September 2019 PMID 30459766

Latitude, Vitamin D, Melatonin, and Gut Microbiota Act in Concert to Initiate Multiple Sclerosis: A New Mechanistic Pathway.

Majid Ghareghani, Russel J Reiter, Kazem Zibara, Naser Farhadi

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Mentions

45
Peak: 14 in Apr 2021
across 4 sources since Feb 2019

Extended reach

1,139,127
potential audience

Total likes

46,832

Video views

1,105,625

Mentions per month

Feb 2019 – Dec 2024

Where it's discussed

  • X / Twitter27 posts
  • News10 articles
  • Facebook5 posts
  • YouTube3 videos

AI synopsis

What people are saying

The analysis highlights that the discussions focus on how geographical latitude influences MS prevalence through biological factors like vitamin D and melatonin, evidenced by comments referencing 'interactions necessary for vitamin D synthesis' and epidemiological links between high-latitude regions and MS. Phrases like 'very interesting' or references to 'Sunlight prescriptions' indicate moderate curiosity and recognition of the study's potential impact, yet the tone remains somewhat cautious and exploratory.

AgreementModerate agreement

Most discussions acknowledge the relevance of the proposed mechanisms connecting latitude, vitamin D, melatonin, and gut microbiota to MS, showing some level of support or curiosity, though not overwhelmingly enthusiastic.

InterestModerate interest

The posts demonstrate moderate interest, with references to the significance of sunlight exposure and biological interactions, but few express deep engagement or detailed critique.

EngagementNeutral engagement

There is limited evidence of deep analysis in the discussion; some posts mention biological pathways or epidemiological observations but stop short of comprehensive engagement.

ImpactModerate impact

The general tone suggests that the research is seen as potentially important but not yet revolutionary, with users recognizing its contribution to understanding MS etiology.

Abstract in brief

  • This article discusses how vitamin D, melatonin, and gut microbiota work together to potentially trigger multiple sclerosis (MS), especially in high-latitude regions with limited sunlight.
  • It highlights that vitamin D deficiency and high melatonin levels, both influenced by sunlight exposure, affect the immune system and gut health, possibly leading to increased inflammation in the central nervous system.
  • The paper proposes a new pathway explaining how these factors might contribute to MS development, focusing on the impact of gut permeability, microbiota-produced endotoxins, and neuroinflammation.

Top posts

Most liked on X and Bluesky
Mitominder
@Mitominder · X

Interesante paper en si, pero muy interesante ver las interacciones necesarios para la sintesis de vitamina D. https://t.co/Uv87iJgT2B https://t.co/omxTUNCNtZ

Apr 26, 2021 · 47 likes · 18 shares · 2,257 followers View post →
htw
@heniek_htw · X

Latitude, #VitaminD, #Melatonin & Gut #Microbiota Act in Concert to Initiate #MultipleSclerosis: A New Mechanistic Pathway (2018)

Jul 31, 2022 · 27 likes · 8 shares · 11,257 followers View post →
Angelo Bona
@AngeloBona · X

Latitude, Vitamin D, Melatonin, and Gut Microbiota Act in Concert to Initiate Multiple Sclerosis: A New Mechanistic Pathway. - PubMed - NCBI https://t.co/Xf7CYMzkzR

Feb 12, 2019 · 3 likes · 375 followers View post →
Dr. Steeles Kiddo, Ph. D.
@steeelez · X

@sparkycarr @davidasinclair @coridrew https://t.co/JJobzyTrDs RGC=“retinal ganglion cell” ‘The circadian rhythm of pineal melatonin is regulated by signals coming from [SCN] of the hypothalamus. ipRGC axons project to the SCN and it is this pathway that ultimately controls pineal melatonin production (58).’

