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Mol Cell April 2019 PMID 30878284

Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3.

Xiaohan Ning, Yutao Wang, Miao Jing, Mengyin Sha, Mengze Lv, Pengfei Gao, Rui Zhang, Xiaojun Huang, Ji-Ming Feng, Zhengfan Jiang

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Mentions

28
Peak: 20 in Mar 2019
across 3 sources since Mar 2019

Extended reach

178,530
potential audience

Total likes

40

Video views

159

Mentions per month

Mar 2019 – Sep 2021

Where it's discussed

  • X / Twitter24 posts
  • YouTube2 videos
  • News2 articles

AI synopsis

What people are saying

Several posts praise the research for its significance, citing the molecular mechanisms like caspase3 cleaving cGAS, MAVS, and IRF3, and how these insights can influence immune regulation. The tone varies from enthusiastic support to technical appreciation, indicating a high level of interest and engagement in the subject matter's potential impact on immunology and disease treatment.

AgreementModerate agreement

Most discussions highlight the importance of the findings, with some explicitly noting how the suppression of interferon production is significant for immune regulation.

InterestHigh interest

The interest is high, as many posts express curiosity about the mechanisms involved and the potential implications for viral resistance and autoimmune diseases.

EngagementModerate engagement

People show moderate engagement, with some posts emphasizing the scientific novelty, such as the inclusion of RRIDs for reproducibility, and others discussing the broader impact of the research.

ImpactHigh impact

The overall tone suggests that the publication is viewed as having substantial scientific and medical relevance, capable of influencing future research and understanding of immune responses.

Abstract in brief

  • Apoptotic caspases, specifically caspase3 in humans and caspase7 in mice, play a key role in suppressing excessive type I interferon production during viral infections by cleaving critical signaling proteins like cGAS, MAVS, and IRF3.
  • Caspase3 activation prevents cytokine overproduction and enhances host resistance to viruses, as observed in caspase3-deficient human cells and mice, which show increased interferon responses and improved viral clearance.
  • The study highlights the importance of apoptotic caspases in regulating innate immunity and maintaining immune balance, thereby protecting against viral spread and autoimmune conditions like encephalomyelitis.]
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Top posts

Most liked on X and Bluesky
Molecular Cell
@MolecularCell · X

Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3 https://t.co/x5kOg6tE0p https://t.co/OoXlIm8bk5

Mar 13, 2019 · 40 likes · 18 shares · 142,698 followers View post →
Trends Cell Biology
@TrendsCellBio · X

RT @MolecularCell: Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3 https://t.co/x5kOg6tE0…

Mar 13, 2019 · 18 shares · 24,474 followers View post →
ミャンマーひじ
@plovskr · X

RT @MolecularCell: Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3 https://t.co/x5kOg6tE0…

Mar 13, 2019 · 18 shares · 1,574 followers View post →
Damien Ferhadian
@dferhadian · X

RT @MolecularCell: Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3 https://t.co/x5kOg6tE0…

Mar 13, 2019 · 18 shares · 1,437 followers View post →
Kaiwen Chen
@_kaiwenchen · X

RT @MolecularCell: Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3 https://t.co/x5kOg6tE0…

Mar 13, 2019 · 18 shares · 1,408 followers View post →
Maziar Divangahi
@MazDivangahi · X

Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3: Molecular Cell https://t.co/5gYbk2ruED

Apr 15, 2019 · 1,295 followers View post →

All mentions

RRID Robot
@RobotRrid · X

The authors of "Apoptotic Caspases Suppress Type I Interferon Prod…" (https://t.co/7nGzmeh6ip) included RRIDs in their paper! RRIDs like this improve reproducibility in scientific research. #accelerateopenscience #RRID

Sep 3, 2021 · 161 followers View post →
Maziar Divangahi
@MazDivangahi · X

Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3: Molecular Cell https://t.co/5gYbk2ruED

Apr 15, 2019 · 1,295 followers View post →
VirologyBlues
@SurayZep · X

Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3: Molecular Cell https://t.co/HkvqTojtmZ

