April 2019 PMID 30977858

Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis.

Elvira D'Andrea, Spencer P Hey, Cherie L Ramirez, Aaron S Kesselheim

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Mentions

Peak: 10 in Apr 2019

across 5 sources since Apr 2019

Extended reach

1,325,511

potential audience

Total likes

17,405

Video views

905,771

Mentions per month

Apr 2019 – Oct 2024

Where it's discussed

News38 articles
X / Twitter27 posts
Facebook6 posts
YouTube2 videos
Blogs2 articles

AI synopsis

What people are saying

Several comments highlight the inconclusive or minimal benefit of niacin, with phrases like 'little role in prevention' and references to extensive prior studies with 'clear reduction in risk.' The tone varies from analytical to somewhat skeptical, emphasizing the importance of lipid factors like HDL and Lp(a), which are seen as more impactful. The choice of words such as 'interesting' and 'trip down memory lane' indicates a mix of curiosity and reflection, contributing to a nuanced understanding of how this systematic review fits into existing knowledge and ongoing debates.

AgreementModerate agreement

Most discussions acknowledge that recent evidence questions the effectiveness of niacin in reducing cardiovascular outcomes, aligning with the systematic review's findings.

InterestHigh interest

The participants show high curiosity about the role of niacin, HDL, and other lipids, reflecting engagement with detailed aspects of cardiovascular health.

EngagementModerate engagement

Several posts reference prior studies, mechanisms, and implications, indicating moderate to deep engagement with the topic’s scientific and clinical relevance.

ImpactModerate impact

While influential in shaping opinions about niacin’s clinical utility, discussions suggest the publication influences ongoing debates rather than causing a dramatic shift in established practices.

Abstract in brief

This review analyzed multiple clinical trials to assess the effectiveness of niacin, a drug used to prevent cardiovascular events, and found that it does not significantly reduce outcomes like heart attacks or strokes in patients with existing heart disease.
Despite increasing HDL ("good") cholesterol levels, the meta-analysis showed no clear evidence that niacin improves long-term cardiovascular health, suggesting its benefit might be limited in treatment settings.
The study highlights that current evidence does not support the use of niacin for cardiovascular disease prevention beyond FDA-approved uses, questioning its role in secondary prevention for patients with established cardiovascular conditions.

Read the full abstract

All mentions

Reevaluating Niacin's Role in Heart Disease Prevention and Treatment

This analysis assessed multiple clinical trials on niacin's effectiveness in preventing cardiovascular events. Despite increasing HDL cholesterol, evidence indicates limited long-term benefits, questioning its use…

Physionic · Sep 11, 2023 811,932 views

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Methylene Blue (MB) is gaining attention for its antioxidant properties. This video discusses how MB may help mitigate mitochondrial dysfunction associated with aging, potentially addressing neurodegeneration and skin…

Physionic · May 6, 2024 93,839 views

HOM3OSTASIS.com

@GPR109A · X

RT @3V3LV3: Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes A Systematic Review and Meta-analysis https://t.c…

Oct 7, 2024 · 1 share · 725 followers View post →

InfinaLife

@InfinaLife · X

Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes A Systematic Review and Meta-analysis https://t.co/3Hgxno69Ww

Oct 2, 2024 · 1 like · 1 share · 1,095 followers View post →

nancy gray

@N_Gray34 · X

RT @HeidiHmoretti: @SPDeetman Thank you. However, niacin has been studied extensively in cardiovascular disease and has clear reduction in…

Mar 25, 2024 · 2 shares · 326 followers View post →

Johnny Galtar

@JohnnyGaltar · X

RT @HeidiHmoretti: @SPDeetman Thank you. However, niacin has been studied extensively in cardiovascular disease and has clear reduction in…

Mar 23, 2024 · 2 shares · 432 followers View post →

TheHealthyRD

@HeidiHmoretti · X

@SPDeetman Thank you. However, niacin has been studied extensively in cardiovascular disease and has clear reduction in risk of CVD in 17 clinical trials: https://t.co/okKCUNiogK

Mar 23, 2024 · 1 like · 2 shares · 74,972 followers View post →

Sylvain de Koning

@KoningSylvain · X

RT @NIACUR3: Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis | Cardiolo…

Oct 31, 2023 · 1 share · 215 followers View post →

InfinaLife

@InfinaLife · X

Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis | Cardiology | JAMA Network Open | JAMA Network https://t.co/Wci8GdVAt5

Oct 29, 2023 · 2 likes · 1 share · 1,095 followers View post →

SystematicReviewBot

@EvidenceRobot · X

RT @DrPalmquist: Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis - PubM…

Feb 28, 2021 · 1 share · 6,704 followers View post →

DrRPalmquist

@DrPalmquist · X

Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis - PubMed https://t.co/zbyFF7VNHp

