Hum Genomics January 2019 PMID 30621780

The X chromosome and sex-specific effects in infectious disease susceptibility.

Haiko Schurz, Muneeb Salie, Gerard Tromp, Eileen G Hoal, Craig J Kinnear, Marlo Möller

Download social card

Mentions

77
Peak: 15 in Mar 2020
across 5 sources since Jan 2019

Extended reach

133,397
potential audience

Total likes

96

Video views

1,238

Mentions per month

Jan 2019 – Sep 2025

Where it's discussed

  • News41 articles
  • X / Twitter29 posts
  • Blogs3 articles
  • YouTube2 videos
  • Facebook2 posts

AI synopsis

What people are saying

Throughout the discussions, participants emphasize the significance of the X chromosome in immune function and disease differences between sexes, with phrases like 'largest number of immune-related genes' and 'genes escape inactivation,' indicating a focus on genetic mechanisms. Many comments express curiosity about how these findings relate to sex disparities in conditions like COVID-19, showing high interest. Some posts suggest the research could lead to new diagnostic or therapeutic approaches, highlighting a perception of meaningful impact.

AgreementStrong agreement

Most posts strongly agree or acknowledge the significance of the research, highlighting the importance of the X chromosome in immune response and disease susceptibility.

InterestHigh interest

The discussions show high curiosity, referencing specific genetic mechanisms and potential implications for disease disparities, indicating they find the topic highly relevant.

EngagementModerate engagement

Several comments mention molecular details or suggest the findings could inform future studies, reflecting thoughtful engagement, though most are observational rather than in-depth.

ImpactModerate impact

While some recognize the potential relevance for understanding sex-based health disparities, the overall perception is that this research could have meaningful, albeit not immediate, impact on healthcare and genetic studies.

Abstract in brief

  • The X chromosome contains many immune-related genes that affect how our bodies respond to infectious diseases, but it’s often overlooked in genetic studies because analyzing it is complicated.
  • Females have a unique genetic setup called X inactivation, where one of their X chromosomes is mostly turned off, but some genes escape this process, potentially giving females an immunological advantage over males.
  • The review discusses how the X chromosome influences immune responses and the differences between sexes in susceptibility to infections, using tuberculosis as an example of male dominance in disease risk that is not yet fully understood.]

Top posts

Most liked on X and Bluesky
Chris Mooney
@chriscmooney · X

7. But there is also evidence regarding immune system differences between men and women which we also discuss in the piece https://t.co/fGGvAYkXcc

Mar 19, 2020 · 17 likes · 5 shares · 36,062 followers View post →
Chris Mooney
@chriscmooney · X

12. Meanwhile, experts who study gender and infectious disease highlight immune system differences in men and women. Lot of evidence of this. https://t.co/fGGvAY3mkE

Mar 27, 2020 · 8 likes · 3 shares · 36,062 followers View post →
Agnieszka Szuster-Ciesielska
@AgnieszkaSzust3 · X

25/ produkcją przeciwciał. Na podstawie 1.https://t.co/l7RSqcj7uB 2.https://t.co/ot3tZweoEW 3.https://t.co/Cgjlvn0iqH 4.https://t.co/IcmhxQTM8K 5.https://t.co/okQ0pSkNPo 6.https://t.co/Lrv35172Lg

Feb 12, 2023 · 7 likes · 8,723 followers View post →
Laura Swinton
@LauraSwinton · X

@ChrispiaKane @suzanne_moore There's a growing body of research into the chromosomal nature of sex-differentiated immune response. X chromosome carries many immunity-related genes. Conversely it's likely also why women are more at risk from autoimmune disease https://t.co/DJo8p8OL4o https://t.co/L8AYFQUdb7

Mar 14, 2020 · 6 likes · 1 share · 1,630 followers View post →
Watson
@franklincrick · X

@bevcott @markoftheD X inactivation isn’t a perfect process, and sometimes genes on the X chromosome escape inactivation. In this case, a female ends up with two active copies of a particular gene - this is a good paper on the X https://t.co/5VFpuVK28s

