Front Immunol September 2020 PMID 30949165

Extra-Neutralizing FcR-Mediated Antibody Functions for a Universal Influenza Vaccine.

Carolyn M Boudreau, Galit Alter

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Mentions

Peak: 4 in Aug 2019

across 2 sources since Aug 2019

Extended reach

30,734

potential audience

Total likes

319

Video views

29,451

Mentions per month

Aug 2019 – Oct 2022

Where it's discussed

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AI synopsis

What people are saying

The discussions highlight the importance of Fc receptor-mediated functions beyond neutralization, with comments emphasizing their role in immune defense, using phrases like 'potential game changer' and 'key to long-lasting immunity.' The tone varies from cautious optimism to curiosity, reflecting interest and recognition of the research's importance.

AgreementModerate agreement

Most discussions acknowledge the potential of Fc-mediated antibody functions, indicating general agreement with the publication's significance.

InterestModerate interest

Participants show moderate curiosity about how these immune mechanisms could improve vaccine development.

EngagementModerate engagement

Users engage by referencing specific immune responses like antibody-dependent cellular cytotoxicity and discussing possible applications.

ImpactModerate impact

There is a shared sense that understanding these Fc functions could lead to substantial advances in universal influenza vaccines.

Abstract in brief

Neutralizing antibody levels, often measured by hemagglutination inhibition, are only modest predictors of protection against seasonal influenza, suggesting that other antibody functions are important for immunity.
Beyond neutralization, antibodies can activate various immune responses such as antibody-dependent cellular cytotoxicity, macrophage phagocytosis, neutrophil activation, complement deposition, and Fc receptor-mediated trafficking, all of which may contribute to protection.
Understanding how the immune system modulates these Fc-mediated antibody functions could lead to the development of a universal influenza vaccine that harnesses these additional protective mechanisms.

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