September 2020 PMID 30915065

Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases.

Daniela Parada Venegas, Marjorie K De la Fuente, Glauben Landskron, María Julieta González, Rodrigo Quera, Gerard Dijkstra, Hermie J M Harmsen, Klaas Nico Faber, Marcela A Hermoso

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Mentions

70
Peak: 10 in Sep 2021
across 6 sources since Mar 2019

Extended reach

181,351
potential audience

Total likes

81

Video views

132

Mentions per month

Mar 2019 – Aug 2025

Where it's discussed

  • X / Twitter36 posts
  • News21 articles
  • Facebook6 posts
  • Blogs4 articles
  • YouTube2 videos
  • Bluesky1 posts

AI synopsis

What people are saying

The discussions highlight the significance of butyrate and other SCFAs in maintaining gut integrity and overall health, with posts mentioning their role in reducing inflammation and supporting immune functions. The tone is enthusiastic, emphasizing the potential for dietary and probiotic strategies to improve health, using words like 'support,' 'strengthen,' and 'benefit,' which reflect both interest and belief in the impact of this research.

AgreementStrong agreement

Most discussions emphasize the positive effects of SCFAs on gut health, immune regulation, and disease management, with many posts explicitly supporting the article's findings and implications.

InterestHigh interest

The discussions demonstrate high curiosity about how SCFAs, especially butyrate, relate to conditions like IBD, MS, and even general health benefits like skin protection and neuroprotection.

EngagementHigh engagement

Many participants actively reference specific mechanisms, such as the role of butyrate in gut barrier function, microbiome health, and immune response, showing deep engagement with the research details.

ImpactHigh impact

Posts convey a strong perception that this research has high relevance for understanding and possibly treating inflammatory and immune-related conditions, framing it as potentially transformative for health strategies.

Abstract in brief

  • The article explains that Inflammatory Bowel Diseases (IBD), including ulcerative colitis and Crohn's disease, are linked to imbalances in gut bacteria (dysbiosis), especially the reduction of bacteria that produce short-chain fatty acids (SCFAs), which are vital for maintaining gut health.
  • SCFAs like acetate, propionate, and butyrate support intestinal barrier function and have immune-regulating roles by activating specific receptors (GPCRs) on cells, which helps control inflammation and immune responses in the gut.
  • The review discusses how SCFAs could be used in treatments for IBD, either by directly supplementing them or promoting their production through dietary strategies like prebiotics and probiotics, highlighting their potential in maintaining gut health and reducing inflammation.]

Top posts

Most liked on X and Bluesky
James Lyons-Weiler
@lifebiomedguru · X

Prebiotics and probiotics increase short-chain fatty acids. E.g., butyrate produced by your gut bacteria when they break down fiber seems to protect against Alzheimer's disease. Ancient poop had much more SCFA-producing bacteria. https://t.co/duYRjFrjH6 https://t.co/nu31910TFt

Sep 23, 2021 · 60 likes · 9 shares · 49,758 followers View post →
Jordi Paleo
@blogpaleodieta · X

Los pacientes en remisión de Colitis y Crohn tenían mayores niveles de Butirato en heces. El Butirato tiene funciones inmunomoduladoras y fortalece la barrera intestinal. Sus efectos secundarios son mínimos. ¿Cuántos médicos lo recetan? https://t.co/flXaU6IO3G

May 11, 2024 · 8 likes · 4 shares · 9,484 followers View post →
Dr. Todd Ewing PhD
@EwingT_PhD · X

@zinocker @ProfCCollins @Nutrients_MDPI Naturally occurring #fiber in whole foods is converted into short-chain fatty acids SCFAs by the least pathogenic microbiome. SCFAs in the host are anti-inflammatory & epigenetic regulators. SCFAs nourish gut epithelial cells & strengthen gut barrier. https://t.co/TwIKTFFDXA

Aug 10, 2019 · 4 likes · 6 shares · 3,602 followers View post →
Harry E. Taylor
@harryetaylor · X

@EpigeneticWhisp @KreedPeterson @hagbarddd @Awithonelison @immunotoxPhD @doritmi @theladychuck @PeggyQPatriot1 @mcfunny @TinFoilAwards Really? https://t.co/xUN1yPaaeV

Oct 17, 2020 · 3 likes · 1 share · 1,788 followers View post →
UltimApe
@ultimape · X

@Nominus9 My grip strength gains coincides with not having M.S or Crohn's symptoms for almost a year now. https://t.co/iAaTsYzdRD

Dec 10, 2022 · 1 like · 6,451 followers View post →
DrRPalmquist
@DrPalmquist · X

Frontiers | Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases | Immunology https://t.co/BxcpLdjvb2

Jun 23, 2022 · 1 like · 1 share · 3,167 followers View post →

All mentions

floridaboy
@william49176827 · X

RT @blogpaleodieta: Los pacientes en remisión de Colitis y Crohn tenían mayores niveles de Butirato en heces. El Butirato tiene funciones i…

Jul 10, 2024 · 4 shares · 698 followers View post →
RecombinantApe
@RecombinantApe · X

