PubHawk
J Am Heart Assoc December 2018 PMID 30561254

Risk of Death Following Application of Paclitaxel-Coated Balloons and Stents in the Femoropopliteal Artery of the Leg: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Konstantinos Katsanos, Stavros Spiliopoulos, Panagiotis Kitrou, Miltiadis Krokidis, Dimitrios Karnabatidis

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Mentions

101
Peak: 21 in Feb 2019
across 5 sources since Jan 2019

Extended reach

258,961
potential audience

Total likes

73

Video views

588

Mentions per month

Jan 2019 – Aug 2024

Where it's discussed

  • X / Twitter54 posts
  • News40 articles
  • Blogs3 articles
  • YouTube2 videos
  • Facebook2 posts

AI synopsis

What people are saying

Several discussions highlight the significance of the article by referencing historical meta-analyses and regulatory responses, such as mentions of increased long-term mortality risks and FDA letters. The tone varies from cautious skepticism to concern, with phrases like 'risk of death,' 'controversial,' and 'potential harm,' emphasizing the serious implications of the publication and its influence on ongoing debates about patient safety.

AgreementModerate agreement

Most discussions acknowledge the findings of the systematic review, with several posts referencing the increased risks identified in previous meta-analyses and meta-analyses, indicating general support or at least recognition of the article’s concerns.

InterestHigh interest

The group shows high curiosity about the implications of the research, with posts discussing whether practices should change and mentioning ongoing studies, reflecting a strong desire to understand the long-term safety issues.

EngagementHigh engagement

Many posts delve into detailed analysis or critique of the findings, citing prior research, regulatory responses, and implications for clinical practice, demonstrating deep engagement with the subject.

ImpactModerate impact

While there is serious discussion about potential safety concerns, some posts suggest uncertainty about immediate changes in practice, indicating perceptions that the article could influence future research and regulation more than current clinical decisi

Abstract in brief

  • A systematic review and meta-analysis of 28 RCTs involving 4663 patients found that while paclitaxel-coated devices reduce restenosis, they are associated with an increased risk of death, especially after 2 and 5 years.
  • The risk of death linked to paclitaxel exposure grows with higher doses and longer follow-up periods, suggesting a potential safety concern that requires further investigation.
  • The study emphasizes the urgent need for more research to understand the safety implications of using paclitaxel-coated balloons and stents in leg arteries, despite their benefits in reducing vessel reblockage.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Joseph L. Mills MD
@jmills1955 · X

Paclitaxel Plot thickens: ? increased mortality from peripheral Paclitaxel DES https://t.co/y3voMJJEU7 https://t.co/UVqjaE5WTq #VascularHealth #ComprehensiveVascularCare @VascularSVS @monteromiguel @basil_trials @profawbradbury @FDADeviceInfo @US_FDA @VIVAPhysicians @CircAHA https://t.co/RnHmUybWww

Feb 20, 2019 · 34 likes · 15 shares · 14,105 followers View post →
Eric Secemsky MD MSc
@EricSecemskyMD · X

2/Exactly 2 years ago a meta-analysis of RCTs was published in JAHA that found PCDs (balloons & stents) were associated w/a 3.4% increased risk of all-cause death in 12 trials at 2 yrs & a 6.5% increased risk in 3 trials at 4-5 yrs versus non-PCDs. https://t.co/yori3sgTI3 https://t.co/1qtjGZ7Ytg

Dec 9, 2020 · 14 likes · 4,620 followers View post →
宇津 貴史 /Utsu, Takashi
@Office_j · X

【雑記】米国FDAは、PADに対するパクリタキセル塗布バルーン/溶出ステントに伴う、長期死亡リスク増加の可能性に関するレターを発出。対照群に比べ２年間死亡リスク比が1.68 [95%CI 1.15-2.47] になるとのRCTメタ解析　[https://t.co/Oz93cfeS9K] を受け。 https://t.co/zG0mqM0TXv

Jan 17, 2019 · 4 likes · 1 share · 4,918 followers View post →
Athanasios Saratzis
@a_saratzis · X

11) ...and a controversial one. Paclitaxel may (?) be associated with increased long-term mortality risk in PAD. https://t.co/2PZV7u4lPr

Jan 11, 2019 · 3 likes · 3 shares · 4,073 followers View post →
Enio
@EnioMDMPH · X

