J Alzheimers Dis September 2020 PMID 30958356

Homocysteine Status Modifies the Treatment Effect of Omega-3 Fatty Acids on Cognition in a Randomized Clinical Trial in Mild to Moderate Alzheimer's Disease: The OmegAD Study.

Fredrik Jernerén, Tommy Cederholm, Helga Refsum, A David Smith, Cheryl Turner, Jan Palmblad, Maria Eriksdotter, Erik Hjorth, Gerd Faxen-Irving, Lars-Olof Wahlund, Marianne Schultzberg, Hans Basun, Yvonne Freund-Levi

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Mentions

21
Peak: 4 in Apr 2019
across 5 sources since Apr 2019

Extended reach

217,287
potential audience

Total likes

1,764

Video views

52,989

Mentions per month

Apr 2019 – Nov 2025

Where it's discussed

  • X / Twitter7 posts
  • News6 articles
  • Facebook4 posts
  • YouTube2 videos
  • Blogs2 articles

AI synopsis

What people are saying

The discussions reflect a positive reception of the study, with comments highlighting that only patients with lower homocysteine levels benefited from omega-3 supplements, and references to cognitive measures like MMSE and CDR suggest moderate interest. The tone is informative and slightly optimistic, emphasizing the potential importance of homocysteine levels in Alzheimer's treatment without overhyping the results.

AgreementModerate agreement

Most posts acknowledge the significance of the findings, especially regarding the link between homocysteine levels and omega-3 efficacy, showing a general consensus that the study offers valuable insights.

InterestHigh interest

Discussions demonstrate high interest, with commenters emphasizing the potential implications for Alzheimer's treatment and referencing specific test results like MMSE and CDR which indicates engagement with the research details.

EngagementModerate engagement

Posts include mentions of the study's methodology and implications, such as the role of B vitamin status and cognitive outcomes, but lack deep critique or alternative viewpoints, reflecting moderate engagement.

ImpactModerate impact

While some express optimism about the findings influencing future therapies, the overall tone suggests the impact is seen as noteworthy but not revolutionary, indicating a moderate perceived effect.

Abstract in brief

  • The study analyzed how levels of plasma homocysteine, which indicates B vitamin status, influence the effectiveness of omega-3 fatty acids in improving cognition in people with mild to moderate Alzheimer's disease.
  • Results showed that omega-3 supplementation significantly benefited patients with lower homocysteine levels (below 117 mol/L), leading to better scores on cognitive tests (MMSE) and clinical assessments (CDRs), compared to those on placebo.
  • The findings suggest that having a healthy B vitamin status, indicated by lower homocysteine, is important for omega-3 fatty acids to effectively support cognitive function in Alzheimer's patients.]

Top posts

Most liked on X and Bluesky
Mg2+ Papi, the BowTied Mg2+
@Grimhood · X

Homocysteine Status Modifies the Treatment Effect of Omega-3 Fatty Acids on Cognition in a Randomized Clinical Trial in Mild to Moderate Alzheimer’s Disease: The OmegAD Study https://t.co/tHJkFJYpuw Full link to study: https://t.co/NXkObkzoFP

Jul 5, 2021 · 12 likes · 1 share · 133,699 followers View post →
J P Fanton
@HealthyFellow · X

#Homocysteine Status Modifies the Treatment Effect of Omega-3 Fatty Acids on #Cognition in a Randomized Clinical #Trial in Mild to Moderate #Alzheimer’s Disease Attn: ⁦@NathanMDCunha⁩ ⁦@NaumovskiNenad⁩ ⁦@DocAmen⁩ https://t.co/PdXFQueg9N

Apr 16, 2019 · 2 likes · 3 shares · 26,021 followers View post →
Nathan M D'Cunha
@NathanMDCunha · X

RT @HealthyFellow: #Homocysteine Status Modifies the Treatment Effect of Omega-3 Fatty Acids on #Cognition in a Randomized Clinical #Trial…

Apr 16, 2019 · 3 shares · 1,482 followers View post →
Prof Nenad Naumovski (PhD)
@NaumovskiNenad · X

RT @HealthyFellow: #Homocysteine Status Modifies the Treatment Effect of Omega-3 Fatty Acids on #Cognition in a Randomized Clinical #Trial…

Apr 16, 2019 · 3 shares · 1,224 followers View post →
Morgan Pfiffner
@MorganPfiffner · X

In OmegaAD trial, ppl with Alzheimer’s disease took 2.3 g of omega-3 (mostly DHA) for 6 months. Only those with lower homocysteine seemed to see cognitive benefits from taking omega-3s according to a couple tests (MMSE, CDRsob). https://t.co/Q13Y9krhtR https://t.co/QL6msuV5Yy

Jul 9, 2022 · 1,111 followers View post →
Best Health 4 You
@besthealthyou · X

RT @HealthyFellow: #Homocysteine Status Modifies the Treatment Effect of Omega-3 Fatty Acids on #Cognition in a Randomized Clinical #Trial…

Apr 17, 2019 · 3 shares · 518 followers View post →

All mentions

Morgan Pfiffner
@MorganPfiffner · X

In OmegaAD trial, ppl with Alzheimer’s disease took 2.3 g of omega-3 (mostly DHA) for 6 months. Only those with lower homocysteine seemed to see cognitive benefits from taking omega-3s according to a couple tests (MMSE, CDRsob). https://t.co/Q13Y9krhtR https://t.co/QL6msuV5Yy

Jul 9, 2022 · 1,111 followers View post →
Sophia Koltavary
@holypaprika23 · X

RT @Grimhood: Homocysteine Status Modifies the Treatment Effect of Omega-3 Fatty Acids on Cognition in a Randomized Clinical Trial in Mild…

Jul 6, 2021 · 1 share · 215 followers View post →
Mg2+ Papi, the BowTied Mg2+
@Grimhood · X

Homocysteine Status Modifies the Treatment Effect of Omega-3 Fatty Acids on Cognition in a Randomized Clinical Trial in Mild to Moderate Alzheimer’s Disease: The OmegAD Study https://t.co/tHJkFJYpuw Full link to study: https://t.co/NXkObkzoFP

Jul 5, 2021 · 12 likes · 1 share · 133,699 followers View post →
Best Health 4 You
@besthealthyou · X

RT @HealthyFellow: #Homocysteine Status Modifies the Treatment Effect of Omega-3 Fatty Acids on #Cognition in a Randomized Clinical #Trial…

Apr 17, 2019 · 3 shares · 518 followers View post →
Prof Nenad Naumovski (PhD)
@NaumovskiNenad · X

RT @HealthyFellow: #Homocysteine Status Modifies the Treatment Effect of Omega-3 Fatty Acids on #Cognition in a Randomized Clinical #Trial…

Apr 16, 2019 · 3 shares · 1,224 followers View post →
Nathan M D'Cunha
@NathanMDCunha · X

RT @HealthyFellow: #Homocysteine Status Modifies the Treatment Effect of Omega-3 Fatty Acids on #Cognition in a Randomized Clinical #Trial…

Apr 16, 2019 · 3 shares · 1,482 followers View post →
J P Fanton
@HealthyFellow · X

#Homocysteine Status Modifies the Treatment Effect of Omega-3 Fatty Acids on #Cognition in a Randomized Clinical #Trial in Mild to Moderate #Alzheimer’s Disease Attn: ⁦@NathanMDCunha⁩ ⁦@NaumovskiNenad⁩ ⁦@DocAmen⁩ https://t.co/PdXFQueg9N

Apr 16, 2019 · 2 likes · 3 shares · 26,021 followers View post →