October 2019 PMID 30909720

Mitochondrial Substrate-Level Phosphorylation as Energy Source for Glioblastoma: Review and Hypothesis.

Christos Chinopoulos, Thomas N Seyfried

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Mentions

Peak: 17 in Sep 2025

across 5 sources since Jan 2019

Extended reach

478,795

potential audience

Total likes

3,832

Video views

111,047

Mentions per month

Jan 2019 – Sep 2025

Where it's discussed

X / Twitter68 posts
News9 articles
Facebook4 posts
YouTube2 videos
Blogs2 articles

AI synopsis

What people are saying

Numerous discussions highlight key points from the research, such as the role of mitochondrial substrate-level phosphorylation in glioblastoma metabolism, with phrases like 'missing link' and 'groundbreaking' indicating both recognition of the research's importance and a call for deeper exploration. Posts like 'What if cancer isn’t primarily a genetic disease but metabolic one?' show a shift in perspective that stimulates further interest and dialogue on this topic.

AgreementModerate agreement

The majority of discussions show a supportive attitude towards the publication and its findings.

InterestHigh interest

There is a marked curiosity about the concepts presented, as many users reference related resources and express enthusiasm.

EngagementModerate engagement

While some posts share general links, a few delve into specifics, discussing the implications of mitochondrial substrate-level phosphorylation and its relevance to cancer metabolism.

ImpactHigh impact

Many users believe this research could lead to significant advancements in understanding and treating glioblastoma.

Abstract in brief

Glioblastoma multiforme (GBM) is a highly aggressive brain cancer characterized by mitochondrial abnormalities that hinder effective energy production through oxidative phosphorylation (OxPhos).
To compensate for impaired ATP production from glycolysis and OxPhos, GBM cells utilize mitochondrial substrate-level phosphorylation (mSLP) via the succinate-CoA ligase reaction, which generates sufficient ATP to support cell growth and invasion.
The metabolism of GBM is heavily reliant on glutamine, and targeting glucose and glutamine availability or inhibiting mSLP could be potential strategies to reduce GBM growth and viability.

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All mentions

Can the Ketogenic Diet Cause Brain Tumors (Glioblastomas)?

Dr. Eric Berg DC · Dec 18, 2019 106,820 views

The Metabolic Basis of Cancer: Insights from Thomas Seyfried

What if cancer isn't primarily a genetic disease but a metabolic one? In this video, Professor Thomas Seyfried discusses how glioblastoma and other cancers utilize glucose and glutamine for energy. He emphasizes…

The Moss Report · Aug 30, 2025 3,972 views

Metabolic Targeting in Cancer Therapy with Professor Seyfried

Professor Seyfried discusses the potential of ketogenic metabolic therapy as a new standard for glioblastoma treatment, focusing on targeting tumor metabolism while preserving healthy tissue.

DC Rebuilding · May 22, 2024 255 views

Robert Olney

@boretrol · X

RT @boretrol: Mitochondrial Substrate-Level Phosphorylation as Energy Source for Glioblastoma: Review and Hypothesis https://t.co/IEOQZPOM1F

Sep 9, 2025 · 1 share · 1,661 followers View post →

Robert Olney

@boretrol · X

RT @tnseyfried: Dr. Christos Chinopoulos & I have identified mitochondrial substrate level phosphorylation as the missing link in Warburg’s…

Sep 9, 2025 · 88 shares · 1,661 followers View post →

Shackley F. Raffetto

@jsraffetto · X

The Metabolic Theory of Cancer: Glucose, Glutamine & Anti-Parasitics, Fe... https://t.co/A40YOzmYnZ via @YouTube

Sep 9, 2025 · 133 followers View post →

BARAD VICTORINE

@Baradbak · X

The Metabolic Theory of Cancer: Glucose, Glutamine & Anti-Parasitics, Fe... https://t.co/FIHRXzsZY0 via @YouTube

Sep 5, 2025 · 118 followers View post →

Yuji Marutani Planning Director

@YujiMarutani · X

@YouTube The Metabolic Theory of Cancer: Glucose, Glutamine & Anti-Parasitics, Fe... https://t.co/K8SgRhaDtN @YouTube

