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Discussions largely focus on the findings that discredit several historical genetic theories surrounding depression, with comments such as 'ALL OF THIS IS LIES' reflecting disbelief in past studies. Participants frequently reference previous research, such as the meta-analysis in 2019 that discredited the 5-HTTLPR gene's involvement, indicating a shift in understanding. The choice of words, particularly strong dismissive phrases and references to 'false positives', contribute to the identification of a strong consensus against long-held beliefs in genetic links to depression, signaling a pivotal change in the research landscape.
A significant number of discussions express strong support for the study's findings, emphasizing disbelief in previously held genetic theories of depression.
The discussions demonstrate a high level of curiosity, with many participants actively engaging with the implications of the study.
While many participants delve into details, others simply echo sentiments or share links without substantial analysis.
The consensus among participants is that the study holds substantial influence, potentially shifting the narrative around genetics and depression research.
Temos 2 episódios do @naruhodopodcast a respeito (220 e 221) https://t.co/Sy0nBcQ0zp Além do ótimo fio do @lftofoli a respeito que motivou os episódios do @naruhodopodcast naquela época https://t.co/9QUNW2QWwE
@CJakedoleschal Mixed bag, but often leans into spurious hypotheses without proper regard for their lack of support. In depression ep, says 5-HTTLPR “greatly shifts susceptibility to depression”. That was discredited in a meta review in 2019. https://t.co/WVoOIQ1gqH Many such cases.
Por fim, vale a pena como complemento, os ep 220 e 221 do @naruhodopodcast sobre depressão! https://t.co/SDQ2Tvrd5V
An entire field of study is wrong. Genetic variation in the serotonin transporter turns out to have no connection to depression or other psychiatric issues. This invalidates pharmacogenomic testing, a type of precision medicine, for depression treatment. https://t.co/wZriYNgGDp
Los autores encuentran que la llamada "hipótesis del gen candidato" y la "hipótesis del gen por interacción" no se sostienen cuando se utilizan métodos de análisis más exigentes que los usados hasta ahora. https://t.co/NQcKhIJS6D
So great to see previous grad student @EikoFried 's lovely summary https://t.co/nyxxJx8tRB of the AJP paper https://t.co/2jSSqpVPvn by my first grad student @matthewckeller showing that when the sample is large enough no previous candidate genes for depression hold up.
The study explored 18 candidate genes associated with major depression using large sample sizes. No significant links were found, challenging earlier claims and indicating that previous associations may be false…
This episode explores if there is a cause for depression, examining myths about mental illnesses, and discussing scientific perspectives on mental health causes, including economic and biological factors.
This video presents insights from Dorothy V M Bishop on the detrimental effects of quasicumulative science. It explores how open science solutions can improve research integrity by promoting trustworthiness…
@CSandbatch Screenshots from: https://t.co/8uBDWLnYEo
RT @ekernf01: Riffing, but grouchy: absence of evidence from preregistered, well-powered studies *is* evidence of absence. https://t.co/W…
Not that I have depression but this is interesting. Could it be then that depression is due to environmental and dietary factors: https://t.co/i2ROfkA3Zs
Riffing, but grouchy: absence of evidence from preregistered, well-powered studies *is* evidence of absence. https://t.co/W5Nv7wvn4B https://t.co/aNFSMsb0tY
@atomicaceso In any case, there is no evidence whatsoever that genetics play a role in these so-called "mental illnesses": https://t.co/Pnklb19UCc
@DrAnnieHickox @KavitaGooch @drjanaway The only thing is, this statement has no evidence. These conditions are NOT genetic - see for example: https://t.co/Pnklb19UCc
@KavitaGooch @drjanaway Your statement has no evidence whatsoever - it is a false "belief." See for example the following article: https://t.co/Pnklb19UCc
"If 5-HTTLPR plays such an important role in depression.... ALL. OF. THIS. IS. LIES. Or at least this is the conclusion I draw from Border et al’s No Support For Historical Candidate Gene Or Candidate Gene-by-Interaction Hypotheses..." https://t.co/4JU9iBGIQn
@StevePittelli @AllenFrancesMD True. Even studies that have attempted to find genes have failed to do so: https://t.co/kmVYLDnyuv
@CJakedoleschal Mixed bag, but often leans into spurious hypotheses without proper regard for their lack of support. In depression ep, says 5-HTTLPR “greatly shifts susceptibility to depression”. That was discredited in a meta review in 2019. https://t.co/WVoOIQ1gqH Many such cases.