@The_Sound_of_IR @HannahClode Please please please include something on the Katsanos et al. Meta-Analysis. Would love to hear some opinions, particularly on if practitioners are changing their practice until further data is available. https://t.co/UUlAWtrPX3

Jan 4, 2019 · 3 likes · 1,539 followers View post →
Chadi Alraies, MD FACC FSCAI
@chadialraies · X

Risk of Death Following Application of Paclitaxel-Coated Balloons and Stents in the Femoropopliteal Artery of the Leg https://t.co/phXsGSmGsD @JAHA_AHA @CircIntv

May 29, 2019 · 2 likes · 34,359 followers View post →

All mentions

Maple the Maine Coon
@ergonod · X

https://t.co/P8201xRfy6 https://t.co/lPDKBhtUhn

Jul 12, 2023 · 204 followers View post →
Devin Zarkowsky
@DevinZarkowsky · X

@sternvascular @esambolmd @EricSecemskyMD @michael_sywak @Mustapja @JaafGolzar @raosid @JayMathewsMD @surgmax @SDhandMD @Kuldeep1926 @kmadass @drsavealimb @baileyannRN @sternvascular is exactly correct. Lest we forget another fiasco with observational data, please see: https://t.co/1W66IThIkM

Mar 24, 2021 · 2,253 followers View post →
Eric Secemsky MD MSc
@EricSecemskyMD · X

2/Exactly 2 years ago a meta-analysis of RCTs was published in JAHA that found PCDs (balloons & stents) were associated w/a 3.4% increased risk of all-cause death in 12 trials at 2 yrs & a 6.5% increased risk in 3 trials at 4-5 yrs versus non-PCDs. https://t.co/yori3sgTI3 https://t.co/1qtjGZ7Ytg

Dec 9, 2020 · 14 likes · 4,620 followers View post →
Robin Shah, DO MBA
@robinsshah · X

@mpneph I don't think it is fully understood but very important point if this becomes widely adopted. Example of some PAD studies (though cannot really compare apples to oranges): https://t.co/wMs2gCqVXf

Sep 8, 2020 · 229 followers View post →
Chadi Alraies, MD FACC FSCAI
@chadialraies · X

Risk of Death Following Application of Paclitaxel-Coated Balloons and Stents in the Femoropopliteal Artery of the Leg https://t.co/phXsGSmGsD @JAHA_AHA @CircIntv

May 29, 2019 · 2 likes · 34,359 followers View post →
JAHA
@JAHA_AHA · X

We'll be discussing the December 2018 meta-analysis on #paclitaxel-coated devices and the risk of mortality by Katsanos et al: https://t.co/RAfEcbCcS6 #JAHAjc #AHAJournals

May 23, 2019 · 31,475 followers View post →
JAHA
@JAHA_AHA · X

In tonight's twitter journal club, we'll revisit the 2018 meta-analysis on #paclitaxel-coated devices and the risk of mortality by Katsanos et al: https://t.co/RAfEcbCcS6 #JAHAjc #AHAjournals @docHJ

May 23, 2019 · 1 like · 1 share · 31,475 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @luiscalderonve: Risk of Death Following Application of Paclitaxel‐Coated Balloons and Stents in the Femoropopliteal Artery of the Leg:…

May 9, 2019 · 1 share · 6,703 followers View post →
Luis Calderon Vera
@luiscalderonve · X

Risk of Death Following Application of Paclitaxel‐Coated Balloons and Stents in the Femoropopliteal Artery of the Leg: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials | Journal of the American Heart Association https://t.co/3e7EKbLn1v

May 9, 2019 · 1 share · 951 followers View post →
水野篤＠心臓の医者✨✨
@atmizu · X

PMDAからの DEB・DES FP領域です。 #CardioJapan https://t.co/K7zW2KLYpx JAHAはこちら https://t.co/2gqcMJZTic

Apr 19, 2019 · 9,924 followers View post →
Henk Jan Out
@HenkJanOut · X

Waarom doen we die studie in NL als er al blijkbaar 28 RCT’s gedaan zijn met die stent? https://t.co/LtZtE5L4lk https://t.co/kpm5OulNJE

Apr 17, 2019 · 2 likes · 2,588 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @ecovascular: Risk of Death Following Application of Paclitaxel‐Coated Balloons and Stents in the Femoropopliteal Artery of the Leg: A S…

Mar 1, 2019 · 1 share · 6,703 followers View post →
Robson Miranda | Ecovascular
@ecovascular · X

