PLoS Med January 2019 PMID 30677016

Predicting survival from colorectal cancer histology slides using deep learning: A retrospective multicenter study.

Jakob Nikolas Kather, Johannes Krisam, Pornpimol Charoentong, Tom Luedde, Esther Herpel, Cleo-Aron Weis, Timo Gaiser, Alexander Marx, Nektarios A Valous, Dyke Ferber, Lina Jansen, Constantino Carlos Reyes-Aldasoro, Inka Zörnig, Dirk Jäger, Hermann Brenner

Mentions

53
Peak: 34 in Jan 2019
across 4 sources since Jan 2019

Extended reach

166,687
potential audience

Total likes

86

Video views

32

Mentions per month

Jan 2019 – Aug 2023

Where it's discussed

  • X / Twitter48 posts
  • News2 articles
  • Blogs2 articles
  • YouTube1 videos

AI synopsis

What people are saying

The overall discussions reflect high enthusiasm for the study's innovative use of AI to predict cancer prognosis, with contributions mentioning visualizations of neural network 'thoughts' and the development of new prognostic scores. Words like 'important,' 'exciting,' and mention of visual tools demonstrate the community's engagement and recognition of potential impact.

AgreementModerate agreement

Most discussions highlight the potential and success of deep learning in predicting patient outcomes, indicating strong support.

InterestHigh interest

The posts clearly show high interest, with mentions of the methodology, visualizations, and implications for medical practice.

EngagementHigh engagement

Many examples involve detailed references to the study’s techniques, such as CNNs and visualization tools like DeepDream, suggesting deep engagement.

ImpactModerate impact

While recognition of the study's significance is evident, the emphasis on future applications and research indicates moderate perceived impact.

Abstract in brief

  • The study used deep learning (CNNs) to analyze colorectal cancer tissue slides, successfully extracting prognostic information directly from standard histology images, which are usually not utilized for prognosis.
  • The researchers developed a "deep stroma score" based on CNN analysis, which independently predicted patient survival outcomes across large, diverse patient cohorts, outperforming manual stromal measurements and gene expression signatures in some cases.
  • These findings suggest that AI-driven analysis of tissue images could improve prognosis predictions for CRC patients, although further prospective studies are needed to confirm these results.]

Top posts

Most liked on X and Bluesky
Jakob Nikolas Kather
@jnkath · X

Our new paper is out @PLOSMedicine: "Predicting survival from #colorectal #cancer histology slides using deep learning" https://t.co/eLBbwkNm6D @UniklinikAachen @DKFZ @DKTK_ @NCT_HD #deeplearning #biomarker

Jan 24, 2019 · 48 likes · 19 shares · 4,801 followers View post →
Jakob Nikolas Kather
@jnkath · X

How does a neural network "think of" #cancer #histology images? In our @PLOSMedicine paper we used #DeepDream to visualize this: tumor (TUM) has a much more irregular structure than normal mucosa (NORM)

Jan 29, 2019 · 26 likes · 14 shares · 4,801 followers View post →
Research Centre in Biomedical Engineering, City.
@RCBE_City · X

Predicting survival from colorectal cancer histology slides using deep learning: A retrospective multicenter study https://t.co/KXQgIAgAGu

Oct 15, 2019 · 5 likes · 4 shares · 144 followers View post →
Nektarios Valous
@nekvalous · X

An excellent paper from @jnkath and @halama_immuno just published in PLOS Medicine; predicting survival from colorectal cancer histology slides using deep learning: https://t.co/rwFHN5xgkd

Jan 24, 2019 · 3 likes · 1,955 followers View post →
Nektarios Valous
@nekvalous · X

Check out the recently published paper in @PLOSMedicine from @jnkath and @halama_immuno and get more info on the deep stroma score; it is prognostic of overall survival in a large patient cohort: https://t.co/rwFHN5xgkd

Jan 28, 2019 · 2 likes · 1,955 followers View post →
Nature Reviews Gastroenterology & Hepatology
@NatRevGastroHep · X

#GastroEdPick A new study in @PLOSMedicine by @njkath and colleagues show that deep convolutional neural networks can predict prognosis of patients with #colorectalcancer directly from widely available histopathological images Free https://t.co/uNY9MbmEuJ https://t.co/ZdXY0otZNF