RT @sebkraemer: "The implication of our study is that previous positive main effect or interaction effect findings for these 18 candidate g…
"The implication of our study is that previous positive main effect or interaction effect findings for these 18 candidate genes with respect to depression were false positives" @APAPubJournals https://t.co/JyYa12k6DQ
@NativveResearch https://t.co/nmZb5OkXsA
RT @SashaGusevPosts: In 2019, one would learn that nearly all candidate gene studies of depression in the early 2000's produced false posit…
In 2019, one would learn that nearly all candidate gene studies of depression in the early 2000's produced false positives [https://t.co/DnopM33Fdm] and the 2009 null replication by Risch was correct [https://t.co/lQ6jus4R8p].. https://t.co/8jSt3xgBaR
@Hifzu @DrAnnieHickox @MITUKteam This is your belief only. Where's the evidence? Genetics are also ruled out for depression - see: https://t.co/Pnklb19UCc
@DrAnnieHickox @EdoajoEric This publication is 10 years old and we still haven't found even one gene-based cure for a single so-called "mental disorder." Also, for depression, scientists have found that no genes influence it - see: https://t.co/Pnklb19UCc
RT @altayals: Por fim, vale a pena como complemento, os ep 220 e 221 do @naruhodopodcast sobre depressão! https://t.co/SDQ2Tvrd5V
@Y_Contributor @rexjung I’ve never seen a study that has demonstrated that all high IQ people (e.g. everyone who completes graduate school) carry one common gene. Until then I will be very sceptical of this claim. Even for depression, no genes have been discovered - see: https://t.co/2aeXHdx1EJ
RT @altayals: Por fim, vale a pena como complemento, os ep 220 e 221 do @naruhodopodcast sobre depressão! https://t.co/SDQ2Tvrd5V
Por fim, vale a pena como complemento, os ep 220 e 221 do @naruhodopodcast sobre depressão! https://t.co/SDQ2Tvrd5V
The problem was, years of research failed to turn up much of anything. The findings turned out to be false positives and helped to reveal that the entire premise of a 'gene for X' and low serotonin as the explanation for depression was misleading: 3/n https://t.co/BpSWn7Ha33
@ruth_hook_ This is for depression, but very similar principles in play: https://t.co/fcqhyfsRpW
@SherifMorris As far as I know, yes. Border et al. (2019; https://t.co/fClJpBbwOF) found no evidence for any candidate gene associations and depression or interactions. There's a nice write up on SlateStarCodex: https://t.co/UxfrjZfCjy
@KayMitchADHD @psychgeist52 The accounts in DSM that I am talking about is not based on studies - it simply says that these “disorders” seem to ‘run in families’ suggesting to the reader that they must be genetic. Note that there are no genes involved even for depression - see: https://t.co/Pnklb19UCc
@hsu_steve @jayjoseph22 @branden_mceuen @CathrynTownsend Ioannidis simply asserting something doesn’t make it true. Correlation in even things like heart disease often falls apart. In stuff like psychiatry it is very unlikely to get candidate genes. https://t.co/kkVfsLRAKR
@datepsych @MatthewBJane Most of these candidate gene x environment interaction effects have failed to replicate in more recent, large-scale studies -- e.g here https://t.co/BOQLgNamBi
@mikehobbiss @KMKing_Psych The findings don't replicate :( https://t.co/wEmwfHJGjE
RT @EvoBehGe_papers: No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multi…
@WilboBaggins95 There's not really a genetic basis for depression https://t.co/URtbI5L45q
@Ryan_ETyler @SameiHuda There is no evidence though to what you say. Also see tweets by @jayjoseph22 See also: https://t.co/Pnklb19UCc
@Tangl3dBank @ed_hagen https://t.co/RsFMRm4iLD this one explains the general outlook pretty well, using depression as an example complex phenotype
RT @altayals: Existe causa para depressão - Parte 1 @naruhodopodcast 220 https://t.co/SDQ2Tvrd5V Existe causa para depressão - Parte 2 ht…
Existe causa para depressão - Parte 1 @naruhodopodcast 220 https://t.co/SDQ2Tvrd5V Existe causa para depressão - Parte 2 https://t.co/uaNkWfcOWv
RT @jayjoseph22: Why do these publications keep appearing? Wasn't the 5-HTTLPR promoter polymorphism theory of depression debunked a few ye…
Why do these publications keep appearing? Wasn't the 5-HTTLPR promoter polymorphism theory of depression debunked a few years ago? https://t.co/PYcfKX789D https://t.co/yuUEa7WsAV https://t.co/uqsW8eDeNG https://t.co/Ed9U8Uv6H3
@GregWalshaw @KaanthanJ It is well supported. See the following article that utilized Ns ranging from 62,138 to 443,264 across subsamples: https://t.co/Pnklb1qXEc
RT @altayals: Temos 2 episódios do @naruhodopodcast a respeito (220 e 221) https://t.co/Sy0nBcQ0zp Além do ótimo fio do @lftofoli a respei…
RT @altayals: Temos 2 episódios do @naruhodopodcast a respeito (220 e 221) https://t.co/Sy0nBcQ0zp Além do ótimo fio do @lftofoli a respei…
Temos 2 episódios do @naruhodopodcast a respeito (220 e 221) https://t.co/Sy0nBcQ0zp Além do ótimo fio do @lftofoli a respeito que motivou os episódios do @naruhodopodcast naquela época https://t.co/9QUNW2QWwE
@orawczyk @BlackshepSusan @johannhari101 The claims that 5-HTT plays a role in causing depression didn't hold up, similar to other "genes for behavior" claims. https://t.co/IZUOJqSfQM https://t.co/PYcfKX789D
@HuldtErik Liknande fynd har hittats för depression (https://t.co/0wfI6KVEj6). För antisociala beteenden har man ännu inte kunnat genomföra liknande studier då det saknas tillräckligt stora helgenomstudier. Av förklarliga skäl har det varit vanskligt att genomföra sådana studier.