@biohacker Not to mention the immune boost from scfa https://t.co/1qiB7uoj2e

Jun 4, 2024 · 26 followers View post →
Manu ॐ मणिपद्मे हूँ
@mmrosello · X

RT @blogpaleodieta: Los pacientes en remisión de Colitis y Crohn tenían mayores niveles de Butirato en heces. El Butirato tiene funciones i…

May 12, 2024 · 4 shares · 406 followers View post →
Raúl Arroyo
@RalA19774067 · X

RT @blogpaleodieta: Los pacientes en remisión de Colitis y Crohn tenían mayores niveles de Butirato en heces. El Butirato tiene funciones i…

May 11, 2024 · 4 shares · 237 followers View post →
Jordi Paleo
@blogpaleodieta · X

Los pacientes en remisión de Colitis y Crohn tenían mayores niveles de Butirato en heces. El Butirato tiene funciones inmunomoduladoras y fortalece la barrera intestinal. Sus efectos secundarios son mínimos. ¿Cuántos médicos lo recetan? https://t.co/flXaU6IO3G

May 11, 2024 · 8 likes · 4 shares · 9,484 followers View post →
Nicholas (@ultimape) Perry
@ultimape.bsky.wovensoup.com · Bluesky

Now I am able to be in the sun for hours at a time even in peak UV and not get burned. There's a feedback loop here that you need to bootstrap into and you can't do it by focusing on the light alone.My skin was burning like my gut https://pubmed.ncbi.nlm.nih.gov/30915065/

May 7, 2023 View post →
Johnny EV
@HoagieHoag · X

Firmicutes... most abundant phyla in the intestine... Firmicutes mostly produce butyrate https://t.co/i7cJUSuzdt ME/CFS microbiome butyrate... less abundant. https://t.co/jJtcKwcsnv Firmicutes generally dominant phylum, 30% to 75%... 7 appendix samples. https://t.co/IwIC0B3zGS

Feb 14, 2023 · 533 followers View post →
luis hernan graffe
@hernangraffe · X

RT @hernangraffe: https://t.co/9fQ8rXxvtm.

Feb 2, 2023 · 1 share · 3,125 followers View post →
luis hernan graffe
@hernangraffe · X

https://t.co/9fQ8rXxvtm.

Feb 1, 2023 · 1 share · 3,125 followers View post →
UltimApe
@ultimape · X

@Nominus9 My grip strength gains coincides with not having M.S or Crohn's symptoms for almost a year now. https://t.co/iAaTsYzdRD

Dec 10, 2022 · 1 like · 6,451 followers View post →
Supergut
@supergut_ · X

15/ Additionally, butyrate has been shown to: - Keep the cells in your intestinal tract (or your gut wall) healthy - Help promote a healthier microbiome - Benefit the brain and nervous system https://t.co/YmoTKx2Rkm https://t.co/3dI0SBSgSa https://t.co/W5yikscyPF

Sep 20, 2022 · 1 like · 1,726 followers View post →
Lonjevity Foods
@LonjevityFoods · X

@LeakyGutFix and leaky gut is caused by dysbiosis, defined by a deficiency of butyrate producing organisms. https://t.co/RezEmVN5jw.

Jul 12, 2022 · 305 followers View post →
Paradise Lost CA
@ParadiseLostCA · X

RT @DrPalmquist: Frontiers | Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammato…

Jun 23, 2022 · 1 share · 749 followers View post →
DrRPalmquist
@DrPalmquist · X

Frontiers | Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases | Immunology https://t.co/BxcpLdjvb2

Jun 23, 2022 · 1 like · 1 share · 3,167 followers View post →
Dglucer
@dglucer · X

RT @lifebiomedguru: Prebiotics and probiotics increase short-chain fatty acids. E.g., butyrate produced by your gut bacteria when they bre…

Sep 24, 2021 · 9 shares · 54 followers View post →
wendylee
@wendylee21742 · X

RT @lifebiomedguru: Prebiotics and probiotics increase short-chain fatty acids. E.g., butyrate produced by your gut bacteria when they bre…

Sep 24, 2021 · 9 shares · 2,025 followers View post →
Bloody Scandal
@bloody_scandal · X

RT @lifebiomedguru: Prebiotics and probiotics increase short-chain fatty acids. E.g., butyrate produced by your gut bacteria when they bre…

Sep 24, 2021 · 9 shares · 6,027 followers View post →
lily
@lily95075891 · X

RT @lifebiomedguru: Prebiotics and probiotics increase short-chain fatty acids. E.g., butyrate produced by your gut bacteria when they bre…

Sep 24, 2021 · 9 shares · 1,600 followers View post →
Zedd
@TrdisOprtr · X

RT @lifebiomedguru: Prebiotics and probiotics increase short-chain fatty acids. E.g., butyrate produced by your gut bacteria when they bre…

Sep 23, 2021 · 9 shares · 349 followers View post →
HRH
@MARS0411 · X

RT @lifebiomedguru: Prebiotics and probiotics increase short-chain fatty acids. E.g., butyrate produced by your gut bacteria when they bre…

