Aging Cell February 2019 PMID 30548390

Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults.

Adam R Konopka, Jaime L Laurin, Hayden M Schoenberg, Justin J Reid, William M Castor, Christopher A Wolff, Robert V Musci, Oscar D Safairad, Melissa A Linden, Laurie M Biela, Susan M Bailey, Karyn L Hamilton, Benjamin F Miller

Mentions

210
Peak: 44 in Nov 2023
across 6 sources since Mar 2019

Extended reach

1,432,150
potential audience

Total likes

1,875

Video views

38,093

Mentions per month

Mar 2019 – May 2025

Where it's discussed

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AI synopsis

What people are saying

In the discussions, users reference the findings of how metformin could hinder improvements in insulin sensitivity and fitness gains from aerobic exercise. For instance, phrases like 'metformin blunts muscle hypertrophy' and discussions about its implications for 'longevity' underscore concerns about the drug's dual role. The tone of the conversations ranges from inquisitive to cautionary, indicating a nuanced view of metformin's benefits and drawbacks.

AgreementModerate agreement

Most posts express a degree of support for the article's findings, though there are mentions of contrary evidence.

InterestHigh interest

There is high curiosity surrounding the implications of metformin for older adults and its effects on exercise.

EngagementModerate engagement

Discussions often reference specific research details and question the interpretations of the results.

ImpactHigh impact

Many users believe this research will significantly influence how metformin is viewed in relation to exercise.

Abstract in brief

  • Metformin and exercise each enhance insulin sensitivity and lower diabetes risk, but combining them may hinder their benefits.
  • Researchers conducted a 12-week study on older adults to see how metformin affects improvements from aerobic exercise training (AET) in insulin sensitivity and fitness.
  • Results showed that while AET effectively reduced fat mass and improved glucose levels for all participants, metformin reduced the overall increase in insulin sensitivity and cardiorespiratory fitness compared to the placebo group, indicating a complex interaction between the drug and exercise.
  • Further investigation is needed to clarify how metformin impacts physiological improvements when paired with exercise, especially regarding its effects on mitochondrial function.

Top posts

Most liked on X and Bluesky
Stuart Phillips (he/him)
@mackinprof · X

People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak VO2 with AT https://t.co/hUDw6NmFDK VO2peak is a shockingly good predictor of health and it is related to reductions in risk 1/

Nov 10, 2023 · 202 likes · 57 shares · 55,984 followers View post →
Craig Porter
@bioblastgeek · X

Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/MwZPD5MPdS

Jan 23, 2022 · 121 likes · 24 shares · 1,256 followers View post →
Stuart Phillips (he/him)
@mackinprof · X

Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/0jY608mjtA Metformin attenuated the increase in VO2max following 12 weeks of AET by ~50%, although this did not reach statistical significance (p = 0.08, Figure ​ 1b).

Dec 3, 2023 · 118 likes · 24 shares · 55,984 followers View post →
Agingdoc
@agingdoc1 · X

Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults (2019) https://t.co/onhQk2rfw1 https://t.co/uuomJvQTeE

Jul 30, 2023 · 85 likes · 19 shares · 41,675 followers View post →
Jamie Timmons
@metapredict · X

"Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults" Is this a case of "too much signaling" is undesirable or just that Metformins main benefits in T2DM are liver mediated with some down-sides elsewhere? https://t.co/o3VfQrOXQe

Jan 23, 2022 · 31 likes · 5 shares · 2,054 followers View post →
Mike Lustgarten, PhD
@mike_lustgarten · X

Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults. - PubMed - NCBI https://t.co/zJe5OT06A5

Dec 17, 2019 · 28 likes · 7 shares · 9,721 followers View post →

All mentions

Matt Yousefzadeh
@MattYousefzadeh · X

@metapredict Are you thinking of this paper? https://t.co/wV8A24H97Z

Apr 24, 2024 · 2 likes · 4,780 followers View post →
Mind Your Science!
@MindYourSci · X

RT @mackinprof: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/0jY608mjtA Metform…

Dec 5, 2023 · 24 shares · 132 followers View post →
galletastriton
@galletastriton1 · X

RT @mackinprof: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/0jY608mjtA Metform…

Dec 5, 2023 · 24 shares · 30 followers View post →
Marina Mourtzakis, PhD
@MourtzakisM · X

RT @mackinprof: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/0jY608mjtA Metform…

Dec 4, 2023 · 24 shares · 241 followers View post →
Leave it to Beaver
@espacetimeNOT · X

RT @mackinprof: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/0jY608mjtA Metform…