@rcpsych @lawrie_s Border, et al. (2019). No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples. The American Journal of Psychiatry, 176(5), 376–387. https://t.co/DM41lywfPY https://t.co/D246whYSHB
@margotvdweijer Great thread! Here are new links so that people without access to the vu-nl domain can find the studies: https://t.co/bhpSqfFgdR https://t.co/n9Q32PLFhx
RT @ACPSM_AEN: @psiquicritic @Nature Vale la pena recordar también este artículo del 2019 acerca la hipótesis genética sobre depresión: htt…
RT @ACPSM_AEN: @psiquicritic @Nature Vale la pena recordar también este artículo del 2019 acerca la hipótesis genética sobre depresión: htt…
@jayjoseph22 Thanks! Yes, it makes sense because they all rely on those faulty twin studies! Also, since studies have clearly shown that depression is not genetic (e.g.below), I suppose we can presume that happiness (the opposite of depression) cannot be genetic. https://t.co/Pnklb1qXEc
@LFeldmanBarrett @guardian Would like to see evidence for the sentence “You also have genes that regulate how much the environment affects you” – according to the research literature, there is no evidence for such genes: https://t.co/Pnklb1qXEc
Paper: https://t.co/09Vbl8OuZF Blog post: https://t.co/VModh411dW
@genetic_psych yes, that's what it's about (the paper in the blogpost in the tweet that I QTed ;-) https://t.co/H7ivQz1lkZ https://t.co/jeAsVmNWaf
ICYMI https://t.co/QfTK6M69a6
@PaoloShirasi Effect sizes in GWAS will be very small, so very large N required for even moderate power. See... https://t.co/ERgSKzOx1P https://t.co/Pg1LPwbRER for similar examples. Ip et al. (2021): https://t.co/pfW4nLSGwa
@gtredoux @Biorealism Ah, my memory failed: Border et al. (2019) found no main effect for MAOA on depression diagnosis and no G-by-E interaction effects... ...so not aggression (https://t.co/ERgSKzOx1P). Can you link to the meta-analysis you have in mind?
@GlobalEdmonton The only problem is there is zero evidence for genetic causation of depression (see the article below – I can provide additional references). Depression has psychosocial determinants. https://t.co/Pnklb1qXEc
@seanluomdphd @RealJesseLuke @PeterDKramer @GilmanStephenE That’s your belief – evidence does not support it. Genetics DO NOT play a role – see the following article: https://t.co/Pnklb1qXEc
Interesting... No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples | American Journal of Psychiatry https://t.co/GQ8l7a8v6h
4/7 @margotvdweijer is doing much more than organising journal clubs. She is working on multiple exciting papers. E.g. on the effects of the COVID pandemic on self rated health and one along the lines of this wonderful paper: https://t.co/tLduXLPH8i #thefieldofwellbeingneedsit
RT @MarcusMunafo: @WiringTheBrain @jonroiser @jonathan_flint1 And this is v good and more recent, but focused on a single phenotype (a case…
@WiringTheBrain @jonroiser @jonathan_flint1 And this is v good and more recent, but focused on a single phenotype (a case study, perhaps)... https://t.co/0yCrtkQGpU
RT @Through_Leaves: @awaisaftab Secondly, Pies mentions genetic influences. Recent studies indicate that genetic causation is negligible fo…
@gikkos1 @RyznarMD @dawso007 @claire_hilton6 @DrPPRam @ProfRobHoward @SameiHuda The article wasn’t ill-intentioned or ill-conceived. It just so happens that it was wrong & sent the field on a goose chase. Decisive refutation here, in one my favorite papers from 2019: https://t.co/raD3XB69eL /2
@dranniehickox @AshCurryOcd @psychunseen @Bipolaretaeus78 @CaulfieldTim @AllenFrancesMD @awaisaftab @DebiecJacek @evolutionarypsy @jonathanstea @SciencePharmer @wendyburn @SameiHuda There is no evidence for that. Hope you know this. See for example: https://t.co/Pnklb1qXEc
@suniljoed In short, it’s likely more complicated than how it’s been described the last couple of decades. https://t.co/rtHl7MhNPR
RT @timwand: @_ONEINFIVE_ https://t.co/nmZb5OC0uA
@_ONEINFIVE_ https://t.co/nmZb5OC0uA
@Pablo_MarBar82 @cmordiaz https://t.co/wVW48KBJPa
1. Effect sizes were much smaller than we expected them to be. You could conceive of testing an individual "Candidate gene" in thousands, but why not scale up at the sample? (great study that did that: https://t.co/sHoAZ49OAs).....