Nov 10, 2019 · 2 likes · 45 followers View post →
For health-promoting environments
@SilkeLeFay · X

#generalpractice #Melbourne #womenshealth #agedcare #microbiome #health Sunlight prescriptions reduce the risk of cancer and neurodegenerative disorders. Latitude, Vitamin D, Melatonin, and Gut Microbiota Act in Concert to Initiate Multiple Sclerosis . https://t.co/YA4Wh9yUup

Oct 18, 2021 · 1 like · 4,600 followers View post →
DrRPalmquist
@DrPalmquist · X

RT @heniek_htw: Latitude, #VitaminD, #Melatonin & Gut #Microbiota Act in Concert to Initiate #MultipleSclerosis: A New Mechanistic Pathway…

Jul 31, 2022 · 8 shares · 3,158 followers View post →

All mentions

Alessandro ⚡
@_lumichrome · X

How do you develop autoimmunity and multiple sclerosis according to latitude? >>Latitude, Vitamin D, Melatonin, and Gut Microbiota Act in Concert to Initiate Multiple Sclerosis: A New Mechanistic Pathway https://t.co/SilBDJydVW

Dec 5, 2024 · 149 followers View post →
Academia Peruana de Nutricion
@apenut_info · X

RT @heniek_htw: Latitude, #VitaminD, #Melatonin & Gut #Microbiota Act in Concert to Initiate #MultipleSclerosis: A New Mechanistic Pathway…

Aug 1, 2022 · 8 shares · 723 followers View post →
René Alfonso
@ReneAlfon_zoo · X

RT @heniek_htw: Latitude, #VitaminD, #Melatonin & Gut #Microbiota Act in Concert to Initiate #MultipleSclerosis: A New Mechanistic Pathway…

Jul 31, 2022 · 8 shares · 410 followers View post →
Oscar Andres
@OscarAndresMD · X

RT @heniek_htw: Latitude, #VitaminD, #Melatonin & Gut #Microbiota Act in Concert to Initiate #MultipleSclerosis: A New Mechanistic Pathway…

Jul 31, 2022 · 8 shares · 554 followers View post →
Madrynha2024
@madrynha2012 · X

RT @heniek_htw: Latitude, #VitaminD, #Melatonin & Gut #Microbiota Act in Concert to Initiate #MultipleSclerosis: A New Mechanistic Pathway…

Jul 31, 2022 · 8 shares · 3,118 followers View post →
DrRPalmquist
@DrPalmquist · X

RT @heniek_htw: Latitude, #VitaminD, #Melatonin & Gut #Microbiota Act in Concert to Initiate #MultipleSclerosis: A New Mechanistic Pathway…

Jul 31, 2022 · 8 shares · 3,158 followers View post →
htw
@heniek_htw · X

Latitude, #VitaminD, #Melatonin & Gut #Microbiota Act in Concert to Initiate #MultipleSclerosis: A New Mechanistic Pathway (2018)

Jul 31, 2022 · 27 likes · 8 shares · 11,257 followers View post →
For health-promoting environments
@SilkeLeFay · X

#generalpractice #Melbourne #womenshealth #agedcare #microbiome #health Sunlight prescriptions reduce the risk of cancer and neurodegenerative disorders. Latitude, Vitamin D, Melatonin, and Gut Microbiota Act in Concert to Initiate Multiple Sclerosis . https://t.co/YA4Wh9yUup

Oct 18, 2021 · 1 like · 4,600 followers View post →
ENDALA klinika zdraví
@endalaclinic · X

Latitude, Vitamin D, Melatonin, and Gut Microbiota Act in Concert to Initiate Multiple Sclerosis: A New Mechanistic Pathway https://t.co/kfLAmO9h6u

Oct 5, 2021 · 254 followers View post →
claimshero.eth
@claimshero__eth · X

RT @Mitominder: Interesante paper en si, pero muy interesante ver las interacciones necesarios para la sintesis de vitamina D. https://…

Apr 28, 2021 · 18 shares · 128 followers View post →
Sergio Zapata
@serzaparin · X

RT @Mitominder: Interesante paper en si, pero muy interesante ver las interacciones necesarios para la sintesis de vitamina D. https://…

Apr 27, 2021 · 18 shares · 315 followers View post →
Ema.pf
@BlackStrongOk · X

Los epidemiólogos han visto una mayor prevalencia de EM en países de latitudes altas, donde la luz solar es limitada y donde las poblaciones tienen deficiencia de vitamina D y niveles altos de melatonina.  https://t.co/PWYnmsT2Dt