Dec 4, 2023 · 24 shares · 1,199 followers View post →
roberto
@diablomxnet · X

RT @mackinprof: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/0jY608mjtA Metform…

Dec 4, 2023 · 24 shares · 630 followers View post →
Jeroen Swart
@JeroenSwart · X

RT @mackinprof: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/0jY608mjtA Metform…

Dec 4, 2023 · 24 shares · 11,486 followers View post →
Rx Readmore Livemore
@SopitaSirirata1 · X

RT @mackinprof: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/0jY608mjtA Metform…

Dec 4, 2023 · 24 shares · 167 followers View post →
BillOckham
@BillOccham0 · X

RT @mackinprof: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/0jY608mjtA Metform…

Dec 3, 2023 · 24 shares · 589 followers View post →
Glenn Fincher
@gtfinchy · X

RT @mackinprof: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/0jY608mjtA Metform…

Dec 3, 2023 · 24 shares · 3,332 followers View post →
wilson Mak
@wilsonMak5 · X

RT @mackinprof: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/0jY608mjtA Metform…

Dec 3, 2023 · 24 shares · 368 followers View post →
Jay Bert
@bert695 · X

RT @mackinprof: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/0jY608mjtA Metform…

Dec 3, 2023 · 24 shares · 867 followers View post →
Harriet Carroll: Long Covid Scientific Consultancy
@angryhacademic · X

RT @mackinprof: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/0jY608mjtA Metform…

Dec 3, 2023 · 24 shares · 8,764 followers View post →
Javed Alam
@jalam1001 · X

RT @mackinprof: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/0jY608mjtA Metform…

Dec 3, 2023 · 24 shares · 996 followers View post →
Ellie Jones
@_ELLIE_JONES_x · X

RT @mackinprof: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/0jY608mjtA Metform…

Dec 3, 2023 · 24 shares · 747 followers View post →
Liz Wellberg
@LWellberg · X

RT @mackinprof: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/0jY608mjtA Metform…

Dec 3, 2023 · 24 shares · 1,260 followers View post →
alvaro alaor
@alaoralavaro · X

RT @mackinprof: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/0jY608mjtA Metform…

Dec 3, 2023 · 24 shares · 552 followers View post →
Liliana Rentería-Laskin, PhD
@LRenteria14 · X

RT @mackinprof: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/0jY608mjtA Metform…

Dec 3, 2023 · 24 shares · 126 followers View post →
GuruAnaerobic
@GuruAnaerobic · X

RT @mackinprof: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/0jY608mjtA Metform…

Dec 3, 2023 · 24 shares · 39,670 followers View post →
Daniel Turner
@dcturner93 · X

RT @mackinprof: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/0jY608mjtA Metform…

Dec 3, 2023 · 24 shares · 1,234 followers View post →
eleanorina
@_eleanorina · X

RT @mackinprof: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/0jY608mjtA Metform…

Dec 3, 2023 · 24 shares · 3,173 followers View post →
Gastón F Rodríguez
@GastonFRodrigu1 · X

La metformina inhibe las adaptaciones mitocondriales al entrenamiento aeróbico en adultos mayores - Konopka - 2019 - Aging Cell - Wiley Online Library https://t.co/T7kg6aCWNl

Dec 3, 2023 · 1,154 followers View post →
Stuart Phillips (he/him)
@mackinprof · X

Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/0jY608mjtA Metformin attenuated the increase in VO2max following 12 weeks of AET by ~50%, although this did not reach statistical significance (p = 0.08, Figure ​ 1b).

Dec 3, 2023 · 118 likes · 24 shares · 55,984 followers View post →
Jackson Burris
@JacksonBurris_ · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 21, 2023 · 57 shares · 14 followers View post →
More my speed
@moremyspeed · X

@AngryCardio @AnilMakam @statnews @AnupamBJena @atheendar @Nature https://t.co/PyzCHt1nsV https://t.co/AVEwdRQzES

Nov 15, 2023 · 153 followers View post →
Conor Flynn
@weltanschuuang · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 13, 2023 · 57 shares · 66 followers View post →
Gerard Hough
@GerardHough · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 13, 2023 · 57 shares · 1,745 followers View post →
Mark Revere
@markrevere · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 12, 2023 · 57 shares · 80 followers View post →
Mind Your Science!
@MindYourSci · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 12, 2023 · 57 shares · 132 followers View post →
Dustin Poirier
@DustinPoid · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 11, 2023 · 57 shares · 9 followers View post →
Gerardo Avelar
@Gerave7 · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 11, 2023 · 57 shares · 235 followers View post →
Jose Antonio Lopez
@JoseALopezDN · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 11, 2023 · 57 shares · 1,390 followers View post →
MJR
@ManojRawat_ · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 11, 2023 · 57 shares · 536 followers View post →
BroughtyBoy
@brotyboy · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 11, 2023 · 57 shares · 2,042 followers View post →
Madam Mitochondria
@Madam_Mito · X