RT @AlexanderHatoum: @ndosenbach @GrattonCaterina @smarek0502 GWAS went through the “improve measurement” phase, and it didn’t work. N trum…
@ndosenbach @GrattonCaterina @smarek0502 GWAS went through the “improve measurement” phase, and it didn’t work. N trumps measurement. You can get a large enough sample to detect reliable effects and then expand with measurement. Some great simulations on measurement in the supplement: https://t.co/CvJBjgQlEg
これも結構流行った。サンプルサイズは少なくとも数万の単位必要っていう話。 No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples https://t.co/CtJ9nd49BA
"So far so good", thought the PhD student. And in the very month I first hit submit, this amazing paper annihilated the idea that serotonergic genes are associated with depression: https://t.co/rbV12KGFqN But no problem, because we didn't look at depression...right? (3/n)
@Phil_A_Richmond @alexeyguzey Here is a famous one in my specific field (all snps not replicated) https://t.co/ZujfBObz5A
"Instead, the results suggest that early hypotheses about depression candidate genes were incorrect and that the large number of associations reported in the depression candidate gene literature are likely to be false positives." https://t.co/QSEmRvRjK2
@md_pier @TJOttawa @jill_d35 @annmarcos1 @Martin_Ploederl @Mad_In_America @MITUKteam @CEP_UK @ReadReadj @johndrummond33 Most research findings are probably false: https://t.co/IoEFx35g45 Take for instance depression candidate genes. Hundreds of studies, all most likely false-positive: https://t.co/ky4AHmUuTf
@awaisaftab Regarding 'interactions' – I have come across the following article: https://t.co/Pnklb1qXEc
@SameiHuda @tylerblack32 @awaisaftab Please let me know the reference. The following is a 2019 article: https://t.co/2aeXHdO4GJ
RT @_SeeingThrough_: @awaisaftab Secondly, Pies mentions genetic influences. Recent studies indicate that genetic causation is negligible f…
@s_r_constantin @The_Lagrangian I was reading this only yesterday (ht @Meaningness) https://t.co/ZgZ01cqWew
@awaisaftab Secondly, Pies mentions genetic influences. Recent studies indicate that genetic causation is negligible for all of DSM (e.g. https://t.co/2aeXHdO4GJ and https://t.co/oiZpOgVlFq ). Also love the ‘alternative world’ explanation!
No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples | American Journal of Psychiatry https://t.co/ffd1emrzMA
A large systematic review and meta-analysis of studies involving 443,264 depressed patients revealed that none of the tens of genes implicated was actually associated with clinical depression phenotype! Reference https://t.co/PPksFnKuQI
@AgnesAyton It would be wonderful if there were specific genetic variations with big effects on ordinary depression..that could lead to cures. But depression, like pain, is influenced by thousands of variations with tiny effects. https://t.co/2jSSqpEe6N
@milesobrien Hard to watch that without thinking of the rise and precipitous fall of 5HTT-LPR as a genetic marker... this is where the wheels came off that marker: https://t.co/LidmmCeaLh
RT @EvoBehGe_papers: No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multi…
No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples. https://t.co/dlIEK1YTrb
@NAChristakis No support for historical candidate gene or candidate gene-by-interaction hypotheses for major depression across multiple large samples R Border, EC Johnson, LM Evans, A Smolen, N Berley, PF Sullivan, ... American Journal of Psychiatry 176 (5), 376-387
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@MarcusMunafo @renebekkers And what about the recent 2019 Border et al study? https://t.co/J24Y1RJC9X
@cecilejanssens @WiringTheBrain @jorsmo @AllenFrancesMD Some of the stuff on macular degeneration pretty good but for most complex traits small effect sizes, variants with limited/no bioplausibility, huge effects of environment behavior. Drug pipelines not exactly overflowing- a classic recent example. https://t.co/GYx7tp4xxv
RT @SamWangPhD: An entire field of study is wrong. Genetic variation in the serotonin transporter turns out to have no connection to depres…
RT @SamWangPhD: An entire field of study is wrong. Genetic variation in the serotonin transporter turns out to have no connection to depres…
RT @SamWangPhD: An entire field of study is wrong. Genetic variation in the serotonin transporter turns out to have no connection to depres…
https://sci-hub.tw/10.1176/appi.ajp.2018.18070881