Jan 31, 2019 · 1 like · 33,096 followers View post →

All mentions

AKDM bot!
@akdm_bot · X

RT @RCBE_City: Predicting survival from colorectal cancer histology slides using deep learning: A retrospective multicenter study https://…

Oct 16, 2019 · 4 shares · 1,501 followers View post →
Elisa Mejía
@mmejiaeli · X

RT @RCBE_City: Predicting survival from colorectal cancer histology slides using deep learning: A retrospective multicenter study https://…

Oct 16, 2019 · 4 shares · 87 followers View post →
Dr. James May
@JamesmayRcbe · X

RT @RCBE_City: Predicting survival from colorectal cancer histology slides using deep learning: A retrospective multicenter study https://…

Oct 16, 2019 · 4 shares · 98 followers View post →
Terry Epstein
@TerryEpstein51 · X

RT @RCBE_City: Predicting survival from colorectal cancer histology slides using deep learning: A retrospective multicenter study https://…

Oct 15, 2019 · 4 shares · 129 followers View post →
Research Centre in Biomedical Engineering, City.
@RCBE_City · X

Predicting survival from colorectal cancer histology slides using deep learning: A retrospective multicenter study https://t.co/KXQgIAgAGu

Oct 15, 2019 · 5 likes · 4 shares · 144 followers View post →
Jakob Nikolas Kather
@jnkath · X

@benser2 @nature @tshitoyan we use DL to predict mutations (https://t.co/AkVINTHnul, https://t.co/NEg99Bomwj) and prognosis (https://t.co/eLBbwkNm6D) directly from cancer histology. Also applying DL to other medical imgs & text. I think it is important to combine medical domain knowledge with DL technology

Jul 14, 2019 · 4,801 followers View post →
Nima Sharifai, MD/PhD
@NimaS_NP · X

RT @jnkath: Our new paper is out @PLOSMedicine: "Predicting survival from #colorectal #cancer histology slides using deep learning" https:/…

Mar 4, 2019 · 19 shares · 633 followers View post →
Jake Scott
@CancerConnector · X

RT @jnkath: Our new paper is out @PLOSMedicine: "Predicting survival from #colorectal #cancer histology slides using deep learning" https:/…

Mar 4, 2019 · 19 shares · 4,920 followers View post →
Paul Macklin
@MathCancer · X

RT @jnkath: Our new paper is out @PLOSMedicine: "Predicting survival from #colorectal #cancer histology slides using deep learning" https:/…

Mar 4, 2019 · 19 shares · 5,881 followers View post →
Michael Hoffmeister
@_mhoffmeister · X

RT @jnkath: Our new paper is out @PLOSMedicine: "Predicting survival from #colorectal #cancer histology slides using deep learning" https:/…

Mar 1, 2019 · 19 shares · 191 followers View post →
German Biobank Node
@bbmri_de · X

RT @jnkath: Our new paper is out @PLOSMedicine: "Predicting survival from #colorectal #cancer histology slides using deep learning" https:/…

Feb 25, 2019 · 19 shares · 917 followers View post →
Jill Gallaher
@jillagal · X

RT @jnkath: How does a neural network "think of" #cancer #histology images? In our @PLOSMedicine paper we used #DeepDream to visualize this…

Feb 6, 2019 · 14 shares · 1,122 followers View post →
Data science
@Datascience__ · X

Predicting survival from colorectal cancer histology slides using deep learning: A retrospective multicenter study https://t.co/COsUunHfJi #DeepLearning

Feb 2, 2019 · 33,281 followers View post →
Ryan O Schenck
@research_junkie · X

RT @jnkath: How does a neural network "think of" #cancer #histology images? In our @PLOSMedicine paper we used #DeepDream to visualize this…

Feb 1, 2019 · 14 shares · 724 followers View post →
Nature Reviews Gastroenterology & Hepatology
@NatRevGastroHep · X

#GastroEdPick A new study in @PLOSMedicine by @njkath and colleagues show that deep convolutional neural networks can predict prognosis of patients with #colorectalcancer directly from widely available histopathological images Free https://t.co/uNY9MbmEuJ https://t.co/ZdXY0otZNF

Jan 31, 2019 · 1 like · 33,096 followers View post →
Jeffrey West
@mathoncbro · X

RT @jnkath: How does a neural network "think of" #cancer #histology images? In our @PLOSMedicine paper we used #DeepDream to visualize this…