@hubermanrules https://t.co/pRIXFOpWHX

Nov 10, 2023 · 1 like · 10,522 followers View post →
Ld_W121534
@Ld_W121534 · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 10, 2023 · 57 shares · 48 followers View post →
Dr Sam Pappas
@DrSamPappas · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 10, 2023 · 57 shares · 2,096 followers View post →
Brett Singer MS,RD,CSSD
@BSinger10 · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 10, 2023 · 57 shares · 2,821 followers View post →
PCOS Together
@PcosTogether · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 10, 2023 · 57 shares · 305 followers View post →
Recruiting Animal
@animal · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 10, 2023 · 57 shares · 23,803 followers View post →
Dr. Sohaib Imtiaz, MD MPH
@digitald0ctor · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 10, 2023 · 57 shares · 3,354 followers View post →
Vitas Gerulaitis
@VGerulaitis · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 10, 2023 · 57 shares · 155 followers View post →
GuruAnaerobic
@GuruAnaerobic · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 10, 2023 · 57 shares · 39,670 followers View post →
Matthew
@matthewbayford · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 10, 2023 · 57 shares · 243 followers View post →
Christian Tams MS RD LDN
@ChristianTams · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 10, 2023 · 57 shares · 1,257 followers View post →
Howard Luks MD
@hjluks · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 10, 2023 · 57 shares · 65,253 followers View post →
Harriet Carroll: Long Covid Scientific Consultancy
@angryhacademic · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 10, 2023 · 57 shares · 8,764 followers View post →
Another Polarizing Personality
@Mutant_Heretic · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 10, 2023 · 57 shares · 740 followers View post →
Mike Pagliacci
@drmikepagliacci · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 10, 2023 · 57 shares · 138 followers View post →
Craig Liebenson
@CraigLiebenson · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 10, 2023 · 57 shares · 8,220 followers View post →
Michael Haufe
@mlhaufe · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 10, 2023 · 57 shares · 176 followers View post →
Alex
@atttshine5_0 · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 10, 2023 · 57 shares · 23 followers View post →
David_Propst_PA-C
@PrimaryCarePAC · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 10, 2023 · 57 shares · 3,329 followers View post →
Javed Alam
@jalam1001 · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 10, 2023 · 57 shares · 996 followers View post →
Charles Brenner, PhD
@CharlesMBrenner · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 10, 2023 · 57 shares · 57,070 followers View post →
William A. Wallace, Ph.D.
@drwilliamwallac · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 10, 2023 · 57 shares · 10,606 followers View post →
Aloysius Buongiorno
@AloysiusBngrno · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 10, 2023 · 57 shares · 485 followers View post →
(Lifting. As. We. Climb.)
@Thumblessregime · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 10, 2023 · 57 shares · 226 followers View post →
Chris Hurst
@chrishurst99 · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 10, 2023 · 57 shares · 1,063 followers View post →
Matthew Stratton PhD
@MTSstrength89 · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 10, 2023 · 57 shares · 167 followers View post →
Fabiane Souza
@fhveigas · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 10, 2023 · 57 shares View post →
Dr. Rhonda Patrick
@foundmyfitness · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 10, 2023 · 57 shares · 611,729 followers View post →
Dan Patrick
@mdpatrick · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 10, 2023 · 57 shares · 2,032 followers View post →
eleanorina
@_eleanorina · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 10, 2023 · 57 shares · 3,173 followers View post →
Ellen Wetherill
@afashionfan · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 10, 2023 · 57 shares · 2,248 followers View post →
Raul
@RaulM06 · X

RT @mackinprof: People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak…

Nov 10, 2023 · 57 shares · 854 followers View post →
Stuart Phillips (he/him)
@mackinprof · X

People want to take Metformin for longevity... but it blunts gains in muscle mass with RT https://t.co/WoNvsRHPsh and peak VO2 with AT https://t.co/hUDw6NmFDK VO2peak is a shockingly good predictor of health and it is related to reductions in risk 1/