Sep 5, 2025 · 1,588 followers View post →

Yuji Marutani Planning Director

@YujiMarutani · X

がんの代謝理論：グルコース、グルタミン、抗寄生虫薬、フェンベンダゾール — トーマス・セイフリード https://t.co/bKNTRnVmA2 @YouTube

Sep 5, 2025 · 1,588 followers View post →

We Are

@Rebln · X

RT @markeatsmeat: @carnivoretravis Check out @tnseyfried

Sep 4, 2025 · 1 share · 3,670 followers View post →

Full Spectrum Outdoors

@fullspecoutdoor · X

The Metabolic Theory of Cancer: Glucose, Glutamine & Anti-Parasitics, Fenbendazole — Thomas Seyfried - YouTube https://t.co/lHkUG2PBsO

Sep 4, 2025 · 1 like · 339 followers View post →

Meat Head

@markeatsmeat · X

@carnivoretravis Check out @tnseyfried

Sep 3, 2025 · 24 likes · 1 share · 45,929 followers View post →

Celedonio Saez

@chuisti · X

RT @chuisti: La teoría somática del cáncer,arrumbada. Al igual q la teoría del cambio climático de origen antropogénico, sólo se mantienen…

Sep 3, 2025 · 1 share · 1,025 followers View post →

Celedonio Saez

@chuisti · X

La teoría somática del cáncer,arrumbada. Al igual q la teoría del cambio climático de origen antropogénico, sólo se mantienen en pie por intereses económicos La teoría metabólica del cáncer: glucosa, glutamina y antiparasitarios, ... https://t.co/s5C5OQeLaG a través de @YouTube

Sep 3, 2025 · 1 share · 1,025 followers View post →

wondering

@ecat3 · X

https://t.co/GypU0sQq3G

Sep 2, 2025 · 1,055 followers View post →

de Rijke Dick

@chris47nl · X

https://t.co/3dQfXJukrs

Sep 2, 2025 · 1 followers View post →

BARAD VICTORINE

@Baradbak · X

The Metabolic Theory of Cancer: Glucose, Glutamine & Anti-Parasitics, Fe... https://t.co/Z8Zrfy8sUz via @YouTube

Sep 2, 2025 · 118 followers View post →

LCE

@LCE1112 · X

The Metabolic Theory of Cancer: Glucose, Glutamine & Anti-Parasitics, Fenbendazole Thomas Seyfried: Rethinking Cancer at Its Core https://t.co/4FpPqieEki via @YouTube https://t.co/iZEH4MEEON

Sep 2, 2025 · 3,650 followers View post →

Sarbu Adrian

@sarbuadria92115 · X

"What if cancer isn’t primarily a genetic disease — but a metabolic one? ... Dr. Seyfried explains how cancer cells depend on glucose and glutamine as their dual fuel supply — and how cutting off both pathways may be the key to shutting cancer down." https://t.co/fthV7jLovS

Sep 1, 2025 · 30 followers View post →

paul6767

@paultraynor67 · X

https://t.co/HdTfO9wk5p

Sep 1, 2025 · 330 followers View post →

JJL

@JJCarnvr · X

Hey ⁦@LanceRoberts⁩ check this doctor out about cancer. https://t.co/Fif7ovJToR

Aug 31, 2025 · 1 like · 220 followers View post →

BARAD VICTORINE

@Baradbak · X

The Metabolic Theory of Cancer: Glucose, Glutamine & Anti-Parasitics, Fe... https://t.co/ZmnTkVyApg via @YouTube

Aug 31, 2025 · 118 followers View post →

LiveFree

@LiveFre56305865 · X

What if cancer isn’t primarily a genetic disease but metabolic one? In this groundbreaking conversation, Thomas N. Seyfried, PhD, author "Cancer as a Metabolic Disease" joins Ralph Moss, PhD & Ben Moss to discuss Mitochondrial & Metabolic Theory of Cancer. https://t.co/ap1beZKzY4

Aug 30, 2025 · 60 followers View post →

CitizenKC

@CitizenKC53 · X

Mitochondria, the oxidative powerhouse of our cells, can also produce ATP using the fermentation of some amino acids, especially glutamine. https://t.co/lYRhFmTmdS

