Br J Anaesth August 2019 PMID 30929760

Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity.

Abdella M Habib, Andrei L Okorokov, Matthew N Hill, Jose T Bras, Man-Cheung Lee, Shengnan Li, Samuel J Gossage, Marie van Drimmelen, Maria Morena, Henry Houlden, Juan D Ramirez, David L H Bennett, Devjit Srivastava, James J Cox

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Mentions

375

Peak: 33 in Mar 2019

across 6 sources since Mar 2019

Extended reach

511,048

potential audience

Total likes

251

Video views

15,084

Mentions per month

Mar 2019 – Jun 2023

Where it's discussed

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AI synopsis

What people are saying

The overall tone reflects strong support and interest in the study's implications for pain relief, with examples such as references to 'superhuman pain tolerance,' the potential for new 'pain medications,' and comments about the 'transformative potential' of this genetic research. The words and tone convey excitement and curiosity about both the scientific details and broader applications.

AgreementModerate agreement

Most discussions support the significance of the study, highlighting its potential for pain management and acknowledging the scientific findings.

InterestHigh interest

Posts demonstrate high curiosity, with many sharing insights, asking questions, or noting the implications for pain and anxiety treatments.

EngagementModerate engagement

Several messages reference specific biological mechanisms and suggest further exploration, showing active discussion and depth of understanding.

ImpactHigh impact

Many comments emphasize the discovery’s potential to revolutionize pain therapy and influence future research, indicating a perception of high impact.

Abstract in brief

A 66-year-old woman with pain insensitivity and quick healing of injuries was found to have a genetic mutation involving a microdeletion in the FAAHOUT pseudogene and a common SNP in FAAH, leading to elevated anandamide levels.
This genetic change results in increased endocannabinoid signaling, which likely explains her lack of pain perception and high anandamide concentrations, pointing to possible new pain relief therapies.
The study uncovers complex interactions at the FAAH gene locus, including the role of FAAHOUT, a pseudogene and noncoding RNA, offering potential new targets for developing drugs to treat pain, anxiety, and related conditions.]

Read the full abstract

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Exploring Anandamide and Pain Insensitivity in Scientific Research

WiTcast 128 discusses the implications of a microdeletion in a FAAH pseudogene, linked to high anandamide levels and pain insensitivity. The video delves into the biological mechanisms behind these findings and how they…

WiTcast · Jun 10, 2023 14,697 views

Microdeletion in Gene Linked to Pain Insensitivity

Researchers estimate that 38% of cancer patients suffer from moderate to severe pain. Cannabinoid research offers a promising avenue for those with challenging health conditions. Learn about the microdeletion in a FAAH…

Global Cannabinoid Solutions · Apr 30, 2023 387 views

Shams Salah Mahdi

@ShamsPath · X

RT @Yasuyuki_Kihara: Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity…

May 14, 2023 · 3 shares · 1,549 followers View post →

Jing Liang

@AppleHelix · X

RT @Yasuyuki_Kihara: Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity…

May 13, 2023 · 3 shares · 10,169 followers View post →

Imad Damaj

@DamajLab · X

RT @Yasuyuki_Kihara: Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity…

May 13, 2023 · 3 shares · 580 followers View post →

Yasu

@Yasuyuki_Kihara · X

Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity https://t.co/ffpT7ib2Qv

May 13, 2023 · 7 likes · 3 shares · 121 followers View post →

Marcos García Ochoa

@gomiam · X

@AurePB @InformaCosmos Lee el artículo a través de, por ejemplo, https://t.co/Gv6v4ubUdc Está publicado en el British Journal of Anaesthesia. https://t.co/ea41ByeZhW

Apr 23, 2023 · 2 likes · 258 followers View post →

TheGeneGeneral

@TheGeneGeneral · X

Further reading (original): https://t.co/HUXZhbc9fg

Jan 20, 2023 · 18 followers View post →

Joe B

@JBianco215 · X

Nov 3, 2022 · 2 likes · 4,577 followers View post →

Anthony Tucker-Bartley, MD

@ATuckerBartley · X

@RamiDiab Very interesting study. The FAAH gene may also be a good target. This patient who had no post-op pain following orthopedic surgery was found to have a FAAH microdeletion which results in pain insensitivity. https://t.co/Oq5u6zYord

