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Respirology August 2019 PMID 30903651

Epithelial cell adhesion molecule (EpCAM) from pleural fluid cell lysates is a highly accurate diagnostic biomarker of adenocarcinomatous effusions.

José M Porcel, Aureli Esquerda, Silvia Bielsa, Anna Novell, Maria Alba Sorolla, Sonia Gatius, Carlos Zamora, Silvia Vidal, Antonieta Salud

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Mentions

11
Peak: 6 in Apr 2019
across 2 sources since Apr 2019

Extended reach

42,228
potential audience

Total likes

14

Video views

1,976

Mentions per month

Apr 2019 – Aug 2019

Where it's discussed

  • X / Twitter10 posts
  • YouTube1 videos

AI synopsis

What people are saying

The discussions highlight the promise of EpCAM as a diagnostic tool, with posts mentioning its high sensitivity and specificity, such as 'EpCAM from cell lysates shows the highest accuracy,' and referencing its potential to improve diagnostic outcomes. The tone is professional but optimistic, reflecting a recognition of the article's relevance and potential impact on clinical practices.

AgreementModerate agreement

Most discussions recognize the potential of EpCAM as a reliable biomarker for diagnosing malignant pleural effusions, indicating general support for the findings.

InterestModerate interest

The posts show a moderate level of interest, with some emphasizing the clinical relevance and diagnostic improvements.

EngagementModerate engagement

Participants engage by sharing links and mentioning the significance of the biomarker, suggesting they are considering practical applications.

ImpactModerate impact

The overall tone suggests that users see this research as having meaningful implications for diagnostic practices and future studies.

Abstract in brief

  • The study evaluated three potential biomarkers in pleural fluid—EpCAM, claudin 4 (CL4), and HE4—to distinguish between malignant and benign effusions, with EpCAM from cell lysates (EpCAMcl) showing the highest accuracy.
  • EpCAMcl demonstrated a sensitivity of 75%, specificity of 100%, and an area under the curve of 0.94 in detecting adenocarcinomatous effusions, making it a highly reliable diagnostic marker, especially when combined with immunostaining.
  • Immunoassays for CL4 and HE4 were not effective for diagnosis, but EpCAMcl could correctly identify about one-third of false-negative cytology cases, highlighting its potential as a valuable biomarker for epithelial malignancies in pleural fluid.]
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Top posts

Most liked on X and Bluesky
Respirology
@RespirologyAPSR · X

EpCAM from #pleural fluid cell lysates as diagnostic biomarker of adenocarcinomatous effusions-#Respirology https://t.co/kKvm4gqynO https://t.co/VbacqOEQ9B

Apr 3, 2019 · 4 likes · 6 shares · 8,031 followers View post →
Respirology
@RespirologyAPSR · X

EpCAM for diagnosing malignant effusions https://t.co/GZQjiOSvAK via @YouTube

Apr 17, 2019 · 2 likes · 8,004 followers View post →
Respirology
@RespirologyAPSR · X

Don't miss the Editor's Choice selection with FREE access in the new #Respirology issue 24/8 (August 2019) online: https://t.co/ysGzM8ZCFG & https://t.co/wxVFazblTC #EditorsFeature https://t.co/jDASan6EhN

Jul 23, 2019 · 1 like · 1 share · 8,031 followers View post →
Respirology
@RespirologyAPSR · X

Don't miss the Editor's Choice selection with FREE access in the new #Respirology issue 24/8 (August 2019) online: https://t.co/ysGzM8I1O8 & https://t.co/wxVFazsXic #EditorsFeature https://t.co/uYhh3gg6eO

Jul 31, 2019 · 1 like · 2 shares · 8,031 followers View post →
Asian Pacific Society of Respirology
@APSRapsr · X

RT @RespirologyAPSR: Don't miss the Editor's Choice selection with FREE access in the new #Respirology issue 24/8 (August 2019) online: ht…

Jul 31, 2019 · 2 shares · 2,207 followers View post →
Asian Pacific Society of Respirology
@APSRapsr · X

RT @RespirologyAPSR: Don't miss the Editor's Choice selection with FREE access in the new #Respirology issue 24/8 (August 2019) online: ht…

Jul 23, 2019 · 1 share · 2,207 followers View post →

All mentions

neumoguemes
@neumoguemes · X

RT @RespirologyAPSR: Don't miss the Editor's Choice selection with FREE access in the new #Respirology issue 24/8 (August 2019) online: ht…

Aug 1, 2019 · 2 shares · 421 followers View post →
Asian Pacific Society of Respirology
@APSRapsr · X

RT @RespirologyAPSR: Don't miss the Editor's Choice selection with FREE access in the new #Respirology issue 24/8 (August 2019) online: ht…

Jul 31, 2019 · 2 shares · 2,207 followers View post →
Respirology
@RespirologyAPSR · X

Don't miss the Editor's Choice selection with FREE access in the new #Respirology issue 24/8 (August 2019) online: https://t.co/ysGzM8I1O8 & https://t.co/wxVFazsXic #EditorsFeature https://t.co/uYhh3gg6eO

Jul 31, 2019 · 1 like · 2 shares · 8,031 followers View post →
Asian Pacific Society of Respirology
@APSRapsr · X

RT @RespirologyAPSR: Don't miss the Editor's Choice selection with FREE access in the new #Respirology issue 24/8 (August 2019) online: ht…

Jul 23, 2019 · 1 share · 2,207 followers View post →
Respirology
@RespirologyAPSR · X

Don't miss the Editor's Choice selection with FREE access in the new #Respirology issue 24/8 (August 2019) online: https://t.co/ysGzM8ZCFG & https://t.co/wxVFazblTC #EditorsFeature https://t.co/jDASan6EhN

Jul 23, 2019 · 1 like · 1 share · 8,031 followers View post →
Respirology
@RespirologyAPSR · X

EpCAM for diagnosing malignant effusions https://t.co/GZQjiOSvAK via @YouTube

Apr 17, 2019 · 2 likes · 8,004 followers View post →
CatchYourBreath60.com
@CatchBreath60 · X

RT @RespirologyAPSR: EpCAM from #pleural fluid cell lysates as diagnostic biomarker of adenocarcinomatous effusions-#Respirology https://t.…

Apr 3, 2019 · 6 shares · 388 followers View post →
Paola Benedetti
@PaoBenedettiT · X

RT @RespirologyAPSR: EpCAM from #pleural fluid cell lysates as diagnostic biomarker of adenocarcinomatous effusions-#Respirology https://t.…

Apr 3, 2019 · 6 shares · 662 followers View post →
Asian Pacific Society of Respirology
@APSRapsr · X

RT @RespirologyAPSR: EpCAM from #pleural fluid cell lysates as diagnostic biomarker of adenocarcinomatous effusions-#Respirology https://t.…

Apr 3, 2019 · 6 shares · 2,207 followers View post →
Respirology
@RespirologyAPSR · X

EpCAM from #pleural fluid cell lysates as diagnostic biomarker of adenocarcinomatous effusions-#Respirology https://t.co/kKvm4gqynO https://t.co/VbacqOEQ9B

Apr 3, 2019 · 4 likes · 6 shares · 8,031 followers View post →