JAMA Netw Open October 2018 PMID 30646252

Association of Cardiorespiratory Fitness With Long-term Mortality Among Adults Undergoing Exercise Treadmill Testing.

Kyle Mandsager, Serge Harb, Paul Cremer, Dermot Phelan, Steven E Nissen, Wael Jaber

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474

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AI synopsis

What people are saying

The group’s discussions reflect strong agreement with the study, with many emphasizing that increasing cardiorespiratory fitness, particularly VO2 max, substantially reduces mortality risk. The tone is enthusiastic and driven by evidence, citing multiple studies and using words like 'protects', 'game changer', and 'must consider,' indicating both high interest and perceived significance of the findings.

AgreementStrong agreement

Most discussions strongly support the study’s findings, emphasizing the clear link between higher fitness levels and reduced mortality.

InterestHigh interest

Posts demonstrate high interest, often referencing VO2 max, longevity, and exercise benefits, indicating active engagement with the topic.

EngagementHigh engagement

Many comments delve into methodological details and implications, showing deep engagement, like discussing specific metrics and studies.

ImpactHigh impact

Several discussions highlight the significance of fitness for long-term health and how these findings may influence personal or public health practices, indicating high impact.

Abstract in brief

Adverse cardiovascular effects of vigorous exercise have led to new questions about the overall benefits of fitness.
The study aimed to explore the relationship between cardiorespiratory fitness levels and all-cause mortality among patients who underwent exercise treadmill testing over a median follow-up of 8.4 years.
Results indicated that higher levels of cardiorespiratory fitness significantly correlate with lower all-cause mortality rates, suggesting that increased fitness can be more beneficial than some traditional risk factors, such as coronary artery disease.

Read the full abstract

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Alex Leaf

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@nntaleb @SentientBlobBob Highest elite level cardiorespiratory fitness reduced risk of premature mortality by 80% compared to lowest. When do you reach "beyond what is needed"? https://t.co/YzcdLBASEa

Oct 28, 2025 · 3 likes · 4,434 followers View post →

Reiner 

@erlesen · X

RT @erlesen: Association of Cardiorespiratory Fitness With Long-term Mortality Among Adults Undergoing Exercise Treadmill Testing https://t…

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Reiner

@erlangen.bsky.social · Bluesky

Association of Cardiorespiratory Fitness With Long-term Mortality Undergoing Exercise Treadmill Testing jamanetwork.com/journals/jam... Get your VO2 max as high as possible! You might have heard VO2 max mentioned as a metric that should be on your radar www.womenshealthmag.com/uk/health/a6...

Oct 1, 2025 · 1 like · 2 shares View post →

Reiner 

@erlesen · X

Association of Cardiorespiratory Fitness With Long-term Mortality Among Adults Undergoing Exercise Treadmill Testing https://t.co/eqcgKQ6TpC Get your VO2 max as high as possible You might have heard VO2max mentioned as a metric that should be on your radar https://t.co/yT2EmaDZ4A

Oct 1, 2025 · 4 likes · 1 share · 7,857 followers View post →

Austin Dudzinski, PharmD, BCACP

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RT @syahrul1988: @afrkml Saran sebagai sesama Nakes, minimal riset kecil2an dulu sblm bahas beginian. Max ngirim O2: QO2Max Max ngambil &…

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RT @syahrul1988: @afrkml Saran sebagai sesama Nakes, minimal riset kecil2an dulu sblm bahas beginian. Max ngirim O2: QO2Max Max ngambil &…

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Association of Cardiorespiratory Fitness With Long-term Mortality Among Adults Undergoing Exercise Treadmill Testing | Cardiology | JAMA Network Open | JAMA Network https://t.co/mmOXx948e8

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Dr. Ozan Ünlü

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@billurcu Tabii ki şu çalışmalara bakabilirsiniz. Çok fazla çalışma var ama hemen hepsi gözlemsel olduğu için kaliteli olmalarına dikkat etmek lazım. 1. Mandsager K, Harb S, Cremer P et al. Association of Cardiorespiratory Fitness With Long-term Mortality Among Adults Undergoing Exercise

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Gis poste

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@Fabbobo @Vargfakta Totalt fel. Träning är en mirakelmedicin som ger 10-15 friska år extra. Minst https://t.co/aDopVvHT8o https://t.co/l4egjnfQ9j

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Longevity of different “performance” groups based on their VO2 max https://t.co/UAIxKBhfwa #longevity #healthspan #rejuvenation https://t.co/gTzFb2eWEh

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Association of Cardiorespiratory Fitness With Long-term Mortality Among Adults Undergoing Exercise Treadmill Testing https://t.co/aTsNL1iflK

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RT @agingdoc1: Association of Cardiorespiratory Fitness With Long-term Mortality Among Adults Undergoing Exercise Treadmill Testing (2018)…

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Leandro Santos

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Se fumar aumenta o risco de mortalidade em 40%. A baixa aptidão cardiorrespiratória (VO2max) aumenta para 400% o risco de morte. Association of Cardiorespiratory Fitness With Long-term Mortality Among Adults Undergoing Exercise Treadmill Testing https://t.co/Za3MRAOiuj

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Ebeneezer WJ nu nu

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Sources for prior notes: vo2max: "Association of Cardiorespiratory Fitness With Long-term Mortality Among Adults Undergoing Exercise Treadmill Testing", N=122k This study has been frequently referenced by @PeterAttiaMD https://t.co/2ylcsgsWik https://t.co/lONEEEizuC

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Sports Clinic NQ

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@kevinnbass Reproduced by other studies most notably in 2018 with 122,007 participants male and female. October 19, 2018 Association of Cardiorespiratory Fitness With Long-term Mortality Among Adults Undergoing Exercise Treadmill Testing

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Association of Cardiorespiratory Fitness With Long-term Mortality Among Adults Undergoing Exercise Treadmill Testing. Cardiorespiratory fitness is inversely associated with long-term mortality with no observed upper limit of benefit! https://t.co/bi1A6SHBZo

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Standard caveats apply, yes there are other factors that may not be accounted for but the high order causal relationship exists. It points to exercise being the best “drug” we have to live a longer, healthier life. Full study here: https://t.co/vYq0Ojt4LD

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There's nothing you can do that's better for you. "Association of Cardiorespiratory Fitness With Long-term Mortality Among Adults Undergoing Exercise Treadmill Testing" https://t.co/kg8McX95yh

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There’s no downside. Association of Cardiorespiratory Fitness With Long-term Mortality Among Adults Undergoing Exercise Treadmill Testing | Cardiology | JAMA Network Open | JAMA Network https://t.co/Ff0oUkoGHR

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[PAPER]: Association of Cardiorespiratory Fitness With Long-term Mortality Among Adults Undergoing Exercise Treadmill Testing. https://t.co/xYk9YnIoX8

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