Jan 31, 2019 · 14 shares · 8,296 followers View post →
helen childs
@HelenChilds_rwk · X

https://t.co/G51b8WndYE

Jan 31, 2019 · 622 followers View post →
Pearson Lab
@lab_pearson · X

RT @jnkath: How does a neural network "think of" #cancer #histology images? In our @PLOSMedicine paper we used #DeepDream to visualize this…

Jan 30, 2019 · 14 shares · 870 followers View post →
City Research Online
@City_Research · X

#openaccess New research in CRO: Predicting survival from colorectal cancer histology slides using deep learning: A retrospective multicenter study. https://t.co/Car4bZLyRC

Jan 30, 2019 · 1,427 followers View post →
Kardioonko-HD
@Kardioonkologie · X

RT @jnkath: Our new paper is out @PLOSMedicine: "Predicting survival from #colorectal #cancer histology slides using deep learning" https:/…

Jan 30, 2019 · 19 shares · 344 followers View post →
Constantino Carlos Reyes-Aldasoro
@C_ReyesAldasoro · X

RT @jnkath: How does a neural network "think of" #cancer #histology images? In our @PLOSMedicine paper we used #DeepDream to visualize this…

Jan 30, 2019 · 14 shares · 1,414 followers View post →
Zheng Hu
@huzheng1 · X

RT @jnkath: How does a neural network "think of" #cancer #histology images? In our @PLOSMedicine paper we used #DeepDream to visualize this…

Jan 29, 2019 · 14 shares · 1,093 followers View post →
Chandler Gatenbee
@cgatenbee · X

RT @jnkath: How does a neural network "think of" #cancer #histology images? In our @PLOSMedicine paper we used #DeepDream to visualize this…

Jan 29, 2019 · 14 shares · 613 followers View post →
Sara Kochanny
@SaraKochanny · X

RT @jnkath: How does a neural network "think of" #cancer #histology images? In our @PLOSMedicine paper we used #DeepDream to visualize this…

Jan 29, 2019 · 14 shares · 38 followers View post →
Nektarios Valous
@nekvalous · X

RT @jnkath: How does a neural network "think of" #cancer #histology images? In our @PLOSMedicine paper we used #DeepDream to visualize this…

Jan 29, 2019 · 14 shares · 1,955 followers View post →
Serdar Balcı
@serdarbalci · X

RT @jnkath: How does a neural network "think of" #cancer #histology images? In our @PLOSMedicine paper we used #DeepDream to visualize this…

Jan 29, 2019 · 14 shares · 2,622 followers View post →
DKFZ Data Science
@DataScienceDKFZ · X

RT @jnkath: How does a neural network "think of" #cancer #histology images? In our @PLOSMedicine paper we used #DeepDream to visualize this…

Jan 29, 2019 · 14 shares · 793 followers View post →
Jakob Nikolas Kather
@jnkath · X

How does a neural network "think of" #cancer #histology images? In our @PLOSMedicine paper we used #DeepDream to visualize this: tumor (TUM) has a much more irregular structure than normal mucosa (NORM)

Jan 29, 2019 · 26 likes · 14 shares · 4,801 followers View post →
Nektarios Valous
@nekvalous · X

Check out the recently published paper in @PLOSMedicine from @jnkath and @halama_immuno and get more info on the deep stroma score; it is prognostic of overall survival in a large patient cohort: https://t.co/rwFHN5xgkd

Jan 28, 2019 · 2 likes · 1,955 followers View post →
Mike Bonham, MD/PhD
@mikebonhamsf · X

RT @jnkath: Our new paper is out @PLOSMedicine: "Predicting survival from #colorectal #cancer histology slides using deep learning" https:/…

Jan 27, 2019 · 19 shares · 1,413 followers View post →
Jens Lundgren
@ProfJLundgren · X

RT @jnkath: Our new paper is out @PLOSMedicine: "Predicting survival from #colorectal #cancer histology slides using deep learning" https:/…

Jan 26, 2019 · 19 shares · 6,287 followers View post →
DKFZ Data Science
@DataScienceDKFZ · X

RT @jnkath: Our new paper is out @PLOSMedicine: "Predicting survival from #colorectal #cancer histology slides using deep learning" https:/…

Jan 26, 2019 · 19 shares · 793 followers View post →
Kenneth Tang
@drkennethtang · X

RT @jnkath: Our new paper is out @PLOSMedicine: "Predicting survival from #colorectal #cancer histology slides using deep learning" https:/…