Aug 30, 2025 · 1 like · 353 followers View post →

Christos Tsakmakis

@khristaki · X

The Metabolic Theory of Cancer: Glucose, Glutamine & Anti-Parasitics, Fenbendazole — Thomas Seyfried https://t.co/dldtxEDbvQ

Aug 30, 2025 · 1 like · 368 followers View post →

Animal

@Animal1878 · X

@soxaholick @Hughes8178 @Royston56428882 @MakisMD @tnseyfried https://t.co/MBGWpb4dvn

Apr 2, 2025 · 775 followers View post →

Marcus

@sysopt · X

@skybluelaw @JoshuaB42069 @CovidConfusion @drdenwalker It saddens me deeply that some people would rather die than explore all the potential cures available Same with the jabero and talking people out of that. Maybe keto she could do? https://t.co/M3UezT8JSH

Oct 6, 2023 · 1 like · 246 followers View post →

Brett Chrest

@Chrest_brett · X

@raphaels7 @AlexJLeaf https://t.co/3vTrKDJaGl

Sep 15, 2023 · 1,528 followers View post →

Robert Olney

@boretrol · X

Mitochondrial Substrate-Level Phosphorylation as Energy Source for Glioblastoma: Review and Hypothesis https://t.co/IEOQZPOM1F

Jul 8, 2023 · 2 likes · 1 share · 1,661 followers View post →

Citizen of EU

@wavetossed · X

RT @tnseyfried: Dr. Christos Chinopoulos & I have identified mitochondrial substrate level phosphorylation as the missing link in Warburg’s…

Oct 13, 2022 · 88 shares · 9,500 followers View post →

Piyush

@drpiyushkr · X

RT @tnseyfried: Dr. Christos Chinopoulos & I have identified mitochondrial substrate level phosphorylation as the missing link in Warburg’s…

Jan 9, 2022 · 88 shares · 2,783 followers View post →

Bram

@eagles20yo · X

RT @tnseyfried: Dr. Christos Chinopoulos & I have identified mitochondrial substrate level phosphorylation as the missing link in Warburg’s…

Sep 28, 2021 · 88 shares · 402 followers View post →

Travis Statham

@Travis_Statham · X

RT @tnseyfried: Dr. Christos Chinopoulos & I have identified mitochondrial substrate level phosphorylation as the missing link in Warburg’s…

Sep 28, 2021 · 88 shares · 12,726 followers View post →

Patrick

@pkamaukinyenje · X

https://t.co/JVHbfYzVel

Oct 10, 2020 · 715 followers View post →

AmSocietyNeurochem

@ASNeurochem · X

Notable Article Highlight: Mitochondrial substrate-level phosphorylation as energy source for glioblastoma: review and hypothesis https://t.co/qNQnpweiND

Aug 20, 2020 · 1 like · 711 followers View post →

Patrick

@pkamaukinyenje · X

https://t.co/JVHbfYzVel

Jun 12, 2020 · 715 followers View post →

Travis Christofferson

@tchristoff1 · X

@Chrest_brett @Pcyryl @tnseyfried Great sluthing. Seems the only way to reconsile the observation of oxphos in malignant cells with Warburgs hypotheisis is with the ability of mito to undergo subtrate level phos in the mito. Its an intersting idea. https://t.co/Y31RqClmDt

Apr 25, 2020 · 1,154 followers View post →

Isabella Cooper

@I_mitochondria · X

RT @tnseyfried: Dr. Christos Chinopoulos & I have identified mitochondrial substrate level phosphorylation as the missing link in Warburg’s…

Apr 5, 2020 · 88 shares · 10,321 followers View post →

The Good Householder

@divine_dividend · X

RT @tnseyfried: Dr. Christos Chinopoulos & I have identified mitochondrial substrate level phosphorylation as the missing link in Warburg’s…

Mar 2, 2020 · 88 shares · 696 followers View post →

palavrossavrvs

@palavrossavrvs · X

https://t.co/CYZPfN3zGs

Dec 18, 2019 · 25,706 followers View post →

AndyMcDandy

@AndyMcDandyCDN · X

Dec 18, 2019 · 781 followers View post →

Tyrone Bush

@tb0ne2u · X

Can the Ketogenic Diet Cause Brain Tumors (Glioblastomas)? https://t.co/QkloIlyW0g via @YouTube