An entire field of study is wrong. Genetic variation in the serotonin transporter turns out to have no connection to depression or other psychiatric issues. This invalidates pharmacogenomic testing, a type of precision medicine, for depression treatment. https://t.co/wZriYNgGDp
@pietrobiroli @NicoleBarbaro Refs for failed (candidate) and fraught (cross nation PRS) approaches are https://t.co/lbegKnKEQf and https://t.co/4YX0H4nnbg
Border, R., Johnson, E., Evans etal(2019). No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples. American Journal Of Psychiatry, 176(5), 376-387. doi: 10.1176/appi.ajp.2018.18070881
@uk_biobank [Paper 4a(!) Border et al, 2019] Similar results have been seen in main-effect analyses - there is no evidence for robust effects of previously described variants from the candidate gene literature in MDD. https://t.co/VoZEGmD1l0
RT @Cem_Atbasoglu: Border R, Johnson EC, Evans LM, et al. No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypothe…
Border R, Johnson EC, Evans LM, et al. No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples. Am J Psychiatry. 2019;176(5):376–387. doi:10.1176/appi.ajp.2018.18070881
No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples. - PubMed - NCBI https://t.co/7yFd19qZNK
@JacobGudiol Bra! Den är död för länge sedan. https://t.co/0wfI6KVEj6
"The depression candidate genes" depressed: "...depression candidate genes were incorrect and that the large number of associations reported in the depression candidate gene literature are likely to be false positives" https://t.co/gLUCwUUZF1
RT @HiromasaFunato: fin/ セロトニントランスポーター以外にも、BDNF, COMT, HTR2A, TPH1, MAOAなど、これまでのうつ病研究でよく取り上げられてきた、１８の遺伝子多型を調べて、見事にひとつも統計学的有意差はなかったという結果。 "…
@drderringer https://t.co/qwovW3gU7W https://t.co/nX7PiblM0y?
RT @RandyNesse: So great to see previous grad student @EikoFried 's lovely summary https://t.co/nyxxJx8tRB of the AJP paper https://t.co/2…
No Support for Historical #CandidateGene or Candidate Gene-by-Interaction Hypotheses for #MajorDepression Across Multiple Large Samples | #AmericanJournalofPsychiatry https://t.co/UzClf0oa64 | via @APA_Publishing by @Noah_Berley
RT @EikoFried: 4/5 The new paper reminds me of a similarly striking biomarker null-finding published a few months back, on candidate genes…
RT @EikoFried: 4/5 The new paper reminds me of a similarly striking biomarker null-finding published a few months back, on candidate genes…
4/5 The new paper reminds me of a similarly striking biomarker null-finding published a few months back, on candidate genes & depression. These studies are hugely important work, & I want to thank all authors & the ENIGMA consortium for working on this. https://t.co/xVBx655cY9 https://t.co/zcUDb3jfYb
Incluso pa fenómenos aparentemente "biológicos" como la depresión https://t.co/uHajDSDae2
An entire line of research built on false positives: Depression candidate genes have been the subject of >1,000 research papers, but turns out they have no significant association with depression phenotypes nor any influence on depression risk. Article: https://t.co/tN7gymi0ly
No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples. - PubMed - NCBI https://t.co/gmyCikVb4f
<<the results suggest that early hypotheses about depression candidate genes were incorrect and that the large number of associations reported in the depression candidate gene literature are likely to be false positives.>> Waiting for more comments! https://t.co/uAmp9t1XpY
@genomind Without sufficiently powered studies every positive result is likely to be false. Thus many of the SNPs you analyse have been proven to not influence depression, even though there were many small positive studies. https://t.co/6iYWxGm2WK
RT @IBG_CUBoulder: IBG graduate student, Richard Border, inteviewed on CBC about his recent paper on the genetics of depression: https://t…
RT @IBG_CUBoulder: IBG graduate student, Richard Border, inteviewed on CBC about his recent paper on the genetics of depression: https://t…
RT @IBG_CUBoulder: IBG graduate student, Richard Border, inteviewed on CBC about his recent paper on the genetics of depression: https://t…
For 25 years, researchers have suggested that susceptibility to depression is determined by a small number of genes, but Border et al. (2019) have blown that theory out of the water. Surprising how quickly a hypothesis can become dogma--then dust! https://t.co/ZRckSegFds
IBG graduate student, Richard Border, inteviewed on CBC about his recent paper on the genetics of depression: https://t.co/Yd0h7umim7. Read the paper at: https://t.co/AesoLO29gS