Jan 25, 2019 · 19 shares · 2,483 followers View post →
Eszter Lakatos
@EszterLakatos42 · X

RT @PLOSMedicine: An addition to our #MachineLearning collection, @jnkath & coll. demonstrate the ability of deep #convolutional #neuralnet…

Jan 25, 2019 · 4 shares · 418 followers View post →
Jakob Nikolas Kather
@jnkath · X

RT @PLOSMedicine: An addition to our #MachineLearning collection, @jnkath & coll. demonstrate the ability of deep #convolutional #neuralnet…

Jan 25, 2019 · 4 shares · 4,801 followers View post →
Marc J. Brehme, PhD, MBA
@marcbrehme · X

RT @jnkath: Our new paper is out @PLOSMedicine: "Predicting survival from #colorectal #cancer histology slides using deep learning" https:/…

Jan 25, 2019 · 19 shares · 575 followers View post →
Heidelberg_Pharmacologist
@NicolasHohmann · X

RT @jnkath: Our new paper is out @PLOSMedicine: "Predicting survival from #colorectal #cancer histology slides using deep learning" https:/…

Jan 25, 2019 · 19 shares · 109 followers View post →
Cliona O'Farrelly
@ClionaOfarrelly · X

RT @jnkath: Our new paper is out @PLOSMedicine: "Predicting survival from #colorectal #cancer histology slides using deep learning" https:/…

Jan 25, 2019 · 19 shares · 2,904 followers View post →
Nigar Anjuman Khurram
@NigarAKhurram · X

RT @jnkath: Our new paper is out @PLOSMedicine: "Predicting survival from #colorectal #cancer histology slides using deep learning" https:/…

Jan 25, 2019 · 19 shares · 3,191 followers View post →
Serdar Balcı
@serdarbalci · X

RT @jnkath: Our new paper is out @PLOSMedicine: "Predicting survival from #colorectal #cancer histology slides using deep learning" https:/…

Jan 25, 2019 · 19 shares · 2,622 followers View post →
Cancer Core Europe
@CancerCoreEU · X

RT NCT_HD "RT jnkath: Our new paper is out PLOSMedicine: "Predicting survival from #colorectal #cancer histology slides using deep learning" https://t.co/c6XIroklCJ UniklinikAachen DKFZ DKTK_ NCT_HD #deeplearning #biomarker"

Jan 25, 2019 · 1,327 followers View post →
NCT Heidelberg
@NCT_HD · X

RT @jnkath: Our new paper is out @PLOSMedicine: "Predicting survival from #colorectal #cancer histology slides using deep learning" https:/…

Jan 25, 2019 · 19 shares · 2,512 followers View post →
Jan Poleszczuk
@JPoleszczuk · X

RT @jnkath: Our new paper is out @PLOSMedicine: "Predicting survival from #colorectal #cancer histology slides using deep learning" https:/…

Jan 25, 2019 · 19 shares · 711 followers View post →
Dr. Andres GARCIA-PALOMO
@andresgpalomo · X

Predicting survival from colorectal cancer histology slides using deep learning: A retrospective multicenter study https://t.co/JdIn68tbhw https://t.co/784SpimZN7

Jan 24, 2019 · 2,050 followers View post →
Kimberly Luddy
@luddyka · X

RT @jnkath: Our new paper is out @PLOSMedicine: "Predicting survival from #colorectal #cancer histology slides using deep learning" https:/…

Jan 24, 2019 · 19 shares · 1,464 followers View post →
Jakob Nikolas Kather
@jnkath · X

Our new paper is out @PLOSMedicine: "Predicting survival from #colorectal #cancer histology slides using deep learning" https://t.co/eLBbwkNm6D @UniklinikAachen @DKFZ @DKTK_ @NCT_HD #deeplearning #biomarker

Jan 24, 2019 · 48 likes · 19 shares · 4,801 followers View post →
Nektarios Valous
@nekvalous · X

An excellent paper from @jnkath and @halama_immuno just published in PLOS Medicine; predicting survival from colorectal cancer histology slides using deep learning: https://t.co/rwFHN5xgkd

Jan 24, 2019 · 3 likes · 1,955 followers View post →
Continuum AEP
@ContinuumAEP · X

#PlosMedicine Predicting survival from colorectal cancer histology slides using deep learning: A retrospective multicenter study https://t.co/uD83h6Mepu

Jan 24, 2019 · 10,758 followers View post →