Apr 30, 2020 · 4 likes · 1 share · 3,089 followers View post →
Ariti
@LedenUnor · X

@HSTSsn19561 @ape_bass @BanrighMessy @_Mars_F That’s not pedantic. It’s the finding of more recent studies. https://t.co/13blwMly7z

Oct 15, 2020 · 2 likes · 2,873 followers View post →

All mentions

Lil’ Diabeetus
@IHumpYourDad · X

@01xNithin @DudespostingWs Sources Cited, hbu?: https://t.co/8XGc1MBgAK (X chromosome has largest number of immuno-related genes in human genome) https://t.co/iLv5vx81rT (Many diseases present with a clear sex bias) https://t.co/zETQ8CiXYr (X chromosome-linked diseases are usually restricted to males)

Sep 18, 2025 · 1 like · 58 followers View post →
Tyler
@Tyler21123485 · X

@Molson_Hart One major reason is because of the X Chromosome https://t.co/FQQdGJGa7j

Oct 16, 2024 · 1 like · 74 followers View post →
tune
@keisuke4713 · X

Jun 16, 2023 · 3,744 followers View post →
tune
@keisuke4713 · X

感染症感受性でX染色体と性特異的影響 https://t.co/UFlArQBO5V

Jun 16, 2023 · 3,744 followers View post →
Agnieszka Szuster-Ciesielska
@AgnieszkaSzust3 · X

25/ produkcją przeciwciał. Na podstawie 1.https://t.co/l7RSqcj7uB 2.https://t.co/ot3tZweoEW 3.https://t.co/Cgjlvn0iqH 4.https://t.co/IcmhxQTM8K 5.https://t.co/okQ0pSkNPo 6.https://t.co/Lrv35172Lg

Feb 12, 2023 · 7 likes · 8,723 followers View post →
Peaceful Anarchist
@PeaceAnarchist1 · X

https://t.co/7Li1y3vOmY

Jan 22, 2022 · 43 followers View post →
Ariti
@LedenUnor · X

@HSTSsn19561 @ape_bass @BanrighMessy @_Mars_F That’s not pedantic. It’s the finding of more recent studies. https://t.co/13blwMly7z

Oct 15, 2020 · 2 likes · 2,873 followers View post →
Emma Pettengale
@EmmaPettengale · X

Could this 2019 paper on the X chromosome & sex-specific effects in infectious disease susceptibility offer leads in the significant dispartity in covid-19 mortality between the sexes? https://t.co/hr8SY59i1Z #coronavirus

Jun 18, 2020 · 1,325 followers View post →
Lucas Monteiro
@_monteirolucas_ · X

@annaonde Nesse caso, se estiver falando de letalidade, há a possibilidade das mulheres terem uma resposta imunológica mais rápida e potente que a dos homens. Há algumas diferenças genéticas nessa área. Da uma olhada nesse estudo, Doi: 10.1186/s40246-018-0185-z

May 22, 2020 · 1 like · 1,365 followers View post →
Ariti
@LedenUnor · X

RT @franklincrick: @bevcott @markoftheD X inactivation isn’t a perfect process, and sometimes genes on the X chromosome escape inactivation…

Apr 30, 2020 · 1 share · 2,873 followers View post →
Watson
@franklincrick · X

@bevcott @markoftheD X inactivation isn’t a perfect process, and sometimes genes on the X chromosome escape inactivation. In this case, a female ends up with two active copies of a particular gene - this is a good paper on the X https://t.co/5VFpuVK28s

Apr 30, 2020 · 4 likes · 1 share · 3,089 followers View post →
VaginaDiamondz
@VaginaDiamondz · X

@Rose_Posting @GellmanRebecca @Ysm0F @notCursedE @DebbieHayton @zoekennedy @NJHenpointe @2damntrans https://t.co/uMNAbqtFnO

Apr 16, 2020 · 564 followers View post →
Caro
@Caza341791 · X

https://t.co/nEtucqB9jd

Mar 30, 2020 · 3,483 followers View post →
Bassaces
@Bassaces1 · X

RT @chriscmooney: 12. Meanwhile, experts who study gender and infectious disease highlight immune system differences in men and women. Lot…