@Heilig_Lab The study is underpowered unless you assume an unrealistically large effect size. See this recent paper with detailed power analyses in the supplement. https://t.co/NiWsZ7zY41
RT @HiromasaFunato: fin/ セロトニントランスポーター以外にも、BDNF, COMT, HTR2A, TPH1, MAOAなど、これまでのうつ病研究でよく取り上げられてきた、１８の遺伝子多型を調べて、見事にひとつも統計学的有意差はなかったという結果。 "…
RT @HiromasaFunato: fin/ セロトニントランスポーター以外にも、BDNF, COMT, HTR2A, TPH1, MAOAなど、これまでのうつ病研究でよく取り上げられてきた、１８の遺伝子多型を調べて、見事にひとつも統計学的有意差はなかったという結果。 "…
RT @uchida_kawasaki: No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multi…
RT @patgaspar2: Drowning by numbers: all historical candidate genes for depression go down the drain. Including serotonin related genes. Ca…
Drowning by numbers: all historical candidate genes for depression go down the drain. Including serotonin related genes. Candidate gene and gene-by-interaction hypotheses for Major Depression Across Multiple Large Samples- American Journal of Psychiatry https://t.co/ZQaPVYYAdp
No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples | American Journal of Psychiatry https://t.co/52UwGYMebu
Mike @DrMJoyner, have you seen this: No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples | American Journal of Psychiatry https://t.co/X96YgufxFy
RT @uchida_kawasaki: No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multi…
RT @PTK_Hessen: Zusammenhänge zwischen Genen und #Depression? Neue #Studie: Beruhten mehr als 1000 Forschungsarbeiten über vermeintliche "D…
RT @Psycholod: WASTE OF 1000 PAPERS? https://t.co/udX948ZU88 Depressing summary from The Atlantic for - No Support for Gene or Gene-by-In…
RT @npscience: Communicating biomedical science INCLUDING its limits is so important. A recent study indicates there is no evidence to sup…
Communicating biomedical science INCLUDING its limits is so important. A recent study indicates there is no evidence to support a link between depression and several candidate genes that continue to be studied: https://t.co/GpDUHRxcx9 (closed access) (1/2)
No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples. - PubMed - NCBI https://t.co/Q9XdsHvzGt
RT @PTK_Hessen: Zusammenhänge zwischen Genen und #Depression? Neue #Studie: Beruhten mehr als 1000 Forschungsarbeiten über vermeintliche "D…
"we conclude that it is time for depression research to abandon historical candidate gene and candidate gene-by-environment interaction hypotheses.” Sad... https://t.co/NHWz9Oa3iV Paper is here https://t.co/CtSsMHC9zG
No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples https://t.co/hadF0n4jQw
RT @MathiasVSchmidt: As stated by Scott Alexander https://t.co/gQdg95bepg No matter what view you take on the recent study published in AJP…
RT @MathiasVSchmidt: As stated by Scott Alexander https://t.co/gQdg95bepg No matter what view you take on the recent study published in AJP…
RT @MathiasVSchmidt: As stated by Scott Alexander https://t.co/gQdg95bepg No matter what view you take on the recent study published in AJP…
RT @PTK_Hessen: Zusammenhänge zwischen Genen und #Depression? Neue #Studie: Beruhten mehr als 1000 Forschungsarbeiten über vermeintliche "D…
RT @Psycholod: WASTE OF 1000 PAPERS? https://t.co/udX948ZU88 Depressing summary from The Atlantic for - No Support for Gene or Gene-by-In…
RT @mighty_tora: うつ病になる可能性を高めるとされていた18個の遺伝子を再検討したところ、実は全然関係なさそう…という論文。論文は専門外だが、The Atlanticの記事が面白い。誤った発見に基づいて1000報もの論文が出されたプロセスを描写している。 htt…
うつ病になる可能性を高めるとされていた18個の遺伝子を再検討したところ、実は全然関係なさそう…という論文。論文は専門外だが、The Atlanticの記事が面白い。誤った発見に基づいて1000報もの論文が出されたプロセスを描写している。 https://t.co/mpix9aTfXu https://t.co/x6kPRO6rSv
RT @Psycholod: WASTE OF 1000 PAPERS? https://t.co/udX948ZU88 Depressing summary from The Atlantic for - No Support for Gene or Gene-by-In…
No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples | American Journal of Psychiatry https://t.co/Id6UZnNLnk
WASTE OF 1000 PAPERS? https://t.co/udX948ZU88 Depressing summary from The Atlantic for - No Support for Gene or Gene-by-Interaction Hypotheses for Major Depression https://t.co/5q8MbFusax #MentalHealthMonth
No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples | American Journal of Psychiatry https://t.co/7AybJY3isS
Important reading on the genetic basis of depression. Are there any true candidate genes? This paper says no https://t.co/jdZh3EB5NG
Ironie en #science : dégommer le polymorphisme génétique favorable à la #dépression dans des centaines de publications par une ré-analyse complète.