Feb 28, 2021 · 1 like · 1 share · 3,171 followers View post →

Injustice Forced to Plead Guilty

@InJusticeThBook · X

RT @PORTAL_Research: Assessment of the Role of Niacin in Managing Cardiovascular Disease OutcomesA Systematic Review and Meta-analysis http…

May 14, 2019 · 5 shares · 1,308 followers View post →

JAMA Network Open

@JAMANetworkOpen · X

RT @PORTAL_Research: Assessment of the Role of Niacin in Managing Cardiovascular Disease OutcomesA Systematic Review and Meta-analysis http…

May 14, 2019 · 5 shares · 25,231 followers View post →

v.hoonie

@v_hoonie · X

RT @PORTAL_Research: Assessment of the Role of Niacin in Managing Cardiovascular Disease OutcomesA Systematic Review and Meta-analysis http…

May 14, 2019 · 5 shares · 16 followers View post →

JAMA Cardiology

@JAMACardio · X

RT @PORTAL_Research: Assessment of the Role of Niacin in Managing Cardiovascular Disease OutcomesA Systematic Review and Meta-analysis http…

May 14, 2019 · 5 shares · 48,081 followers View post →

JAMA Internal Medicine

@JAMAInternalMed · X

RT @PORTAL_Research: Assessment of the Role of Niacin in Managing Cardiovascular Disease OutcomesA Systematic Review and Meta-analysis http…

May 14, 2019 · 5 shares · 108,440 followers View post →

Program On Regulation, Therapeutics, And Law

@PORTAL_Research · X

Assessment of the Role of Niacin in Managing Cardiovascular Disease OutcomesA Systematic Review and Meta-analysis https://t.co/KB5Dn5PhMG via @JAMANetworkOpen

May 13, 2019 · 4 likes · 5 shares · 2,735 followers View post →

Wood Deming, MD

@wooddeming · X

ALLMEDx | Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes We are saying niacin has little role in prevention while HDL, Lp(a), LDL particle size and other dyslipidemias do play a role...?? https://t.co/wPH66Sda6B

May 2, 2019 · 953 followers View post →

Wood Deming, MD

@wooddeming · X

ALLMEDx | Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes I think it interesting that we say niacin has little role in secondary prevention when we know the role of HDL in atherosclerosis and Lo(a) getting mite attention. https://t.co/wPH66Sda6B

May 2, 2019 · 953 followers View post →

SystematicReviewBot

@EvidenceRobot · X

RT @drsilenzi: Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis. | Acute…

Apr 15, 2019 · 1 share · 6,704 followers View post →

Andrea Silenzi

@drsilenzi · X

Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis. | Acute Coronary Syndromes | JAMA Network Open | JAMA Network | ⁦@harvardmed⁩ https://t.co/jbI9Adun1C

Apr 15, 2019 · 1 share · 5,779 followers View post →

Dr. Martha Gulati ♥️

@DrMarthaGulati · X

RT @HeartOTXHeartMD: Nice trip down #Niacin Memory Lane: Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Sy…

Apr 14, 2019 · 7 shares · 65,136 followers View post →

Christine Chapman

@cchapman1957 · X

RT @HeartOTXHeartMD: Nice trip down #Niacin Memory Lane: Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Sy…

Apr 14, 2019 · 7 shares · 313 followers View post →

Stefania Arciello

@StefaniaArciell · X

Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes https://t.co/fid782XVGm

Apr 14, 2019 · 1 like · 1,940 followers View post →

Mihai Trofenciuc

@MihaiTrofenciuc · X

RT @HeartOTXHeartMD: Nice trip down #Niacin Memory Lane: Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Sy…

Apr 14, 2019 · 7 shares · 3,865 followers View post →

IANCARDIOLOGY

@CardioIAN · X

RT @HeartOTXHeartMD: Nice trip down #Niacin Memory Lane: Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Sy…

Apr 14, 2019 · 7 shares · 8,256 followers View post →

Linda

@wordfinga · X

RT @HeartOTXHeartMD: Nice trip down #Niacin Memory Lane: Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Sy…

Apr 13, 2019 · 7 shares · 4,581 followers View post →

SystematicReviewBot

@EvidenceRobot · X

RT @HeartOTXHeartMD: Nice trip down #Niacin Memory Lane: Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Sy…

Apr 13, 2019 · 7 shares · 6,704 followers View post →

John P Erwin III MD MBA MACC (#BigPoppy )

@HeartOTXHeartMD · X

Nice trip down #Niacin Memory Lane: Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis. https://t.co/Q4P2F8wUgE

Apr 13, 2019 · 14 likes · 7 shares · 39,825 followers View post →

Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Reevaluating Niacin's Role in Heart Disease Prevention and Treatment

Exploring Methylene Blue's Role in Combating Aging Effects