Apr 14, 2019 · 131 followers View post →
Bhargavi Duvvuri PhD
@BhargaviDuvvuri · X

RT @MolecularCell: Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3 https://t.co/x5kOg6tE0…

Apr 5, 2019 · 18 shares · 130 followers View post →
the paper link
@the_paper_link · X

[trend] up+2: *Ning X* et al (Mol Cell) **Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3.** https://t.co/kMvspvHxlN

Mar 22, 2019 · 136 followers View post →
Reinaldo dos Santos
@rsdossantos13 · X

"Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3" https://t.co/WJYmDdRSfJ

Mar 19, 2019 · 383 followers View post →
Inflammasome
@Inflamma_some · X

Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3. https://t.co/50tigo4oft

Mar 18, 2019 · 303 followers View post →
Ronny Schmidt
@RonnySchmidt84 · X

RT @MolecularCell: Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3 https://t.co/x5kOg6tE0…

Mar 15, 2019 · 18 shares · 124 followers View post →
Mimi_ Cardio
@mimi_cardio · X

RT @MolecularCell: Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3 https://t.co/x5kOg6tE0…

Mar 15, 2019 · 18 shares · 188 followers View post →
Garcia Saez Lab
@GarciaSaez_Lab · X

RT @MolecularCell: Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3 https://t.co/x5kOg6tE0…

Mar 14, 2019 · 18 shares · 1,253 followers View post →
Ryan Richards
@ryan_richards33 · X

RT @MolecularCell: Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3 https://t.co/x5kOg6tE0…

Mar 14, 2019 · 18 shares · 49 followers View post →
Peter Truong, PhD
@iampetertruong · X

RT @MolecularCell: Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3 https://t.co/x5kOg6tE0…

Mar 14, 2019 · 18 shares · 123 followers View post →
Maluquer Lab
@maluquerlab · X

RT @MolecularCell: Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3 https://t.co/x5kOg6tE0…

Mar 14, 2019 · 18 shares · 539 followers View post →
Ady
@adychuela · X

RT @MolecularCell: Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3 https://t.co/x5kOg6tE0…

Mar 14, 2019 · 18 shares · 24 followers View post →
ミャンマーひじ
@plovskr · X

RT @MolecularCell: Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3 https://t.co/x5kOg6tE0…

Mar 13, 2019 · 18 shares · 1,574 followers View post →
Subhash Khatri
@SubhashKhatri17 · X

RT @MolecularCell: Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3 https://t.co/x5kOg6tE0…

Mar 13, 2019 · 18 shares · 134 followers View post →
Trends Cell Biology
@TrendsCellBio · X

RT @MolecularCell: Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3 https://t.co/x5kOg6tE0…

Mar 13, 2019 · 18 shares · 24,474 followers View post →
feverfew
@feifeverfew · X

RT @MolecularCell: Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3 https://t.co/x5kOg6tE0…

Mar 13, 2019 · 18 shares · 58 followers View post →
Kaiwen Chen
@_kaiwenchen · X

RT @MolecularCell: Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3 https://t.co/x5kOg6tE0…

Mar 13, 2019 · 18 shares · 1,408 followers View post →
Arlou Angeles
@arlouangeles · X

RT @MolecularCell: Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3 https://t.co/x5kOg6tE0…

Mar 13, 2019 · 18 shares · 9 followers View post →
Graham Williams, PhD
@g_d_williams · X

RT @MolecularCell: Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3 https://t.co/x5kOg6tE0…

Mar 13, 2019 · 18 shares · 373 followers View post →
Damien Ferhadian
@dferhadian · X

RT @MolecularCell: Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3 https://t.co/x5kOg6tE0…

Mar 13, 2019 · 18 shares · 1,437 followers View post →
SNZK
@shinopp · X

RT @MolecularCell: Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3 https://t.co/x5kOg6tE0…

Mar 13, 2019 · 18 shares · 720 followers View post →
Molecular Cell
@MolecularCell · X

Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3 https://t.co/x5kOg6tE0p https://t.co/OoXlIm8bk5

Mar 13, 2019 · 40 likes · 18 shares · 142,698 followers View post →