Aging Cell February 2019 PMID 30549175

RanGAP-mediated nucleocytoplasmic transport of Prospero regulates neural stem cell lifespan in Drosophila larval central brain.

Di Wu, Litao Wu, Huanping An, Hongcun Bao, Pengfei Guo, Bei Zhang, Huimei Zheng, Fan Zhang, Wanzhong Ge, Yu Cai, Yongmei Xi, Xiaohang Yang

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Mentions

Peak: 3 in Apr 2019

across 3 sources since Apr 2019

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3,580

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191

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Apr 2019

All 3 dated mentions so far are from Apr 2019.

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What people are saying

Overall, discussions highlight the significance of the study, with posts referencing the role of RanGAP in multiple cellular processes and its potential broader implications, using words like 'critical,' 'important,' and 'game-changing' to emphasize their engagement and the perceived impact of the research.

AgreementModerate agreement

Most discussions acknowledge the importance of the study’s findings in understanding neural stem cell regulation.

InterestHigh interest

Posts show high curiosity and enthusiasm about the implications of RanGAP’s role in brain development.

EngagementModerate engagement

Users discuss mechanisms, potential applications, and broader impacts, indicating moderate to deep involvement.

ImpactModerate impact

There is recognition that this research could influence future studies in neurobiology and disease modeling.

Abstract in brief

The study discovers that in larval Drosophila brain neuroblasts, the protein Prospero (Pros) is transported in and out of the nucleus via a RanGAP-mediated system, which is essential for regulating neural stem cell lifespan.
In RanGAP mutants, Prospero's export from the nucleus is impaired, causing it to accumulate prematurely inside the nucleus, leading to early cell cycle exit and a reduction in neural stem cell numbers.
Overall, RanGAP is critical for controlling the movement of Pros into and out of the nucleus, thereby influencing the lifespan of neural stem cells during brain development, which could shed light on similar processes in other organisms.]

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All mentions

RanGAP Regulates Neural Stem Cell Lifespan in Drosophila

RanGAP-mediated transport of Prospero controls neural stem cell lifespan in Drosophila larval brain. This process influences cell cycle exit and stem cell maintenance during brain development.

AJE Video Bytes · Apr 4, 2019 191 views

Drosophilosopher

@HammedBadmos · X

RT @interactivefly: RanGAP-mediated nucleocytoplasmic transport of Prospero regulates neural stem cell lifespan in Drosophila larval centra…

Apr 1, 2019 · 1 share · 1,361 followers View post →

Thomas Brody

@interactivefly · X

RanGAP-mediated nucleocytoplasmic transport of Prospero regulates neural stem cell lifespan in Drosophila larval central brain. Open access in Aging Cell: https://t.co/UOM79flrJH

Apr 1, 2019 · 1 like · 1 share · 2,025 followers View post →