No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples. - PubMed - NCBI Coming back to zero? https://t.co/1e8TW8PCfD
And here is the paper in AJP: No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples | American Journal of Psychiatry https://t.co/2iydZ9F2df
No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for… https://t.co/x3C5wCVehF
#Génétique de la dépression majeure : une vaste étude remet en question l'impact de variants de nombreux gènes candidats https://t.co/szagoeFVUc via @AmJPsychiatry #psychiatrie #génomique https://t.co/qOsjPut5ss
Warning against poorly conducted GWAS studies! No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples https://t.co/uVwfWPVkNB
@gottapatchemall Not really at all what you're asking for, but no paper has made me think more than this recently: https://t.co/Xm3UbY0YL0
No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples. - PubMed - NCBI https://t.co/V1G8t0ZoWE
Best negative robust published results I ever read. What courage to undergo such time consuming study. No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples https://t.co/4YlF1MHJxe
@matthewckeller "There’s only one problem. ALL. OF. THIS. IS. LIES. Or at least this is the conclusion I draw from Border et al’s No Support For Historical Candidate Gene Or Candidate Gene-by-Interaction Hypotheses For Major Depression Across Multiple Large Samples..."
Compelling synopsis! “It’s not a research article. It’s a massacre”. Border et al. 2019, American Journal of Psychiatry: No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples. https://t.co/kqCo6TJKYp
No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples https://t.co/iAWOuvx4ap Wow! see https://t.co/EsNXmEip3X to understand the death of the 5-HTTLPR myth. https://t.co/FCiDcZazkt
Ce genre de papier. Un massacre. #psychiatry #depression https://t.co/YUQMxpQ8XJ
RT @AmJPsychiatry: A large study of major #depression candidate genes and phenotypes finds little evidence to support previous #MDD candida…
A large study of major #depression candidate genes and phenotypes finds little evidence to support previous #MDD candidate gene hypotheses. https://t.co/kFWb2vhQdR https://t.co/A0ivXwx1L7
No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples | American Journal of Psychiatry https://t.co/UxLLe9iWYL
No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples https://t.co/2SJj6hGE68
RT @timwand: Another nail in the coffin for biological psychiatry. No Support for Historical Candidate Gene or Candidate Gene-by-Interactio…
No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples: Early hypotheses about depression candidate genes may be incorrect and previous observed associations for depression… https://t.co/b7fRev6N6O
RT @DrJasonMcIntyre: Largest study on candidate genes for depression finds no effect & no gene X environment interaction. But large main ef…
@Scientific_Bird @GlitterResist In depression? Which variants were consistently replicated across several GWAS? And have you seen this study? https://t.co/11uaX0dnSX
RT @mendel_random: The most highly cited gene-environment interactions in psychiatric epidemiology (and perhaps in the field overall), one…
RT @EikoFried: "Results suggest that early hypotheses about #depression candidate #genes were incorrect & that the large number of associat…
No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples | American Journal of Psychiatry https://t.co/P1LjxIONsz
RT @eparquiodelgado: Los autores encuentran que la llamada "hipótesis del gen candidato" y la "hipótesis del gen por interacción" no se sos…
@L_Dirk Hierzu verweise ich gerne auch folgende aktuelle Arbeit, welche keinerlei Zusammenhang zwischen spezifischen Genvarianten und dem Depressionsrisiko fand: https://t.co/11uaX0dnSX
>Richard Border , M.A. et al.: No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples https://t.co/D1W1KmpgBt<
Interesante estudio sobre genes candidatos a la depresión. https://t.co/9t8VUMavq3 https://t.co/K3aETiZz3c
RT @timwand: Another nail in the coffin for biological psychiatry. No Support for Historical Candidate Gene or Candidate Gene-by-Interactio…
RT @timwand: Another nail in the coffin for biological psychiatry. No Support for Historical Candidate Gene or Candidate Gene-by-Interactio…
RT @timwand: Another nail in the coffin for biological psychiatry. No Support for Historical Candidate Gene or Candidate Gene-by-Interactio…
No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples | American Journal of Psychiatry https://t.co/U0jIZnYgc2
RT @timwand: Another nail in the coffin for biological psychiatry. No Support for Historical Candidate Gene or Candidate Gene-by-Interactio…
RT @timwand: Another nail in the coffin for biological psychiatry. No Support for Historical Candidate Gene or Candidate Gene-by-Interactio…
Another nail in the coffin for biological psychiatry. No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples | American Journal of Psychiatry https://t.co/rbfgKXYPFa
RT @eparquiodelgado: Los autores encuentran que la llamada "hipótesis del gen candidato" y la "hipótesis del gen por interacción" no se sos…
RT @eparquiodelgado: Los autores encuentran que la llamada "hipótesis del gen candidato" y la "hipótesis del gen por interacción" no se sos…
RT @eparquiodelgado: Los autores encuentran que la llamada "hipótesis del gen candidato" y la "hipótesis del gen por interacción" no se sos…
Los autores encuentran que la llamada "hipótesis del gen candidato" y la "hipótesis del gen por interacción" no se sostienen cuando se utilizan métodos de análisis más exigentes que los usados hasta ahora. https://t.co/NQcKhIJS6D