Sep 23, 2021 · 9 shares · 2,884 followers View post →
Nεuroboroσ and Me
@vahuebner · X

RT @lifebiomedguru: Prebiotics and probiotics increase short-chain fatty acids. E.g., butyrate produced by your gut bacteria when they bre…

Sep 23, 2021 · 9 shares · 705 followers View post →
BillMallardFin
@FinMallard · X

RT @lifebiomedguru: Prebiotics and probiotics increase short-chain fatty acids. E.g., butyrate produced by your gut bacteria when they bre…

Sep 23, 2021 · 9 shares · 627 followers View post →
Agnieszka_
@a_matu_ · X

RT @lifebiomedguru: Prebiotics and probiotics increase short-chain fatty acids. E.g., butyrate produced by your gut bacteria when they bre…

Sep 23, 2021 · 9 shares · 547 followers View post →
James Lyons-Weiler
@lifebiomedguru · X

Prebiotics and probiotics increase short-chain fatty acids. E.g., butyrate produced by your gut bacteria when they break down fiber seems to protect against Alzheimer's disease. Ancient poop had much more SCFA-producing bacteria. https://t.co/duYRjFrjH6 https://t.co/nu31910TFt

Sep 23, 2021 · 60 likes · 9 shares · 49,758 followers View post →
Liz Lzcano MD
@LizTrics · X

Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases https://t.co/kuxod1T4vi

May 14, 2021 · 232 followers View post →
F
@drafanysol · X

Frontiers | Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases | Immunology https://t.co/feQcDORADL

Feb 16, 2021 · 338 followers View post →
Dawna Mughal PhD RDN
@DawnaMughalPhD · X

@ScepticalDoctor @NutritionalThe3 There are many refs on the benefits of SCFAs to health-microbiome & intestinal health.This article relates them to IBD. "SCFAs are an important fuel for intestinal epithelial cells and are known to strengthen the gut barrier function."https://t.co/tLd8VT7GLA

Nov 9, 2020 · 1 like · 2,164 followers View post →
(((Dorit Reiss)))
@doritmi · X

RT @harryetaylor: @EpigeneticWhisp @KreedPeterson @hagbarddd @Awithonelison @immunotoxPhD @doritmi @theladychuck @PeggyQPatriot1 @mcfunny @…

Oct 17, 2020 · 1 share · 14,564 followers View post →
Harry E. Taylor
@harryetaylor · X

@EpigeneticWhisp @KreedPeterson @hagbarddd @Awithonelison @immunotoxPhD @doritmi @theladychuck @PeggyQPatriot1 @mcfunny @TinFoilAwards Really? https://t.co/xUN1yPaaeV

Oct 17, 2020 · 3 likes · 1 share · 1,788 followers View post →
CamGlycoscience
@camglyco · X

Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases. https://t.co/5xcElcN08m

Sep 12, 2020 · 702 followers View post →
TheAnachronist1
@TheAnachronist1 · X

@The_Nutrivore Another good one: https://t.co/UjAMDX8Qwo. https://t.co/PfPIME3VRg

Aug 29, 2020 · 153 followers View post →
Claudio Chinaglia
@claudiochinagli · X

RT @EwingT_PhD: @zinocker @ProfCCollins @Nutrients_MDPI Naturally occurring #fiber in whole foods is converted into short-chain fatty acids…

Aug 10, 2019 · 6 shares · 119 followers View post →
ValuableToKnow
@ValuableToKnow · X

RT @EwingT_PhD: @zinocker @ProfCCollins @Nutrients_MDPI Naturally occurring #fiber in whole foods is converted into short-chain fatty acids…

Aug 10, 2019 · 6 shares · 1,713 followers View post →
The Zen Llama
@thezenllama1 · X

RT @EwingT_PhD: @zinocker @ProfCCollins @Nutrients_MDPI Naturally occurring #fiber in whole foods is converted into short-chain fatty acids…

Aug 10, 2019 · 6 shares · 247 followers View post →
Kristie Leong M.D.
@DrKristieLeong · X

RT @EwingT_PhD: @zinocker @ProfCCollins @Nutrients_MDPI Naturally occurring #fiber in whole foods is converted into short-chain fatty acids…

Aug 10, 2019 · 6 shares · 59,592 followers View post →
Dr. Todd Ewing PhD
@EwingT_PhD · X

@zinocker @ProfCCollins @Nutrients_MDPI Naturally occurring #fiber in whole foods is converted into short-chain fatty acids SCFAs by the least pathogenic microbiome. SCFAs in the host are anti-inflammatory & epigenetic regulators. SCFAs nourish gut epithelial cells & strengthen gut barrier. https://t.co/TwIKTFFDXA

Aug 10, 2019 · 4 likes · 6 shares · 3,602 followers View post →
Symbiosis papers
@Symbiosispapers · X

Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases. https://t.co/v6rVQcKp4s

Mar 28, 2019 · 1,113 followers View post →