Nat Microbiol May 2019 PMID 30804542

Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host.

Matae Ahn, Danielle E Anderson, Qian Zhang, Chee Wah Tan, Beng Lee Lim, Katarina Luko, Ming Wen, Wan Ni Chia, Shailendra Mani, Loo Chien Wang, Justin Han Jia Ng, Radoslaw M Sobota, Charles-Antoine Dutertre, Florent Ginhoux, Zheng-Li Shi

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Mentions

71
Peak: 10 in Feb 2019
across 5 sources since Feb 2019

Extended reach

75,352
potential audience

Total likes

89

Video views

3,189

Mentions per month

Feb 2019 – May 2025

Where it's discussed

  • X / Twitter33 posts
  • News26 articles
  • Blogs8 articles
  • YouTube2 videos
  • Reddit2 posts

AI synopsis

What people are saying

Across the discussions, posters consistently highlight the significance of the dampened NLRP3 inflammasome in bats, describing it as a key mechanism for their ability to host viruses without severe disease. Words like 'revolutionary' and mentions of 'implications for longevity and viral reservoirs' reflect a shared excitement about potential breakthroughs, while technical references to gene alterations and immune responses demonstrate deep engagement with the research.

AgreementModerate agreement

Many discussions praise the findings, highlighting the significance of bats' unique immune response and suggesting consensus on its importance.

InterestHigh interest

The topic draws high interest, with posts mentioning the relevance to disease resistance, COVID-19, and implications for understanding viral reservoirs.

EngagementHigh engagement

Posts show deep engagement by referencing specific immunological concepts like the NLRP3 inflammasome and comparing bat physiology to human responses, indicating thoughtful consideration.

ImpactHigh impact

The discussions recognize the potential impact on virology, immunology, and even public health, with posts calling it 'revolutionary' and noting its implications for future research.

Abstract in brief

  • Bats have a unique ability to host emerging viruses and show a significantly reduced activation of the NLRP3 inflammasome, which is involved in inflammation, compared to humans and mice.
  • This dampened inflammasome response in bats is caused by changes in the NLRP3 gene, including lower gene activity, a new splice variant, and alterations in specific protein domains, allowing bats to control inflammation without affecting viral loads.
  • These findings suggest that bats' reduced inflammatory response may be linked to their longevity and their role as viral reservoirs, providing insight into how they manage emerging infections without severe disease.

Top posts

Most liked on X and Bluesky
David Hayman
@dtsh2 · X

Here's a commentary on bat tolerance to viral infections https://t.co/6paOxnjEa7 after excellent work by Ahn et al. Nat. Microbiol. https://t.co/ipItmvX5e2

Apr 28, 2019 · 19 likes · 6 shares · 1,279 followers View post →
Jochen Reiser MD PhD
@JochenReiser · X

Why bats don’t care about #COVID19 Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host | Nature Microbiology https://t.co/psozPJYtbH

Apr 3, 2020 · 8 likes · 1 share · 4,614 followers View post →
Bat Researcher - A.Prof. Aaron Irving
@BatResearch · X

@MLConradLab Amongst other things, I am a #bat #immunologist. We have shown most bat species pretty actively try and kill the inflammasome. https://t.co/UDNXlEes98 Inspiration: @VirusesImmunity @FGinhoux @cadutertre @VirusWhisperer @IdoAmitLab @LabBroz @hornung_lab & more not on twitter!

Aug 29, 2020 · 8 likes · 2 shares · 2,537 followers View post →
Mathew Dyors @dyorsmathew@mstdn.science
@DyorsMathew · X

11/ What makes bats special might not be their antiviral ability, but rather their antidisease features. https://t.co/CXds4LdLDG https://t.co/jj3nFGR0wY https://t.co/7ozl7VM1yN

Sep 28, 2022 · 8 likes · 1 share · 1,260 followers View post →
Bat Researcher - A.Prof. Aaron Irving
@BatResearch · X

Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host. Nature Microbiology (2019), 25th Feb. https://t.co/KcZSLLq2l4 #Batpapers #NLRP3 #Virus #inflammasome #MERSCoV #PRV3M #IAV finally..