Dec 18, 2019 · 333 followers View post →

Maria

@FrostyPumpkin67 · X

Can the Ketogenic Diet Cause Brain Tumors (Glioblastomas)? https://t.co/tJMN2vdKMd via @YouTube

Dec 18, 2019 · 576 followers View post →

OAK77uk

@OAK77uk · X

Can the Ketogenic Diet Cause Brain Tumors (Glioblastomas)? https://t.co/2Xz91co3N4 via @YouTube

Dec 18, 2019 · 5,191 followers View post →

Deborah E. Blair, M.S., Ph.D.

@DeboraheBlair · X

Dr. BERG discusses the MISUNDERSTOOD study the media will use WRONGLY to lie about Ketogenic diet-the actual Harvard Doctor who did the study did so on specialized, genetically challenged mice-this doctor actually has AMAZING health results w Keto&cancer https://t.co/O3k3UgifJq

Dec 18, 2019 · 1 like · 2,168 followers View post →

任思麒 Kandice Z. ☮️✌

@BlackUniGryphon · X

A typical think tank smear: Can the Ketogenic Diet Cause Brain Tumors (Glioblastomas)? https://t.co/ZYrRL7wqzX via @YouTube

Dec 18, 2019 · 631 followers View post →

Roxy ❤️Carmichael

@RoxyCarmichael8 · X

Watch "Can the Ketogenic Diet Cause Brain Tumors (Glioblastomas)?" on YouTube https://t.co/XoFdK4c2lN Keto Diet and Intermittent Fasting has changed my life. Get off sugar.

Dec 18, 2019 · 1,448 followers View post →

BeTheCrypto

@GenLarkLin · X

New video by Dr. Eric Berg DC: Can the Ketogenic Diet Cause Brain Tumors (Glioblastomas)? https://t.co/sO8aRWcZWn

Dec 18, 2019 · 895 followers View post →

LIVE!

@Hapivit · X

RT @tnseyfried: Dr. Christos Chinopoulos & I have identified mitochondrial substrate level phosphorylation as the missing link in Warburg’s…

Dec 16, 2019 · 88 shares · 21,886 followers View post →

J J Thomson

@Josiejo120 · X

RT @tnseyfried: Dr. Christos Chinopoulos & I have identified mitochondrial substrate level phosphorylation as the missing link in Warburg’s…

Oct 24, 2019 · 88 shares · 171 followers View post →

AmSocietyNeurochem

@ASNeurochem · X

Check out this ASN Neuro article: Mitochondrial Substrate-Level Phosphorylation as Energy Source for Glioblastoma: Review and Hypothesis. https://t.co/d4U93vQoQ4 https://t.co/98DCYtW8bW

Aug 27, 2019 · 711 followers View post →

Dominic D'Agostino

@DominicDAgosti2 · X

@FrigoCoder @MaryanneDemasi @CrossFitHealth Discussed here. https://t.co/fyzhkzvCGz

Aug 1, 2019 · 1 like · 78,007 followers View post →

AmSocietyNeurochem

@ASNeurochem · X

Jul 28, 2019 · 2 likes · 711 followers View post →

DesignedByNature

@DesignedNature · X

I just posted "Mitochondrial Substrate-Level Phosphorylation as Energy Source for Glioblastoma: Review and Hypothesis - December 2018" on Reddit https://t.co/vr620SatXh

Jul 27, 2019 · 440 followers View post →

Paul

@GulagAgos · X

RT @tnseyfried: @manwithahammer @Mangan150 Most if not all cancers use fermentation for energy. Fats cannot be fermented. Fats, however,…

Jun 14, 2019 · 7 shares · 153 followers View post →

Dr. Declan Daly

@DecoDaly · X

RT @tnseyfried: @manwithahammer @Mangan150 Most if not all cancers use fermentation for energy. Fats cannot be fermented. Fats, however,…

Jun 11, 2019 · 7 shares · 158 followers View post →

Darren Schmidt, D.C.