Feb 23, 2022 · 1 like · 191 followers View post →

CoiCanna

@CoiCanna · X

RT @zivacooper: A world without pain and anxiety? What makes Jo so unique? Microdeletion in a FAAH pseudogene identified in a patient wit…

Oct 14, 2020 · 4 shares · 176 followers View post →

Gooey Rabinski

@RobbinsGroupLLC · X

RT @zivacooper: A world without pain and anxiety? What makes Jo so unique? Microdeletion in a FAAH pseudogene identified in a patient wit…

Oct 14, 2020 · 4 shares · 12,271 followers View post →

Greenthumb_one

@Greenthumb_one · X

Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity https://t.co/bpZxITaDlv #FAAH #anandamide #eCS https://t.co/IXP365bC2H https://t.co/6QXO48EjCX

Oct 14, 2020 · 1 like · 4,510 followers View post →

Higher Learning LV

@HigherLvtm · X

RT @zivacooper: A world without pain and anxiety? What makes Jo so unique? Microdeletion in a FAAH pseudogene identified in a patient wit…

Oct 13, 2020 · 4 shares · 1,781 followers View post →

The Higher Learning LV Podcast

@TheHLLVPodcast · X

RT @zivacooper: A world without pain and anxiety? What makes Jo so unique? Microdeletion in a FAAH pseudogene identified in a patient wit…

Oct 13, 2020 · 4 shares · 1,183 followers View post →

Ziva Cooper

@zivacooper · X

Oct 13, 2020 · 4 likes · 4 shares · 3,446 followers View post →

UCLA Center for Cannabis and Cannabinoids

@UCLACannabis · X

Oct 13, 2020 · 2 likes · 878 followers View post →

JULIO SOLIS-Bioinformatician & Molecular Biologist

@Jsolis_s · X

A los que deseen comprender el dogma central de la Biologia Molecular, les recomiendo este articulo de PSEUDOGENES . Los bioinformaticos tambien deben leerlo https://t.co/eCLGy7K9g1 https://t.co/qE2RCo3mku https://t.co/V2yMhoRclO

Aug 21, 2020 · 431 followers View post →

JULIO SOLIS-Bioinformatician & Molecular Biologist

@Jsolis_s · X

LESS DARK MATTER IN OUR DNA: active pseudogenes 1.Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity 2. Overcoming challenges and dogmas to understand the functions of pseudogenes https://t.co/qVKgRw4eR1

Aug 21, 2020 · 2 likes · 431 followers View post →

JULIO SOLIS-Bioinformatician & Molecular Biologist

@Jsolis_s · X

El gen de la felicidad y reduccion de dolor: FAAH , las farmaceuticas no desean ver este gene para seguir vendiendo analgesicos https://t.co/eCLGy7K9g1 https://t.co/g5g7sNKt8d

Aug 21, 2020 · 431 followers View post →

A&C Scientific SAC

@scientific_sac · X

RT @Jsolis_s: Un uso de maca para buscar inhibidores de FAAH, un gen de Hidrolasa de ácidos grasos, la enzima responsable de la degradación…

Aug 21, 2020 · 1 share · 337 followers View post →

Rene Sugar

@renesugar · X

Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity. https://t.co/jA1F3FoZtC “concentrations of anandamide and related fatty-acid amides (palmitoylethanolamide and oleoylethanolamine) were significantly elevated”

Jan 25, 2020 · 3,971 followers View post →

Dave Lambert

@DaveGLambert · X

RT @BJAJournals: The Altmetric 2019 top 100 @BJAJournals article is Microdeletion in a FAAH pseudogene identified in a patient with… https:…

Dec 20, 2019 · 2 shares · 383 followers View post →

Jennie Hunter

@JennieH31968241 · X

RT @BJAJournals: The Altmetric 2019 top 100 @BJAJournals article is Microdeletion in a FAAH pseudogene identified in a patient with… https:…