Apr 27, 2021 · 51 followers View post →
Anubis
@pacos7836 · X

RT @Mitominder: Interesante paper en si, pero muy interesante ver las interacciones necesarios para la sintesis de vitamina D. https://…

Apr 27, 2021 · 18 shares · 1,136 followers View post →
Magally Ramirez
@magallyandrea · X

RT @Mitominder: Interesante paper en si, pero muy interesante ver las interacciones necesarios para la sintesis de vitamina D. https://…

Apr 27, 2021 · 18 shares · 76 followers View post →
Jordi Garcia Alberch
@JGA_bdn · X

RT @Mitominder: Interesante paper en si, pero muy interesante ver las interacciones necesarios para la sintesis de vitamina D. https://…

Apr 27, 2021 · 18 shares · 119 followers View post →
Medicina Eterna
@Fvelaz · X

RT @Mitominder: Interesante paper en si, pero muy interesante ver las interacciones necesarios para la sintesis de vitamina D. https://…

Apr 27, 2021 · 18 shares · 301 followers View post →
Cristina de la Mata
@Crisirenedlm · X

RT @Mitominder: Interesante paper en si, pero muy interesante ver las interacciones necesarios para la sintesis de vitamina D. https://…

Apr 26, 2021 · 18 shares · 282 followers View post →
Oscar Andres
@OscarAndresMD · X

RT @Mitominder: Interesante paper en si, pero muy interesante ver las interacciones necesarios para la sintesis de vitamina D. https://…

Apr 26, 2021 · 18 shares · 554 followers View post →
Joan Franco
@joanulloa1 · X

RT @Mitominder: Interesante paper en si, pero muy interesante ver las interacciones necesarios para la sintesis de vitamina D. https://…

Apr 26, 2021 · 18 shares · 316 followers View post →
JoaquimLamora
@JoaquimLamora · X

RT @Mitominder: Interesante paper en si, pero muy interesante ver las interacciones necesarios para la sintesis de vitamina D. https://…

Apr 26, 2021 · 18 shares · 1,137 followers View post →
Silvia de Dios
@SilviadeDios12 · X

RT @Mitominder: Interesante paper en si, pero muy interesante ver las interacciones necesarios para la sintesis de vitamina D. https://…

Apr 26, 2021 · 18 shares · 217 followers View post →
Ver Mas Mar
@Masmar2962 · X

RT @Mitominder: Interesante paper en si, pero muy interesante ver las interacciones necesarios para la sintesis de vitamina D. https://…

Apr 26, 2021 · 18 shares · 125 followers View post →
Mitominder
@Mitominder · X

Interesante paper en si, pero muy interesante ver las interacciones necesarios para la sintesis de vitamina D. https://t.co/Uv87iJgT2B https://t.co/omxTUNCNtZ

Apr 26, 2021 · 47 likes · 18 shares · 2,257 followers View post →
.
@MarigoldMania · X

@bpassela Just did a quick Google search and sunlight does help: https://t.co/xoslpgggvz

May 29, 2020 · 257 followers View post →
Debbie Potts
@thewholeathlete · X

Latitude, Vitamin D, Melatonin, and Gut Microbiota Act in Concert to Initiate Multiple Sclerosis: A New Mechanistic Pathway https://t.co/Tj2HIaYEga

May 14, 2020 · 1,025 followers View post →
Dr. Steeles Kiddo, Ph. D.
@steeelez · X

@sparkycarr @davidasinclair @coridrew https://t.co/JJobzyTrDs RGC=“retinal ganglion cell” ‘The circadian rhythm of pineal melatonin is regulated by signals coming from [SCN] of the hypothalamus. ipRGC axons project to the SCN and it is this pathway that ultimately controls pineal melatonin production (58).’

Nov 10, 2019 · 2 likes · 45 followers View post →
Angelo Bona
@AngeloBona · X

Latitude, Vitamin D, Melatonin, and Gut Microbiota Act in Concert to Initiate Multiple Sclerosis: A New Mechanistic Pathway. - PubMed - NCBI https://t.co/Xf7CYMzkzR

Feb 12, 2019 · 3 likes · 375 followers View post →