@realfoodcures · X

RT @tnseyfried: @manwithahammer @Mangan150 Most if not all cancers use fermentation for energy. Fats cannot be fermented. Fats, however,…

Jun 11, 2019 · 7 shares · 5,826 followers View post →

Iveta Kristjansone-Mazīte

@nonambitious · X

RT @tnseyfried: @manwithahammer @Mangan150 Most if not all cancers use fermentation for energy. Fats cannot be fermented. Fats, however,…

Jun 11, 2019 · 7 shares · 409 followers View post →

Isabella Cooper

@I_mitochondria · X

RT @tnseyfried: @manwithahammer @Mangan150 Most if not all cancers use fermentation for energy. Fats cannot be fermented. Fats, however,…

Jun 10, 2019 · 7 shares · 10,321 followers View post →

Thomas N. Seyfried

@tnseyfried · X

Jun 5, 2019 · 21 likes · 7 shares · 52,839 followers View post →

MZet

@Tezakrim · X

RT @tnseyfried: Dr. Christos Chinopoulos & I have identified mitochondrial substrate level phosphorylation as the missing link in Warburg’s…

May 8, 2019 · 88 shares · 710 followers View post →

Wendy

@WendyAtTheBay · X

RT @tnseyfried: Dr. Christos Chinopoulos & I have identified mitochondrial substrate level phosphorylation as the missing link in Warburg’s…

Apr 21, 2019 · 88 shares · 924 followers View post →

FrezzaLab

@FrezzaLab · X

Mitochondrial Substrate-Level Phosphorylation as Energy Source for Glioblastoma: Review and Hypothesis - Christos Chinopoulos, Thomas N. Seyfried, 2018 https://t.co/yHJn7mHLGR

Mar 28, 2019 · 27,000 followers View post →

JenH.

@Jenn9925 · X

RT @tnseyfried: Dr. Christos Chinopoulos & I have identified mitochondrial substrate level phosphorylation as the missing link in Warburg’s…

Feb 26, 2019 · 88 shares · 3,335 followers View post →

Sage Health & Nursing

@SageHealthInfo · X

Mitochondrial Substrate-Level #Phosphorylation as Energy Source for #Glioblastoma: Review and Hypothesis https://t.co/e6ehOHgBri

Feb 16, 2019 · 5,033 followers View post →

Alto

@luomoalto · X

RT @tnseyfried: Dr. Christos Chinopoulos & I have identified mitochondrial substrate level phosphorylation as the missing link in Warburg’s…

Jan 16, 2019 · 88 shares · 70 followers View post →

Gloria McDonough

@GloriaMcDonoug8 · X

RT @tnseyfried: Dr. Christos Chinopoulos & I have identified mitochondrial substrate level phosphorylation as the missing link in Warburg’s…

Jan 13, 2019 · 88 shares · 3,253 followers View post →

Jay

@jihad4jesus · X

RT @tnseyfried: Dr. Christos Chinopoulos & I have identified mitochondrial substrate level phosphorylation as the missing link in Warburg’s…

Jan 11, 2019 · 88 shares · 145 followers View post →

Thom King

@thomking · X

RT @DominicDAgosti2: Mitochondrial Substrate-Level Phosphorylation as Energy Source for Glioblastoma: Review and Hypothesis. https://t.co/K…

Jan 3, 2019 · 12 shares · 3,948 followers View post →

Felix Scholkmann

@FScholkmann · X

Jan 2, 2019 · 2 likes · 1,930 followers View post →

KanLi NDn - Holistic Approach, Learn & Teach

@CalinNadasan · X

RT @tnseyfried: Dr. Christos Chinopoulos & I have identified mitochondrial substrate level phosphorylation as the missing link in Warburg’s…

Jan 2, 2019 · 88 shares · 131 followers View post →

Mitochondrial Substrate-Level Phosphorylation as Energy Source for Glioblastoma: Review and Hypothesis.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Can the Ketogenic Diet Cause Brain Tumors (Glioblastomas)?

The Metabolic Basis of Cancer: Insights from Thomas Seyfried

Metabolic Targeting in Cancer Therapy with Professor Seyfried