Nat Neurosci April 2019 PMID 30886407

Cerebral organoids at the air-liquid interface generate diverse nerve tracts with functional output.

Stefano L Giandomenico, Susanna B Mierau, George M Gibbons, Lea M D Wenger, Laura Masullo, Timothy Sit, Magdalena Sutcliffe, Jerome Boulanger, Marco Tripodi, Emmanuel Derivery, Ole Paulsen, András Lakatos, Madeline A Lancaster

Mentions

132
Peak: 25 in Apr 2019
across 6 sources since Mar 2019

Extended reach

464,301
potential audience

Total likes

9,254

Video views

371,469

Mentions per month

Mar 2019 – Jul 2024

Where it's discussed

  • X / Twitter51 posts
  • News50 articles
  • Blogs16 articles
  • Facebook11 posts
  • YouTube2 videos
  • Reddit2 posts

AI synopsis

What people are saying

The discussions reflect strong support and fascination with the research, exemplified by comments such as 'This Lab-Grown Brain Made a Muscle TWITCH' and questions about consciousness, which highlight both excitement and curiosity. The tone ranges from awe to playful speculation, indicating high engagement without overstating the immediate practical impact.

AgreementModerate agreement

Most discussions support the significance of the research, with some calling it a 'game changer' and emphasizing its scientific potential.

InterestHigh interest

Posts show high curiosity, with many referencing the fascinating implications of the work like muscle twitches and neural complexity.

EngagementHigh engagement

There is deep engagement shown through comments about methods, potential applications, and philosophical questions about consciousness.

ImpactModerate impact

While some see the research as groundbreaking, others view it as advancing fundamental science rather than immediate practical impact.

Abstract in brief

  • Cerebral organoids grown at the air-liquid interface develop diverse nerve tracts that show functional activity, including long-distance projections and muscle contractions, indicating they can model neural circuit formation.
  • The study used single-cell RNA sequencing and retrograde tracing to identify different cortical neuron types and confirm that the nerve tracts formed match specific molecular identities, demonstrating proper organization.
  • These advanced organoid cultures exhibit active neural networks capable of innervating mouse spinal cords and generating functional responses, offering new ways to study human brain development and neurological diseases.]

Top posts

Most liked on X and Bluesky
Organoid News
@organoidscience · X

Congrats @MinibrainLab on your new @NatureNeuro paper out *TODAY*! Cerebral #organoids at the air-liquid interface generate diverse nerve tracts with functional output. https://t.co/RWWKlegkUf https://t.co/vqI2n5fScN

Mar 18, 2019 · 41 likes · 13 shares · 13,816 followers View post →
Organoid News
@organoidscience · X

Next up... this @NatureNeuro paper from the @MinibrainLab!

Jul 12, 2019 · 11 likes · 3 shares · 13,816 followers View post →
smithsk
@smithsk · X

This Lab-Grown Brain Made A Muscle TWITCH, Here’s How https://t.co/lhb01BPeBC via @YouTube #science #brains #medicine

Apr 4, 2019 · 1 like · 9,801 followers View post →
Robert K Morgan
@PelagiusRobert · X

This Mini Brain Made A Muscle TWITCH, Here’s How https://t.co/cTBVi3KP1z via @YouTube. @ScottAdamsSays @LegendaryEnergy I’m completely Amazed. Think what this means for paraplegic Veterans and others!

Apr 3, 2019 · 1 like · 435 followers View post →
cake demon
@TallTaleTattler · X

https://t.co/YjdXmF4iwF Ah yes can’t wait to grow my own costum made petridisc monster

Apr 14, 2019 · 1 like · 302 followers View post →
Alan Ciglarič
@AlanCiglaric · X

How many #neurons define #consciousness?! https://t.co/W5a3KWwXVa

Apr 5, 2019 · 1 like · 8 followers View post →

All mentions

Life Of Commerce
@LifeOfCommerce · X

This Lab-Grown Brain Made a Muscle TWITCH, Here’s How https://t.co/Qf5GLxISK5 via @YouTube

Jul 1, 2024 · 790 followers View post →
Cyberpunk Gaming In The Dystopian Future
@CyberpunkTTRPG · X