Risk of Death Following Application of Paclitaxel‐Coated Balloons and Stents in the Femoropopliteal Artery of the Leg: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials | Journal of the American Heart Association https://t.co/HUhCmUnwSQ

Mar 1, 2019 · 1 share · 943 followers View post →
Nikolaos Saratzis
@NSaratzis · X

RT @jmills1955: Paclitaxel Plot thickens: ? increased mortality from peripheral Paclitaxel DES https://t.co/y3voMJJEU7 https://t.co/UVqjaE…

Feb 24, 2019 · 15 shares · 41 followers View post →
Aphelion / Cardeation
@AphelionCapital · X

RT @jmills1955: Paclitaxel Plot thickens: ? increased mortality from peripheral Paclitaxel DES https://t.co/y3voMJJEU7 https://t.co/UVqjaE…

Feb 22, 2019 · 15 shares · 243 followers View post →
Lori Pounds
@LoriPounds1 · X

RT @jmills1955: Paclitaxel Plot thickens: ? increased mortality from peripheral Paclitaxel DES https://t.co/y3voMJJEU7 https://t.co/UVqjaE…

Feb 21, 2019 · 15 shares · 339 followers View post →
Elissa Freer
@Deepthi24257507 · X

RT @jmills1955: Paclitaxel Plot thickens: ? increased mortality from peripheral Paclitaxel DES https://t.co/y3voMJJEU7 https://t.co/UVqjaE…

Feb 21, 2019 · 15 shares · 12 followers View post →
Sheryl
@sunflowerscent · X

RT @jmills1955: Paclitaxel Plot thickens: ? increased mortality from peripheral Paclitaxel DES https://t.co/y3voMJJEU7 https://t.co/UVqjaE…

Feb 21, 2019 · 15 shares · 242 followers View post →
Oliver Aalami
@DrAalami · X

RT @jmills1955: Paclitaxel Plot thickens: ? increased mortality from peripheral Paclitaxel DES https://t.co/y3voMJJEU7 https://t.co/UVqjaE…

Feb 20, 2019 · 15 shares · 1,754 followers View post →
Dr. Ibrahim Riza
@vascular10 · X

RT @jmills1955: Paclitaxel Plot thickens: ? increased mortality from peripheral Paclitaxel DES https://t.co/y3voMJJEU7 https://t.co/UVqjaE…

Feb 20, 2019 · 15 shares · 1,762 followers View post →
leegoldstein
@leegoldstein · X

RT @jmills1955: Paclitaxel Plot thickens: ? increased mortality from peripheral Paclitaxel DES https://t.co/y3voMJJEU7 https://t.co/UVqjaE…

Feb 20, 2019 · 15 shares · 885 followers View post →
Kenneth Ziegler, MD, FACS, FSVS, RPVI
@ziegler_md · X

RT @jmills1955: Paclitaxel Plot thickens: ? increased mortality from peripheral Paclitaxel DES https://t.co/y3voMJJEU7 https://t.co/UVqjaE…

Feb 20, 2019 · 15 shares · 2,372 followers View post →
Anand Brahmandam
@andybrahm · X

RT @jmills1955: Paclitaxel Plot thickens: ? increased mortality from peripheral Paclitaxel DES https://t.co/y3voMJJEU7 https://t.co/UVqjaE…

Feb 20, 2019 · 15 shares · 667 followers View post →
Patrick Coughlin
@coughlin_pa · X

RT @jmills1955: Paclitaxel Plot thickens: ? increased mortality from peripheral Paclitaxel DES https://t.co/y3voMJJEU7 https://t.co/UVqjaE…

Feb 20, 2019 · 15 shares · 596 followers View post →
Benjamin Roush, MD
@BenRoushMD · X

RT @jmills1955: Paclitaxel Plot thickens: ? increased mortality from peripheral Paclitaxel DES https://t.co/y3voMJJEU7 https://t.co/UVqjaE…

Feb 20, 2019 · 15 shares · 1,244 followers View post →
Athanasios Saratzis
@a_saratzis · X

RT @jmills1955: Paclitaxel Plot thickens: ? increased mortality from peripheral Paclitaxel DES https://t.co/y3voMJJEU7 https://t.co/UVqjaE…

Feb 20, 2019 · 15 shares · 4,073 followers View post →
Devaraj S
@devaraj_vasc · X

RT @jmills1955: Paclitaxel Plot thickens: ? increased mortality from peripheral Paclitaxel DES https://t.co/y3voMJJEU7 https://t.co/UVqjaE…