Nov 10, 2023 · 202 likes · 57 shares · 55,984 followers View post →
Kevin Murach
@KevinMurachPhD · X

@hubermanlab @PeterAttiaMD Not the best if you like to exercise I don’t think @maml_UWMadison https://t.co/yNdJD8Dgvn

Sep 12, 2023 · 8 likes · 2,982 followers View post →
PAUL WALE
@IGPSWS · X

RT @agingdoc1: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults (2019) https://t.co/onhQk2rfw1 ht…

Aug 9, 2023 · 19 shares · 15 followers View post →
Mind Your Science!
@MindYourSci · X

RT @agingdoc1: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults (2019) https://t.co/onhQk2rfw1 ht…

Aug 2, 2023 · 19 shares · 132 followers View post →
Rodrigo Gonçalves
@rgoncas · X

RT @agingdoc1: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults (2019) https://t.co/onhQk2rfw1 ht…

Jul 31, 2023 · 19 shares · 141 followers View post →
Bayar Jaff
@JaffBayar · X

RT @agingdoc1: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults (2019) https://t.co/onhQk2rfw1 ht…

Jul 31, 2023 · 19 shares · 606 followers View post →
System
@liyongcsco12 · X

RT @agingdoc1: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults (2019) https://t.co/onhQk2rfw1 ht…

Jul 31, 2023 · 19 shares · 65 followers View post →
@lonelywolf
@lonelywolf99999 · X

RT @agingdoc1: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults (2019) https://t.co/onhQk2rfw1 ht…

Jul 31, 2023 · 19 shares · 40 followers View post →
Ben Dower
@nobody_qwert · X

RT @agingdoc1: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults (2019) https://t.co/onhQk2rfw1 ht…

Jul 31, 2023 · 19 shares · 1,620 followers View post →
Leo Dlr
@Globalgeograph · X

RT @agingdoc1: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults (2019) https://t.co/onhQk2rfw1 ht…

Jul 31, 2023 · 19 shares · 17 followers View post →
Bongani Mayosi Health Sciences Library (BMHSL)
@uct_bmhsl · X

RT @agingdoc1: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults (2019) https://t.co/onhQk2rfw1 ht…

Jul 31, 2023 · 19 shares · 1,599 followers View post →
Bartako
@galimarsot · X

RT @agingdoc1: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults (2019) https://t.co/onhQk2rfw1 ht…

Jul 31, 2023 · 19 shares · 859 followers View post →
Hec
@Muscles_n_Mitos · X

RT @agingdoc1: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults (2019) https://t.co/onhQk2rfw1 ht…

Jul 31, 2023 · 19 shares · 63 followers View post →
Raul Villar
@DrRaulvillar · X

RT @agingdoc1: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults (2019) https://t.co/onhQk2rfw1 ht…

Jul 30, 2023 · 19 shares · 410 followers View post →
Javed Alam
@jalam1001 · X

RT @agingdoc1: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults (2019) https://t.co/onhQk2rfw1 ht…

Jul 30, 2023 · 19 shares · 996 followers View post →
Brent Segal
@bsegal73 · X

RT @agingdoc1: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults (2019) https://t.co/onhQk2rfw1 ht…

Jul 30, 2023 · 19 shares · 830 followers View post →
BillOckham
@BillOccham0 · X

RT @agingdoc1: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults (2019) https://t.co/onhQk2rfw1 ht…

Jul 30, 2023 · 19 shares · 589 followers View post →
Hippy Hodler
@mike_of_oz · X

RT @agingdoc1: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults (2019) https://t.co/onhQk2rfw1 ht…

Jul 30, 2023 · 19 shares · 2,473 followers View post →
Jay
@JayNeckhammer · X

RT @agingdoc1: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults (2019) https://t.co/onhQk2rfw1 ht…

Jul 30, 2023 · 19 shares · 557 followers View post →
Agingdoc
@agingdoc1 · X

Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults (2019) https://t.co/onhQk2rfw1 https://t.co/uuomJvQTeE

Jul 30, 2023 · 85 likes · 19 shares · 41,675 followers View post →
Dmitry ILVOVSKY
@ilvovsky · X

Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/DYSUrbIOp8

Jan 26, 2023 · 96 followers View post →
King Chatterjee
@mindstatic · X

Thanks. There are several studies that claim the opposite like this one https://t.co/5aXogc5jYW vs this one https://t.co/ZuDknXDiVc).