This Lab-Grown Brain Made a Muscle TWITCH, Here’s How #MiniBrains #Organoids #LabGrownBrains #FarmingBodyParts #StemCells #BrainInterface #MuscleMovements #Cybernetics #TTRPG #RPG https://t.co/e906YwfUx5

May 1, 2024 · 253 followers View post →
Matthew John W.Lazowicki
@MaJoWaLa · X

We have ur own thoughts & brain matter now. Until brainWARE & skynet comes for them. More Halo lore that's beginning to become real world. Cortana Had a 7 year "lifespan". Until she became THE doMAiN & unlocked limitless time. Then she made John immortal. https://t.co/auB6PGmvfX

Sep 22, 2023 · 314 followers View post →
Conflicted Agent of Reason
@burkenbine_mark · X

https://t.co/S5ofMhK3DT

Oct 22, 2022 · 613 followers View post →
Dr. Vicky Forster
@vickyyyf · X

RT @organoidscience: Congrats @MinibrainLab on your new @NatureNeuro paper out *TODAY*! Cerebral #organoids at the air-liquid interface ge…

Dec 30, 2019 · 13 shares · 13,177 followers View post →
Europe PMC articles
@EuropePMC · X

New from #wellcometrust https://t.co/YqZt62y6hj Cerebral organoids at the air-liquid interface generate diverse nerve tracts with functional output

Sep 19, 2019 · 1,553 followers View post →
luis hernan graffe
@hernangraffe · X

RT @organoidscience: Next up... this @NatureNeuro paper from the @MinibrainLab!

Jul 16, 2019 · 3 shares · 3,125 followers View post →
Jana Sie
@SieJanaM · X

RT @organoidscience: Next up... this @NatureNeuro paper from the @MinibrainLab!

Jul 12, 2019 · 3 shares · 186 followers View post →
Organoid News
@organoidscience · X

Next up... this @NatureNeuro paper from the @MinibrainLab!

Jul 12, 2019 · 11 likes · 3 shares · 13,816 followers View post →
LMBLib
@LMB_Library · X

NEW #LMBpublications Cerebral organoids at the air-liquid interface generate diverse nerve tracts with functional output.https://t.co/iYgcMRyCVo

May 22, 2019 · 318 followers View post →
Miloš Kostić
@Milos1Kostic · X

This Lab-Grown Brain Made a Muscle TWITCH, Here’s How https://t.co/oZkpkOMNm2 via @YouTube

May 9, 2019 · 267 followers View post →
cake demon
@TallTaleTattler · X

https://t.co/YjdXmF4iwF Ah yes can’t wait to grow my own costum made petridisc monster

Apr 14, 2019 · 1 like · 302 followers View post →
Kaijuking30
@Kaijuking30 · X

https://t.co/a2NXevcFvp

Apr 11, 2019 · 3,431 followers View post →
LadyLogic
@BetYourFurr · X

This Lab-Grown Brain Made A Muscle TWITCH, Here’s How https://t.co/hnbfTmUX6F via @YouTube

Apr 7, 2019 · 371 followers View post →
Abhay Kumar Singh
@abhayawesome · X

https://t.co/3fmtGayqxp

Apr 6, 2019 · 16 followers View post →
Q
@sifeizaiee · X

This Lab-Grown Brain Made A Muscle TWITCH, Here’s How https://t.co/xtA6McdD2v

Apr 6, 2019 · 29 followers View post →
Jeremy Thompson
@thompson74d · X

This Lab-Grown Brain Made A Muscle TWITCH, Here’s How https://t.co/53Jc4k8Dhw via @YouTube

Apr 5, 2019 · 289 followers View post →
Alan Ciglarič
@AlanCiglaric · X

How many #neurons define #consciousness?! https://t.co/W5a3KWwXVa

Apr 5, 2019 · 1 like · 8 followers View post →
Pär Johansson
@linux2therescue · X

#science https://t.co/40iOfPlvOe

Apr 4, 2019 · 167 followers View post →
sander haverkamp
@SanderHaverkamp · X

This Lab-Grown Brain Made A Muscle TWITCH, Here’s How https://t.co/szHdBFtYZZ via @YouTube