Feb 20, 2019 · 15 shares · 338 followers View post →
Andrew Barleben
@AndrewBarleben · X

RT @jmills1955: Paclitaxel Plot thickens: ? increased mortality from peripheral Paclitaxel DES https://t.co/y3voMJJEU7 https://t.co/UVqjaE…

Feb 20, 2019 · 15 shares · 206 followers View post →
Joseph L. Mills MD
@jmills1955 · X

Paclitaxel Plot thickens: ? increased mortality from peripheral Paclitaxel DES https://t.co/y3voMJJEU7 https://t.co/UVqjaE5WTq #VascularHealth #ComprehensiveVascularCare @VascularSVS @monteromiguel @basil_trials @profawbradbury @FDADeviceInfo @US_FDA @VIVAPhysicians @CircAHA https://t.co/RnHmUybWww

Feb 20, 2019 · 34 likes · 15 shares · 14,105 followers View post →
Vladimir Stoyanov
@nephrospot · X

RT @SocietyAccess: What do you think? Does this apply to VA? Risk of Death Following Application of Paclitaxel‐Coated Balloons and Stents i…

Feb 18, 2019 · 2 shares · 259 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @SocietyAccess: What do you think? Does this apply to VA? Risk of Death Following Application of Paclitaxel‐Coated Balloons and Stents i…

Feb 17, 2019 · 2 shares · 6,703 followers View post →
VascularAccessSociety
@SocietyAccess · X

What do you think? Does this apply to VA? Risk of Death Following Application of Paclitaxel‐Coated Balloons and Stents in the Femoropopliteal Artery of the Leg: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials | https://t.co/CrwuKJPENq

Feb 17, 2019 · 2 shares · 1,730 followers View post →
Meshbesher & Spence
@meshbesher · X

A recent study published in the Journal of the American Heart Association reported an increased long-term risk of death beyond the first year following use of Paclitaxel-coated balloons in the femoropopliteal artery of the leg. Learn more here: https://t.co/qSVi1osDx0

Feb 17, 2019 · 1 like · 1 share · 1,117 followers View post →
Ryan Chizner, DO, MPH, RPVI, FACC
@ChiznerRyan · X

RT @GreggWStone: Meta-analysis in 4432 ts in 28 RCTs shows 68% higher mortality after paclitaxel-balloon vs control in fem-pop ds, but only…

Feb 3, 2019 · 19 shares · 340 followers View post →
Andrew Althouse
@ADAlthousePhD · X

@TPA_Debray @MaartenvSmeden @ihtanboga @alikaragozmd @Geointheworld Background: this meta-analysis came out in December showing possible harm with DCB: https://t.co/I0hSxn0rzo

Jan 27, 2019 · 1 like · 11,047 followers View post →
Andrew Althouse
@ADAlthousePhD · X

@TPA_Debray @MaartenvSmeden @ihtanboga @alikaragozmd @Geointheworld A meta analysis published in December included 28 RCT and used study-level data, finding a potential harm of DCB: https://t.co/I0hSxn0rzo

Jan 27, 2019 · 1 like · 11,047 followers View post →
Rahul Velineni
@RahulVelineni · X

RT @myxworld: Increased risk of death (7.2% at 2 years) after application of paclitaxel‐coated balloons and stents in the femoropopliteal a…

Jan 22, 2019 · 3 shares · 931 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @DrGroof: دراسة أخرى ديسمبر 2018 تقول بإزدياد إحتمال الوفاة من إستخدام علاج البالون و النفخ و الدعامة لشرايين الساقين Risk of Death Fol…

Jan 19, 2019 · 1 share · 6,703 followers View post →
Ala Groof
@DrGroof · X

دراسة أخرى ديسمبر 2018 تقول بإزدياد إحتمال الوفاة من إستخدام علاج البالون و النفخ و الدعامة لشرايين الساقين Risk of Death Following Application of Paclitaxel‐Coated Balloons and Stents in the Femoropopliteal Artery of the Leg: A Systematic Review and Meta‐Analysis of RCT J AHA

Jan 19, 2019 · 1 share · 556 followers View post →
Baldo
@BaldinoGiuseppe · X

https://t.co/1MfDnWYppa

Jan 19, 2019 · 11 followers View post →
名前
@akkiii0830 · X

RT @Office_j: 【雑記】米国FDAは、PADに対するパクリタキセル塗布バルーン/溶出ステントに伴う、長期死亡リスク増加の可能性に関するレターを発出。対照群に比べ２年間死亡リスク比が1.68 [95%CI 1.15-2.47] になるとのRCTメタ解析　[https:…