Dec 18, 2019 · 2 shares · 572 followers View post →

British Journal of Anaesthesia

@BJAJournals · X

The Altmetric 2019 top 100 @BJAJournals article is Microdeletion in a FAAH pseudogene identified in a patient with… https://t.co/FaOIxWulkD

Dec 18, 2019 · 2 likes · 2 shares · 40,346 followers View post →

Stephen Pimentel

@StephenPiment · X

Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity https://t.co/FR91epWwpN

Aug 11, 2019 · 1 like · 12,810 followers View post →

Oxford Psychiatry

@OxPsychiatry · X

Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity. https://t.co/aYV4ZdrSMv

Aug 8, 2019 · 1 like · 22,067 followers View post →

Sara Cifuentes (she/her)

@sagaciro · X

Será que esta niña sufre lo mismo de una publicación muy reciente y que fue noticia mundial @ecuavisa @devsrivastava16 ? “Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity” en https://t.co/4bFs8bIYEj https://t.co/WGnK1ENRQ9

May 21, 2019 · 504 followers View post →

Rina Saltman

@rinatie_ceo · X

Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity - ScienceDirect https://t.co/21sVRUd473

May 21, 2019 · 3,562 followers View post →

Megan Kelly

@gisellestopped · X

Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity https://t.co/X4IozKHofO

May 12, 2019 · 1,865 followers View post →

Mike Sliczniak

@badc0fee · X

@BrownTristanh >Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity https://t.co/XSiUcwdgJ1

Apr 17, 2019 · 164 followers View post →

CannaLytica

@CannaLytica · X

@nytimes Habib et al.'s FAAH-OUT paper, @BJAJournals DOI: 10.1016/j.bja.2019.02.019 https://t.co/d2OzoHS27w

Apr 10, 2019 · 1,087 followers View post →

Radmir Sarsenov

@RadmirSarsenov · X

Microdeletion in a FAAH pseudogene identified in a patient with high a... https://t.co/OZ1JdPeCsF

Apr 5, 2019 · 8 followers View post →

Centre for Genetics Education, HETI NSW Health

@CGE_HETI · X

Interesting article on a woman who feels no pain. Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity https://t.co/Aa5wVpXm9P. Read about genetic and genomic testing in our Fact Sheet https://t.co/uK0We2r1dg https://t.co/XyxJxc8S6t

Apr 4, 2019 · 807 followers View post →

Andrew

@Andrew_Jiang_NZ · X

Interesting article, unfortunately not too much said about emotional pain! Microdeletion in a FAAH pseudogene identified in a patient with high a... https://t.co/0ezlSoUnwa

Apr 3, 2019 · 1 like · 36 followers View post →

Sean Kelly

@SkellySTL · X

She has become comfortably numb? Microdeletion in a FAAH pseudogene identified in a patient with high a... https://t.co/4OzHU7w6XB

Apr 2, 2019 · 3 likes · 167 followers View post →

Randall French

@RandallFrench14 · X

This is what is responsible for the woman who has never felt pain. FAAH is an excellent target for a whole new class of pain medications Microdeletion in a FAAH pseudogene identified in a patient with high a... https://t.co/qWMfXAlwf9

Apr 2, 2019 · 18,700 followers View post →

Vasudha Aggarwal

@vasuagg · X

superhuman pain tolerance! #CRISPR can come to rescue. Microdeletion in a FAAH pseudogene identified in a patient with high a... https://t.co/vJSe0b0cYS

Apr 2, 2019 · 234 followers View post →

UCL Discovery

@ucl_discovery · X

Open Access UCL Research: Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity https://t.co/yAodG7DY84

Apr 2, 2019 · 2,516 followers View post →

TwiterHero

@TwiterHero · X

Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity - ScienceDirect https://t.co/qAvFxiYlhf

Apr 1, 2019 · 1 like · 256,258 followers View post →

PerthMLGroup

@PerthMLGroup · X

RT @thebarneslab: A great finding for pain research and perhaps more importantly a paper that shows we ignore pseudogenes and lincRNA at ou…