Feb 25, 2019 · 7 likes · 5 shares · 2,537 followers View post →
Phil Ross
@philippzross · X

@VirusesImmunity Great insight! I don't know much about pyroptosis, but this makes me think back to a study done on NLRP3 inflammasome in bats! Maybe explains why bats make a good reservoir for SARS-CoVs. https://t.co/7isG6YPcye

Apr 5, 2020 · 3 likes · 1 share · 463 followers View post →

All mentions

VintageKidsGoodies
@VintageKidsNL · X

RT @jhas5: @tony_vandongen Take any weird immunological parts of SARS2 (e.g. NLR3P) https://t.co/0ORs5R2rSH And search for it in bat vax…

May 8, 2025 · 3 shares · 545 followers View post →
カレー粉
@yamadataro55 · X

どうしてコウモリが凶悪なウイルスの感染源になっているのか。 コウモリが飛行能力を獲得する過程で、“炎症反応”を抑えてしまったからではないかという説。https://t.co/VaRmBDDhO6

Apr 6, 2025 · 103 followers View post →
Paul Becker
@PaulBec70789962 · X

RT @jhas5: @tony_vandongen Take any weird immunological parts of SARS2 (e.g. NLR3P) https://t.co/0ORs5R2rSH And search for it in bat vax…

Dec 26, 2023 · 3 shares · 1,247 followers View post →
Paul Becker
@PaulBec70789962 · X

RT @jhas5: @tony_vandongen Take any weird immunological parts of SARS2 (e.g. NLR3P) https://t.co/0ORs5R2rSH And search for it in bat vax…

Oct 20, 2023 · 3 shares · 1,247 followers View post →
Jim Haslam
@jhas5 · X

@tony_vandongen Take any weird immunological parts of SARS2 (e.g. NLR3P) https://t.co/0ORs5R2rSH And search for it in bat vax literature https://t.co/LXxKH6Menm

Oct 9, 2023 · 1 like · 3 shares · 3,696 followers View post →
Bharath Beligeous
@BBeligeous · X

RT @newtonnidhi: #COVID19 is a christened new virus, it is nothing but a programmed recombinant Middle East respiratory virus(MERS) & a ba…

Feb 28, 2023 · 1 share · 12 followers View post →
Dr. SRINIDHI B.V
@newtonnidhi · X

#COVID19 is a christened new virus, it is nothing but a programmed recombinant Middle East respiratory virus(MERS) & a bat virus to mess up our cytokines cause immunity mediated damage to our own cells. Study was done in #Wuhan. https://t.co/hb3BWEFkx9

Feb 28, 2023 · 1 like · 1 share · 40 followers View post →
ウィルスについて勉強中
@mirarai0study · X

RT @DyorsMathew: 11/ What makes bats special might not be their antiviral ability, but rather their antidisease features. https://t.co/CXds…

Sep 29, 2022 · 1 share · 76 followers View post →
Mathew Dyors @dyorsmathew@mstdn.science
@DyorsMathew · X

11/ What makes bats special might not be their antiviral ability, but rather their antidisease features. https://t.co/CXds4LdLDG https://t.co/jj3nFGR0wY https://t.co/7ozl7VM1yN

Sep 28, 2022 · 8 likes · 1 share · 1,260 followers View post →
Julia B.
@JuliaB_fitness · X

@FrontImmunol Also: Dampened #NLRP3-mediated inflammation in bats and implications for a special viral reservoir host. «Our results elucidate an important mechanism through which bats dampen inflammation with implications for longevity & unique viral reservoir status.» https://t.co/7bcHE7U6sO

Nov 1, 2021 · 1 like · 2,272 followers View post →
bryan grahn
@bryangrahn · X

RT @BatResearch: @MLConradLab Amongst other things, I am a #bat #immunologist. We have shown most bat species pretty actively try and kill…

Aug 31, 2020 · 2 shares · 294 followers View post →
Bat Researcher - A.Prof. Aaron Irving
@BatResearch · X

@MLConradLab Amongst other things, I am a #bat #immunologist. We have shown most bat species pretty actively try and kill the inflammasome. https://t.co/UDNXlEes98 Inspiration: @VirusesImmunity @FGinhoux @cadutertre @VirusWhisperer @IdoAmitLab @LabBroz @hornung_lab & more not on twitter!

