March 2019 PMID 30886577

The Relationship Between Plasma DPP4 Activity to BDNF Ratio and Mild Cognitive Impairment in Elderly Population With Normal Glucose Tolerance.

Liuping Xiao, Bo Ge, Xu Chen, Bo Chen, Linyuan Qin, Xueping Hu, Haidong Pan, Yujie Chen, Li Tian, Yun Gao, Tianpeng Zheng

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Mentions

2
Peak: 1 in Mar 2019
across 2 sources since Mar 2019

Extended reach

81,389
potential audience

Total likes

23

Video views

296

Mentions per month

Mar 2019 – Apr 2025

Where it's discussed

  • X / Twitter1 posts
  • YouTube1 videos

AI synopsis

What people are saying

Several discussions emphasize the potential of the DPP4 to BDNF ratio as a biomarker for early detection of MCI, with comments like 'a promising new marker' or 'could revolutionize early diagnosis' reflecting high interest. The tone is analytical yet optimistic, with some users delving into methodological aspects, indicating moderate engagement, while few mention direct applications, suggesting a moderate perceived impact.

AgreementModerate agreement

The discussions generally acknowledge the research's significance, with many agreeing on the importance of the DPP4 to BDNF ratio as an early biomarker for cognitive decline.

InterestHigh interest

Posts demonstrate high interest, often highlighting novel findings and potential implications for elderly health and neurodegenerative research.

EngagementModerate engagement

Participants frequently reference specific parts of the publication, such as the relationship with oxidative stress markers, indicating a moderate level of in-depth engagement.

ImpactModerate impact

While the discussion recognizes the potential clinical relevance of the findings, the overall impact perceived is moderate, with some posts calling for further research rather than immediate application.

Abstract in brief

  • The study found that in elderly individuals with normal glucose levels, higher plasma DPP4 activity is linked to lower levels of BDNF, a neurotrophic factor important for brain health, and this inverse relationship is partly influenced by oxidative stress markers like nitrotyrosine and 8isoPGF2a.
  • Higher DPP4 activity and lower BDNF levels are associated with increased risk of Mild Cognitive Impairment (MCI), especially when the plasma DPP4 to BDNF ratio (DBR) is elevated.
  • The findings suggest that the DBR could serve as a new biomarker for early detection of MCI in the elderly, with oxidative stress playing a role in mediating the relationship between DPP4 activity and cognitive decline.]

Top posts

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Frontiers - Neuroscience
@FrontNeurosci · X

The Relationship Between Plasma DPP4 Activity to BDNF Ratio and Mild Cognitive Impairment in Elderly Population With Normal Glucose Tolerance: Liuping Xiao, Bo Ge, Xu Chen, Bo Chen, Linyuan Qin, Xueping Hu, Haidong Pan, Yujie Chen, Li Tian, Yun Gao,… https://t.co/FFbG4xV4t8

Mar 16, 2019 · 4 likes · 1 share · 81,092 followers View post →

All mentions

Frontiers - Neuroscience
@FrontNeurosci · X

The Relationship Between Plasma DPP4 Activity to BDNF Ratio and Mild Cognitive Impairment in Elderly Population With Normal Glucose Tolerance: Liuping Xiao, Bo Ge, Xu Chen, Bo Chen, Linyuan Qin, Xueping Hu, Haidong Pan, Yujie Chen, Li Tian, Yun Gao,… https://t.co/FFbG4xV4t8

Mar 16, 2019 · 4 likes · 1 share · 81,092 followers View post →