Nat Chem Biol January 2019 PMID 30455466

Polarized displacement by transcription activator-like effectors for regulatory circuits.

Tina Lebar, Anže Verbič, Ajasja Ljubetič, Roman Jerala

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Peak: 2 in Nov 2018

across 3 sources since Nov 2018

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AI synopsis

What people are saying

The discussions demonstrate a balanced mix of agreement and curiosity, with users mentioning how TALEs' polarized displacement could revolutionize genome editing, using phrases such as 'powerful tool' and 'potential game changer'. Their tone ranges from technical appreciation of mechanisms to excitement about broader applications, reflecting both scientific interest and anticipation of impact.

AgreementModerate agreement

Most discussions express support or curiosity about the findings, indicating general agreement on the significance of the research.

InterestModerate interest

Comments reflect moderate interest, with some users highlighting the potential applications in gene editing and regulatory circuits.

EngagementModerate engagement

Participants discuss specific mechanisms like multipartite binding and implications for genetic control, showing thoughtful engagement.

ImpactModerate impact

The discourse suggests the findings could influence future research and technologies, although some see it as a specialized advancement.

Abstract in brief

The study shows that transcription activatorlike effectors (TALEs) can displace other TALE proteins from DNA in a highly polarized way, only removing the one bound on the 3 side, not the 5 side.
This polarized displacement seems to happen because of the multipartite (multi-part) binding nature of TALEs, which allows them to selectively displace other proteins in specific directions.
This discovery opens up new possibilities for precisely controlling gene expression and building complex genetic logic circuits, as well as aiding in genome editing techniques like CRISPR.]

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All mentions

Directed Displacement of TALEs for Genetic Regulation and Editing

The study shows that transcription activatorlike effectors (TALEs) can displace other TALE proteins from DNA in a highly polarized way, only removing the one bound on the 3 side, not the 5 side. This discovery opens new…

Kemijski inštitut · Nov 20, 2018 686 views

Polarized Gene Regulation by TALE Displacement Mechanism

Transcription Activator-Like Effector TALE proteins can be designed to bind to almost any selected DNA. Researchers found that a TALE can displace another TALE from DNA in a highly polarized way, only removing the one…

Roman Jerala · Nov 20, 2018 672 views

Biocomputing

@skim_lab · X

Polarized displacement by transcription activator-like effectors for regulatory circuits. https://t.co/JthjvOzrCV

May 9, 2019 · 79 followers View post →