers View post →
KALLEL Labs
@labs_sir · X

RT @agingdoc1: Autophagy and aging: Maintaining the proteome through exercise and caloric restriction https://t.co/C4ruyIdbxo

Sep 15, 2020 · 2 shares · 114 followers View post →
Agingdoc
@agingdoc1 · X

Autophagy and aging: Maintaining the proteome through exercise and caloric restriction https://t.co/C4ruyIdbxo

Sep 14, 2020 · 3 likes · 2 shares · 42,509 followers View post →
Side Hustle For Freedom
@wehatedebt37 · X

RT @Mangan150: Autophagy and aging: Maintaining the proteome through exercise and caloric restriction Don't need to restrict calories, int…

Jul 9, 2020 · 30 shares · 49 followers View post →
bellidu⚔
@bellidux · X

RT @Mangan150: Autophagy and aging: Maintaining the proteome through exercise and caloric restriction Don't need to restrict calories, int…

Jun 26, 2020 · 30 shares · 37 followers View post →
Swarupa
@swarupa007 · X

RT @Mangan150: Autophagy and aging: Maintaining the proteome through exercise and caloric restriction Don't need to restrict calories, int…

Jun 26, 2020 · 30 shares · 1,563 followers View post →
Lesley Astbury
@astbury_lesley · X

RT @Mangan150: Autophagy and aging: Maintaining the proteome through exercise and caloric restriction Don't need to restrict calories, int…

Jun 26, 2020 · 30 shares · 101 followers View post →
Adi
@Adrian06661136 · X

RT @Mangan150: Autophagy and aging: Maintaining the proteome through exercise and caloric restriction Don't need to restrict calories, int…

Jun 26, 2020 · 30 shares · 484 followers View post →
ENDALA klinika zdraví
@endalaclinic · X

Autophagy and aging: Maintaining the proteome through exercise and caloric restriction - Escobar - 2019 - Aging Cell - Wiley Online Library https://t.co/wK1H1fSw4I

Jun 26, 2020 · 252 followers View post →
Ankit Kumar
@ankit_helios · X

RT @Mangan150: Autophagy and aging: Maintaining the proteome through exercise and caloric restriction Don't need to restrict calories, int…

Jun 25, 2020 · 30 shares · 118 followers View post →
laili
@laili_lai · X

RT @Mangan150: Autophagy and aging: Maintaining the proteome through exercise and caloric restriction Don't need to restrict calories, int…

Jun 25, 2020 · 30 shares · 68 followers View post →
mtbmasaya1, Masaya
@mtbmasaya1 · X

RT @Mangan150: Autophagy and aging: Maintaining the proteome through exercise and caloric restriction Don't need to restrict calories, int…

Jun 25, 2020 · 30 shares · 750 followers View post →
DC Home Fitness
@TFuelNation · X

RT @Mangan150: Autophagy and aging: Maintaining the proteome through exercise and caloric restriction Don't need to restrict calories, int…

Jun 25, 2020 · 30 shares · 265 followers View post →
Bernie
@miseenplace86 · X

RT @Mangan150: Autophagy and aging: Maintaining the proteome through exercise and caloric restriction Don't need to restrict calories, int…

Jun 25, 2020 · 30 shares · 110 followers View post →
I don't know much
@paquibena · X

RT @Mangan150: Autophagy and aging: Maintaining the proteome through exercise and caloric restriction Don't need to restrict calories, int…

Jun 25, 2020 · 30 shares · 263 followers View post →
Jorge Riquelme
@RiquelmeJorge · X

RT @Mangan150: Autophagy and aging: Maintaining the proteome through exercise and caloric restriction Don't need to restrict calories, int…

Jun 25, 2020 · 30 shares · 844 followers View post →
JPJ
@whileitravel · X

RT @Mangan150: Autophagy and aging: Maintaining the proteome through exercise and caloric restriction Don't need to restrict calories, int…

Jun 25, 2020 · 30 shares · 779 followers View post →
Rodrigo Rondón
@rjrondonleon · X

RT @Mangan150: Autophagy and aging: Maintaining the proteome through exercise and caloric restriction Don't need to restrict calories, int…

Jun 25, 2020 · 30 shares · 156 followers View post →
Ana Cláudia
@Anawsantos · X

RT @Mangan150: Autophagy and aging: Maintaining the proteome through exercise and caloric restriction Don't need to restrict calories, int…

Jun 25, 2020 · 30 shares · 360 followers View post →
Michael
@mst4truth · X

RT @Mangan150: Autophagy and aging: Maintaining the proteome through exercise and caloric restriction Don't need to restrict calories, int…

Jun 25, 2020 · 30 shares · 807 followers View post →
J P Fanton
@HealthyFellow · X

RT @Mangan150: Autophagy and aging: Maintaining the proteome through exercise and caloric restriction Don't need to restrict calories, int…

Jun 25, 2020 · 30 shares · 26,013 followers View post →
Paul Bell
@opcode22 · X

RT @Mangan150: Autophagy and aging: Maintaining the proteome through exercise and caloric restriction Don't need to restrict calories, int…

Jun 25, 2020 · 30 shares · 551 followers View post →
Mark Bski
@MarkBski · X

RT @Mangan150: Autophagy and aging: Maintaining the proteome through exercise and caloric restriction Don't need to restrict calories, int…

Jun 25, 2020 · 30 shares · 8,336 followers View post →
LeVortex
@LeVortexZen · X

RT @Mangan150: Autophagy and aging: Maintaining the proteome through exercise and caloric restriction Don't need to restrict calories, int…

Jun 25, 2020 · 30 shares · 593 followers View post →
DIE with a T
@DIEwithaTFilm · X

RT @Mangan150: Autophagy and aging: Maintaining the proteome through exercise and caloric restriction Don't need to restrict calories, int…

Jun 25, 2020 · 30 shares · 612 followers View post →
Cloward-Piven citizen
@paulojsvaz · X

RT @Mangan150: Autophagy and aging: Maintaining the proteome through exercise and caloric restriction Don't need to restrict calories, int…

Jun 25, 2020 · 30 shares · 240 followers View post →
Lαzαɾմs
@gran1_ly · X

RT @Mangan150: Autophagy and aging: Maintaining the proteome through exercise and caloric restriction Don't need to restrict calories, int…

Jun 25, 2020 · 30 shares · 214 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

Autophagy and aging: Maintaining the proteome through exercise and caloric restriction Don't need to restrict calories, intermittent fasting will do the job. Exercise powerfully promotes autophagy. Inhibition of autophagy -> premature aging Get on it https://t.co/mTfFrk3Fxx

Jun 25, 2020 · 133 likes · 30 shares · 294,643 followers View post →
Cardea/Chile +569 81394757 +569 84095586
@cardeacl · X

Autophagy and aging: Maintaining the proteome through exercise and caloric restriction. - PubMed - NCBI https://t.co/F8nqtA0nG5

Oct 11, 2019 · 409 followers View post →
Alexander Mathews
@alexmat81 · X

Exercise and calorie restriction promotes autophagy which in turn enhances longevity https://t.co/A9KM1blE85

Apr 21, 2019 · 94 followers View post →
Artur Claudio Pinto
@ArturClaudioPin · X

Autophagy and aging: Maintaining the proteome through exercise and caloric restriction https://t.co/HbMYhMuvNM

Feb 23, 2019 · 89 followers View post →
Alex
@AlexViKu · X

Autophagy and aging: Maintaining the proteome through exercise and caloric restriction/ 2019 https://t.co/7WbDZxVFy5

Feb 2, 2019 · 97 followers View post →