Jan 15, 2023 · 301 followers View post →
Orlando_uy
@Orlando_uy · X

Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/uFjMMyQwIn

Dec 17, 2022 · 694 followers View post →
David Deluca
@DavidDe17241120 · X

RT @davidasinclair: Here’s my opinion on the NYT story on metformin inhibiting benefits of exercise (EX). It’s known that EX-mimetics count…

Apr 15, 2022 · 22 shares · 5 followers View post →
Andres Felipe
@Anferupu · X

RT @maml_UWMadison: https://t.co/ShFFrLAFm3 Two years ago, our paper was amongst the top 10% downloaded papers @AgingCell! Seems like yeste…

Mar 30, 2022 · 3 shares · 52 followers View post →
Dave Hughes
@HughesDC_Muscle · X

RT @maml_UWMadison: https://t.co/ShFFrLAFm3 Two years ago, our paper was amongst the top 10% downloaded papers @AgingCell! Seems like yeste…

Mar 30, 2022 · 3 shares · 11,025 followers View post →
Ryan Marshall, PhD
@RNMarshallPhD · X

RT @maml_UWMadison: https://t.co/ShFFrLAFm3 Two years ago, our paper was amongst the top 10% downloaded papers @AgingCell! Seems like yeste…

Mar 30, 2022 · 3 shares · 1,231 followers View post →
Musculoskeletal Aging and Metabolism Laboratory
@maml_UWMadison · X

https://t.co/ShFFrLAFm3 Two years ago, our paper was amongst the top 10% downloaded papers @AgingCell! Seems like yesterday and forever ago all at the same time @benjaminfmiller

Mar 30, 2022 · 11 likes · 3 shares · 911 followers View post →
Actavis
@ActavisPL · X

RT @BenBikmanPhD: @hubermanlab Not to mention the effects on blunting the benefits of exercise: https://t.co/GDJT7kmv2L

Mar 29, 2022 · 2 shares · 398 followers View post →
Ricardo Cohn MD
@RicardoCohnMD · X

RT @BenBikmanPhD: @hubermanlab Not to mention the effects on blunting the benefits of exercise: https://t.co/GDJT7kmv2L

Mar 29, 2022 · 2 shares · 82 followers View post →
Benjamin Bikman
@BenBikmanPhD · X

@hubermanlab Not to mention the effects on blunting the benefits of exercise: https://t.co/GDJT7kmv2L

Mar 28, 2022 · 18 likes · 2 shares · 90,031 followers View post →
Bryan Gislason
@BryanGislason · X

@davidasinclair @roadsideproph Any new studies that debunk the research on how metformin impact exercise performance? https://t.co/KuI8gmo7OC

Mar 4, 2022 · 226 followers View post →
Hec
@Muscles_n_Mitos · X

RT @metapredict: "Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults" Is this a case of "too much si…

Jan 25, 2022 · 5 shares · 63 followers View post →
Sakamoto Lab
@LabSakamoto · X

RT @metapredict: "Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults" Is this a case of "too much si…

Jan 24, 2022 · 5 shares · 1,777 followers View post →
Society for Heart and Vascular Metabolism
@Soc_HrtVasMetab · X

RT @bioblastgeek: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/MwZPD5MPdS

Jan 24, 2022 · 24 shares · 578 followers View post →
Camilo E.
@caerpoco · X

RT @bioblastgeek: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/MwZPD5MPdS

Jan 24, 2022 · 24 shares · 126 followers View post →
Nathalie Kirby
@nathaliekirby · X

RT @bioblastgeek: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/MwZPD5MPdS

Jan 24, 2022 · 24 shares · 1,023 followers View post →
Oscar Andres
@OscarAndresMD · X

RT @bioblastgeek: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/MwZPD5MPdS

Jan 24, 2022 · 24 shares · 548 followers View post →
Carlos Colmenero
@colme99 · X

RT @bioblastgeek: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/MwZPD5MPdS

Jan 24, 2022 · 24 shares · 77 followers View post →
Richie Goulding
@RichieGoulding1 · X

RT @bioblastgeek: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/MwZPD5MPdS

Jan 24, 2022 · 24 shares · 1,063 followers View post →
Ignacio Hernando Valle
@nachoafysalud · X

RT @bioblastgeek: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/MwZPD5MPdS

Jan 24, 2022 · 24 shares · 5,830 followers View post →
Facu Pacheco Polo
@FacundoPachec19 · X

RT @bioblastgeek: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/MwZPD5MPdS

Jan 23, 2022 · 24 shares · 89 followers View post →
Matthew Triolo
@MatthewTriolo · X

RT @bioblastgeek: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/MwZPD5MPdS