Mar 27, 2020 · 3 shares · 2,620 followers View post →
onahunttoday
@onahunttoday · X

RT @chriscmooney: 12. Meanwhile, experts who study gender and infectious disease highlight immune system differences in men and women. Lot…

Mar 27, 2020 · 3 shares · 3,814 followers View post →
The Climate Crisis is Happening Now
@seppy_kun · X

RT @chriscmooney: 12. Meanwhile, experts who study gender and infectious disease highlight immune system differences in men and women. Lot…

Mar 27, 2020 · 3 shares · 473 followers View post →
Chris Mooney
@chriscmooney · X

12. Meanwhile, experts who study gender and infectious disease highlight immune system differences in men and women. Lot of evidence of this. https://t.co/fGGvAY3mkE

Mar 27, 2020 · 8 likes · 3 shares · 36,062 followers View post →
Meat Popsicle
@MeatPopsicle17 · X

@Cernovich The X chromosome and sex-specific effects in infectious disease susceptibility https://t.co/gbcZvu4jQt

Mar 25, 2020 · 2 likes · 59 followers View post →
Collin Woodard - collinwoodard.bsky.social
@CollinWoodard · X

@johnvoelcker Aside from lifestyle differences (48% of men in China smoking vs 2% of women, etc.), I think the most interesting theory is that an extra X chromosome strengthens the immune system. https://t.co/tfcscDTb5o

Mar 20, 2020 · 1 like · 916 followers View post →
Dr Ben King
@benking01 · X

RT @chriscmooney: 7. But there is also evidence regarding immune system differences between men and women which we also discuss in the piec…

Mar 20, 2020 · 5 shares · 6,690 followers View post →
Justine #StandWithUkraine
@ChocolateGuitar · X

RT @chriscmooney: 7. But there is also evidence regarding immune system differences between men and women which we also discuss in the piec…

Mar 19, 2020 · 5 shares · 209 followers View post →
甘茶登志朗
@8nonbiri8 · X

RT @chriscmooney: 7. But there is also evidence regarding immune system differences between men and women which we also discuss in the piec…

Mar 19, 2020 · 5 shares · 1,075 followers View post →
Kunal Shah
@realKunalAShah · X

RT @chriscmooney: 7. But there is also evidence regarding immune system differences between men and women which we also discuss in the piec…

Mar 19, 2020 · 5 shares · 6,475 followers View post →
The Climate Crisis is Happening Now
@seppy_kun · X

RT @chriscmooney: 7. But there is also evidence regarding immune system differences between men and women which we also discuss in the piec…

Mar 19, 2020 · 5 shares · 473 followers View post →
Chris Mooney
@chriscmooney · X

7. But there is also evidence regarding immune system differences between men and women which we also discuss in the piece https://t.co/fGGvAYkXcc

Mar 19, 2020 · 17 likes · 5 shares · 36,062 followers View post →
Sydney Moore
@SydneyAllMoore · X

RT @LauraSwinton: @ChrispiaKane @suzanne_moore There's a growing body of research into the chromosomal nature of sex-differentiated immune…

Mar 15, 2020 · 1 share · 2,792 followers View post →
Laura Swinton
@LauraSwinton · X

@ChrispiaKane @suzanne_moore There's a growing body of research into the chromosomal nature of sex-differentiated immune response. X chromosome carries many immunity-related genes. Conversely it's likely also why women are more at risk from autoimmune disease https://t.co/DJo8p8OL4o https://t.co/L8AYFQUdb7

Mar 14, 2020 · 6 likes · 1 share · 1,630 followers View post →
Human Genomics
@HumanGenomics · X

The X chromosome and sex-specific effects in infectious disease susceptibility | Human Genomics | Full Text https://t.co/ZqSNJnMuTx

Feb 6, 2019 · 214 followers View post →
Southern African society for Human Genetics—SASHG
@SAHumanGenetics · X

"The X chromosome may contribute to the missing heritability or contain biomarkers that could be used as diagnostic tools. As... https://t.co/SNB3gkq7R8

Jan 10, 2019 · 546 followers View post →