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Mol Cancer January 2019 PMID 30646912

Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape.

Xianjie Jiang, Jie Wang, Xiangying Deng, Fang Xiong, Junshang Ge, Bo Xiang, Xu Wu, Jian Ma, Ming Zhou, Xiaoling Li, Yong Li, Guiyuan Li, Wei Xiong, Can Guo, Zhaoyang Zeng

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Mentions

8
Peak: 2 in Dec 2022
across 3 sources since Jan 2019

Extended reach

7,781
potential audience

Total likes

67

Video views

2,078

Mentions per month

Jan 2019 – Dec 2022

Where it's discussed

  • X / Twitter4 posts
  • YouTube2 videos
  • News2 articles

AI synopsis

What people are saying

The discussions demonstrate a strong interest in how tumor microenvironments influence immune escape, with posts emphasizing the critical role of PD-L1/PD-1 signaling and its therapeutic potential, using words like 'crucial' and 'game-changing.' The tone and context reflect a serious engagement with the molecular aspects and clinical implications, showing recognition of the article's significance in cancer research.

AgreementModerate agreement

Most discussions acknowledge the importance of the PD-L1/PD-1 pathway in cancer immune evasion, indicating general agreement with the article's focus.

InterestHigh interest

Posts show high interest in understanding tumor microenvironment mechanisms, with some emphasizing the potential for improved therapies.

EngagementModerate engagement

Some comments reference molecular details and suggest significance for future research, reflecting moderate engagement.

ImpactModerate impact

Discussions highlight the relevance of this research for developing new treatments, indicating a perceived moderate to high impact.

Abstract in brief

  • Tumor immune escape is a key strategy for tumor survival, primarily achieved through immunosuppression mechanisms that inhibit T cell activation.
  • The PD-L1/PD-1 signaling pathway plays a critical role in this process by promoting immune tolerance in tumor cells, making it a target for cancer therapies.
  • Despite its potential, the effectiveness of PD-L1/PD-1 targeting remains limited, emphasizing the need for a better understanding of the molecular mechanisms regulating this pathway in the tumor microenvironment.
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Top posts

Most liked on X and Bluesky
tune
@keisuke4713 · X

PD-L1/PD-1介した腫瘍免疫逃避:腫瘍微小環境の役割 https://t.co/TJ2WbP2ZU6 program死ligand-1/program死-1(PD-L1/PD-1)signal伝達経路は腫瘍免疫抑制の重要要素、Tリンパ球活性化を阻害、腫瘍細胞の免疫寛容⬆️ ⇨腫瘍免疫逃避を達成 腫瘍微小環境:炎症性因子によるPD-L1誘導がPD-L1/PD-1遮断治療影響

Dec 21, 2022 · 6 likes · 2 shares · 3,734 followers View post →
Victoria Hendry
@HendryVictoria · X

Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape. https://t.co/JAxnOn3Zxp ⁦@alanlparker⁩

Jan 18, 2019 · 1 like · 1,322 followers View post →
大爲爾の歌
@modRNA_2 · X

RT @keisuke4713: PD-L1/PD-1介した腫瘍免疫逃避:腫瘍微小環境の役割 https://t.co/TJ2WbP2ZU6 program死ligand-1/program死-1(PD-L1/PD-1)signal伝達経路は腫瘍免疫抑制の重要要素、Tリンパ球活…

Dec 24, 2022 · 2 shares · 640 followers View post →
lymphaticpapers
@lymphaticpaper · X

Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape. https://t.co/HIJdQ0byfO

Jun 5, 2019 View post →

All mentions

大爲爾の歌
@modRNA_2 · X

RT @keisuke4713: PD-L1/PD-1介した腫瘍免疫逃避:腫瘍微小環境の役割 https://t.co/TJ2WbP2ZU6 program死ligand-1/program死-1(PD-L1/PD-1)signal伝達経路は腫瘍免疫抑制の重要要素、Tリンパ球活…

Dec 24, 2022 · 2 shares · 640 followers View post →
tune
@keisuke4713 · X

PD-L1/PD-1介した腫瘍免疫逃避:腫瘍微小環境の役割 https://t.co/TJ2WbP2ZU6 program死ligand-1/program死-1(PD-L1/PD-1)signal伝達経路は腫瘍免疫抑制の重要要素、Tリンパ球活性化を阻害、腫瘍細胞の免疫寛容⬆️ ⇨腫瘍免疫逃避を達成 腫瘍微小環境:炎症性因子によるPD-L1誘導がPD-L1/PD-1遮断治療影響

Dec 21, 2022 · 6 likes · 2 shares · 3,734 followers View post →
lymphaticpapers
@lymphaticpaper · X

Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape. https://t.co/HIJdQ0byfO

Jun 5, 2019 View post →
Victoria Hendry
@HendryVictoria · X

Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape. https://t.co/JAxnOn3Zxp ⁦@alanlparker⁩

Jan 18, 2019 · 1 like · 1,322 followers View post →