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Mol Psychiatry July 2020 PMID 30886334

Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort.

Golam M Khandaker, Verena Zuber, Jessica M B Rees, Livia Carvalho, Amy M Mason, Christopher N Foley, Apostolos Gkatzionis, Peter B Jones, Stephen Burgess

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Mentions

39
Peak: 7 in Jan 2019
across 4 sources since Jan 2019

Extended reach

858,722
potential audience

Total likes

15,734

Video views

669,873

Mentions per month

Jan 2019 – Sep 2025

Where it's discussed

  • News21 articles
  • X / Twitter14 posts
  • YouTube2 videos
  • Blogs2 articles

AI synopsis

What people are saying

The discussions exhibit enthusiasm for the study's findings, such as mentions of triglycerides, IL-6, and CRP as causal factors, which indicates active interest in the biological mechanisms. The tone is generally analytical and optimistic about the potential for these discoveries to influence treatment approaches, but the engagement remains fairly moderate, focusing on sharing key findings rather than deep technical analysis.

AgreementModerate agreement

Most discussions recognize the significance of the research, especially highlighting the causal role of factors like triglycerides, IL-6, and CRP, indicating general agreement with the findings.

InterestHigh interest

The discussions demonstrate high interest, with many references to the biological mechanisms and potential implications for health, signaling strong engagement with the topic.

EngagementModerate engagement

Posts often mention the biological factors discussed in the study and speculate on the clinical implications, reflecting moderate but not deep engagement.

ImpactModerate impact

While the posts acknowledge the importance of identifying shared mechanisms between heart disease and depression, they mostly focus on potential implications rather than direct practical impact, resulting in a modest impact score.

Abstract in brief

  • The study found that having a family history of heart disease increases the risk of depression, but genetic susceptibility to coronary heart disease (CHD) itself does not seem to directly cause depression.
  • Shared environmental factors, rather than genetic ones, are likely responsible for the comorbidity between depression and CHD, with factors like IL6, CRP, and triglycerides possibly playing causal roles in depression.
  • The research suggests that targeting these biological factors (IL6, CRP, triglycerides) could be beneficial for preventing or treating depression associated with cardiovascular issues.
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Top posts

Most liked on X and Bluesky
bioRxiv
@biorxivpreprint · X

Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort https://t.co/jbplQs02dg #bioRxiv

Jan 29, 2019 · 4 likes · 2 shares · 137,005 followers View post →
Paul Whiteley
@PaulWhiteleyPhD · X

Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort https://t.co/9wLcXhkbsm "triglycerides, interleukin-6 (IL-6), and C-reactive protein (CRP) are likely causal risk factors for depression."

Mar 19, 2019 · 2 likes · 4,934 followers View post →
Selina Rajan
@Selinarajan · X

Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort | Molecular Psychiatry https://t.co/2puhq1O3XH

Mar 28, 2019 · 1 like · 989 followers View post →
Adam Kaplin
@akaplin · X

Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort | Molecular Psychiatry https://t.co/736r9c6wYu

Mar 27, 2019 · 1 like · 308 followers View post →
Zhaowen Liu
@zhaowenliu_kaka · X

Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort https://t.co/WvBPooVT1k

Mar 19, 2019 · 1 like · 1 share · 149 followers View post →
CLaE
@leafs_s · X

Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort https://t.co/plpBWl7nyP

Mar 19, 2019 · 28,116 followers View post →

All mentions

Selina Rajan
@Selinarajan · X

Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort | Molecular Psychiatry https://t.co/2puhq1O3XH

Mar 28, 2019 · 1 like · 989 followers View post →
Adam Kaplin
@akaplin · X

Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort | Molecular Psychiatry https://t.co/736r9c6wYu

Mar 27, 2019 · 1 like · 308 followers View post →
Stefano Berto, PhD
@StefanoBerto83 · X

Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort. https://t.co/48HEgAnd5o

Mar 20, 2019 · 7,767 followers View post →
Paul Whiteley
@PaulWhiteleyPhD · X

Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort https://t.co/9wLcXhkbsm "triglycerides, interleukin-6 (IL-6), and C-reactive protein (CRP) are likely causal risk factors for depression."

Mar 19, 2019 · 2 likes · 4,934 followers View post →
CLaE
@leafs_s · X

Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort https://t.co/plpBWl7nyP

Mar 19, 2019 · 28,116 followers View post →
Wei Cheng
@WeiFDU · X

RT @zhaowenliu_kaka: Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based coh…

Mar 19, 2019 · 1 share · 433 followers View post →
Zhaowen Liu
@zhaowenliu_kaka · X

Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort https://t.co/WvBPooVT1k

Mar 19, 2019 · 1 like · 1 share · 149 followers View post →
Dan Dalton
@drdandalton · X

RT @biorxivpreprint: Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based coh…

Jan 30, 2019 · 2 shares · 543 followers View post →
Lanzule, Inc.
@lanzule · X

RT @biorxivpreprint: Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based coh…

Jan 29, 2019 · 2 shares · 1,052 followers View post →
bxv_genetics
@bxv_genetics · X

Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort https://t.co/4c3hQ9JXfb

Jan 29, 2019 · 415 followers View post →
Renato Polimanti
@RenatoPolimanti · X

RT @biorxiv_genetic: Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based coh…

Jan 29, 2019 · 1 share · 714 followers View post →
aDNA_papers
@aDNA_papers · X

Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort https://t.co/I9JR4scSds

Jan 29, 2019 · 1,713 followers View post →
bioRxiv
@biorxivpreprint · X

Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort https://t.co/jbplQs02dg #bioRxiv

Jan 29, 2019 · 4 likes · 2 shares · 137,005 followers View post →
bioRxiv Genetics
@biorxiv_genetic · X

Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort https://t.co/alwZykefX9 #biorxiv_genetic

Jan 29, 2019 · 1 share · 4,691 followers View post →