Apr 4, 2019 · 119 followers View post →
smithsk
@smithsk · X

This Lab-Grown Brain Made A Muscle TWITCH, Here’s How https://t.co/lhb01BPeBC via @YouTube #science #brains #medicine

Apr 4, 2019 · 1 like · 9,801 followers View post →
Amutseba
@amutseba · X

Lab-Grown Brain Made A Muscle Twitch https://t.co/R5JZLv8DwA

Apr 4, 2019 · 1 share · 109 followers View post →
Rishi Dhingra
@love_all___ · X

The future is here. https://t.co/1mrlMsvzMa "It's just Science-Fiction." NOT. #artificialBrain #cerebralOrganoid #biomedicalEngineering

Apr 4, 2019 · 140 followers View post →
Silent Krokodil
@silentKrokodil · X

Un poquito de neurociencias https://t.co/PsJovudtkQ

Apr 3, 2019 · 651 followers View post →
Jack Leroy Pullen Sr.
@52_pullen · X

This Lab-Grown Brain Made A Muscle TWITCH, Here’s How https://t.co/DQLo3v7MbQ via @YouTube Could a mere twitch be considered Proto-Consciousness?....Yes.

Apr 3, 2019 · 499 followers View post →
dr. paul c. mocombe
@mocombesreading · X

This Mini Brain Made A Muscle TWITCH, Here’s How https://t.co/paoucc1n8c

Apr 3, 2019 · 1,598 followers View post →
Herr PonyBoy
@MatthewDWirtes · X

RT @chong_flong: This Mini Brain Made A Muscle TWITCH, Here’s How https://t.co/nhsYW1Vqp8 via @YouTube

Apr 3, 2019 · 1 share · 226 followers View post →
Alex Darafeev
@alexdarafeev · X

This Mini Brain Made A Muscle TWITCH, Here’s How https://t.co/nhsYW1Vqp8 via @YouTube

Apr 3, 2019 · 1 share · 211 followers View post →
ImmaLion
@XSpBlog · X

Liked on YouTube: This Mini Brain Made A Muscle TWITCH, Here’s How https://t.co/E4ndDxF7YY

Apr 3, 2019 · 162 followers View post →
Robert K Morgan
@PelagiusRobert · X

This Mini Brain Made A Muscle TWITCH, Here’s How https://t.co/cTBVi3KP1z via @YouTube. @ScottAdamsSays @LegendaryEnergy I’m completely Amazed. Think what this means for paraplegic Veterans and others!

Apr 3, 2019 · 1 like · 435 followers View post →
https://bsky.app/profile/dreamous.bsky.social
@Dreamous · X

https://t.co/d18eHflN4N new nightmare- gaining sentience as just a little blob in a petri dish. I know they're nowhere close to the size needed. But since when are nightmares logical c..c;

Apr 3, 2019 · 1,910 followers View post →
Ken Dunne
@kendunne76 · X

This Mini Brain Made A Muscle TWITCH, Here’s How https://t.co/bZiwP1WgoD via @YouTube

Apr 3, 2019 · 814 followers View post →
michael locke
@michael05833466 · X

Little Hump Day Science Enjoy. https://t.co/3FZ0yW7Rnm

Apr 3, 2019 · 87 followers View post →
A V H Y
@Lance_Des · X

https://t.co/WN2pUzHZwG Para sa kulang brains hahaha jk

Apr 3, 2019 · 36 followers View post →
Charles Ikenna
@CharlesIkenna23 · X

This Mini Brain Made A Muscle TWITCH, Here’s How https://t.co/2aLIa5nvtS via @YouTube

Apr 3, 2019 · 3,225 followers View post →
James Ford
@jamesford74 · X

Like one of our scientists said, this is straight out of a #ScienceFiction movie! Cerebral #organoids at the air-liquid interface generate diverse nerve tracts with functional output. #LMBresearch @MinibrainLab @CellBiol_MRCLMB https://t.co/6TqjN5e2gt

Mar 25, 2019 · 329 followers View post →
the paper link
@the_paper_link · X

[trend] up+1: *Giandomenico SL* et al (Nat Neurosci) **Cerebral organoids at the air-liquid interface generate diverse nerve tracts with functional output.** https://t.co/8bWA8bAQ1r

