Diabetes February 2019 PMID 30487265

Estrogen Improves Insulin Sensitivity and Suppresses Gluconeogenesis via the Transcription Factor Foxo1.

Hui Yan, Wangbao Yang, Fenghua Zhou, Xiaopeng Li, Quan Pan, Zheng Shen, Guichun Han, Annie Newell-Fugate, Yanan Tian, Ravikumar Majeti, Wenshe Liu, Yong Xu, Chaodong Wu, Kimberly Allred, Clinton Allred

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Mentions

Peak: 8 in Sep 2021

across 3 sources since Jan 2019

Extended reach

138,385

potential audience

Total likes

Video views

1,100

Mentions per month

Jan 2019 – Dec 2025

Where it's discussed

X / Twitter15 posts
News5 articles
YouTube2 videos

AI synopsis

What people are saying

The discussions demonstrate a strong interest in how estrogen affects insulin sensitivity, with examples like mentions of menopause-related insulin resistance and strategies involving supplements or lifestyle changes. The tone varies from scientific acknowledgment to practical implications, reflecting both curiosity and recognition of the study's importance in health management.

AgreementModerate agreement

Most discussions reflect support or acknowledgment of the research's findings, especially emphasizing estrogen's role in metabolic regulation.

InterestHigh interest

Posts consistently show curiosity about how estrogen influences insulin sensitivity, with several referencing menopause and potential treatments.

EngagementModerate engagement

The discussions include references to the biological mechanisms and implications for health, indicating moderate thoughtful engagement.

ImpactModerate impact

The conversations point to the potential significance of hormonal regulation in managing or understanding metabolic diseases, suggesting a noteworthy impact.

Abstract in brief

Estrogen enhances insulin sensitivity and reduces gluconeogenesis via the transcription factor Foxo1, which helps maintain better glucose control in premenopausal women compared to men, but this advantage diminishes after menopause.
In mice, estrogen treatment improves insulin sensitivity and suppresses liver gluconeogenesis through activation of the estrogen receptor and the PI3K-Akt pathway, with Foxo1 being essential for these effects.
The findings suggest that targeting estrogen receptors could be a promising strategy to regulate glucose metabolism and prevent type 2 diabetes, especially in postmenopausal women.]

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All mentions

Understanding How Estrogen Regulates Glucose Metabolism and Insulin Sensitivity

After a year of menstrual cycle workshops, I share the top 10 lessons I learned, including insights on how estrogen improves insulin sensitivity and suppresses gluconeogenesis via Foxo1, offering potential strategies to…

Ser Salud - Laura Vela · Apr 2, 2025 1,074 views

FDA Removes Black Box Warning on Estrogen Therapy and Its Implications

The FDA has officially removed the black box warning from estrogen therapy, a major milestone in women's health. This video explains the significance of this change, debunks outdated research, and discusses safe…

Wellness For Life Anacortes · Dec 8, 2025 26 views