Apr 1, 2019 · 2 shares · 436 followers View post →

Vincent Ricouleau

@ricouleauvincen · X

Microdeletion in a FAAH pseudogene identified in a patient with high a... https://t.co/Y5HQtCN4qO

Mar 31, 2019 · 1,094 followers View post →

Michele Curatolo, MD, PhD

@MicheleCuratolo · X

Gene mutation explaining pain insensitivity? Single case, but potentially relevant if confirmed. Microdeletion in a FAAH pseudogene identified in a patient with high a... https://t.co/ZqlnfnmqQC

Mar 30, 2019 · 1 like · 592 followers View post →

AssistedEvolution

@AssistedEvolve · X

RT @thebarneslab: A great finding for pain research and perhaps more importantly a paper that shows we ignore pseudogenes and lincRNA at ou…

Mar 30, 2019 · 2 shares · 304 followers View post →

Sandra Paulina Smieszek, Ph.D.

@s108801s · X

Microdeletion in a FAAH pseudogene identified in a patient with high a... https://t.co/nkT34y1bxJ

Mar 30, 2019 · 558 followers View post →

Michael Barnes

@thebarneslab · X

A great finding for pain research and perhaps more importantly a paper that shows we ignore pseudogenes and lincRNA at our peril. Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity https://t.co/x1oWJSuRq9

Mar 30, 2019 · 2 likes · 2 shares · 292 followers View post →

Neil Gerardo-MRX Chairman- ID#32140089

@NeilGerardo · X

Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity https://t.co/Dd5FlHDmTF

Mar 30, 2019 · 787 followers View post →

Dr. Mohini Rawat, DPT, ECS, OCS, RMSK

@mohinirawat · X

Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity - ScienceDirect https://t.co/J6uLacBuTe

Mar 29, 2019 · 1 like · 174 followers View post →

Julie Kiefer

@JulieCKiefer · X

@TGOliver2 I know, I'm surprised the article doesn't say. Here's the paper: Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity https://t.co/4I0QbyWLjt

Mar 29, 2019 · 2,451 followers View post →

Arun K Anguraj Vadivel

@arunkumaranAV · X

Microdeletion in a FAAH pseudogene identified in a patient with high a... https://t.co/OwYbqyk1hP

Mar 29, 2019 · 2 likes · 110 followers View post →

Lluís Canals

@LluisCanalsCan · X

Una vida sense dolor físic i menys ansietat? Això és el que ha experimentat Jo Cameron, una dona que té una mutació en un gen que manté més activat el sistema d’endocannabinoïdes. Microdeletion in a FAAH pseudogene identified in a patient with high a... https://t.co/acrkMy44ap

Mar 29, 2019 · 101 followers View post →

Wafik S. El-Deiry, MD, PhD, FACP

@weldeiry · X

Microdeletion in a FAAH pseudogene identified in a patient with high anandamide - https://t.co/mT42FwBIHv Interesting but refs 7 and 8 suggest more work needed to advance an effective nontoxic approach potentially targeting FAAH to minimize pain & anxiety https://t.co/oBJhh0ASLd

Mar 29, 2019 · 18,545 followers View post →

Nitish

@13nitish · X

RT @VJ_Ulaganathan: Scientists find genetic mutation in a transmembrane protein that makes woman feel no pain For Layperson @guardian ht…

Mar 29, 2019 · 2 shares · 76 followers View post →

British Journal of Anaesthesia

@BJAJournals · X

RT @VJ_Ulaganathan: Scientists find genetic mutation in a transmembrane protein that makes woman feel no pain For Layperson @guardian ht…

Mar 29, 2019 · 2 shares · 40,346 followers View post →

Elena De Vita

@Elena_De_Vita · X

Microdeletion in a FAAH pseudogene identified in a patient with high a... https://t.co/8EJKL0f13s

Mar 29, 2019 · 478 followers View post →

Adam Zamzow, MD

@AdamZamzowMD · X

Microdeletion in a FAAH pseudogene identified in a patient with high a... https://t.co/R4f40FAD8h

Mar 28, 2019 · 46 followers View post →

Harvey Fishman, MD PhD

@drfishman · X

Microdeletion in a FAAH pseudogene identified in a patient with high a... https://t.co/Bf1a3VMJzw