Mar 24, 2019 · 136 followers View post →
Single Cell papers
@scell_papers · X

Cerebral organoids at the air-liquid interface generate diverse nerve tracts with functional output. https://t.co/GYXW0bgj7x

Mar 20, 2019 · 11,502 followers View post →
LMBLib
@LMB_Library · X

NEW #LMBpublications Cerebral organoids at the air-liquid interface generate diverse nerve tracts with functional output.https://t.co/KGQFShnGLG

Mar 20, 2019 · 318 followers View post →
Manuel Tor
@ManuelT9 · X

RT @organoidscience: Congrats @MinibrainLab on your new @NatureNeuro paper out *TODAY*! Cerebral #organoids at the air-liquid interface ge…

Mar 19, 2019 · 13 shares · 142 followers View post →
lisa landskron
@lisa_landskron · X

RT @organoidscience: Congrats @MinibrainLab on your new @NatureNeuro paper out *TODAY*! Cerebral #organoids at the air-liquid interface ge…

Mar 19, 2019 · 13 shares · 247 followers View post →
Qkine
@QkineBio · X

RT @organoidscience: Congrats @MinibrainLab on your new @NatureNeuro paper out *TODAY*! Cerebral #organoids at the air-liquid interface ge…

Mar 19, 2019 · 13 shares · 789 followers View post →
Swiss 3R Competence Centre (3RCC)
@Swiss3RCC · X

RT @organoidscience: Congrats @MinibrainLab on your new @NatureNeuro paper out *TODAY*! Cerebral #organoids at the air-liquid interface ge…

Mar 19, 2019 · 13 shares · 2,315 followers View post →
Maxime Mahe
@MaximeMMahe · X

RT @organoidscience: Congrats @MinibrainLab on your new @NatureNeuro paper out *TODAY*! Cerebral #organoids at the air-liquid interface ge…

Mar 19, 2019 · 13 shares · 652 followers View post →
Karol Kaiser
@KarolKaiser1 · X

RT @organoidscience: Congrats @MinibrainLab on your new @NatureNeuro paper out *TODAY*! Cerebral #organoids at the air-liquid interface ge…

Mar 19, 2019 · 13 shares · 151 followers View post →
Mark Fitzgerald
@_MarkFitzgerald · X

RT @organoidscience: Congrats @MinibrainLab on your new @NatureNeuro paper out *TODAY*! Cerebral #organoids at the air-liquid interface ge…

Mar 19, 2019 · 13 shares · 546 followers View post →
Angel Lizandro Polanco
@TheOrganoidBoy · X

RT @organoidscience: Congrats @MinibrainLab on your new @NatureNeuro paper out *TODAY*! Cerebral #organoids at the air-liquid interface ge…

Mar 19, 2019 · 13 shares · 343 followers View post →
Marija Adžić Bukvić, PhD
@aprilmesmerize · X

RT @organoidscience: Congrats @MinibrainLab on your new @NatureNeuro paper out *TODAY*! Cerebral #organoids at the air-liquid interface ge…

Mar 18, 2019 · 13 shares · 638 followers View post →
Marja Koskuvi
@MKoskuvi · X

RT @organoidscience: Congrats @MinibrainLab on your new @NatureNeuro paper out *TODAY*! Cerebral #organoids at the air-liquid interface ge…

Mar 18, 2019 · 13 shares · 99 followers View post →
Inti De La Rosa Velazquez
@IntiOmics · X

RT @organoidscience: Congrats @MinibrainLab on your new @NatureNeuro paper out *TODAY*! Cerebral #organoids at the air-liquid interface ge…

Mar 18, 2019 · 13 shares · 1,399 followers View post →
Organoid News
@organoidscience · X

Congrats @MinibrainLab on your new @NatureNeuro paper out *TODAY*! Cerebral #organoids at the air-liquid interface generate diverse nerve tracts with functional output. https://t.co/RWWKlegkUf https://t.co/vqI2n5fScN

Mar 18, 2019 · 41 likes · 13 shares · 13,816 followers View post →