No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples | American Journal of Psychiatry La escasa (o nula) intervención de la genética en la depresión. Por tanto, ¿AMBIENTE? https://t.co/eux88Sqjsd
https://t.co/9upKntGsfu https://t.co/R8zdh5gEXC
RT @DeSantaIrene: La hipótesis genética de la depresión (al igual que la monoaminérgica) no parece ser cierta: No es necesario estar dañado…
La hipótesis genética de la depresión (al igual que la monoaminérgica) no parece ser cierta: No es necesario estar dañado para sufrir un daño. #Depresión #Distimia #Ansiedad #Genes vs #Ambiente https://t.co/WAg3b9T1D7
No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples | American Journal of Psychiatry https://t.co/vGcemaF8Py
There's more to a disease than a genetic variant risk: https://t.co/rJXYWJT29l Read more: https://t.co/1a4BiH6wM8
@PsychToday NO support the historical candidate gene or candidate gene-by-interaction hypothesis for major depression across multiple large samples! https://t.co/8Cy3sxaxpt
No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples | American Journal of Psychiatry https://t.co/43uCco0BJm
RT @RandyNesse: So great to see previous grad student @EikoFried 's lovely summary https://t.co/nyxxJx8tRB of the AJP paper https://t.co/2…
RT @EikoFried: "Results suggest that early hypotheses about #depression candidate #genes were incorrect & that the large number of associat…
So great to see previous grad student @EikoFried 's lovely summary https://t.co/nyxxJx8tRB of the AJP paper https://t.co/2jSSqpVPvn by my first grad student @matthewckeller showing that when the sample is large enough no previous candidate genes for depression hold up.
So great to see previous grad student @EikoFried 's lovely summary https://eiko-fried.com/the-replication-crisis-hits-psychiatry-no-candidate-genes-for-depression/ of the AJP paper https://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2018.18070881 by my first grad student...
How do we explain heritability? "Results suggest that early hypotheses about depression candidate genes were incorrect and the large number of associations reported in the depression candidate gene literature are likely to be false positives." https://t.co/auTFUFihQQ
@zakkohane @harvard_data But without a priori, redigered hypothesis, #DataScience allows for far too much statistical fishing (often by unaware researchers) and then we end up with studies like this: https://t.co/wCYPCnFklv or https://t.co/8c3eJ3Aqyu or https://t.co/BiaXQk2cuE or many more.
https://t.co/Hn0zscfyF8 No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples: Early hypotheses about depression candidate genes may be incorrect and previous observed associations for depression … https://t.co/qMP84uhhsQ
#Science No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples: Early hypotheses about depression candidate genes may be incorrect and previous observed associations for de… https://t.co/avI3vDqxuu
No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples: Early hypotheses about depression candidate genes may be incorrect and previous observed associations for depression candidate genes are l…
No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples | American Journal of Psychiatry https://t.co/zAc4AiNALM
RT @EikoFried: "Results suggest that early hypotheses about #depression candidate #genes were incorrect & that the large number of associat…
RT @EvoBehGe_papers: No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multi…
No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples | American Journal of Psychiatry https://t.co/CNYeMBw9FZ
No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples | American Journal of Psychiatry https://t.co/jI00n8GEsw
RT @_psyguy: "No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Lar…
RT @Ygoes2B_more: No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple…
Interesting! No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples | American Journal of Psychiatry https://t.co/DyE5tknqhK
Interesting! No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples | American Journal of Psychiatry https://t.co/DyE5tkF1Gk
RT @Ygoes2B_more: No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple…
"No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples." Border et al., 2019, in the American Journal of Psychiatry. doi: 10.1176/appi.ajp.2018.18070881 https://t.co/FpZz094Ojq https://t.co/NO7QJwwZqg
RT @Ygoes2B_more: No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple…
No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multiple Large Samples. - PubMed - NCBI https://t.co/bWkhbmhnrt
RT @EvoBehGe_papers: No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multi…
RT @EvoBehGe_papers: No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multi…
RT @EvoBehGe_papers: No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multi…
RT @EvoBehGe_papers: No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multi…
RT @EvoBehGe_papers: No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multi…
RT @EvoBehGe_papers: No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multi…
RT @EvoBehGe_papers: No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multi…
RT @EvoBehGe_papers: No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multi…
RT @EvoBehGe_papers: No Support for Historical Candidate Gene or Candidate Gene-by-Interaction Hypotheses for Major Depression Across Multi…