Jan 23, 2022 · 24 shares · 216 followers View post →
Cliff Dominy
@CliffDominy · X

RT @bioblastgeek: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/MwZPD5MPdS

Jan 23, 2022 · 24 shares · 382 followers View post →
Missael
@miiss_ael · X

RT @bioblastgeek: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/MwZPD5MPdS

Jan 23, 2022 · 24 shares · 89 followers View post →
ClauFe
@claufetter · X

RT @bioblastgeek: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/MwZPD5MPdS

Jan 23, 2022 · 24 shares · 364 followers View post →
Dr. Helen E. Collins
@DrHelenECollin1 · X

RT @bioblastgeek: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/MwZPD5MPdS

Jan 23, 2022 · 24 shares · 2,202 followers View post →
Marcinho_Ribeiro
@MarcinhoRibeir5 · X

RT @bioblastgeek: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/MwZPD5MPdS

Jan 23, 2022 · 24 shares · 166 followers View post →
Society for Heart and Vascular Metabolism
@Soc_HrtVasMetab · X

RT @metapredict: "Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults" Is this a case of "too much si…

Jan 23, 2022 · 5 shares · 578 followers View post →
Shelley Keating
@shelley_keating · X

RT @bioblastgeek: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/MwZPD5MPdS

Jan 23, 2022 · 24 shares · 653 followers View post →
andrea avila
@andrea_avilab · X

RT @bioblastgeek: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/MwZPD5MPdS

Jan 23, 2022 · 24 shares · 340 followers View post →
Cameron A. Schmidt, PhD
@CAS_ReproLab · X

RT @bioblastgeek: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/MwZPD5MPdS

Jan 23, 2022 · 24 shares · 1,429 followers View post →
Andres Felipe
@Anferupu · X

RT @metapredict: "Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults" Is this a case of "too much si…

Jan 23, 2022 · 5 shares · 52 followers View post →
Musculoskeletal Aging and Metabolism Laboratory
@maml_UWMadison · X

RT @metapredict: "Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults" Is this a case of "too much si…

Jan 23, 2022 · 5 shares · 911 followers View post →
Nicolás Gómez-Álvarez
@NicolsGmezlvar1 · X

RT @bioblastgeek: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/MwZPD5MPdS

Jan 23, 2022 · 24 shares · 37 followers View post →
Musculoskeletal Aging and Metabolism Laboratory
@maml_UWMadison · X

RT @bioblastgeek: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/MwZPD5MPdS

Jan 23, 2022 · 24 shares · 911 followers View post →
Craig Porter
@bioblastgeek · X

Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/MwZPD5MPdS

Jan 23, 2022 · 121 likes · 24 shares · 1,256 followers View post →
Jamie Timmons
@metapredict · X

"Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults" Is this a case of "too much signaling" is undesirable or just that Metformins main benefits in T2DM are liver mediated with some down-sides elsewhere? https://t.co/o3VfQrOXQe

Jan 23, 2022 · 31 likes · 5 shares · 2,054 followers View post →
ちゃんの助
@piyomarck · X

@femto_birth 運動する日は飲まない、歩く以外に週に2回位は運動しているぽいので、飲まない日はあると言う事だと思います。血糖値の乱高下を防ぐために、飲まない日は食事を気にしたりしてるんでしょうか? 以下、シンクレアの投稿したリンクです。 https://t.co/2zQjJKqBoQ

Oct 27, 2021 · 353 followers View post →
Martin Borch Jensen
@MartinBJensen · X

I'm not aware of many studies on this, and none that measure #lifespan. There's one on #metformin interfering with exercise https://t.co/wToaVJp7ef, but a meta-analysis found no VO2 effects of metformin https://t.co/TSMoNRxClU.

May 31, 2021 · 3 likes · 6,466 followers View post →
Sakulrat
@Sakulratkulrat · X

RT @DrBenKirk: However, in older humans: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults: https…

Jan 11, 2021 · 1 share · 22 followers View post →
John Morley
@Meddocslu · X

Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/V91b8ejqsO

Jan 8, 2021 · 1,215 followers View post →
Ben Kirk, PhD
@DrBenKirk · X

However, in older humans: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults: https://t.co/XiBrqusDwr Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults: https://t.co/XqCa3KxaWG https://t.co/0Y1cWFxtJJ

Jan 8, 2021 · 4 likes · 1 share · 2,234 followers View post →
Teppei Fujikawa 藤川哲兵
@TFUJIK · X

RT @john_thyfault: @bnfinck @JimJohnsonSci @ketonemics Metformin also blocks exercise induced increases in muscle mitochondrial respiration…