Mar 28, 2019 · 2,507 followers View post →

Ⓝ

@iNut · X

Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity https://t.co/g5oOJkaxBG

Mar 28, 2019 · 2,294 followers View post →

Food&Pharma

@rengerwitkamp · X

Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity https://t.co/4QLewZVxhs

Mar 28, 2019 · 1 like · 2,078 followers View post →

Vanessa King

@VanessaE_King · X

RT @r_devraj: awesome data.., and with many decent inhibitors available to choose from. Microdeletion in a FAAH pseudogene identified in…

Mar 28, 2019 · 1 share · 982 followers View post →

Zhenrun Jerry Zhang

@SZhangJerry · X

Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity https://t.co/z6EBesyQwo

Mar 28, 2019 · 341 followers View post →

Rajesh Devraj

@r_devraj · X

awesome data.., and with many decent inhibitors available to choose from. Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity - ScienceDirect - https://t.co/8vSW3pWwtv https://t.co/oGWc4hPOEV

Mar 28, 2019 · 1 share · 629 followers View post →

Jeff Craig

@DrChromo · X

Fascinating genomics story with a great 'gene' name: 'FAAH-OUT' (a long noncoding RNA) and translational implications "Microdeletion in a FAAH pseudogene identified in a patient with high a..". https://t.co/feLqRpCYpz

Mar 28, 2019 · 3,379 followers View post →

Alexis Wren

@alexisnwren · X

RT @VUMC_MedPSTP: Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity - S…

Mar 28, 2019 · 1 share · 48 followers View post →

101stmonk3y ◼️

@101stmonk3y · X

Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity. https://t.co/gObHfQc5dx

Mar 28, 2019 · 945 followers View post →

Tae Hoon Kim

@taehoonkim · X

At 71, She’s Never Felt Pain or Anxiety. Now Scientists Know Why: Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity https://t.co/9UhUygYIw3

Mar 28, 2019 · 2 likes · 796 followers View post →

Vanderbilt PSTP/Harrison Society

@VUMC_MedPSTP · X

Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity - ScienceDirect - https://t.co/PMKgXj0TAE https://t.co/0m0jSsVzBo

Mar 28, 2019 · 1 like · 1 share · 1,422 followers View post →

PainDoctor

@Doctor4Pain · X

#precisionmedicine Another step towards targeted #pain therapy discussed “microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and #pain insensitivity - ScienceDirect - https://t.co/A7FysQx9E5 https://t.co/zEEK2GTYec

Mar 28, 2019 · 587 followers View post →

Luis Fernando Gómez

@luisfergomguch · X

Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity. Cameron no tiene dolor x mutación en su genoma q impide acción d la enzima FAAH q normalmente degrada la Anandamina Cannabinoide endógeno https://t.co/oEzYDo71GS https://t.co/jrDownVIEH

Mar 28, 2019 · 190 followers View post →

Iratxe

@IraGonLa · X

Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity https://t.co/okZJMHtPj4

Mar 28, 2019 · 1 like · 10 followers View post →

Vaibhavkumar Gawali PhD

@vaibhavkumar_g · X

Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity https://t.co/IrZE9mGPBV

Mar 28, 2019 · 266 followers View post →

Jose Torres

@Jovitope · X

Amazing paper: Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity https://t.co/pyTkLiHeeL

Mar 28, 2019 · 592 followers View post →

Jill MacKay

@jilly_mackay · X

A fun lunch time read of a very nice case-report that's been in the news lately. 13. Habib et al (2019) Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity https://t.co/AbqHjHbafI #100papers

Mar 28, 2019 · 1 like · 1,244 followers View post →

Unsilenced Science

@UnsilencedSci · X

"Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity." #CandidateGeneResearch #TwitterScience #Mendelian #Pain #Anxiety https://t.co/Oqk8PyYqQS

Mar 28, 2019 · 1,763 followers View post →

Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Exploring Anandamide and Pain Insensitivity in Scientific Research

Microdeletion in Gene Linked to Pain Insensitivity