Aug 29, 2020 · 8 likes · 2 shares · 2,537 followers View post →
DomTheBoss
@uberrimaefidei1 · X

RT @philippzross: @VirusesImmunity Great insight! I don't know much about pyroptosis, but this makes me think back to a study done on NLRP3…

Apr 10, 2020 · 1 share · 627 followers View post →
Phil Ross
@philippzross · X

@VirusesImmunity Great insight! I don't know much about pyroptosis, but this makes me think back to a study done on NLRP3 inflammasome in bats! Maybe explains why bats make a good reservoir for SARS-CoVs. https://t.co/7isG6YPcye

Apr 5, 2020 · 3 likes · 1 share · 463 followers View post →
Sinch Health
@SinchHealth · X

RT @JochenReiser: Why bats don’t care about #COVID19 Dampened NLRP3-mediated inflammation in bats and implications for a special viral res…

Apr 4, 2020 · 1 share · 28 followers View post →
Jochen Reiser MD PhD
@JochenReiser · X

Why bats don’t care about #COVID19 Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host | Nature Microbiology https://t.co/psozPJYtbH

Apr 3, 2020 · 8 likes · 1 share · 4,614 followers View post →
Dr. Jon Epstein
@EpsteinJon · X

RT @dtsh2: Here's a commentary on bat tolerance to viral infections https://t.co/6paOxnjEa7 after excellent work by Ahn et al. Nat. Microbi…

Apr 29, 2019 · 6 shares · 4,591 followers View post →
Kevin J Olival
@nycbat · X

RT @dtsh2: Here's a commentary on bat tolerance to viral infections https://t.co/6paOxnjEa7 after excellent work by Ahn et al. Nat. Microbi…

Apr 29, 2019 · 6 shares · 3,194 followers View post →
Daniel Becker
@danjbecker · X

RT @dtsh2: Here's a commentary on bat tolerance to viral infections https://t.co/6paOxnjEa7 after excellent work by Ahn et al. Nat. Microbi…

Apr 29, 2019 · 6 shares · 3,197 followers View post →
Michelle Wille
@DuckSwabber · X

RT @dtsh2: Here's a commentary on bat tolerance to viral infections https://t.co/6paOxnjEa7 after excellent work by Ahn et al. Nat. Microbi…

Apr 29, 2019 · 6 shares · 5,396 followers View post →
James Wood
@jw132 · X

RT @dtsh2: Here's a commentary on bat tolerance to viral infections https://t.co/6paOxnjEa7 after excellent work by Ahn et al. Nat. Microbi…

Apr 29, 2019 · 6 shares · 3,442 followers View post →
Michal Tal, PhD
@ImmunoFever · X

RT @dtsh2: Here's a commentary on bat tolerance to viral infections https://t.co/6paOxnjEa7 after excellent work by Ahn et al. Nat. Microbi…

Apr 28, 2019 · 6 shares · 14,325 followers View post →
David Hayman
@dtsh2 · X

Here's a commentary on bat tolerance to viral infections https://t.co/6paOxnjEa7 after excellent work by Ahn et al. Nat. Microbiol. https://t.co/ipItmvX5e2

Apr 28, 2019 · 19 likes · 6 shares · 1,279 followers View post →
UCD BatLab
@BatLabUCD · X

RT @BatResearch: Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host. Nature Microbiology (201…

Feb 27, 2019 · 5 shares · 1,544 followers View post →
HungryMicrobe
@hungrymicrobe · X

Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host https://t.co/WVJqrKxznD

Feb 26, 2019 · 1,451 followers View post →
Edwin Leeansyah
@ELeeansyah · X

RT @BatResearch: Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host. Nature Microbiology (201…

Feb 26, 2019 · 5 shares · 540 followers View post →
Martin Hölzer
@martinhoelzer · X

RT @BatResearch: Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host. Nature Microbiology (201…

Feb 26, 2019 · 5 shares · 709 followers View post →
Arinjay Banerjee
@sci_questions · X

Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host | Nature Microbiology ⁦@NatureMicrobiol⁩ https://t.co/PfCe7rEHdJ

Feb 25, 2019 · 1 like · 9,444 followers View post →
C.A. Dutertre
@cadutertre · X

RT @BatResearch: Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host. Nature Microbiology (201…

Feb 25, 2019 · 5 shares · 507 followers View post →
Heather Davies
@flywithgeodata · X

RT @BatResearch: Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host. Nature Microbiology (201…

Feb 25, 2019 · 5 shares · 138 followers View post →
Bat Researcher - A.Prof. Aaron Irving
@BatResearch · X

Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host. Nature Microbiology (2019), 25th Feb. https://t.co/KcZSLLq2l4 #Batpapers #NLRP3 #Virus #inflammasome #MERSCoV #PRV3M #IAV finally..

Feb 25, 2019 · 7 likes · 5 shares · 2,537 followers View post →
micropapers
@micro_papers · X

Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host https://t.co/JbKzq2Tbt5

Feb 25, 2019 · 1 like · 332 followers View post →
Wanrong Sia
@wanrongsia · X

Its out!! Still mins fresh! Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host. Congrats Star and the bat lab peeps!! :) Another revolutionary paper.

Feb 25, 2019 · 2 likes · 285 followers View post →