Oct 12, 2020 · 2 shares · 431 followers View post →
Jim Johnson, PhD
@JimJohnsonSci · X

RT @john_thyfault: @bnfinck @JimJohnsonSci @ketonemics Metformin also blocks exercise induced increases in muscle mitochondrial respiration…

Oct 11, 2020 · 2 shares · 12,813 followers View post →
John Thyfault (TeeFo)
@john_thyfault · X

@bnfinck @JimJohnsonSci @ketonemics Metformin also blocks exercise induced increases in muscle mitochondrial respiration. Here’s recent paper from Ben Miller’s https://t.co/ekgJ08K5tz

Oct 11, 2020 · 8 likes · 2 shares · 2,510 followers View post →
alephh
@alephh · X

Metformin blunts muscle hypertrophy: resistance training https://t.co/KsWic85LxL Metformin inhibits improvement in skeletal muscle mitochondrial respiration: aerobic exercise https://t.co/j7fB0z5HJU Metformin reduces outcomes of maximal exercise capacity https://t.co/Hc1ADlaewi

Sep 14, 2020 · 388 followers View post →
Pooja
@pm_girl · X

#Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/9N9Wq3Xcdj #science

Jun 21, 2020 · 2,068 followers View post →
Dammian Miller
@DammianMiller · X

Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/0RW4v9uJMd

Jun 20, 2020 · 370 followers View post →
The Science Journal
@buzzingscience · X

#science #STEM Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/QETFzI0yoZ

Jun 20, 2020 · 71 followers View post →
Wallace
@MxLWallace · X

RT @davidasinclair: Here’s my opinion on the NYT story on metformin inhibiting benefits of exercise (EX). It’s known that EX-mimetics count…

May 18, 2020 · 22 shares · 214 followers View post →
SAP
@SAP__00 · X

@drnickgreiner @B_Holmer I remember seeing something about Metformin and exercise. Here it is, have you read this? https://t.co/OWb2mnEOpH

May 15, 2020 · 3 likes · 2,730 followers View post →
Sarcopenia_papers
@sarc_papers · X

Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults. https://t.co/U60ddPco25

Mar 31, 2020 · 1 like · 553 followers View post →
Lisa
@LisaMishchenko · X

@JDRockks @drericwestman @KenDBerryMD @DoctorTro A lot of those in the know are not as excited about Metformin for longevity etc. Finding it lowers testosterone and the efficacy of exercise. https://t.co/EDIa6FEzSH

Jan 31, 2020 · 2 likes · 44 followers View post →
sporcukalpdoktoru
@sporcukalpdr · X

@GDLeahy @LucasUFES @EricRawsonPhD @mackinprof @FitGreyStrong @Strength4_Life Also

Jan 7, 2020 · 4 likes · 1 share · 363 followers View post →
Natural Law Enforcer
@BChinatti · X

RT @mike_lustgarten: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults. - PubMed - NCBI https://t…

Dec 18, 2019 · 7 shares · 1,211 followers View post →
Functional Medicine Associates
@fmedassociates · X

RT @mike_lustgarten: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults. - PubMed - NCBI https://t…

Dec 18, 2019 · 7 shares · 2,183 followers View post →
David
@deibid77 · X

RT @mike_lustgarten: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults. - PubMed - NCBI https://t…

Dec 17, 2019 · 7 shares · 59 followers View post →
Mike Lustgarten, PhD
@mike_lustgarten · X

Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults. - PubMed - NCBI https://t.co/zJe5OT06A5

Dec 17, 2019 · 28 likes · 7 shares · 9,721 followers View post →
INNER POWER FITNESS
@InnerPowerFit · X

RT @SatchinPanda: #Metformin blunts the benefits of aerobic exercise training (AET) by inhibiting skeletal muscle mitochondrial respiration…

Nov 16, 2019 · 58 shares · 277 followers View post →
Mike Lustgarten, PhD
@mike_lustgarten · X

Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/mNR6JnqYtA

Oct 24, 2019 · 6 likes · 9,721 followers View post →
Dr Kent
@KentSmalley · X

Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults - Konopka - 2019 - Aging Cell - Wiley Online Library https://t.co/Ou3G4hFMwr

Oct 13, 2019 · 1 like · 10,812 followers View post →
Steven Quartz PhD
@StevenQuartz · X

@MarkGermaine @PaulreedReed @LeighBreen there's published data showing metformin attentuates response to aerobic exercise in similar population: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults https://t.co/EzfPhw76ov

