Expert Rev Clin Immunol June 2019 PMID 30884251

Recent advances in our understanding of mast cell activation - or should it be mast cell mediator disorders?

Theoharis C Theoharides, Irene Tsilioni, Huali Ren

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Mentions

22
Peak: 4 in Mar 2019
across 5 sources since Mar 2019

Extended reach

32,096
potential audience

Total likes

181

Video views

3,327

Mentions per month

Mar 2019 – Dec 2025

Where it's discussed

  • X / Twitter11 posts
  • News5 articles
  • Reddit3 posts
  • YouTube2 videos
  • Instagram1 posts

AI synopsis

What people are saying

Overall, the discussions demonstrate high interest, with participants referencing specific triggers such as Borrelia toxin and neuropsychiatric symptoms, and some engage deeply by connecting the research to broader clinical challenges. The tone is analytical and somewhat optimistic about the potential implications for diagnosis and treatment.

AgreementModerate agreement

Most discussions acknowledge the importance of recent research, with some referencing the role of Borrelia toxin as a trigger, indicating at least moderate agreement with the article's significance.

InterestHigh interest

The prominence of the topic across multiple posts, including mentions of triggers like Borrelia and discussions on mediators, reflects high interest among participants.

EngagementModerate engagement

Some posts engage deeply by referencing specific elements of the research, such as triggers, neuropsychiatric symptoms, and diagnostic challenges, though not all contribute detailed analysis.

ImpactModerate impact

The discussions suggest that the research is viewed as potentially impactful, especially in understanding complex disorders like MCAS and their triggers, but without expressing outright revolutionary changes yet.

Abstract in brief

  • Recent research highlights that mast cell activation, or mast cell mediator disorders (MCMD), can cause symptoms across multiple organs, including the brain, due to the release of various mediators.
  • These disorders are complex, often involving non-histamine and non-tryptase mediators, making diagnosis and management challenging, particularly as neuropsychiatric symptoms are frequently overlooked.
  • Expert opinion suggests focusing on identifying specific mast cell mediators and developing targeted treatments to better diagnose and manage MCMD, especially when elevated levels are present without other explanations.

Top posts

Most liked on X and Bluesky
David Curtiss
@WhatsLeftOfTheD · X

@LonnieRhea Donta hypothesized there was a Bb toxin, and looked w/no luck- albeit with older tools. I was surprised to see “Borrelia toxin” listed as one of the “Unappreciated triggers” of MCAS in this recent paper by Theoharides et al. at Tufts. https://t.co/Tk1VcW4wTR

Jan 27, 2020 · 3 likes · 1 share · 561 followers View post →
David Curtiss
@WhatsLeftOfTheD · X

Recent advances in our understanding of mast cell activation – or should it be mast cell mediator disorders? (Comorbidity w/PTLDS; also Bb as a trigger) https://t.co/InmK9faSBS

Jul 31, 2019 · 2 likes · 2 shares · 561 followers View post →
LymeDisease.org
@Lymenews · X

Theoharides | Recent advances in our understanding of mast cell activation – or should it be mast cell mediator disorders? #ILADSboston2019 https://t.co/M3c7K6CyYC

Nov 1, 2019 · 1 like · 1 share · 17,224 followers View post →
Sharon
@SharonV777 · X

@ChronicWholenes you can get full paper on sci hub https://t.co/INdoQOE75w

Mar 25, 2019 · 1 like · 352 followers View post →
Bayard T. Horton
@bayard_horton · X

Recent advances in our understanding of #mastcell activation – or should it be mast cell mediator disorders?. https://t.co/u4hwcem680 #Histamine #VitaminC #Inflammation #OxidativeStress #Treg #Immunotherapy #MCAS #MECFS https://t.co/QtiyLhPtZ5

Mar 21, 2019 · 1 like · 219 followers View post →
Lonnie R Marcum, PT, BSHCA
@LonnieRhea · X

RT @WhatsLeftOfTheD: Recent advances in our understanding of mast cell activation – or should it be mast cell mediator disorders? (Comorb…

Jul 31, 2019 · 2 shares · 3,828 followers View post →

All mentions

David Curtiss
@WhatsLeftOfTheD · X

RT @WhatsLeftOfTheD: @LonnieRhea Donta hypothesized there was a Bb toxin, and looked w/no luck- albeit with older tools. I was surprised to…

May 24, 2024 · 1 share · 561 followers View post →
Ramin Nayersina
@biotechinvent · X

Recent advances in our understanding of mast cell activation – or should it be mast cell mediator disorders? By Theoharis C. Theoharides, Irene Tsilioni, and Huali Rene https://t.co/u9Pzpod8zO Expert Rev Clin Immunol. 2019 Jun; 15(6): 639–656.

Mar 6, 2024 · 4 followers View post →
David Curtiss
@WhatsLeftOfTheD · X

@LonnieRhea Donta hypothesized there was a Bb toxin, and looked w/no luck- albeit with older tools. I was surprised to see “Borrelia toxin” listed as one of the “Unappreciated triggers” of MCAS in this recent paper by Theoharides et al. at Tufts. https://t.co/Tk1VcW4wTR

Jan 27, 2020 · 3 likes · 1 share · 561 followers View post →
LymeDisease.org
@Lymenews · X

Theoharides | Recent advances in our understanding of mast cell activation – or should it be mast cell mediator disorders? #ILADSboston2019 https://t.co/M3c7K6CyYC

Nov 1, 2019 · 1 like · 1 share · 17,224 followers View post →
Lonnie R Marcum, PT, BSHCA
@LonnieRhea · X

RT @WhatsLeftOfTheD: Recent advances in our understanding of mast cell activation – or should it be mast cell mediator disorders? (Comorb…

Jul 31, 2019 · 2 shares · 3,828 followers View post →
gale hane
@galehane · X

RT @WhatsLeftOfTheD: Recent advances in our understanding of mast cell activation – or should it be mast cell mediator disorders? (Comorb…

Jul 31, 2019 · 2 shares · 127 followers View post →
David Curtiss
@WhatsLeftOfTheD · X

Recent advances in our understanding of mast cell activation – or should it be mast cell mediator disorders? (Comorbidity w/PTLDS; also Bb as a trigger) https://t.co/InmK9faSBS

Jul 31, 2019 · 2 likes · 2 shares · 561 followers View post →
Sharon
@SharonV777 · X

@ChronicWholenes you can get full paper on sci hub https://t.co/INdoQOE75w

Mar 25, 2019 · 1 like · 352 followers View post →
Bayard T. Horton
@bayard_horton · X

Recent advances in our understanding of #mastcell activation – or should it be mast cell mediator disorders?. https://t.co/u4hwcem680 #Histamine #VitaminC #Inflammation #OxidativeStress #Treg #Immunotherapy #MCAS #MECFS https://t.co/QtiyLhPtZ5

Mar 21, 2019 · 1 like · 219 followers View post →
Alisontomyradioooo
@arisonsned · X

Recent advances in our understanding of mast cell activation – or should it be mast cell mediator disorders? Theoharis C. Theoharides,Irene Tsilioni & Huali Ren https://t.co/cPk3ynm8tI

Mar 21, 2019 · 2,984 followers View post →
supportinginvestinme
@arisonned · X

Recent advances in our understanding of mast cell activation – or should it be mast cell mediator disorders?: Expert Review of Clinical Immunology: https://t.co/VqCdZMMg39

Mar 21, 2019 · 2,241 followers View post →
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