Jan 17, 2019 · 1 share · 246 followers View post →
宇津 貴史 /Utsu, Takashi
@Office_j · X

【雑記】米国FDAは、PADに対するパクリタキセル塗布バルーン/溶出ステントに伴う、長期死亡リスク増加の可能性に関するレターを発出。対照群に比べ２年間死亡リスク比が1.68 [95%CI 1.15-2.47] になるとのRCTメタ解析　[https://t.co/Oz93cfeS9K] を受け。 https://t.co/zG0mqM0TXv

Jan 17, 2019 · 4 likes · 1 share · 4,918 followers View post →
David Lim
@davidalim · X

RT @anitamulero: #FDA issues letter on paclitaxel coated balloons and eluting stents after @ahahospitals article (https://t.co/fCNrircEQy)…

Jan 17, 2019 · 1 share · 14,283 followers View post →
Ana Mulero, MBA-HCM
@anitamulero · X

#FDA issues letter on paclitaxel coated balloons and eluting stents after @ahahospitals article (https://t.co/fCNrircEQy) suggested a possible increased risk of death at 2 years and beyond in patients w a type of peripheral arterial disease https://t.co/uL9346uTSL

Jan 17, 2019 · 1 share · 1,410 followers View post →
Vimal Gokani
@VimalGokani · X

RT @a_saratzis: 11) ...and a controversial one. Paclitaxel may (?) be associated with increased long-term mortality risk in PAD. https://t…

Jan 12, 2019 · 3 shares · 2,492 followers View post →
Ved Ramnani
@VascularSci · X

RT @a_saratzis: 11) ...and a controversial one. Paclitaxel may (?) be associated with increased long-term mortality risk in PAD. https://t…

Jan 11, 2019 · 3 shares · 1,165 followers View post →
Prof Ramesh K Tripathi
@RKTvascular · X

RT @a_saratzis: 11) ...and a controversial one. Paclitaxel may (?) be associated with increased long-term mortality risk in PAD. https://t…

Jan 11, 2019 · 3 shares · 7,018 followers View post →
Athanasios Saratzis
@a_saratzis · X

11) ...and a controversial one. Paclitaxel may (?) be associated with increased long-term mortality risk in PAD. https://t.co/2PZV7u4lPr

Jan 11, 2019 · 3 likes · 3 shares · 4,073 followers View post →
Nacho Díaz
@NDiazLorenzo · X

Jan 9, 2019 · 1 like · 429 followers View post →
ᗰIGᑌEᒪ ᗰOᑎTEᖇO-ᗷᗩKEᖇ
@monteromiguel · X

RT @monteromiguel: Should ALL on-going studies (industry and non-industry) in humans using #paclitaxel based technologies for the therapy o…

Jan 7, 2019 · 1 share · 5,301 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @DKadiandodov: It will be interesting to see what longer term data reveals about these technologies and the ultimate patient risk ⚖️ ben…

Jan 7, 2019 · 1 share · 6,703 followers View post →
Daniella KadianDodov
@DKadiandodov · X

It will be interesting to see what longer term data reveals about these technologies and the ultimate patient risk ⚖️ benefit especially in light of recent meta-analysis showing ⬆️ death following paclitaxel DCB and DES in fem-pop disease. https://t.co/1zpdT6JD5l https://t.co/zLcEh2FHUs

Jan 7, 2019 · 1 like · 1 share · 1,154 followers View post →
ᗰIGᑌEᒪ ᗰOᑎTEᖇO-ᗷᗩKEᖇ
@monteromiguel · X

Should ALL on-going studies (industry and non-industry) in humans using #paclitaxel based technologies for the therapy of PAD be stopped until further in-depth analysis of this signal towards higher mortality when exposed to this drug? (https://t.co/tDhGwdsZeY)

Jan 5, 2019 · 1 share · 5,301 followers View post →
Enio
@EnioMDMPH · X

@The_Sound_of_IR @HannahClode Please please please include something on the Katsanos et al. Meta-Analysis. Would love to hear some opinions, particularly on if practitioners are changing their practice until further data is available. https://t.co/UUlAWtrPX3

Jan 4, 2019 · 3 likes · 1,539 followers View post →