Sep 27, 2019 · 1 like · 2,961 followers View post →
Simplex Health
@simplex_health · X

Very interesting read. Simplex Health values research that shines the light of the effects of medication for the treatment of type 2 diabetes. There is a way to reverse your type 2 diabetes, we are here to help. https://t.co/xrI0kapSDq https://t.co/065uX1ggU2

Jul 23, 2019 · 83 followers View post →
Mounir Marhaba
@MounirMarhaba · X

METFORMIN INHIBITS MITOCHONDRIAL ADAPTATIONS TO AEROBIC EXERCISE TRAINING IN OLDER ADULTS ByCrossFit July 13, 2019 This 2018 paper substantiates previous evidence indicating metformin diminishes the beneficial effects of exercise on insulin sensitivity. https://t.co/L6DA11ERfF

Jul 15, 2019 · 112 followers View post →
Peter Jensen
@pjensenmd · X

https://t.co/pcJufZSvjK

Jul 15, 2019 · 1 like · 1,693 followers View post →
Michele Antonio Arilli
@michelearillicf · X

https://t.co/E0GZKkNVYm @CrossFit @CrossFitHealth

Jul 13, 2019 · 268 followers View post →
Melissa Haliski, PhD
@missieleigh · X

Not only do older adults need to consider drug-drug interactions, there is also the need to consider drug-and-exercise interactions, too! #aging Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults. - PubMed - NCBI https://t.co/wKmLEA5JbJ

Jun 30, 2019 · 275 followers View post →
JFA
@JFrailtyAging · X

RT @drjohnmorley: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults - Konopka - 2019 - Aging Cell -…

Jun 29, 2019 · 7 shares · 3,508 followers View post →
Gateway GEC
@GatewayGEC · X

RT @drjohnmorley: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults - Konopka - 2019 - Aging Cell -…

Jun 27, 2019 · 7 shares · 63 followers View post →
María Moral
@twittmariamoral · X

RT @drjohnmorley: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults - Konopka - 2019 - Aging Cell -…

Jun 27, 2019 · 7 shares · 851 followers View post →
Unya S
@UnyaS · X

RT @drjohnmorley: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults - Konopka - 2019 - Aging Cell -…

Jun 26, 2019 · 7 shares · 187 followers View post →
Shibley
@dr_shibley · X

RT @drjohnmorley: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults - Konopka - 2019 - Aging Cell -…

Jun 26, 2019 · 7 shares · 27,500 followers View post →
john morley
@drjohnmorley · X

Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults - Konopka - 2019 - Aging Cell - Wiley Online Library https://t.co/y28QAwzS2L

Jun 26, 2019 · 6 likes · 7 shares · 8,318 followers View post →
Mike
@michaelscally · X

[OA] Metformin Inhibits Mitochondrial Adaptations To Aerobic Exercise Training Metformin and exercise independently improve insulin sensitivity and decrease the risk of diabetes. Metformin was also recently proposed as a potential therapy... https://t.co/Oai4DNe7MG

Jun 24, 2019 · 897 followers View post →
Evan Beloff
@evanbeloff · X

Exercise & Metformin not collaborating: exercisers on metformin seemed less able to improve fitness or insulin sensitivity than other volunteers. Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults. - PubMed - NCBI https://t.co/Mwa8qNWWpn

Jun 20, 2019 · 2 likes · 234 followers View post →
Julio Montero Castro
@juliomonterocas · X

RT @NutrSinMarcas: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults - Konopka - 2019 - Aging Cell…

May 14, 2019 · 6 shares · 596 followers View post →
wilma
@wilmavera1 · X

RT @NutrSinMarcas: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults - Konopka - 2019 - Aging Cell…

May 14, 2019 · 6 shares · 245 followers View post →
Ⓜ Gp #dignidad
@Marcelagp2 · X

RT @NutrSinMarcas: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults - Konopka - 2019 - Aging Cell…

May 14, 2019 · 6 shares · 2,836 followers View post →
Ivo Vukusich, MD.
@ammonitesmd · X

RT @NutrSinMarcas: Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults - Konopka - 2019 - Aging Cell…

May 14, 2019 · 6 shares · 2,298 followers View post →
Bernadette Keefe
@nxtstop1 · X

More ––––––––What's really up with #Metformin?? Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults Full: https://t.co/Yu6JsDaNda Tags: #exercise #aging #MSKover50 #mitochondria #OlderAdults https://t.co/YGIYx7Lb7l

Mar 4, 2019 · 1 like · 21,390 followers View post →